JP2003507389A5 - - Google Patents
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- Publication number
- JP2003507389A5 JP2003507389A5 JP2001517554A JP2001517554A JP2003507389A5 JP 2003507389 A5 JP2003507389 A5 JP 2003507389A5 JP 2001517554 A JP2001517554 A JP 2001517554A JP 2001517554 A JP2001517554 A JP 2001517554A JP 2003507389 A5 JP2003507389 A5 JP 2003507389A5
- Authority
- JP
- Japan
- Prior art keywords
- gly
- arg
- seq
- cys
- asp
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000000203 mixture Substances 0.000 description 25
- 150000001875 compounds Chemical class 0.000 description 23
- 108090000190 Thrombin Proteins 0.000 description 21
- 150000001413 amino acids Chemical group 0.000 description 19
- 238000000034 method Methods 0.000 description 18
- 235000001014 amino acid Nutrition 0.000 description 15
- 229940024606 amino acid Drugs 0.000 description 15
- 229960004072 thrombin Drugs 0.000 description 13
- XUJNEKJLAYXESH-REOHCLBHSA-N L-Cysteine Chemical compound SC[C@H](N)C(O)=O XUJNEKJLAYXESH-REOHCLBHSA-N 0.000 description 8
- 235000018417 cysteine Nutrition 0.000 description 8
- XUJNEKJLAYXESH-UHFFFAOYSA-N cysteine Natural products SCC(N)C(O)=O XUJNEKJLAYXESH-UHFFFAOYSA-N 0.000 description 8
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 description 5
- 230000002401 inhibitory effect Effects 0.000 description 5
- 101001098529 Homo sapiens Proteinase-activated receptor 1 Proteins 0.000 description 3
- 101000713169 Homo sapiens Solute carrier family 52, riboflavin transporter, member 2 Proteins 0.000 description 3
- 102100036862 Solute carrier family 52, riboflavin transporter, member 2 Human genes 0.000 description 3
- 208000007536 Thrombosis Diseases 0.000 description 3
- 230000004913 activation Effects 0.000 description 2
- 210000004027 cell Anatomy 0.000 description 2
- 229950003499 fibrin Drugs 0.000 description 2
- 210000002950 fibroblast Anatomy 0.000 description 2
- 210000005260 human cell Anatomy 0.000 description 2
- 108090000765 processed proteins & peptides Proteins 0.000 description 2
- 208000010110 spontaneous platelet aggregation Diseases 0.000 description 2
- DCXYFEDJOCDNAF-UHFFFAOYSA-N Asparagine Natural products OC(=O)C(N)CC(N)=O DCXYFEDJOCDNAF-UHFFFAOYSA-N 0.000 description 1
- 102000009123 Fibrin Human genes 0.000 description 1
- 108010073385 Fibrin Proteins 0.000 description 1
- BWGVNKXGVNDBDI-UHFFFAOYSA-N Fibrin monomer Chemical compound CNC(=O)CNC(=O)CN BWGVNKXGVNDBDI-UHFFFAOYSA-N 0.000 description 1
- DCXYFEDJOCDNAF-REOHCLBHSA-N L-asparagine Chemical compound OC(=O)[C@@H](N)CC(N)=O DCXYFEDJOCDNAF-REOHCLBHSA-N 0.000 description 1
- 230000002776 aggregation Effects 0.000 description 1
- 238000004220 aggregation Methods 0.000 description 1
- 229960001230 asparagine Drugs 0.000 description 1
- 235000009582 asparagine Nutrition 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 210000004958 brain cell Anatomy 0.000 description 1
- 210000002889 endothelial cell Anatomy 0.000 description 1
- 230000027425 release of sequestered calcium ion into cytosol Effects 0.000 description 1
- 210000000329 smooth muscle myocyte Anatomy 0.000 description 1
- 230000000638 stimulation Effects 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US09/375,808 | 1999-08-17 | ||
| US09/375,808 US6544750B1 (en) | 1999-08-17 | 1999-08-17 | Peptide analogs as selective inhibitors of thrombin activation of protease activated receptor 1 |
| PCT/US2000/040669 WO2001012656A1 (en) | 1999-08-17 | 2000-08-17 | Peptide analogs as selective inhibitors of thrombin activation of protease activated receptor 1 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2003507389A JP2003507389A (ja) | 2003-02-25 |
| JP2003507389A5 true JP2003507389A5 (enExample) | 2007-10-11 |
Family
ID=23482441
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2001517554A Pending JP2003507389A (ja) | 1999-08-17 | 2000-08-17 | プロテアーゼ活性化レセプター１のトロンビン活性の選択的インヒビターとしてのペプチドアナログ |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US6544750B1 (enExample) |
| EP (1) | EP1212352B1 (enExample) |
| JP (1) | JP2003507389A (enExample) |
| AT (1) | ATE342914T1 (enExample) |
| AU (1) | AU764707B2 (enExample) |
| CA (1) | CA2382056A1 (enExample) |
| DE (1) | DE60031422T2 (enExample) |
| IL (1) | IL148173A0 (enExample) |
| WO (1) | WO2001012656A1 (enExample) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6346510B1 (en) | 1995-10-23 | 2002-02-12 | The Children's Medical Center Corporation | Therapeutic antiangiogenic endostatin compositions |
| US6841354B2 (en) * | 2000-12-21 | 2005-01-11 | Philadelphia, Health & Education Corporation | Screening assay for anti-thrombotic/anti-platelet activity |
| US20060142203A1 (en) * | 2002-06-26 | 2006-06-29 | Todd Hembrough | Compositions and methods comprising protein activated receptor antagonists |
| US7074765B2 (en) * | 2003-05-01 | 2006-07-11 | The Regents Of The University Of Michigan | Synthetic peptide analogs of Arg-Pro-Pro-Gly-Phe as selective inhibitors of thrombin and thrombin activation of protease activated receptors 1 and 4 |
| JP2008510726A (ja) * | 2004-08-20 | 2008-04-10 | エントレメッド インコーポレイテッド | プロテイナーゼ活性化受容体アンタゴニストを含む組成物および方法 |
| CN102225966B (zh) | 2004-10-19 | 2012-12-26 | 隆萨股份公司 | 用于固相肽合成的方法 |
| US10299714B2 (en) | 2010-12-02 | 2019-05-28 | Becton, Dickinson And Company | Blood collection devices containing blood stabilization agent including variegin or analog thereof and/or a polysulfated disaccharide |
| EP2988130A1 (en) * | 2014-08-20 | 2016-02-24 | Eppendorf Ag | Method for coating a solid support |
| US20180214476A1 (en) * | 2017-02-01 | 2018-08-02 | North Carolina State University | Thrombin-responsive hydrogels and devices for auto-anticoagulant regulation |
| CN113429459B (zh) * | 2021-06-16 | 2022-07-26 | 昆明医科大学第一附属医院 | 一种抗血小板多肽及其药物组合物与其应用 |
| CN116370339A (zh) * | 2023-05-24 | 2023-07-04 | 南京百沃锐医药研究院有限公司 | 一种环肽用作抗皮肤光老化活性因子及用于制备抗光老化化妆品的用途 |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0410540A1 (en) * | 1989-07-28 | 1991-01-30 | Merck & Co. Inc. | Fibrinogen receptor antagonists |
| AU652193B2 (en) | 1990-10-11 | 1994-08-18 | Pro-Soma S.A.R.L. | Diagnostic method |
| US5461032A (en) * | 1991-03-01 | 1995-10-24 | Fmc Corporation | Insecticidally effective peptides |
| IE20030749A1 (en) | 1991-05-03 | 2003-11-12 | Indiana University Foundation | Human notch and delta binding domains in torporythmic proteins, and methods based thereon |
| AU2548992A (en) | 1991-08-13 | 1993-03-16 | Temple University - Of The Commonwealth System Of Higher Education | Modulation of blood pressure and inhibition of platelet activation with kininogen fragment |
| US5225531A (en) * | 1992-04-09 | 1993-07-06 | Washington University | Hexapeptide Lys Gly Ala Gly Asp Val |
| US5747447A (en) * | 1992-04-30 | 1998-05-05 | Cor Therapeutics | Stable polypeptide composition |
| US5589458A (en) | 1992-11-13 | 1996-12-31 | Thomas Jefferson University | Compounds that inhibit T cell proliferation and methods for using the same |
| US5631131A (en) | 1993-03-19 | 1997-05-20 | Universite De Montreal | cDNA probes and antibodies for human methenyltetrahydrofolate synthetase |
| US5491086A (en) | 1993-05-14 | 1996-02-13 | Hoffmann-La Roche Inc. | Purified thermostable nucleic acid polymerase and DNA coding sequences from pyrodictium species |
| US5762939A (en) | 1993-09-13 | 1998-06-09 | Mg-Pmc, Llc | Method for producing influenza hemagglutinin multivalent vaccines using baculovirus |
| US6143719A (en) * | 1995-06-09 | 2000-11-07 | The Regents Of The University Of Michigan | Bradykinin analogs as selective thrombin inhibitors |
| JP2001518119A (ja) | 1997-04-23 | 2001-10-09 | ザ リージェンツ オブ ザ ユニバーシティ オブ ミシガン | 細胞活性化の選択的阻害剤としてのブラジキニン類似体 |
| AU2662999A (en) | 1998-02-09 | 1999-08-23 | Genzyme Corporation | Nucleic acid delivery vehicles |
| US6111075A (en) | 1998-04-01 | 2000-08-29 | Zymogenetics, Inc. | Protese-activated receptor PAR4 (ZCHEMR2) |
-
1999
- 1999-08-17 US US09/375,808 patent/US6544750B1/en not_active Expired - Fee Related
-
2000
- 2000-08-17 CA CA002382056A patent/CA2382056A1/en not_active Abandoned
- 2000-08-17 IL IL14817300A patent/IL148173A0/xx unknown
- 2000-08-17 WO PCT/US2000/040669 patent/WO2001012656A1/en not_active Ceased
- 2000-08-17 DE DE60031422T patent/DE60031422T2/de not_active Expired - Fee Related
- 2000-08-17 EP EP00968987A patent/EP1212352B1/en not_active Expired - Lifetime
- 2000-08-17 AT AT00968987T patent/ATE342914T1/de not_active IP Right Cessation
- 2000-08-17 JP JP2001517554A patent/JP2003507389A/ja active Pending
- 2000-08-17 AU AU78822/00A patent/AU764707B2/en not_active Ceased
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