DE69011531T2 - Von faktor vii abgeleitete peptide mit antihämostatischer wirkung. - Google Patents

Von faktor vii abgeleitete peptide mit antihämostatischer wirkung.

Info

Publication number
DE69011531T2
DE69011531T2 DE69011531T DE69011531T DE69011531T2 DE 69011531 T2 DE69011531 T2 DE 69011531T2 DE 69011531 T DE69011531 T DE 69011531T DE 69011531 T DE69011531 T DE 69011531T DE 69011531 T2 DE69011531 T2 DE 69011531T2
Authority
DE
Germany
Prior art keywords
factor vii
peptides derived
hemostatic effect
peptides
factor
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69011531T
Other languages
English (en)
Other versions
DE69011531D1 (de
Inventor
Daryl Fair
Anuradha Kumar
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Texas System
Original Assignee
University of Texas System
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University of Texas System filed Critical University of Texas System
Application granted granted Critical
Publication of DE69011531D1 publication Critical patent/DE69011531D1/de
Publication of DE69011531T2 publication Critical patent/DE69011531T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C12N9/6437—Coagulation factor VIIa (3.4.21.21)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/40—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against enzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/21—Serine endopeptidases (3.4.21)
    • C12Y304/21021—Coagulation factor VIIa (3.4.21.21)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • Zoology (AREA)
  • Medicinal Chemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Immunology (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
DE69011531T 1989-11-13 1990-11-13 Von faktor vii abgeleitete peptide mit antihämostatischer wirkung. Expired - Fee Related DE69011531T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US07/435,657 US5190919A (en) 1989-11-13 1989-11-13 Antihemostatic factor vii peptides
PCT/US1990/006617 WO1991007432A1 (en) 1989-11-13 1990-11-13 Antihemostatic factor vii peptides

Publications (2)

Publication Number Publication Date
DE69011531D1 DE69011531D1 (de) 1994-09-15
DE69011531T2 true DE69011531T2 (de) 1994-12-08

Family

ID=23729271

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69011531T Expired - Fee Related DE69011531T2 (de) 1989-11-13 1990-11-13 Von faktor vii abgeleitete peptide mit antihämostatischer wirkung.

Country Status (7)

Country Link
US (1) US5190919A (de)
EP (1) EP0500800B1 (de)
AT (1) ATE109794T1 (de)
AU (1) AU6963491A (de)
DE (1) DE69011531T2 (de)
DK (1) DK0500800T3 (de)
WO (1) WO1991007432A1 (de)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5506134A (en) * 1990-10-22 1996-04-09 Corvas International, Inc. Hypridoma and monoclonal antibody which inhibits blood coagulation tissue factor/factor VIIa complex
US5788965A (en) * 1991-02-28 1998-08-04 Novo Nordisk A/S Modified factor VII
US5817788A (en) * 1991-02-28 1998-10-06 Zymogenetics, Inc. Modified factor VII
US5861374A (en) * 1991-02-28 1999-01-19 Novo Nordisk A/S Modified Factor VII
US5833982A (en) * 1991-02-28 1998-11-10 Zymogenetics, Inc. Modified factor VII
US5997864A (en) 1995-06-07 1999-12-07 Novo Nordisk A/S Modified factor VII
JPH06505496A (ja) * 1991-03-11 1994-06-23 ザ・ジェネラル・ホスピタル・コーポレーション 活性因子ｘ１１１の活性化を阻害するための組成物と方法
JP3180824B2 (ja) * 1991-08-30 2001-06-25 シスメックス株式会社 血液凝固試薬
US6039944A (en) * 1992-02-28 2000-03-21 Zymogenetics, Inc. Modified Factor VII
JPH07507769A (ja) * 1992-03-20 1995-08-31 コアー・セラピュティックス・インコーポレーテッド Ｘ因子のグリコシル化媒介による阻害
GB9425381D0 (en) * 1994-12-15 1995-02-15 Nycomed Pharma As Peptides
EP0987274A1 (de) * 1998-09-15 2000-03-22 Hoechst Marion Roussel Deutschland GmbH Faktor VIIa Inhibitore
JP2003530819A (ja) 1999-06-14 2003-10-21 ノボ ノルディスク アクティーゼルスカブ ＦＶＩＩａ／ＴＦ活性阻害化合物
AU2017206445B2 (en) 2016-01-15 2019-07-18 Rigshospitalet Quantitative pet imaging of tissue factor expression using 18F-labled active site inhibited factor VII
US20190358351A1 (en) 2016-11-17 2019-11-28 Minerva Imaging Aps 177-lu labeled active site inhibited factor vii

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8305985D0 (en) * 1983-03-04 1983-04-07 Szelke M Enzyme inhibition
DE3572179D1 (en) * 1984-09-21 1989-09-14 Boehringer Ingelheim Int Blood coagulation inhibiting proteins, process for preparing them and their use
DE3689525D1 (de) * 1985-07-17 1994-02-24 Hoechst Ag Neue Polypeptide mit blutgerinnungshemmender Wirkung, Verfahren zu deren Herstellung bzw. Gewinnung, deren Verwendung und diese enthaltende Mittel.
EP0391999A4 (en) * 1988-09-23 1991-03-13 Corvas, Inc. Peptidyl inhibitors of the initiation of coagulation

Also Published As

Publication number Publication date
ATE109794T1 (de) 1994-08-15
AU6963491A (en) 1991-06-13
US5190919A (en) 1993-03-02
EP0500800B1 (de) 1994-08-10
DE69011531D1 (de) 1994-09-15
WO1991007432A1 (en) 1991-05-30
DK0500800T3 (da) 1994-12-05
EP0500800A1 (de) 1992-09-02

Similar Documents

Publication Publication Date Title
DE69011531T2 (de) Von faktor vii abgeleitete peptide mit antihämostatischer wirkung.
ATE236981T1 (de) Von menschlichen t-zellen immunodominante epiropen des virus der c-hepatitis
DE3789413T2 (de) Lymphokin-ähnliche Peptide.
ATE110743T1 (de) Antikoagulierende peptide.
DE69008262T2 (de) Trennung von Gasmischungen.
DE69008622T2 (de) Überzugsmischung.
DK197990A (da) Oploesningsmiddelmodstandsdygtige, straalingshaerdelige belaegninger
DE69009405D1 (de) Trennung von Gasgemischen.
DE69001697D1 (de) Einwickeln von laenglichen gegenstaenden.
DE268297T1 (de) Peptide mit sulfatestergruppen.
AP9100296A0 (en) Peptides and analogues and mixtures thereof for detecting antibodies to HTLV-1 and HTLV11 viruses.
ATE173022T1 (de) Produktion von peptid-amiden
DE69001575D1 (de) Entfernung von sulphiden.
DE69002881D1 (de) Peptide und deren Benutzung.
DE59109235D1 (de) Peptide des HIV-gag Proteins, ihre Herstellung und Verwendung
DE69008406T2 (de) N-Hydroxycarbyloxy-Derivate von s-Triazinen mit gehinderter Aminogruppe.
SE9402253D0 (sv) Process
DE69017903D1 (de) Peptidsubstrate zur identifikation von faktor xa.
DE68909118D1 (de) Verfahren zur Ausscheidung von 2,6-Dimethylnaphthalin.
DE3769740D1 (de) Befestigung von artikeln.
PT84798A (de) Cyclische peptide mit cytoprotektiver wirkung
DE68914057D1 (de) Peptide.
DE68904904T2 (de) Synthetische scm-aktive, krebserkennende peptide.
DE68905673T2 (de) Verfahren zur Ausscheidung von 2,6-Dimethylnaphthalin.
DE69007658T2 (de) Beschichtung von Filamenten.

Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee