JP2003507389A - プロテアーゼ活性化レセプター１のトロンビン活性の選択的インヒビターとしてのペプチドアナログ - Google Patents
プロテアーゼ活性化レセプター１のトロンビン活性の選択的インヒビターとしてのペプチドアナログInfo
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- JP2003507389A JP2003507389A JP2001517554A JP2001517554A JP2003507389A JP 2003507389 A JP2003507389 A JP 2003507389A JP 2001517554 A JP2001517554 A JP 2001517554A JP 2001517554 A JP2001517554 A JP 2001517554A JP 2003507389 A JP2003507389 A JP 2003507389A
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- asp
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/745—Blood coagulation or fibrinolysis factors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Hematology (AREA)
- Zoology (AREA)
- Toxicology (AREA)
- Gastroenterology & Hepatology (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Diabetes (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US09/375,808 US6544750B1 (en) | 1999-08-17 | 1999-08-17 | Peptide analogs as selective inhibitors of thrombin activation of protease activated receptor 1 |
| US09/375,808 | 1999-08-17 | ||
| PCT/US2000/040669 WO2001012656A1 (en) | 1999-08-17 | 2000-08-17 | Peptide analogs as selective inhibitors of thrombin activation of protease activated receptor 1 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2003507389A true JP2003507389A (ja) | 2003-02-25 |
| JP2003507389A5 JP2003507389A5 (enExample) | 2007-10-11 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2001517554A Pending JP2003507389A (ja) | 1999-08-17 | 2000-08-17 | プロテアーゼ活性化レセプター１のトロンビン活性の選択的インヒビターとしてのペプチドアナログ |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US6544750B1 (enExample) |
| EP (1) | EP1212352B1 (enExample) |
| JP (1) | JP2003507389A (enExample) |
| AT (1) | ATE342914T1 (enExample) |
| AU (1) | AU764707B2 (enExample) |
| CA (1) | CA2382056A1 (enExample) |
| DE (1) | DE60031422T2 (enExample) |
| IL (1) | IL148173A0 (enExample) |
| WO (1) | WO2001012656A1 (enExample) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6346510B1 (en) | 1995-10-23 | 2002-02-12 | The Children's Medical Center Corporation | Therapeutic antiangiogenic endostatin compositions |
| US6841354B2 (en) * | 2000-12-21 | 2005-01-11 | Philadelphia, Health & Education Corporation | Screening assay for anti-thrombotic/anti-platelet activity |
| JP2005537245A (ja) * | 2002-06-26 | 2005-12-08 | エントレメッド インコーポレイテッド | タンパク質活性化レセプターのアンタゴニストを含む組成物および方法 |
| US7074765B2 (en) | 2003-05-01 | 2006-07-11 | The Regents Of The University Of Michigan | Synthetic peptide analogs of Arg-Pro-Pro-Gly-Phe as selective inhibitors of thrombin and thrombin activation of protease activated receptors 1 and 4 |
| WO2006023844A2 (en) * | 2004-08-20 | 2006-03-02 | Entremed, Inc. | Compositions and methods comprising proteinase activated receptor antagonists |
| WO2006045503A1 (en) | 2004-10-19 | 2006-05-04 | Lonza Ag | Method for solid phase peptide synthesis |
| AU2011336345B2 (en) | 2010-12-02 | 2016-07-07 | Becton, Dickinson And Company | Blood collection devices containing blood stabilization agent |
| EP2988130A1 (en) * | 2014-08-20 | 2016-02-24 | Eppendorf Ag | Method for coating a solid support |
| US20180214476A1 (en) * | 2017-02-01 | 2018-08-02 | North Carolina State University | Thrombin-responsive hydrogels and devices for auto-anticoagulant regulation |
| CN113429459B (zh) * | 2021-06-16 | 2022-07-26 | 昆明医科大学第一附属医院 | 一种抗血小板多肽及其药物组合物与其应用 |
| CN116370339A (zh) * | 2023-05-24 | 2023-07-04 | 南京百沃锐医药研究院有限公司 | 一种环肽用作抗皮肤光老化活性因子及用于制备抗光老化化妆品的用途 |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1999040214A2 (en) * | 1998-02-09 | 1999-08-12 | Genzyme Corporation | Nucleic acid delivery vehicles |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0410540A1 (en) * | 1989-07-28 | 1991-01-30 | Merck & Co. Inc. | Fibrinogen receptor antagonists |
| WO1992007269A1 (en) | 1990-10-11 | 1992-04-30 | Pro-Soma S.A.R.L. | Diagnostic method |
| US5461032A (en) * | 1991-03-01 | 1995-10-24 | Fmc Corporation | Insecticidally effective peptides |
| IE20030749A1 (en) | 1991-05-03 | 2003-11-12 | Indiana University Foundation | Human notch and delta binding domains in torporythmic proteins, and methods based thereon |
| AU2548992A (en) | 1991-08-13 | 1993-03-16 | Temple University - Of The Commonwealth System Of Higher Education | Modulation of blood pressure and inhibition of platelet activation with kininogen fragment |
| US5225531A (en) * | 1992-04-09 | 1993-07-06 | Washington University | Hexapeptide Lys Gly Ala Gly Asp Val |
| US5747447A (en) * | 1992-04-30 | 1998-05-05 | Cor Therapeutics | Stable polypeptide composition |
| US5589458A (en) | 1992-11-13 | 1996-12-31 | Thomas Jefferson University | Compounds that inhibit T cell proliferation and methods for using the same |
| US5631131A (en) | 1993-03-19 | 1997-05-20 | Universite De Montreal | cDNA probes and antibodies for human methenyltetrahydrofolate synthetase |
| US5491086A (en) | 1993-05-14 | 1996-02-13 | Hoffmann-La Roche Inc. | Purified thermostable nucleic acid polymerase and DNA coding sequences from pyrodictium species |
| US5762939A (en) | 1993-09-13 | 1998-06-09 | Mg-Pmc, Llc | Method for producing influenza hemagglutinin multivalent vaccines using baculovirus |
| ATE235912T1 (de) * | 1995-06-09 | 2003-04-15 | Univ Michigan | Bradikininanaloge als selektive thrombininhibitoren |
| IL132546A0 (en) | 1997-04-23 | 2001-03-19 | Univ Michigan | Bradykinin analogs as selective inhibitors of cell activation |
| US6111075A (en) | 1998-04-01 | 2000-08-29 | Zymogenetics, Inc. | Protese-activated receptor PAR4 (ZCHEMR2) |
-
1999
- 1999-08-17 US US09/375,808 patent/US6544750B1/en not_active Expired - Fee Related
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2000
- 2000-08-17 WO PCT/US2000/040669 patent/WO2001012656A1/en not_active Ceased
- 2000-08-17 AT AT00968987T patent/ATE342914T1/de not_active IP Right Cessation
- 2000-08-17 CA CA002382056A patent/CA2382056A1/en not_active Abandoned
- 2000-08-17 IL IL14817300A patent/IL148173A0/xx unknown
- 2000-08-17 DE DE60031422T patent/DE60031422T2/de not_active Expired - Fee Related
- 2000-08-17 EP EP00968987A patent/EP1212352B1/en not_active Expired - Lifetime
- 2000-08-17 AU AU78822/00A patent/AU764707B2/en not_active Ceased
- 2000-08-17 JP JP2001517554A patent/JP2003507389A/ja active Pending
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1999040214A2 (en) * | 1998-02-09 | 1999-08-12 | Genzyme Corporation | Nucleic acid delivery vehicles |
Also Published As
| Publication number | Publication date |
|---|---|
| IL148173A0 (en) | 2002-09-12 |
| ATE342914T1 (de) | 2006-11-15 |
| WO2001012656A1 (en) | 2001-02-22 |
| AU764707B2 (en) | 2003-08-28 |
| DE60031422D1 (de) | 2006-11-30 |
| EP1212352A1 (en) | 2002-06-12 |
| AU7882200A (en) | 2001-03-13 |
| EP1212352A4 (en) | 2002-12-04 |
| EP1212352B1 (en) | 2006-10-18 |
| DE60031422T2 (de) | 2007-08-23 |
| US6544750B1 (en) | 2003-04-08 |
| CA2382056A1 (en) | 2001-02-22 |
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