JP2003504045A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2003504045A5 JP2003504045A5 JP2001509473A JP2001509473A JP2003504045A5 JP 2003504045 A5 JP2003504045 A5 JP 2003504045A5 JP 2001509473 A JP2001509473 A JP 2001509473A JP 2001509473 A JP2001509473 A JP 2001509473A JP 2003504045 A5 JP2003504045 A5 JP 2003504045A5
- Authority
- JP
- Japan
- Prior art keywords
- monoclonal antibody
- wild
- type protein
- protein
- factor
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 108090000623 proteins and genes Proteins 0.000 description 16
- 102000004169 proteins and genes Human genes 0.000 description 16
- 238000000034 method Methods 0.000 description 9
- 102000001690 Factor VIII Human genes 0.000 description 7
- 108010054218 Factor VIII Proteins 0.000 description 7
- 229960000301 factor viii Drugs 0.000 description 7
- 239000008194 pharmaceutical composition Substances 0.000 description 4
- 210000004027 cell Anatomy 0.000 description 3
- 239000012634 fragment Substances 0.000 description 3
- 230000023597 hemostasis Effects 0.000 description 3
- 108010047041 Complementarity Determining Regions Proteins 0.000 description 2
- 241001465754 Metazoa Species 0.000 description 2
- 239000004480 active ingredient Substances 0.000 description 2
- 239000000427 antigen Substances 0.000 description 2
- 102000036639 antigens Human genes 0.000 description 2
- 108091007433 antigens Proteins 0.000 description 2
- 210000003719 b-lymphocyte Anatomy 0.000 description 2
- 210000004369 blood Anatomy 0.000 description 2
- 239000008280 blood Substances 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 108020001580 protein domains Proteins 0.000 description 2
- 241000124008 Mammalia Species 0.000 description 1
- 238000005842 biochemical reaction Methods 0.000 description 1
- 230000023555 blood coagulation Effects 0.000 description 1
- 230000000295 complement effect Effects 0.000 description 1
- 239000003937 drug carrier Substances 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 239000003527 fibrinolytic agent Substances 0.000 description 1
- 230000028993 immune response Effects 0.000 description 1
- 230000003053 immunization Effects 0.000 description 1
- 238000002649 immunization Methods 0.000 description 1
- 230000000415 inactivating effect Effects 0.000 description 1
- 230000003993 interaction Effects 0.000 description 1
- 244000005700 microbiome Species 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 230000001575 pathological effect Effects 0.000 description 1
- 102000040430 polynucleotide Human genes 0.000 description 1
- 108091033319 polynucleotide Proteins 0.000 description 1
- 239000002157 polynucleotide Substances 0.000 description 1
- 230000002797 proteolythic effect Effects 0.000 description 1
- 230000008685 targeting Effects 0.000 description 1
- 229960000103 thrombolytic agent Drugs 0.000 description 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US14389199P | 1999-07-14 | 1999-07-14 | |
| GBGB9916450.1A GB9916450D0 (en) | 1999-07-14 | 1999-07-14 | Ligands for use in therapeutic compounds for the treatment of hemostasis disorders |
| US60/143,891 | 1999-07-14 | ||
| GB9916450.1 | 1999-07-14 | ||
| PCT/EP2000/006677 WO2001004269A1 (en) | 1999-07-14 | 2000-07-13 | Ligands for use in therapeutic compositions for the treatment of hemostasis disorders |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008198354A Division JP4297225B2 (ja) | 1999-07-14 | 2008-07-31 | 止血障害処置のための治療組成物に使用するためのリガンド |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2003504045A JP2003504045A (ja) | 2003-02-04 |
| JP2003504045A5 true JP2003504045A5 (enExample) | 2006-01-05 |
| JP4297207B2 JP4297207B2 (ja) | 2009-07-15 |
Family
ID=26315767
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2001509473A Expired - Fee Related JP4297207B2 (ja) | 1999-07-14 | 2000-07-13 | 止血障害処置のための治療組成物に使用するためのリガンド |
| JP2008198354A Expired - Fee Related JP4297225B2 (ja) | 1999-07-14 | 2008-07-31 | 止血障害処置のための治療組成物に使用するためのリガンド |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008198354A Expired - Fee Related JP4297225B2 (ja) | 1999-07-14 | 2008-07-31 | 止血障害処置のための治療組成物に使用するためのリガンド |
Country Status (11)
| Country | Link |
|---|---|
| EP (1) | EP1194528B1 (enExample) |
| JP (2) | JP4297207B2 (enExample) |
| AT (1) | ATE356201T1 (enExample) |
| AU (1) | AU781638B2 (enExample) |
| CA (1) | CA2381125C (enExample) |
| CY (1) | CY1107638T1 (enExample) |
| DE (1) | DE60033814T2 (enExample) |
| DK (1) | DK1194528T3 (enExample) |
| ES (1) | ES2283308T3 (enExample) |
| PT (1) | PT1194528E (enExample) |
| WO (1) | WO2001004269A1 (enExample) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7829085B2 (en) | 1999-07-14 | 2010-11-09 | Life Sciences Research Partners Vzw | Methods of treating hemostasis disorders using antibodies binding the C1 domain of factor VIII |
| ES2346189T3 (es) | 2001-01-11 | 2010-10-13 | Life Sciences Research Partners Vzw | Metodo y composicion farmaceutica para prevenir y/o tratar el sindrome de respuesta inflamatoria generalizada. |
| DE60230037D1 (de) * | 2001-06-12 | 2009-01-08 | Chemo Sero Therapeut Res Inst | Humanantikörper gegen blutgerinnungsfaktor viii |
| EP1388544A1 (en) | 2002-07-31 | 2004-02-11 | D. Collen Research Foundation vzw | Anti-idiotypic antibodies against factor VIII inhibitor and uses thereof |
| JP4422430B2 (ja) | 2003-05-14 | 2010-02-24 | 帝國製薬株式会社 | エストロゲン及び／又はプロゲストゲン含有外用貼付剤 |
| JP4934796B2 (ja) * | 2003-08-14 | 2012-05-16 | トロンボジェニクス・ナムローゼ・フエンノートシャップ | 可変抗体 |
| JP2008512097A (ja) | 2004-09-07 | 2008-04-24 | アーケミックス コーポレイション | アプタマー医薬品化学 |
| US7566701B2 (en) | 2004-09-07 | 2009-07-28 | Archemix Corp. | Aptamers to von Willebrand Factor and their use as thrombotic disease therapeutics |
| CA2616902A1 (en) * | 2005-07-29 | 2007-02-15 | Life Sciences Research Partners Vzw | Human inhibitory anti-factor viii antibodies binding to the a2 domain |
| FR2892724B1 (fr) | 2005-11-02 | 2008-01-04 | Lab Francais Du Fractionnement | Anticorps cytotoxiques diriges contre des anticorps inhibiteurs du facteur viii. |
| FR2897868B1 (fr) * | 2006-02-24 | 2012-08-31 | Lab Francais Du Fractionnement | Anticorps anti-idiotypiques neutralisant l'activite inhibitrice d'un anticorps inhibiteur dirige contre le domaine c1 du facteur viii. |
| EP2451835A1 (en) | 2009-07-10 | 2012-05-16 | ThromboGenics N.V. | Variants of plasminogen and plasmin |
| ES2534911T3 (es) | 2009-08-28 | 2015-04-30 | Thrombogenics N.V. | Uso de plasmina para el tratamiento de fallo de filtración después de trabeculectomía |
| RU2604807C2 (ru) | 2011-01-05 | 2016-12-10 | ТромбоДженикс НВ | Варианты плазминогена и плазмина |
| JP6000353B2 (ja) | 2011-08-12 | 2016-09-28 | スロンボジェニックス・ナムローゼ・フェンノートシャップＴｈｒｏｍｂｏＧｅｎｉｃｓ ＮＶ | プラスミノーゲンおよびプラスミンの変異体 |
| ES2628321T3 (es) | 2011-12-01 | 2017-08-02 | Thrombogenics N.V. | Mejora del resultado de una trabeculectomía |
| KR101395736B1 (ko) * | 2012-07-10 | 2014-05-16 | 아주대학교산학협력단 | 인간 혈액응고인자 ⅷ 도메인 특이적 항체 및 이의 제조방법 |
| JP2019507746A (ja) | 2016-03-10 | 2019-03-22 | オクシュリオン エヌブイ | 胎盤増殖因子のアンタゴナイズによる後眼部線維症の阻害 |
| CA3062238A1 (en) * | 2017-05-11 | 2018-11-15 | Vib Vzw | Glycosylation of variable immunoglobulin domains |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MA24512A1 (fr) * | 1996-01-17 | 1998-12-31 | Univ Vermont And State Agrienl | Procede pour la preparation d'agents anticoagulants utiles dans le traitement de la thrombose |
-
2000
- 2000-07-13 ES ES00949329T patent/ES2283308T3/es not_active Expired - Lifetime
- 2000-07-13 AU AU62730/00A patent/AU781638B2/en not_active Ceased
- 2000-07-13 WO PCT/EP2000/006677 patent/WO2001004269A1/en not_active Ceased
- 2000-07-13 PT PT00949329T patent/PT1194528E/pt unknown
- 2000-07-13 AT AT00949329T patent/ATE356201T1/de active
- 2000-07-13 DE DE60033814T patent/DE60033814T2/de not_active Expired - Lifetime
- 2000-07-13 JP JP2001509473A patent/JP4297207B2/ja not_active Expired - Fee Related
- 2000-07-13 EP EP00949329A patent/EP1194528B1/en not_active Expired - Lifetime
- 2000-07-13 CA CA2381125A patent/CA2381125C/en not_active Expired - Fee Related
- 2000-07-13 DK DK00949329T patent/DK1194528T3/da active
-
2007
- 2007-05-24 CY CY20071100703T patent/CY1107638T1/el unknown
-
2008
- 2008-07-31 JP JP2008198354A patent/JP4297225B2/ja not_active Expired - Fee Related
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| DE69519929T2 (de) | Verfahren und zusammensetzungen für die spezifische koagulation von tumorgefässen | |
| JP4313531B2 (ja) | 第ＩＸ因子／第ＩＸａ因子の抗体および抗体誘導体 | |
| Kasperkiewicz et al. | Pemphigoid diseases: pathogenesis, diagnosis, and treatment | |
| Oldham | Monoclonal antibodies in cancer therapy. | |
| JP2022104941A (ja) | ヒト化抗ｃｄ７３抗体 | |
| Zone et al. | IgA autoimmune disorders: development of a passive transfer mouse model | |
| CA2380783A1 (en) | Human monoclonal antibodies to prostate specific membrane antigen | |
| JP3360108B2 (ja) | 二つのエフェクター機能を有する二元特異性異種抗体 | |
| WO2004045512A3 (en) | Human monoclonal antibodies against cd25 | |
| WO2001009187A3 (en) | Human monoclonal antibodies to her2/neu | |
| EP1245676A4 (en) | HUMANE MONOCLONAL ANTIBODIES AGAINST THE TGF-BETA II RECEPTOR AND THEIR MEDICAL USE | |
| WO2004043989A3 (en) | Human monoclonal antibodies to heparanase | |
| RU2000128668A (ru) | Cd19 х cd3-специфические полипептиды и их применение | |
| WO2003017935A3 (en) | Human antibodies specific for interleukin 15 (il-15) | |
| WO2003040169A3 (en) | Human monoclonal antibodies to dendritic cells | |
| WO2001085798A3 (en) | Human monoclonal antibodies to dendritic cells | |
| EP1151012A1 (en) | Rhamm antagonist antibodies | |
| NZ501215A (en) | Treatment of thrombosis using anti-Factor IX monoclonal antibodies | |
| WO2009132821A1 (en) | Interleukin (il-21) binding proteins and methods of making and using same | |
| KR20230007368A (ko) | 항-tmprss6 항체 및 이의 용도 | |
| CN109071673A (zh) | 抗pcsk9抗体及其应用 | |
| CA2333975A1 (en) | Method of inhibiting angiogenesis and tumor growth and preventing tumor growth and metastases | |
| JP2001502895A (ja) | アルファ―２―抗プラスミンに対するキメラ、ヒト化および一本鎖抗体 | |
| Luiten et al. | Chimeric immunoglobulin E reactive with tumor-associated antigen activates human FcεRI bearing cells | |
| CN116333145B (zh) | 结合活化凝血因子ix的抗体 |