CA2382056A1 - Peptide analogs as selective inhibitors of thrombin activation of protease activated receptor 1 - Google Patents

Peptide analogs as selective inhibitors of thrombin activation of protease activated receptor 1 Download PDF

Info

Publication number
CA2382056A1
CA2382056A1 CA002382056A CA2382056A CA2382056A1 CA 2382056 A1 CA2382056 A1 CA 2382056A1 CA 002382056 A CA002382056 A CA 002382056A CA 2382056 A CA2382056 A CA 2382056A CA 2382056 A1 CA2382056 A1 CA 2382056A1
Authority
CA
Canada
Prior art keywords
seq
arg
gly
cys
asp
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002382056A
Other languages
English (en)
French (fr)
Inventor
Alvin H. Schmaier
Ahmed A. K. Hasan
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Michigan System
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2382056A1 publication Critical patent/CA2382056A1/en
Abandoned legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/745—Blood coagulation or fibrinolysis factors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Hematology (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Diabetes (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
CA002382056A 1999-08-17 2000-08-17 Peptide analogs as selective inhibitors of thrombin activation of protease activated receptor 1 Abandoned CA2382056A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US09/375,808 US6544750B1 (en) 1999-08-17 1999-08-17 Peptide analogs as selective inhibitors of thrombin activation of protease activated receptor 1
US09/375,808 1999-08-17
PCT/US2000/040669 WO2001012656A1 (en) 1999-08-17 2000-08-17 Peptide analogs as selective inhibitors of thrombin activation of protease activated receptor 1

Publications (1)

Publication Number Publication Date
CA2382056A1 true CA2382056A1 (en) 2001-02-22

Family

ID=23482441

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002382056A Abandoned CA2382056A1 (en) 1999-08-17 2000-08-17 Peptide analogs as selective inhibitors of thrombin activation of protease activated receptor 1

Country Status (9)

Country Link
US (1) US6544750B1 (enExample)
EP (1) EP1212352B1 (enExample)
JP (1) JP2003507389A (enExample)
AT (1) ATE342914T1 (enExample)
AU (1) AU764707B2 (enExample)
CA (1) CA2382056A1 (enExample)
DE (1) DE60031422T2 (enExample)
IL (1) IL148173A0 (enExample)
WO (1) WO2001012656A1 (enExample)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6346510B1 (en) 1995-10-23 2002-02-12 The Children's Medical Center Corporation Therapeutic antiangiogenic endostatin compositions
US6841354B2 (en) * 2000-12-21 2005-01-11 Philadelphia, Health & Education Corporation Screening assay for anti-thrombotic/anti-platelet activity
JP2005537245A (ja) * 2002-06-26 2005-12-08 エントレメッド インコーポレイテッド タンパク質活性化レセプターのアンタゴニストを含む組成物および方法
US7074765B2 (en) 2003-05-01 2006-07-11 The Regents Of The University Of Michigan Synthetic peptide analogs of Arg-Pro-Pro-Gly-Phe as selective inhibitors of thrombin and thrombin activation of protease activated receptors 1 and 4
WO2006023844A2 (en) * 2004-08-20 2006-03-02 Entremed, Inc. Compositions and methods comprising proteinase activated receptor antagonists
WO2006045503A1 (en) 2004-10-19 2006-05-04 Lonza Ag Method for solid phase peptide synthesis
AU2011336345B2 (en) 2010-12-02 2016-07-07 Becton, Dickinson And Company Blood collection devices containing blood stabilization agent
EP2988130A1 (en) * 2014-08-20 2016-02-24 Eppendorf Ag Method for coating a solid support
US20180214476A1 (en) * 2017-02-01 2018-08-02 North Carolina State University Thrombin-responsive hydrogels and devices for auto-anticoagulant regulation
CN113429459B (zh) * 2021-06-16 2022-07-26 昆明医科大学第一附属医院 一种抗血小板多肽及其药物组合物与其应用
CN116370339A (zh) * 2023-05-24 2023-07-04 南京百沃锐医药研究院有限公司 一种环肽用作抗皮肤光老化活性因子及用于制备抗光老化化妆品的用途

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0410540A1 (en) * 1989-07-28 1991-01-30 Merck & Co. Inc. Fibrinogen receptor antagonists
WO1992007269A1 (en) 1990-10-11 1992-04-30 Pro-Soma S.A.R.L. Diagnostic method
US5461032A (en) * 1991-03-01 1995-10-24 Fmc Corporation Insecticidally effective peptides
IE20030749A1 (en) 1991-05-03 2003-11-12 Indiana University Foundation Human notch and delta binding domains in torporythmic proteins, and methods based thereon
AU2548992A (en) 1991-08-13 1993-03-16 Temple University - Of The Commonwealth System Of Higher Education Modulation of blood pressure and inhibition of platelet activation with kininogen fragment
US5225531A (en) * 1992-04-09 1993-07-06 Washington University Hexapeptide Lys Gly Ala Gly Asp Val
US5747447A (en) * 1992-04-30 1998-05-05 Cor Therapeutics Stable polypeptide composition
US5589458A (en) 1992-11-13 1996-12-31 Thomas Jefferson University Compounds that inhibit T cell proliferation and methods for using the same
US5631131A (en) 1993-03-19 1997-05-20 Universite De Montreal cDNA probes and antibodies for human methenyltetrahydrofolate synthetase
US5491086A (en) 1993-05-14 1996-02-13 Hoffmann-La Roche Inc. Purified thermostable nucleic acid polymerase and DNA coding sequences from pyrodictium species
US5762939A (en) 1993-09-13 1998-06-09 Mg-Pmc, Llc Method for producing influenza hemagglutinin multivalent vaccines using baculovirus
ATE235912T1 (de) * 1995-06-09 2003-04-15 Univ Michigan Bradikininanaloge als selektive thrombininhibitoren
IL132546A0 (en) 1997-04-23 2001-03-19 Univ Michigan Bradykinin analogs as selective inhibitors of cell activation
AU2662999A (en) 1998-02-09 1999-08-23 Genzyme Corporation Nucleic acid delivery vehicles
US6111075A (en) 1998-04-01 2000-08-29 Zymogenetics, Inc. Protese-activated receptor PAR4 (ZCHEMR2)

Also Published As

Publication number Publication date
IL148173A0 (en) 2002-09-12
JP2003507389A (ja) 2003-02-25
ATE342914T1 (de) 2006-11-15
WO2001012656A1 (en) 2001-02-22
AU764707B2 (en) 2003-08-28
DE60031422D1 (de) 2006-11-30
EP1212352A1 (en) 2002-06-12
AU7882200A (en) 2001-03-13
EP1212352A4 (en) 2002-12-04
EP1212352B1 (en) 2006-10-18
DE60031422T2 (de) 2007-08-23
US6544750B1 (en) 2003-04-08

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Legal Events

Date Code Title Description
EEER Examination request
FZDE Discontinued