JP2003508435A - インスリン抵抗性の治療薬を製造するためのアミノ酸の使用 - Google Patents
インスリン抵抗性の治療薬を製造するためのアミノ酸の使用Info
- Publication number
- JP2003508435A JP2003508435A JP2001519903A JP2001519903A JP2003508435A JP 2003508435 A JP2003508435 A JP 2003508435A JP 2001519903 A JP2001519903 A JP 2001519903A JP 2001519903 A JP2001519903 A JP 2001519903A JP 2003508435 A JP2003508435 A JP 2003508435A
- Authority
- JP
- Japan
- Prior art keywords
- insulin
- use according
- amino acids
- ile
- therapeutic agent
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000003814 drug Substances 0.000 title claims abstract description 26
- 150000001413 amino acids Chemical class 0.000 title claims abstract description 21
- 206010022489 Insulin Resistance Diseases 0.000 title claims abstract description 20
- 208000001072 type 2 diabetes mellitus Diseases 0.000 title claims abstract description 20
- 229940124597 therapeutic agent Drugs 0.000 title claims 5
- 229940079593 drug Drugs 0.000 claims abstract description 12
- 150000002596 lactones Chemical class 0.000 claims abstract description 11
- NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 claims description 123
- 230000000694 effects Effects 0.000 claims description 75
- 102000004877 Insulin Human genes 0.000 claims description 60
- 108090001061 Insulin Proteins 0.000 claims description 60
- 229940125396 insulin Drugs 0.000 claims description 60
- OSCCDBFHNMXNME-UHFFFAOYSA-N gamma-hydroxyisoleucine Natural products CC(O)C(C)C(N)C(O)=O OSCCDBFHNMXNME-UHFFFAOYSA-N 0.000 claims description 51
- 102000003993 Phosphatidylinositol 3-kinases Human genes 0.000 claims description 36
- 108090000430 Phosphatidylinositol 3-kinases Proteins 0.000 claims description 36
- 102000003746 Insulin Receptor Human genes 0.000 claims description 23
- 108010001127 Insulin Receptor Proteins 0.000 claims description 23
- 230000009471 action Effects 0.000 claims description 23
- 150000001875 compounds Chemical class 0.000 claims description 16
- 102100025087 Insulin receptor substrate 1 Human genes 0.000 claims description 12
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- 108090000608 Phosphoric Monoester Hydrolases Proteins 0.000 claims description 12
- 238000004519 manufacturing process Methods 0.000 claims description 12
- 101710201824 Insulin receptor substrate 1 Proteins 0.000 claims description 11
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- OSCCDBFHNMXNME-YUPRTTJUSA-N (4S)-4-hydroxy-L-isoleucine zwitterion Chemical compound C[C@H](O)[C@H](C)[C@H](N)C(O)=O OSCCDBFHNMXNME-YUPRTTJUSA-N 0.000 description 49
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- 102000002727 Protein Tyrosine Phosphatase Human genes 0.000 description 5
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- 239000000758 substrate Substances 0.000 description 5
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 4
- 108010034219 Insulin Receptor Substrate Proteins Proteins 0.000 description 4
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- 108091008606 PDGF receptors Proteins 0.000 description 3
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- 102000004022 Protein-Tyrosine Kinases Human genes 0.000 description 3
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- 230000003213 activating effect Effects 0.000 description 3
- 150000001412 amines Chemical class 0.000 description 3
- 238000006243 chemical reaction Methods 0.000 description 3
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- 239000012133 immunoprecipitate Substances 0.000 description 3
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- 238000007912 intraperitoneal administration Methods 0.000 description 3
- 230000001960 triggered effect Effects 0.000 description 3
- 238000011684 zucker rat (obese) Methods 0.000 description 3
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 2
- 102000004190 Enzymes Human genes 0.000 description 2
- 108090000790 Enzymes Proteins 0.000 description 2
- 101000879758 Homo sapiens Sjoegren syndrome nuclear autoantigen 1 Proteins 0.000 description 2
- AGPKZVBTJJNPAG-WHFBIAKZSA-N L-isoleucine Chemical compound CC[C@H](C)[C@H](N)C(O)=O AGPKZVBTJJNPAG-WHFBIAKZSA-N 0.000 description 2
- 102000043136 MAP kinase family Human genes 0.000 description 2
- 108091054455 MAP kinase family Proteins 0.000 description 2
- DFPAKSUCGFBDDF-UHFFFAOYSA-N Nicotinamide Chemical compound NC(=O)C1=CC=CN=C1 DFPAKSUCGFBDDF-UHFFFAOYSA-N 0.000 description 2
- 108091007960 PI3Ks Proteins 0.000 description 2
- 102100037330 Sjoegren syndrome nuclear autoantigen 1 Human genes 0.000 description 2
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 2
- 244000250129 Trigonella foenum graecum Species 0.000 description 2
- 235000001484 Trigonella foenum graecum Nutrition 0.000 description 2
- 229940093740 amino acid and derivative Drugs 0.000 description 2
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- 102000058061 Glucose Transporter Type 4 Human genes 0.000 description 1
- 238000012404 In vitro experiment Methods 0.000 description 1
- 208000031773 Insulin resistance syndrome Diseases 0.000 description 1
- 229940122355 Insulin sensitizer Drugs 0.000 description 1
- OUYCCCASQSFEME-QMMMGPOBSA-N L-tyrosine Chemical compound OC(=O)[C@@H](N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-QMMMGPOBSA-N 0.000 description 1
- 108091005804 Peptidases Proteins 0.000 description 1
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- 102000010780 Platelet-Derived Growth Factor Human genes 0.000 description 1
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- 239000004365 Protease Substances 0.000 description 1
- 102100037486 Reverse transcriptase/ribonuclease H Human genes 0.000 description 1
- 108091006300 SLC2A4 Proteins 0.000 description 1
- ZSJLQEPLLKMAKR-UHFFFAOYSA-N Streptozotocin Natural products O=NN(C)C(=O)NC1C(O)OC(CO)C(O)C1O ZSJLQEPLLKMAKR-UHFFFAOYSA-N 0.000 description 1
- 206010067584 Type 1 diabetes mellitus Diseases 0.000 description 1
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- 239000005556 hormone Substances 0.000 description 1
- 125000002349 hydroxyamino group Chemical group [H]ON([H])[*] 0.000 description 1
- 238000001114 immunoprecipitation Methods 0.000 description 1
- 230000003914 insulin secretion Effects 0.000 description 1
- 230000002473 insulinotropic effect Effects 0.000 description 1
- 230000003834 intracellular effect Effects 0.000 description 1
- 238000007918 intramuscular administration Methods 0.000 description 1
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- 238000001990 intravenous administration Methods 0.000 description 1
- 229960000310 isoleucine Drugs 0.000 description 1
- AGPKZVBTJJNPAG-UHFFFAOYSA-N isoleucine Natural products CCC(C)C(N)C(O)=O AGPKZVBTJJNPAG-UHFFFAOYSA-N 0.000 description 1
- 201000007270 liver cancer Diseases 0.000 description 1
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- 229960003966 nicotinamide Drugs 0.000 description 1
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- ZSJLQEPLLKMAKR-GKHCUFPYSA-N streptozocin Chemical compound O=NN(C)C(=O)N[C@H]1[C@@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O ZSJLQEPLLKMAKR-GKHCUFPYSA-N 0.000 description 1
- 229960001052 streptozocin Drugs 0.000 description 1
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- 150000003626 triacylglycerols Chemical class 0.000 description 1
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- GPRLSGONYQIRFK-MNYXATJNSA-N triton Chemical compound [3H+] GPRLSGONYQIRFK-MNYXATJNSA-N 0.000 description 1
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- 125000001493 tyrosinyl group Chemical group [H]OC1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])(N([H])[H])C(*)=O 0.000 description 1
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
- A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
- A61K31/198—Alpha-amino acids, e.g. alanine or edetic acid [EDTA]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
- A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
Landscapes
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Diabetes (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Hematology (AREA)
- Endocrinology (AREA)
- Obesity (AREA)
- Emergency Medicine (AREA)
- Child & Adolescent Psychology (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Peptides Or Proteins (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR9910874A FR2797767B1 (fr) | 1999-08-27 | 1999-08-27 | Utilisation d'acides amines pour la fabrication de medicaments destines au traitement des insulino-resistances |
| FR99/10874 | 1999-08-27 | ||
| PCT/FR2000/002361 WO2001015689A1 (fr) | 1999-08-27 | 2000-08-23 | Utilisation d'acides amines pour la fabrication de medicaments destines au traitement des insulino-resistances |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| JP2003508435A true JP2003508435A (ja) | 2003-03-04 |
Family
ID=9549397
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2001519903A Pending JP2003508435A (ja) | 1999-08-27 | 2000-08-23 | インスリン抵抗性の治療薬を製造するためのアミノ酸の使用 |
Country Status (15)
| Country | Link |
|---|---|
| US (2) | US7402611B1 (da) |
| EP (2) | EP1421937A1 (da) |
| JP (1) | JP2003508435A (da) |
| CN (1) | CN1208055C (da) |
| AT (1) | ATE281159T1 (da) |
| AU (1) | AU7015700A (da) |
| CA (1) | CA2382835A1 (da) |
| DE (1) | DE60015560T2 (da) |
| DK (1) | DK1206257T3 (da) |
| ES (1) | ES2231247T3 (da) |
| FR (1) | FR2797767B1 (da) |
| HK (1) | HK1052456A1 (da) |
| PT (1) | PT1206257E (da) |
| WO (1) | WO2001015689A1 (da) |
| ZA (1) | ZA200201619B (da) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2008500955A (ja) * | 2003-10-27 | 2008-01-17 | イノディア インコーポレイテッド | 糖尿病の治療に使用するための方法及び組成物 |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7338675B2 (en) * | 2002-05-10 | 2008-03-04 | Tsi Health Sciences, Inc. | Fenugreek seed bio-active compositions and methods for extracting same |
| FR2847897B1 (fr) * | 2002-12-02 | 2006-02-24 | Centre Nat Rech Scient | Procede de preparation de diasteroisomeres et d'enantiomeres de la 4-hydroxyisoleucine et de ses derives |
| KR20050110018A (ko) | 2003-03-19 | 2005-11-22 | 교와 핫꼬 고교 가부시끼가이샤 | 당뇨병 치료제 |
| FR2856297B1 (fr) * | 2003-06-18 | 2005-08-05 | Caster | Utilisation de (2s,3r,4s)-4-hydroxyisoleucine dans des compositions cosmetiques pour application topique |
| US7645466B2 (en) | 2004-03-02 | 2010-01-12 | Tsi Group Limited | Methods for deriving, isolating, and/or extracting amino acid compositions from Fenugreek seed |
| US20060057228A1 (en) * | 2004-07-09 | 2006-03-16 | Pure World Botanicals, Inc. | Weight loss composition |
| BRPI0607140A2 (pt) * | 2005-02-18 | 2009-08-11 | Innodia Inc | composto, uso do composto e/ou uso de um sal, lactona ou pró-medicamento farmaceuticamente aceitável do dito composto, composição farmacêutica, kit farmacêutico, método para estimular a captação de glicose pelas células musculares e/ou células de adipócito, método para estimular a secreção de insulina pelas células pancreáticas células-(beta) e método para o tratamento de um mamìfero que tem um distúrbio do metabolismo de carboidratos ou de lipìdios |
| WO2006131836A2 (en) * | 2005-03-22 | 2006-12-14 | Innodia Inc. | Compounds and compositions for use in the prevention and treatment of obesity and related syndromes |
| WO2007107008A1 (en) * | 2006-03-22 | 2007-09-27 | Innodia Inc. | Compounds and compositions for use in the prevention and treatment of disorders of fat metabolism and obesity |
| US20100124583A1 (en) * | 2008-04-30 | 2010-05-20 | Xyleco, Inc. | Processing biomass |
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| JPH06157302A (ja) * | 1992-09-07 | 1994-06-03 | Lab Monal | 非インスリン依存性糖尿病治療を目的としたインスリン分泌刺激組成物 |
| WO1997032577A1 (fr) * | 1996-03-08 | 1997-09-12 | Societe Civile De Gestion Jouvenet | Composition antidiabetique a base de (2s, 3r, 4s)4-hydroxyisoleucine |
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| SU1011126A1 (ru) * | 1981-07-14 | 1983-04-15 | Всесоюзный научно-исследовательский и испытательный институт медицинской техники | Средство дл лечени сахарного диабета |
| US5178867A (en) * | 1991-08-19 | 1993-01-12 | Alza Corporation | Dosage form for delivering drug in short-time period |
| US5591709A (en) | 1991-08-30 | 1997-01-07 | Life Medical Sciences, Inc. | Compositions and methods for treating wounds |
| IL108583A (en) | 1994-02-07 | 1997-06-10 | Yissum Res Dev Co | Galactomannan emulsions and comestible products containing the same |
| GB9517443D0 (en) * | 1994-12-17 | 1995-10-25 | Univ Nottingham | Increasing creatine and glycogen concentration in muscle |
| WO1998021592A1 (en) * | 1996-11-13 | 1998-05-22 | Receptron Corporation | Assays for non-insulin dependent diabetes |
| ES2242995T3 (es) | 1997-01-15 | 2005-11-16 | Telik, Inc. | Moduladores de la actividad del receptor de la insulina. |
| CA2206157C (en) | 1997-05-26 | 2000-06-13 | Cheng, Peter | Method of extraction of commercially valuable fractions of fenugreek |
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2000
- 2000-08-23 DE DE60015560T patent/DE60015560T2/de not_active Expired - Fee Related
- 2000-08-23 AU AU70157/00A patent/AU7015700A/en not_active Abandoned
- 2000-08-23 WO PCT/FR2000/002361 patent/WO2001015689A1/fr active IP Right Grant
- 2000-08-23 EP EP03291523A patent/EP1421937A1/fr not_active Withdrawn
- 2000-08-23 DK DK00958726T patent/DK1206257T3/da active
- 2000-08-23 AT AT00958726T patent/ATE281159T1/de not_active IP Right Cessation
- 2000-08-23 CN CNB008133166A patent/CN1208055C/zh not_active Expired - Fee Related
- 2000-08-23 EP EP00958726A patent/EP1206257B1/fr not_active Expired - Lifetime
- 2000-08-23 JP JP2001519903A patent/JP2003508435A/ja active Pending
- 2000-08-23 PT PT00958726T patent/PT1206257E/pt unknown
- 2000-08-23 US US10/069,574 patent/US7402611B1/en not_active Expired - Fee Related
- 2000-08-23 CA CA002382835A patent/CA2382835A1/fr not_active Abandoned
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- 2002-11-22 HK HK02108489A patent/HK1052456A1/xx not_active IP Right Cessation
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| WO1997032577A1 (fr) * | 1996-03-08 | 1997-09-12 | Societe Civile De Gestion Jouvenet | Composition antidiabetique a base de (2s, 3r, 4s)4-hydroxyisoleucine |
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| JP2008500955A (ja) * | 2003-10-27 | 2008-01-17 | イノディア インコーポレイテッド | 糖尿病の治療に使用するための方法及び組成物 |
Also Published As
| Publication number | Publication date |
|---|---|
| CN1208055C (zh) | 2005-06-29 |
| EP1206257A1 (fr) | 2002-05-22 |
| US20080287344A1 (en) | 2008-11-20 |
| CN1376062A (zh) | 2002-10-23 |
| DK1206257T3 (da) | 2005-03-14 |
| FR2797767A1 (fr) | 2001-03-02 |
| DE60015560T2 (de) | 2005-12-15 |
| WO2001015689A1 (fr) | 2001-03-08 |
| US7402611B1 (en) | 2008-07-22 |
| ATE281159T1 (de) | 2004-11-15 |
| HK1052456A1 (en) | 2003-09-19 |
| ZA200201619B (en) | 2003-07-30 |
| ES2231247T3 (es) | 2005-05-16 |
| EP1421937A1 (fr) | 2004-05-26 |
| PT1206257E (pt) | 2005-03-31 |
| CA2382835A1 (fr) | 2001-03-08 |
| AU7015700A (en) | 2001-03-26 |
| FR2797767B1 (fr) | 2002-06-14 |
| EP1206257B1 (fr) | 2004-11-03 |
| DE60015560D1 (de) | 2004-12-09 |
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