ATE356201T1 - Monoklonaler antikörper der faktor viii selbst in molarem überschuss nur teilweise inaktiviert und eine methode zur herstellung solch eines antikörpers - Google Patents
Monoklonaler antikörper der faktor viii selbst in molarem überschuss nur teilweise inaktiviert und eine methode zur herstellung solch eines antikörpersInfo
- Publication number
- ATE356201T1 ATE356201T1 AT00949329T AT00949329T ATE356201T1 AT E356201 T1 ATE356201 T1 AT E356201T1 AT 00949329 T AT00949329 T AT 00949329T AT 00949329 T AT00949329 T AT 00949329T AT E356201 T1 ATE356201 T1 AT E356201T1
- Authority
- AT
- Austria
- Prior art keywords
- ligands
- factor viii
- factor
- molar excess
- complex
- Prior art date
Links
- 229960000301 factor viii Drugs 0.000 title abstract 6
- 238000004519 manufacturing process Methods 0.000 title abstract 2
- 239000003446 ligand Substances 0.000 abstract 8
- 102000001690 Factor VIII Human genes 0.000 abstract 4
- 108010054218 Factor VIII Proteins 0.000 abstract 4
- 230000000694 effects Effects 0.000 abstract 2
- 206010053567 Coagulopathies Diseases 0.000 abstract 1
- 208000032843 Hemorrhage Diseases 0.000 abstract 1
- 208000034158 bleeding Diseases 0.000 abstract 1
- 230000000740 bleeding effect Effects 0.000 abstract 1
- 208000015294 blood coagulation disease Diseases 0.000 abstract 1
- 230000009852 coagulant defect Effects 0.000 abstract 1
- 230000015271 coagulation Effects 0.000 abstract 1
- 238000005345 coagulation Methods 0.000 abstract 1
- 239000012634 fragment Substances 0.000 abstract 1
- 230000023597 hemostasis Effects 0.000 abstract 1
- 230000002779 inactivation Effects 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 230000001575 pathological effect Effects 0.000 abstract 1
- 239000000825 pharmaceutical preparation Substances 0.000 abstract 1
- 230000035790 physiological processes and functions Effects 0.000 abstract 1
- 230000001732 thrombotic effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/36—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against blood coagulation factors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Biophysics (AREA)
- Vascular Medicine (AREA)
- Immunology (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Urology & Nephrology (AREA)
- Biochemistry (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US14389199P | 1999-07-14 | 1999-07-14 | |
| GBGB9916450.1A GB9916450D0 (en) | 1999-07-14 | 1999-07-14 | Ligands for use in therapeutic compounds for the treatment of hemostasis disorders |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE356201T1 true ATE356201T1 (de) | 2007-03-15 |
Family
ID=26315767
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT00949329T ATE356201T1 (de) | 1999-07-14 | 2000-07-13 | Monoklonaler antikörper der faktor viii selbst in molarem überschuss nur teilweise inaktiviert und eine methode zur herstellung solch eines antikörpers |
Country Status (11)
| Country | Link |
|---|---|
| EP (1) | EP1194528B1 (de) |
| JP (2) | JP4297207B2 (de) |
| AT (1) | ATE356201T1 (de) |
| AU (1) | AU781638B2 (de) |
| CA (1) | CA2381125C (de) |
| CY (1) | CY1107638T1 (de) |
| DE (1) | DE60033814T2 (de) |
| DK (1) | DK1194528T3 (de) |
| ES (1) | ES2283308T3 (de) |
| PT (1) | PT1194528E (de) |
| WO (1) | WO2001004269A1 (de) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7829085B2 (en) | 1999-07-14 | 2010-11-09 | Life Sciences Research Partners Vzw | Methods of treating hemostasis disorders using antibodies binding the C1 domain of factor VIII |
| EP1222929B8 (de) | 2001-01-11 | 2010-07-07 | Life Sciences Research Partners VZW | Verfahren und pharmazeutische Zusammensetzung zur Vorbeugung und/oder Behandlung des Syndroms der systemischen entzündlichen Reaktion |
| JP4205576B2 (ja) * | 2001-06-12 | 2009-01-07 | 財団法人化学及血清療法研究所 | ヒト型抗血液凝固第ｖｉｉｉ因子抗体 |
| EP1388544A1 (de) | 2002-07-31 | 2004-02-11 | D. Collen Research Foundation vzw | Anti-Idiotypische Antikörper gegen Factor VIII-Inhibitor und Verwendungen davon |
| JP4422430B2 (ja) | 2003-05-14 | 2010-02-24 | 帝國製薬株式会社 | エストロゲン及び／又はプロゲストゲン含有外用貼付剤 |
| AU2004264265C1 (en) * | 2003-08-14 | 2012-06-28 | Thrombogenics Nv | Antibodies against factor VIII with modified glycosylation in the variable region |
| US7566701B2 (en) | 2004-09-07 | 2009-07-28 | Archemix Corp. | Aptamers to von Willebrand Factor and their use as thrombotic disease therapeutics |
| WO2006029258A2 (en) | 2004-09-07 | 2006-03-16 | Archemix Corp. | Aptamer medicinal chemistry |
| EP1910420B1 (de) | 2005-07-29 | 2011-05-18 | Life Sciences Research Partners VZW | An die a2-domäne bindende, humane inhibitorische anti-faktor-viii-antikörper |
| FR2892724B1 (fr) | 2005-11-02 | 2008-01-04 | Lab Francais Du Fractionnement | Anticorps cytotoxiques diriges contre des anticorps inhibiteurs du facteur viii. |
| FR2897868B1 (fr) * | 2006-02-24 | 2012-08-31 | Lab Francais Du Fractionnement | Anticorps anti-idiotypiques neutralisant l'activite inhibitrice d'un anticorps inhibiteur dirige contre le domaine c1 du facteur viii. |
| AU2010270146B9 (en) | 2009-07-10 | 2015-04-02 | Thrombogenics Nv | Variants of plasminogen and plasmin |
| US20120189609A1 (en) | 2009-08-28 | 2012-07-26 | Thrombogenics Nv | Improvement to trabeculectomy |
| CN103384722B (zh) | 2011-01-05 | 2016-11-16 | 斯路姆基因公司 | 纤溶酶原和纤溶酶变体 |
| WO2013024074A1 (en) | 2011-08-12 | 2013-02-21 | Thrombogenics N.V. | Plasminogen and plasmin variants |
| EP2785739B1 (de) | 2011-12-01 | 2017-03-15 | ThromboGenics N.V. | Verbesserung eines augendrucksenkungsergebnisses |
| KR101395736B1 (ko) * | 2012-07-10 | 2014-05-16 | 아주대학교산학협력단 | 인간 혈액응고인자 ⅷ 도메인 특이적 항체 및 이의 제조방법 |
| JP2019507746A (ja) | 2016-03-10 | 2019-03-22 | オクシュリオン エヌブイ | 胎盤増殖因子のアンタゴナイズによる後眼部線維症の阻害 |
| CA3062238A1 (en) * | 2017-05-11 | 2018-11-15 | Vib Vzw | Glycosylation of variable immunoglobulin domains |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MA24512A1 (fr) * | 1996-01-17 | 1998-12-31 | Univ Vermont And State Agrienl | Procede pour la preparation d'agents anticoagulants utiles dans le traitement de la thrombose |
-
2000
- 2000-07-13 EP EP00949329A patent/EP1194528B1/de not_active Expired - Lifetime
- 2000-07-13 ES ES00949329T patent/ES2283308T3/es not_active Expired - Lifetime
- 2000-07-13 PT PT00949329T patent/PT1194528E/pt unknown
- 2000-07-13 CA CA2381125A patent/CA2381125C/en not_active Expired - Fee Related
- 2000-07-13 AU AU62730/00A patent/AU781638B2/en not_active Ceased
- 2000-07-13 AT AT00949329T patent/ATE356201T1/de active
- 2000-07-13 DE DE60033814T patent/DE60033814T2/de not_active Expired - Lifetime
- 2000-07-13 WO PCT/EP2000/006677 patent/WO2001004269A1/en not_active Ceased
- 2000-07-13 DK DK00949329T patent/DK1194528T3/da active
- 2000-07-13 JP JP2001509473A patent/JP4297207B2/ja not_active Expired - Fee Related
-
2007
- 2007-05-24 CY CY20071100703T patent/CY1107638T1/el unknown
-
2008
- 2008-07-31 JP JP2008198354A patent/JP4297225B2/ja not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| AU781638B2 (en) | 2005-06-02 |
| CY1107638T1 (el) | 2013-04-18 |
| ES2283308T3 (es) | 2007-11-01 |
| DE60033814T2 (de) | 2007-11-08 |
| DE60033814D1 (de) | 2007-04-19 |
| DK1194528T3 (da) | 2007-07-09 |
| CA2381125A1 (en) | 2001-01-18 |
| WO2001004269A1 (en) | 2001-01-18 |
| PT1194528E (pt) | 2007-05-31 |
| EP1194528B1 (de) | 2007-03-07 |
| JP4297225B2 (ja) | 2009-07-15 |
| JP2008295455A (ja) | 2008-12-11 |
| CA2381125C (en) | 2013-04-23 |
| JP2003504045A (ja) | 2003-02-04 |
| EP1194528A1 (de) | 2002-04-10 |
| AU6273000A (en) | 2001-01-30 |
| JP4297207B2 (ja) | 2009-07-15 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification |
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