JP2003508527A5 - - Google Patents
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- Publication number
- JP2003508527A5 JP2003508527A5 JP2001522211A JP2001522211A JP2003508527A5 JP 2003508527 A5 JP2003508527 A5 JP 2003508527A5 JP 2001522211 A JP2001522211 A JP 2001522211A JP 2001522211 A JP2001522211 A JP 2001522211A JP 2003508527 A5 JP2003508527 A5 JP 2003508527A5
- Authority
- JP
- Japan
- Prior art keywords
- group
- ring atoms
- ring
- unsubstituted
- nhcoch
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
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- 125000006413 ring segment Chemical group 0.000 description 32
- 150000001875 compounds Chemical class 0.000 description 28
- 125000001424 substituent group Chemical group 0.000 description 22
- 125000000217 alkyl group Chemical group 0.000 description 18
- 125000000623 heterocyclic group Chemical group 0.000 description 17
- 125000002837 carbocyclic group Chemical group 0.000 description 15
- 229920006395 saturated elastomer Polymers 0.000 description 13
- 125000005842 heteroatom Chemical group 0.000 description 10
- 125000001183 hydrocarbyl group Chemical group 0.000 description 9
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 description 9
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 description 8
- 125000003118 aryl group Chemical group 0.000 description 7
- -1 2-hydroxyphenyl Chemical group 0.000 description 6
- 239000003814 drug Substances 0.000 description 6
- 238000004519 manufacturing process Methods 0.000 description 5
- 229940034982 antineoplastic agent Drugs 0.000 description 4
- 239000002246 antineoplastic agent Substances 0.000 description 4
- 125000003349 3-pyridyl group Chemical group N1=C([H])C([*])=C([H])C([H])=C1[H] 0.000 description 3
- 125000000339 4-pyridyl group Chemical group N1=C([H])C([H])=C([*])C([H])=C1[H] 0.000 description 3
- ZDZOTLJHXYCWBA-VCVYQWHSSA-N N-debenzoyl-N-(tert-butoxycarbonyl)-10-deacetyltaxol Chemical compound O([C@H]1[C@H]2[C@@](C([C@H](O)C3=C(C)[C@@H](OC(=O)[C@H](O)[C@@H](NC(=O)OC(C)(C)C)C=4C=CC=CC=4)C[C@]1(O)C3(C)C)=O)(C)[C@@H](O)C[C@H]1OC[C@]12OC(=O)C)C(=O)C1=CC=CC=C1 ZDZOTLJHXYCWBA-VCVYQWHSSA-N 0.000 description 3
- 229930012538 Paclitaxel Natural products 0.000 description 3
- 125000005336 allyloxy group Chemical group 0.000 description 3
- 230000001028 anti-proliverative effect Effects 0.000 description 3
- 229960003668 docetaxel Drugs 0.000 description 3
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 3
- 229960001592 paclitaxel Drugs 0.000 description 3
- 239000008194 pharmaceutical composition Substances 0.000 description 3
- RCINICONZNJXQF-MZXODVADSA-N taxol Chemical compound O([C@@H]1[C@@]2(C[C@@H](C(C)=C(C2(C)C)[C@H](C([C@]2(C)[C@@H](O)C[C@H]3OC[C@]3([C@H]21)OC(C)=O)=O)OC(=O)C)OC(=O)[C@H](O)[C@@H](NC(=O)C=1C=CC=CC=1)C=1C=CC=CC=1)O)C(=O)C1=CC=CC=C1 RCINICONZNJXQF-MZXODVADSA-N 0.000 description 3
- 206010028980 Neoplasm Diseases 0.000 description 2
- 208000035269 cancer or benign tumor Diseases 0.000 description 2
- 125000004432 carbon atom Chemical group C* 0.000 description 2
- 229910052757 nitrogen Inorganic materials 0.000 description 2
- 150000003839 salts Chemical class 0.000 description 2
- 239000012453 solvate Substances 0.000 description 2
- UNDYVEDXFDFDRI-UHFFFAOYSA-N 1-(3,4,5-trimethoxyphenyl)prop-2-en-1-one Chemical compound COC1=CC(C(=O)C=C)=CC(OC)=C1OC UNDYVEDXFDFDRI-UHFFFAOYSA-N 0.000 description 1
- 125000004182 2-chlorophenyl group Chemical group [H]C1=C([H])C(Cl)=C(*)C([H])=C1[H] 0.000 description 1
- 125000002941 2-furyl group Chemical group O1C([*])=C([H])C([H])=C1[H] 0.000 description 1
- 125000003762 3,4-dimethoxyphenyl group Chemical group [H]C1=C([H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C([H])=C1* 0.000 description 1
- LAWDSOAXOCOSPV-UHFFFAOYSA-N 3-(3-methylbut-2-enoxy)-4-(3-phenylprop-2-enoyl)xanthen-9-one Chemical compound CC(C)=CCOC1=CC=C(C(C2=CC=CC=C2O2)=O)C2=C1C(=O)C=CC1=CC=CC=C1 LAWDSOAXOCOSPV-UHFFFAOYSA-N 0.000 description 1
- CXKQXJPYPVCTRV-UHFFFAOYSA-N 3-(3-methylbut-2-enoxy)-4-[3-(3,4,5-trimethoxyphenyl)prop-2-enoyl]xanthen-9-one Chemical compound COC1=C(OC)C(OC)=CC(C=CC(=O)C=2C3=C(C(C4=CC=CC=C4O3)=O)C=CC=2OCC=C(C)C)=C1 CXKQXJPYPVCTRV-UHFFFAOYSA-N 0.000 description 1
- AEQVLDDVEGAKDQ-UHFFFAOYSA-N 4-(3-phenylprop-2-enoyl)-3-prop-2-enoxyxanthen-9-one Chemical compound C=CCOC1=CC=C(C(C2=CC=CC=C2O2)=O)C2=C1C(=O)C=CC1=CC=CC=C1 AEQVLDDVEGAKDQ-UHFFFAOYSA-N 0.000 description 1
- NVLXRSGZLQABNZ-UHFFFAOYSA-N 4-[3-(3-methoxyphenyl)prop-2-enoyl]-3-(3-methylbut-2-enoxy)xanthen-9-one Chemical compound COC1=CC=CC(C=CC(=O)C=2C3=C(C(C4=CC=CC=C4O3)=O)C=CC=2OCC=C(C)C)=C1 NVLXRSGZLQABNZ-UHFFFAOYSA-N 0.000 description 1
- 125000004172 4-methoxyphenyl group Chemical group [H]C1=C([H])C(OC([H])([H])[H])=C([H])C([H])=C1* 0.000 description 1
- 208000001132 Osteoporosis Diseases 0.000 description 1
- 125000006615 aromatic heterocyclic group Chemical group 0.000 description 1
- 125000004429 atom Chemical group 0.000 description 1
- 210000000481 breast Anatomy 0.000 description 1
- 238000002648 combination therapy Methods 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 description 1
- 125000001041 indolyl group Chemical group 0.000 description 1
- 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 description 1
- 230000009245 menopause Effects 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 125000004123 n-propyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])* 0.000 description 1
- 125000004433 nitrogen atom Chemical group N* 0.000 description 1
- 210000001672 ovary Anatomy 0.000 description 1
- 229910052760 oxygen Inorganic materials 0.000 description 1
- 125000003854 p-chlorophenyl group Chemical group [H]C1=C([H])C(*)=C([H])C([H])=C1Cl 0.000 description 1
- 125000001037 p-tolyl group Chemical group [H]C1=C([H])C(=C([H])C([H])=C1*)C([H])([H])[H] 0.000 description 1
- 239000000546 pharmaceutical excipient Substances 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
- 208000016691 refractory malignant neoplasm Diseases 0.000 description 1
- 229910052717 sulfur Inorganic materials 0.000 description 1
- 125000001544 thienyl group Chemical group 0.000 description 1
- 125000001680 trimethoxyphenyl group Chemical group 0.000 description 1
- 210000004291 uterus Anatomy 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB9920910.8 | 1999-09-03 | ||
| GBGB9920910.8A GB9920910D0 (en) | 1999-09-03 | 1999-09-03 | Novel chalcones |
| PCT/EP2000/008366 WO2001017988A1 (en) | 1999-09-03 | 2000-08-28 | Novel chalcones |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2003508527A JP2003508527A (ja) | 2003-03-04 |
| JP2003508527A5 true JP2003508527A5 (enExample) | 2007-09-06 |
Family
ID=10860346
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2001522211A Withdrawn JP2003508527A (ja) | 1999-09-03 | 2000-08-28 | 新規カルコン類 |
Country Status (21)
| Country | Link |
|---|---|
| US (1) | US6620842B2 (enExample) |
| EP (1) | EP1212315B1 (enExample) |
| JP (1) | JP2003508527A (enExample) |
| KR (1) | KR100819576B1 (enExample) |
| CN (1) | CN1177843C (enExample) |
| AT (1) | ATE235483T1 (enExample) |
| AU (1) | AU776226B2 (enExample) |
| CA (1) | CA2382130A1 (enExample) |
| CZ (1) | CZ2002787A3 (enExample) |
| DE (1) | DE60001851T2 (enExample) |
| DK (1) | DK1212315T3 (enExample) |
| ES (1) | ES2193106T3 (enExample) |
| GB (1) | GB9920910D0 (enExample) |
| HK (1) | HK1043999B (enExample) |
| HU (1) | HUP0202579A3 (enExample) |
| NO (1) | NO20021049L (enExample) |
| PL (1) | PL353064A1 (enExample) |
| PT (1) | PT1212315E (enExample) |
| RU (1) | RU2252938C2 (enExample) |
| SK (1) | SK3112002A3 (enExample) |
| WO (1) | WO2001017988A1 (enExample) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP4664597B2 (ja) | 2002-04-17 | 2011-04-06 | サイトキネティクス・インコーポレーテッド | 化合物、組成物および方法 |
| US20030229136A1 (en) * | 2002-04-18 | 2003-12-11 | Nurulain Zaveri | Novel flavanoids as chemotherapeutic, chemopreventive, and antiangiogenic agents |
| US7638554B2 (en) * | 2002-04-18 | 2009-12-29 | Sri International | Flavanoids as chemotherapeutic, chemopreventive, and antiangiogenic agents |
| ATE423110T1 (de) | 2002-07-17 | 2009-03-15 | Cytokinetics Inc | Verbindungen, zusammensetzungen und verfahren zur behandlung von zellulären proliferativen erkrankungen |
| US6864264B1 (en) * | 2002-08-20 | 2005-03-08 | Gloria L. Anderson | 1-adamantyl chalcones for the treatment of proliferative disorders |
| CN100336797C (zh) * | 2005-08-19 | 2007-09-12 | 浙江大学 | 四取代查耳酮衍生物及制备方法和用途 |
| WO2013127361A1 (en) | 2012-03-01 | 2013-09-06 | The Hong Kong Polytechnic University | Alkyne-, azide- and triazole-containing flavonoids as modulators for multidrug resistance in cancers |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0459983A1 (en) * | 1988-12-21 | 1991-12-11 | PHARMACIA & UPJOHN COMPANY | Antiatherosclerotic and antithrombotic 1-benzopyran-4-ones and 2-amino-1,3-benzoxazine-4-ones |
| US5023341A (en) * | 1989-09-19 | 1991-06-11 | Allergan, Inc. | Compounds having a disubstituted acetylene moiety and retinoic acid-like biological activity |
| US4996230A (en) * | 1990-02-16 | 1991-02-26 | Eli Lilly And Company | Leukotriene antagonists |
| JPH05509078A (ja) * | 1990-05-17 | 1993-12-16 | ベイラー カレッジ オブ メディシン | 成長抑制因とガンおよび細胞増殖性疾患措置法 |
| IT1271301B (it) * | 1994-12-20 | 1997-05-27 | Indena Spa | Calconi naturali e sintetici e loro esteri ad attivita' antiproliferativa nei tumori dell'utero,dell'ovaio e del seno e formulazioni che li contengono |
| US5525625A (en) | 1995-01-24 | 1996-06-11 | Warner-Lambert Company | 2-(2-Amino-3-methoxyphenyl)-4-oxo-4H-[1]benzopyran for treating proliferative disorders |
-
1999
- 1999-09-03 GB GBGB9920910.8A patent/GB9920910D0/en not_active Ceased
-
2000
- 2000-08-28 HU HU0202579A patent/HUP0202579A3/hu unknown
- 2000-08-28 CA CA002382130A patent/CA2382130A1/en not_active Abandoned
- 2000-08-28 AU AU75109/00A patent/AU776226B2/en not_active Ceased
- 2000-08-28 PT PT00964042T patent/PT1212315E/pt unknown
- 2000-08-28 KR KR1020027002798A patent/KR100819576B1/ko not_active Expired - Fee Related
- 2000-08-28 DK DK00964042T patent/DK1212315T3/da active
- 2000-08-28 PL PL00353064A patent/PL353064A1/xx not_active IP Right Cessation
- 2000-08-28 DE DE60001851T patent/DE60001851T2/de not_active Expired - Fee Related
- 2000-08-28 EP EP00964042A patent/EP1212315B1/en not_active Expired - Lifetime
- 2000-08-28 JP JP2001522211A patent/JP2003508527A/ja not_active Withdrawn
- 2000-08-28 SK SK311-2002A patent/SK3112002A3/sk unknown
- 2000-08-28 WO PCT/EP2000/008366 patent/WO2001017988A1/en not_active Ceased
- 2000-08-28 ES ES00964042T patent/ES2193106T3/es not_active Expired - Lifetime
- 2000-08-28 CZ CZ2002787A patent/CZ2002787A3/cs unknown
- 2000-08-28 RU RU2002108566/04A patent/RU2252938C2/ru not_active IP Right Cessation
- 2000-08-28 AT AT00964042T patent/ATE235483T1/de not_active IP Right Cessation
- 2000-08-28 CN CNB008123039A patent/CN1177843C/zh not_active Expired - Fee Related
- 2000-08-28 HK HK02105661.5A patent/HK1043999B/en unknown
-
2002
- 2002-02-15 US US10/075,626 patent/US6620842B2/en not_active Expired - Fee Related
- 2002-03-01 NO NO20021049A patent/NO20021049L/no not_active Application Discontinuation
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