JP2003505519A5 - - Google Patents
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- JP2003505519A5 JP2003505519A5 JP2001513442A JP2001513442A JP2003505519A5 JP 2003505519 A5 JP2003505519 A5 JP 2003505519A5 JP 2001513442 A JP2001513442 A JP 2001513442A JP 2001513442 A JP2001513442 A JP 2001513442A JP 2003505519 A5 JP2003505519 A5 JP 2003505519A5
- Authority
- JP
- Japan
- Prior art keywords
- kit
- contrast agent
- target
- sequence
- contrast
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000002872 contrast media Substances 0.000 description 32
- 239000008280 blood Substances 0.000 description 19
- 210000004369 blood Anatomy 0.000 description 19
- 230000003068 static effect Effects 0.000 description 16
- 238000003384 imaging method Methods 0.000 description 12
- 238000002583 angiography Methods 0.000 description 11
- 229910052760 oxygen Inorganic materials 0.000 description 11
- 239000002616 MRI contrast agent Substances 0.000 description 10
- 210000005166 vasculature Anatomy 0.000 description 9
- 238000000034 method Methods 0.000 description 8
- 229910021645 metal ion Inorganic materials 0.000 description 7
- 230000005298 paramagnetic effect Effects 0.000 description 7
- 230000005291 magnetic effect Effects 0.000 description 6
- 229910052757 nitrogen Inorganic materials 0.000 description 6
- 208000005189 Embolism Diseases 0.000 description 5
- 229910052799 carbon Inorganic materials 0.000 description 5
- 239000013522 chelant Substances 0.000 description 5
- 108090000623 proteins and genes Proteins 0.000 description 5
- 102000004169 proteins and genes Human genes 0.000 description 5
- 229910052717 sulfur Inorganic materials 0.000 description 5
- 102000009123 Fibrin Human genes 0.000 description 4
- 108010073385 Fibrin Proteins 0.000 description 4
- BWGVNKXGVNDBDI-UHFFFAOYSA-N Fibrin monomer Chemical compound CNC(=O)CNC(=O)CN BWGVNKXGVNDBDI-UHFFFAOYSA-N 0.000 description 4
- 208000007536 Thrombosis Diseases 0.000 description 4
- 125000003342 alkenyl group Chemical group 0.000 description 4
- 125000000217 alkyl group Chemical group 0.000 description 4
- 125000000304 alkynyl group Chemical group 0.000 description 4
- 125000004432 carbon atom Chemical group C* 0.000 description 4
- 229950003499 fibrin Drugs 0.000 description 4
- 229910052736 halogen Inorganic materials 0.000 description 4
- 108090000765 processed proteins & peptides Proteins 0.000 description 4
- 102000008186 Collagen Human genes 0.000 description 3
- 108010035532 Collagen Proteins 0.000 description 3
- QPCDCPDFJACHGM-UHFFFAOYSA-N N,N-bis{2-[bis(carboxymethyl)amino]ethyl}glycine Chemical compound OC(=O)CN(CC(O)=O)CCN(CC(=O)O)CCN(CC(O)=O)CC(O)=O QPCDCPDFJACHGM-UHFFFAOYSA-N 0.000 description 3
- 208000001435 Thromboembolism Diseases 0.000 description 3
- 125000004429 atom Chemical group 0.000 description 3
- 229920001436 collagen Polymers 0.000 description 3
- 238000002059 diagnostic imaging Methods 0.000 description 3
- 230000002708 enhancing effect Effects 0.000 description 3
- 125000005843 halogen group Chemical group 0.000 description 3
- 238000000264 spin echo pulse sequence Methods 0.000 description 3
- 239000000126 substance Substances 0.000 description 3
- LDGWQMRUWMSZIU-LQDDAWAPSA-M 2,3-bis[(z)-octadec-9-enoxy]propyl-trimethylazanium;chloride Chemical compound [Cl-].CCCCCCCC\C=C/CCCCCCCCOCC(C[N+](C)(C)C)OCCCCCCCC\C=C/CCCCCCCC LDGWQMRUWMSZIU-LQDDAWAPSA-M 0.000 description 2
- HHLZCENAOIROSL-UHFFFAOYSA-N 2-[4,7-bis(carboxymethyl)-1,4,7,10-tetrazacyclododec-1-yl]acetic acid Chemical compound OC(=O)CN1CCNCCN(CC(O)=O)CCN(CC(O)=O)CC1 HHLZCENAOIROSL-UHFFFAOYSA-N 0.000 description 2
- 206010002329 Aneurysm Diseases 0.000 description 2
- RPNUMPOLZDHAAY-UHFFFAOYSA-N Diethylenetriamine Chemical compound NCCNCCN RPNUMPOLZDHAAY-UHFFFAOYSA-N 0.000 description 2
- VTLYFUHAOXGGBS-UHFFFAOYSA-N Fe3+ Chemical compound [Fe+3] VTLYFUHAOXGGBS-UHFFFAOYSA-N 0.000 description 2
- WDLRUFUQRNWCPK-UHFFFAOYSA-N Tetraxetan Chemical compound OC(=O)CN1CCN(CC(O)=O)CCN(CC(O)=O)CCN(CC(O)=O)CC1 WDLRUFUQRNWCPK-UHFFFAOYSA-N 0.000 description 2
- 239000002738 chelating agent Substances 0.000 description 2
- 238000002075 inversion recovery Methods 0.000 description 2
- 230000005415 magnetization Effects 0.000 description 2
- 125000004433 nitrogen atom Chemical group N* 0.000 description 2
- 238000011084 recovery Methods 0.000 description 2
- 230000001629 suppression Effects 0.000 description 2
- 102000003886 Glycoproteins Human genes 0.000 description 1
- 108090000288 Glycoproteins Proteins 0.000 description 1
- 230000017531 blood circulation Effects 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
- 239000012634 fragment Substances 0.000 description 1
- 150000004676 glycans Chemical class 0.000 description 1
- 150000002367 halogens Chemical class 0.000 description 1
- 239000012216 imaging agent Substances 0.000 description 1
- 238000002595 magnetic resonance imaging Methods 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 230000003287 optical effect Effects 0.000 description 1
- 229960003330 pentetic acid Drugs 0.000 description 1
- 229920001282 polysaccharide Polymers 0.000 description 1
- 239000005017 polysaccharide Substances 0.000 description 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US14641499P | 1999-07-29 | 1999-07-29 | |
| US16365099P | 1999-11-04 | 1999-11-04 | |
| US60/146,414 | 1999-11-04 | ||
| US60/163,650 | 1999-11-04 | ||
| PCT/US2000/020536 WO2001008712A2 (en) | 1999-07-29 | 2000-07-28 | Targeting multimeric imaging agents through multilocus binding |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2002341392A Division JP2003201258A (ja) | 1999-07-29 | 2002-11-25 | 多座結合を介した多量体画像化剤の標的化 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2003505519A JP2003505519A (ja) | 2003-02-12 |
| JP2003505519A5 true JP2003505519A5 (https=) | 2006-01-05 |
Family
ID=26843871
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2001513442A Pending JP2003505519A (ja) | 1999-07-29 | 2000-07-28 | 多座結合を介した多量体画像化剤の標的化 |
| JP2002341392A Pending JP2003201258A (ja) | 1999-07-29 | 2002-11-25 | 多座結合を介した多量体画像化剤の標的化 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2002341392A Pending JP2003201258A (ja) | 1999-07-29 | 2002-11-25 | 多座結合を介した多量体画像化剤の標的化 |
Country Status (20)
| Country | Link |
|---|---|
| US (2) | US6652835B1 (https=) |
| EP (1) | EP1210124A2 (https=) |
| JP (2) | JP2003505519A (https=) |
| KR (1) | KR20020057946A (https=) |
| CN (2) | CN1382062A (https=) |
| AU (1) | AU6386000A (https=) |
| BR (1) | BR0013171A (https=) |
| CA (1) | CA2384565A1 (https=) |
| CZ (1) | CZ2002343A3 (https=) |
| EA (1) | EA200200220A1 (https=) |
| HK (1) | HK1048952A1 (https=) |
| HU (1) | HUP0202635A3 (https=) |
| IL (1) | IL147854A0 (https=) |
| IS (1) | IS6241A (https=) |
| MX (1) | MXPA02001017A (https=) |
| NO (1) | NO20020474L (https=) |
| NZ (1) | NZ517017A (https=) |
| PL (1) | PL353336A1 (https=) |
| WO (1) | WO2001008712A2 (https=) |
| YU (1) | YU6502A (https=) |
Families Citing this family (55)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TW319763B (https=) * | 1995-02-01 | 1997-11-11 | Epix Medical Inc | |
| US6713045B1 (en) | 1995-06-02 | 2004-03-30 | Research Corporation Technologies, Inc. | Targeted magnetic resonance imaging agents for the detection of physiological processes |
| WO1999025389A2 (en) | 1997-11-17 | 1999-05-27 | Research Corporation Technologies, Inc. | Magnetic resonance imaging agents for the detection of physiological agents |
| TWI290146B (en) * | 1999-07-29 | 2007-11-21 | Dyax Corp | Binding moieties for fibrin |
| BR0013171A (pt) * | 1999-07-29 | 2002-05-28 | Epix Medical Inc | Agentes multimericos para formação de imagem de objetivação através de ligação multi-local |
| US6673333B1 (en) | 2000-05-04 | 2004-01-06 | Research Corporation Technologies, Inc. | Functional MRI agents for cancer imaging |
| US6656450B2 (en) | 2000-07-17 | 2003-12-02 | California Institute Of Technology, Inc. | Macrocyclic magnetic resonance imaging contrast agents |
| US6670456B2 (en) * | 2001-02-28 | 2003-12-30 | Dow Global Technologies Inc. | Actinium-225 complexes and conjugates for targeted radiotherapy |
| TWI240632B (en) | 2001-07-30 | 2005-10-01 | Epix Medical Inc | Purified peptides for peptide-based multimeric targeted contrast agents |
| TWI221406B (en) | 2001-07-30 | 2004-10-01 | Epix Medical Inc | Systems and methods for targeted magnetic resonance imaging of the vascular system |
| EP1443953A4 (en) * | 2001-10-16 | 2005-11-23 | Epix Pharm Inc | IDENTIFICATION AND TREATMENT OF INTRAVASCULAR LESIONS |
| US7504364B2 (en) * | 2002-03-01 | 2009-03-17 | Receptors Llc | Methods of making arrays and artificial receptors |
| US7344704B2 (en) | 2002-07-10 | 2008-03-18 | Schering Ag | Use of perfluoroalkyl-containing metal complexes as contrast media in MR-imaging for visualization of intravascular thrombi |
| DE10231799B4 (de) * | 2002-07-10 | 2006-10-05 | Schering Ag | Verwendung von perfluoralkylhaltigen Metallkomplexen als Kontrastmittel im MR-Imaging zur Darstellung von Intravasalen Thromben |
| WO2005003326A2 (en) * | 2003-03-28 | 2005-01-13 | Receptors Llc. | Artificial receptors including reversibly immobilized building blocks and methods |
| US20050037429A1 (en) * | 2003-03-28 | 2005-02-17 | Receptors Llc | Artificial receptors including reversibly immobilized building blocks and methods |
| US7469076B2 (en) * | 2003-09-03 | 2008-12-23 | Receptors Llc | Sensors employing combinatorial artificial receptors |
| US20060051802A1 (en) * | 2002-09-16 | 2006-03-09 | Receptors Llc | Artificial receptors, building blocks, and methods |
| US20050136483A1 (en) * | 2003-09-03 | 2005-06-23 | Receptors Llc | Nanodevices employing combinatorial artificial receptors |
| US20040137481A1 (en) * | 2002-09-16 | 2004-07-15 | Receptors Llc | Artificial receptor building blocks, components, and kits |
| US20060057625A1 (en) * | 2002-09-16 | 2006-03-16 | Carlson Robert E | Scaffold-based artificial receptors and methods |
| US20050037381A1 (en) * | 2002-09-16 | 2005-02-17 | Receptors Llc | Artificial receptors, building blocks, and methods |
| WO2005001415A2 (en) | 2003-05-23 | 2005-01-06 | Epix Pharmaceuticals, Inc. | Optically pure and enriched isomers of chelating ligands and contrast agents |
| DE10325752A1 (de) * | 2003-06-06 | 2004-12-30 | Faustus Forschungs Cie. Translational Cancer Research Gmbh | Lektin-Konjugate |
| AR047692A1 (es) * | 2003-07-10 | 2006-02-08 | Epix Medical Inc | Imagenes de blancos estacionarios |
| CA2445420A1 (en) | 2003-07-29 | 2005-01-29 | Invitrogen Corporation | Kinase and phosphatase assays |
| US7619059B2 (en) | 2003-07-29 | 2009-11-17 | Life Technologies Corporation | Bimolecular optical probes |
| US7557577B2 (en) * | 2003-12-08 | 2009-07-07 | Siemens Aktiengesselschaft | Water-soluble paramagnetic substance reducing the relaxation time of the coolant in an MRI system |
| WO2005079274A2 (en) * | 2004-02-12 | 2005-09-01 | Mount Sinai School Of Medicine | Magnetic resonance imaging of atherosclerotic plaque |
| EP1789797A1 (en) * | 2004-09-03 | 2007-05-30 | Receptors LLC | Combinatorial artifical receptors including tether building blocks |
| WO2006027244A2 (en) * | 2004-09-10 | 2006-03-16 | Bracco Imaging S.P.A. | Paramagnetic metal polyamino complexes for mri visualization of internalized polynucleotides |
| WO2006029383A2 (en) | 2004-09-11 | 2006-03-16 | Receptors Llc | Combinatorial artificial receptors including peptide building blocks |
| WO2006056227A1 (en) * | 2004-11-27 | 2006-06-01 | Eberhard-Karls- Universität Tübingen Universitätsklinikum | Conjugates comprising the active agent and flanking or branched-chain peptides |
| DE102004062258B3 (de) * | 2004-12-23 | 2006-01-05 | Schering Ag | Hydroxypyridinon-Derivate, deren Metallkomplexe und deren Verwendung zur Herstellung von Konjugaten mit Biomolekülen |
| JP2008527119A (ja) | 2005-01-13 | 2008-07-24 | シンベンション アーゲー | 炭素ナノ粒子を含有する複合材料 |
| WO2006121889A2 (en) * | 2005-05-06 | 2006-11-16 | Epix Pharmaceuticals, Inc. | Chemical exchange saturation transfer contrast agents |
| EP1901659B1 (en) * | 2005-07-13 | 2018-04-25 | Georgia State University Research Foundation, Inc. | Contrast agents and methods for preparing contrast agents |
| AU2006303324A1 (en) * | 2005-10-18 | 2007-04-26 | Cinvention Ag | Thermoset particles and methods for production thereof |
| EP1955071A4 (en) | 2005-10-28 | 2009-03-18 | Invitrogen Corp | ASSAYS OF ACTIVITY KINASE AND UBIQUITINATION |
| US20080058636A1 (en) | 2005-12-29 | 2008-03-06 | Epix Pharmaceuticals, Inc. | Methods of myocardial imaging |
| KR101336505B1 (ko) * | 2006-08-17 | 2013-12-05 | 에픽스 파마슈티칼스, 인코포레이티드 | 림프계의 영상화 방법 |
| US20080280778A1 (en) * | 2007-05-03 | 2008-11-13 | Urdea Michael S | Binding reagents that contain small epitope binding molecules |
| DE102007028090A1 (de) | 2007-06-12 | 2008-12-18 | Eberhard-Karls-Universität Tübingen Universitätsklinikum | Aktivierbare diagnostische und therapeutische Verbindung |
| WO2009023813A1 (en) * | 2007-08-15 | 2009-02-19 | Applied Soil Water Technologies Llc | Metals recovery from mining heap leach ore |
| US20090214436A1 (en) | 2008-02-18 | 2009-08-27 | Washington University | Dichromic fluorescent compounds |
| US8722020B2 (en) | 2010-03-31 | 2014-05-13 | General Electric Company | Hydroxylated contrast enhancement agents |
| US8765977B2 (en) | 2010-03-31 | 2014-07-01 | General Electric Company | Hydroxylated contrast enhancement agents and imaging method |
| US8362281B2 (en) | 2010-03-31 | 2013-01-29 | General Electric Company | Intermediates for hydroxylated contrast enhancement agents |
| WO2013112554A1 (en) | 2012-01-23 | 2013-08-01 | Washington University | Goggle imaging systems and methods |
| US9849201B2 (en) | 2013-05-03 | 2017-12-26 | Washington University | Homing agents |
| US10806804B2 (en) | 2015-05-06 | 2020-10-20 | Washington University | Compounds having RD targeting motifs and methods of use thereof |
| US10301358B2 (en) | 2015-06-29 | 2019-05-28 | Collagen Medical, LLC | Collagen imaging compositions |
| WO2017027834A1 (en) | 2015-08-13 | 2017-02-16 | The General Hospital Corporation | Manganese-based chelate conjugates for molecular mr imaging |
| US11499008B2 (en) * | 2017-02-02 | 2022-11-15 | University Of Akron | Functionalized poly (propylene fumarate) polymers made by ring opening polymerization using magnesium catalysts |
| US11712482B2 (en) | 2019-12-13 | 2023-08-01 | Washington University | Near infrared fluorescent dyes, formulations and related methods |
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-
2000
- 2000-07-28 BR BR0013171-7A patent/BR0013171A/pt not_active IP Right Cessation
- 2000-07-28 KR KR1020027001126A patent/KR20020057946A/ko not_active Withdrawn
- 2000-07-28 US US09/627,719 patent/US6652835B1/en not_active Expired - Fee Related
- 2000-07-28 YU YU6502A patent/YU6502A/sh unknown
- 2000-07-28 CN CN00813045A patent/CN1382062A/zh active Pending
- 2000-07-28 CZ CZ2002343A patent/CZ2002343A3/cs unknown
- 2000-07-28 IL IL14785400A patent/IL147854A0/xx unknown
- 2000-07-28 NZ NZ517017A patent/NZ517017A/en unknown
- 2000-07-28 CA CA002384565A patent/CA2384565A1/en not_active Abandoned
- 2000-07-28 MX MXPA02001017A patent/MXPA02001017A/es unknown
- 2000-07-28 HU HU0202635A patent/HUP0202635A3/hu unknown
- 2000-07-28 HK HK03101252.8A patent/HK1048952A1/zh unknown
- 2000-07-28 CN CNA2004100567047A patent/CN1626246A/zh active Pending
- 2000-07-28 PL PL00353336A patent/PL353336A1/xx not_active Application Discontinuation
- 2000-07-28 JP JP2001513442A patent/JP2003505519A/ja active Pending
- 2000-07-28 WO PCT/US2000/020536 patent/WO2001008712A2/en not_active Ceased
- 2000-07-28 EP EP00950815A patent/EP1210124A2/en not_active Withdrawn
- 2000-07-28 EA EA200200220A patent/EA200200220A1/ru unknown
- 2000-07-28 AU AU63860/00A patent/AU6386000A/en not_active Abandoned
-
2002
- 2002-01-18 IS IS6241A patent/IS6241A/is unknown
- 2002-01-29 NO NO20020474A patent/NO20020474L/no not_active Application Discontinuation
- 2002-11-25 JP JP2002341392A patent/JP2003201258A/ja active Pending
-
2003
- 2003-05-27 US US10/445,544 patent/US20040005274A1/en not_active Abandoned
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