JP2003503309A5 - - Google Patents
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- Publication number
- JP2003503309A5 JP2003503309A5 JP2000600553A JP2000600553A JP2003503309A5 JP 2003503309 A5 JP2003503309 A5 JP 2003503309A5 JP 2000600553 A JP2000600553 A JP 2000600553A JP 2000600553 A JP2000600553 A JP 2000600553A JP 2003503309 A5 JP2003503309 A5 JP 2003503309A5
- Authority
- JP
- Japan
- Prior art keywords
- composition
- antisense oligonucleotide
- seq
- trpm
- antisense
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000000203 mixture Substances 0.000 description 15
- 108091034117 Oligonucleotide Proteins 0.000 description 11
- 239000000074 antisense oligonucleotide Substances 0.000 description 11
- 238000012230 antisense oligonucleotides Methods 0.000 description 11
- 102000003780 Clusterin Human genes 0.000 description 8
- 108090000197 Clusterin Proteins 0.000 description 8
- 230000000692 anti-sense effect Effects 0.000 description 6
- 239000008194 pharmaceutical composition Substances 0.000 description 6
- 229940046166 oligodeoxynucleotide Drugs 0.000 description 5
- 210000004881 tumor cell Anatomy 0.000 description 4
- 239000003098 androgen Substances 0.000 description 3
- 108020004999 messenger RNA Proteins 0.000 description 3
- 208000023958 prostate neoplasm Diseases 0.000 description 3
- 102100021569 Apoptosis regulator Bcl-2 Human genes 0.000 description 2
- 101000971171 Homo sapiens Apoptosis regulator Bcl-2 Proteins 0.000 description 2
- 206010028980 Neoplasm Diseases 0.000 description 2
- 239000004480 active ingredient Substances 0.000 description 2
- 201000011510 cancer Diseases 0.000 description 2
- 230000000295 complement effect Effects 0.000 description 2
- 239000003937 drug carrier Substances 0.000 description 2
- 239000000463 material Substances 0.000 description 2
- 108010063104 Apoptosis Regulatory Proteins Proteins 0.000 description 1
- 102000010565 Apoptosis Regulatory Proteins Human genes 0.000 description 1
- 101710135898 Myc proto-oncogene protein Proteins 0.000 description 1
- 102100038895 Myc proto-oncogene protein Human genes 0.000 description 1
- 101710150448 Transcriptional regulator Myc Proteins 0.000 description 1
- 210000004027 cell Anatomy 0.000 description 1
- 238000002512 chemotherapy Methods 0.000 description 1
- 230000001934 delay Effects 0.000 description 1
- 230000002708 enhancing effect Effects 0.000 description 1
- 230000002401 inhibitory effect Effects 0.000 description 1
- 125000003473 lipid group Chemical group 0.000 description 1
- 210000001519 tissue Anatomy 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US12172699P | 1999-02-26 | 1999-02-26 | |
| US60/121,726 | 1999-02-26 | ||
| PCT/US2000/004875 WO2000049937A2 (en) | 1999-02-26 | 2000-02-25 | Trpm-2 antisense therapy |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2003503309A JP2003503309A (ja) | 2003-01-28 |
| JP2003503309A5 true JP2003503309A5 (enExample) | 2007-03-22 |
| JP4785252B2 JP4785252B2 (ja) | 2011-10-05 |
Family
ID=22398429
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2000600553A Expired - Fee Related JP4785252B2 (ja) | 1999-02-26 | 2000-02-25 | Ｔｒｐｍ−２アンチセンス療法 |
Country Status (15)
| Country | Link |
|---|---|
| US (7) | US7534773B1 (enExample) |
| EP (1) | EP1163254B1 (enExample) |
| JP (1) | JP4785252B2 (enExample) |
| KR (2) | KR100820266B1 (enExample) |
| AT (1) | ATE385237T1 (enExample) |
| AU (1) | AU767133B2 (enExample) |
| CA (2) | CA2371814C (enExample) |
| DE (1) | DE60037938T2 (enExample) |
| DK (1) | DK1163254T3 (enExample) |
| ES (1) | ES2300257T3 (enExample) |
| HU (1) | HU227190B1 (enExample) |
| IL (2) | IL144975A0 (enExample) |
| NO (1) | NO330799B1 (enExample) |
| NZ (1) | NZ513757A (enExample) |
| WO (1) | WO2000049937A2 (enExample) |
Families Citing this family (96)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6383808B1 (en) * | 2000-09-11 | 2002-05-07 | Isis Pharmaceuticals, Inc. | Antisense inhibition of clusterin expression |
| US6900187B2 (en) * | 1999-02-26 | 2005-05-31 | The University Of British Columbia | TRPM-2 antisense therapy using an oligonucleotide having 2′-O-(2-methoxy)ethyl modifications |
| NZ513757A (en) | 1999-02-26 | 2004-12-24 | Univ British Columbia | Antisense oligonucleotides to inhibit TRPM-2 expression and delay androgen independance in prostatic tumour cells |
| US7569551B2 (en) | 2000-02-25 | 2009-08-04 | The University Of British Columbia | Chemo- and radiation-sensitization of cancer by antisense TRPM-2 oligodeoxynucleotides |
| WO2003062421A1 (en) | 2002-01-17 | 2003-07-31 | The University Of British Columbia | Bispecific antisense olignucleotides that inhibit igfbp-2 and igfbp-5 and methods of using same |
| US7351404B2 (en) | 2002-02-04 | 2008-04-01 | Allergan, Inc. | Method of enhancing hair growth |
| US9216183B2 (en) | 2002-02-04 | 2015-12-22 | Allergan, Inc. | Topical treatment for chemotherapy induced eyelash loss or hypotrichosis using prostamide F2 alpha agonists |
| US8758733B2 (en) | 2002-02-04 | 2014-06-24 | Allergan, Inc. | Topical treatment for chemotherapy induced eyelash loss or hypotrichosis using prostamide F2 alpha agonists |
| KR101117673B1 (ko) | 2002-08-21 | 2012-03-07 | 더 유니버시티 오브 브리티쉬 콜롬비아 | 암-관련 단백질을 표적으로 하는 알엔에이아이 프로브 |
| US7285541B2 (en) | 2002-08-21 | 2007-10-23 | The University Of British Columbia | Treatment of melanoma by reduction in clusterin levels |
| CA2507863A1 (en) * | 2002-12-04 | 2004-06-17 | Algos Therapeutics, Inc. | Methods and materials for modulating trpm2 |
| US20040220131A1 (en) * | 2003-04-18 | 2004-11-04 | The University Of British Columbia | Method for treatment of cancerous angiogenic disorders |
| CA2520518A1 (en) * | 2003-04-18 | 2004-10-28 | The University Of British Columbia | Method for treatment of angiogenic disorders |
| US7399853B2 (en) | 2003-04-28 | 2008-07-15 | Isis Pharmaceuticals | Modulation of glucagon receptor expression |
| US7480382B2 (en) * | 2003-09-30 | 2009-01-20 | Microsoft Corporation | Image file container |
| US7879545B2 (en) * | 2003-11-05 | 2011-02-01 | H. Lee Moffitt Cancer Center And Research Institute, Inc. | Identification of novel targets for radio sensitization using a genomic-based radiation sensitivity classifier |
| US8710020B2 (en) | 2004-04-02 | 2014-04-29 | The University Of British Columbia | Clusterin antisense therapy for treatment of cancer |
| EP1799859B1 (en) | 2004-09-17 | 2014-07-02 | Isis Pharmaceuticals, Inc. | Enhanced antisense oligonucleotides |
| SI1814595T1 (sl) * | 2004-11-23 | 2014-06-30 | The University Of British Columbia | Zdravljenje raka s kombinacijo sredstva, ki moti EGF signalno pot, in oligonukleotida, ki zniĹľuje nivoje klusterina |
| ES2543341T3 (es) | 2005-09-13 | 2015-08-18 | National Research Council Of Canada | Métodos y composiciones para modular la actividad de células tumorales |
| CN103301475B (zh) * | 2005-12-28 | 2016-08-03 | 斯克里普斯研究所 | 药物组合物和表达载体以及调节基因表达的方法和核酸分子的应用 |
| ES2310434B1 (es) | 2006-01-19 | 2009-11-12 | Consejo Superior Investig. Cientificas | Un pmto de identificacion de un proceso de fibrosis renal, pmto de identificacion de compuestos inhibidores, uso de los compuestos inhibidores de la expresion del gen del factor de transcripcion snail en la elaboracion de composiciones farmaceuticas, dichas composiciones..... |
| WO2008094640A2 (en) | 2007-01-30 | 2008-08-07 | Geron Corporation | Compounds having anti-adhesive effects on cancer cells |
| ES2310469B1 (es) | 2007-03-08 | 2009-11-16 | Consejo Superior Investig. Cientificas | Uso compuestos inhibidores actividad snail1 en elaboracion composiciones farmaceuticas utiles para tratamiento de condrodisplasias, procedimiento identificacion compuestos inhibidores, dichas composiciones farmaceuticas, procedimiento diagnostico condrodisplasias y aplicaciones. |
| US20090076734A1 (en) * | 2007-03-22 | 2009-03-19 | Torres-Roca Javier F | Gene Signature for the Prediction of Radiation Therapy Response |
| US20080234946A1 (en) * | 2007-03-22 | 2008-09-25 | University Of South Florida | Predictive radiosensitivity network model |
| WO2009036388A2 (en) * | 2007-09-14 | 2009-03-19 | University Of South Florida | Gene signature for the prediction of radiation therapy response |
| ES2345091B1 (es) * | 2007-12-05 | 2011-07-18 | Consejo Superior De Investigaciones Científicas (Csic) | Peptidos y anticuerpos utiles para la elaboracion de medicamentos para el tratamiento o prevencion de enfermedades humanas neurodegenerativas. medicamentos asi obtenidos y sus aplicaciones. |
| WO2009126160A1 (en) * | 2008-04-10 | 2009-10-15 | University Of Florida Research Foundation | Compositions and methods for the treatment of prostate carcinoma |
| US20110197293A1 (en) * | 2008-09-29 | 2011-08-11 | Giovanni Lavorgna | Sense and antisense transcripts of trpm2 and uses thereof |
| MY188457A (en) * | 2008-10-03 | 2021-12-10 | Opko Curna Llc | Treatment of apolipoprotein-a1 related diseases by inhibition of natural antisense transcript to apolipoprotein-a1 |
| US20100204335A1 (en) * | 2008-12-01 | 2010-08-12 | Allergan, Inc. | Kit and composition for eyelash growth |
| CA2745329C (en) | 2008-12-04 | 2022-07-12 | Opko Curna, Llc | Treatment of erythropoietin (epo) related diseases by inhibition of natural antisense transcript to epo |
| WO2010065671A2 (en) | 2008-12-04 | 2010-06-10 | Curna, Inc. | Treatment of vascular endothelial growth factor (vegf) related diseases by inhibition of natural antisense transcript to vegf |
| KR20110091796A (ko) | 2008-12-04 | 2011-08-12 | 오피케이오 큐알엔에이, 엘엘씨 | 종양 억제 유전자에 대한 천연 안티센스 전사체의 억제에 의해 종양 억제 유전자 관련된 질환의 치료 |
| JP2012514645A (ja) * | 2009-01-08 | 2012-06-28 | アラーガン インコーポレイテッド | 爪成長の増進用組成物 |
| HUE026280T2 (en) | 2009-02-12 | 2016-06-28 | Curna Inc | Treatment of brain-derived neurotrophic factor (BDNF) -related diseases by inhibition of natural antisense transcripts associated with BDNF \ t |
| MX2011009751A (es) | 2009-03-16 | 2011-09-29 | Opko Curna Llc | Tratamiento de enfermedades relacionadas con factor nuclear (eritroide derivado 2) tipo 2 (nrf2) por inhibicion del transcrito antisentido natural a nrf2. |
| US9708604B2 (en) | 2009-03-17 | 2017-07-18 | Curna, Inc. | Treatment of delta-like 1 homolog (DLK1) related diseases by inhibition of natural antisense transcript to DLK1 |
| CN102459596B (zh) | 2009-05-06 | 2016-09-07 | 库尔纳公司 | 通过针对脂质转运和代谢基因的天然反义转录物的抑制治疗脂质转运和代谢基因相关疾病 |
| ES2609655T3 (es) | 2009-05-06 | 2017-04-21 | Curna, Inc. | Tratamiento de enfermedades relacionadas con tristetraprolina (TTP) mediante inhibición de transcrito antisentido natural para TTP |
| EP2427554B1 (en) | 2009-05-08 | 2016-11-16 | CuRNA, Inc. | Treatment of dystrophin family related diseases by inhibition of natural antisense transcript to dmd family |
| DK2432881T3 (en) | 2009-05-18 | 2018-02-26 | Curna Inc | TREATMENT OF REPROGRAMMING FACTOR-RELATED DISEASES BY INHIBITING NATURAL ANTISENSE TRANSCRIPTS TO A REPROGRAMMING FACTOR |
| KR101703695B1 (ko) | 2009-05-22 | 2017-02-08 | 큐알엔에이, 인크. | 전사 인자 ｅ3(ｔｆｅ3)에 대한 천연 안티센스 전사체의 억제에 의해 ｔｆｅ3 및 인슐린 수용체 기질 2(ｉｒｓ2)의 치료 |
| KR101704988B1 (ko) | 2009-05-28 | 2017-02-08 | 큐알엔에이, 인크. | 항바이러스 유전자에 대한 천연 안티센스 전사체의 억제에 의한 항바이러스 유전자 관련된 질환의 치료 |
| WO2010148050A2 (en) | 2009-06-16 | 2010-12-23 | Curna, Inc. | Treatment of collagen gene related diseases by inhibition of natural antisense transcript to a collagen gene |
| ES2629339T3 (es) | 2009-06-16 | 2017-08-08 | Curna, Inc. | Tratamiento de enfermedades relacionadas con la paraoxonasa 1 (pon1) por inhibición de transcrito antisentido natural a pon1 |
| ES2618894T3 (es) | 2009-06-24 | 2017-06-22 | Curna, Inc. | Tratamiento de enfermedades relacionadas con el receptor del factor de necrosis tumoral 2 (tnfr2) por inhibición del transcrito natural antisentido para tnfr2 |
| CN102482672B (zh) | 2009-06-26 | 2016-11-09 | 库尔纳公司 | 通过抑制唐氏综合征基因的天然反义转录物治疗唐氏综合征基因相关疾病 |
| KR101801407B1 (ko) | 2009-07-24 | 2017-11-24 | 큐알엔에이, 인크. | 시르투인 (ｓｉｒｔ)에 대한 천연 안티센스 전사체의 억제에 의한 시르투인 관련된 질환의 치료 |
| CA2769665A1 (en) | 2009-08-05 | 2011-02-10 | Opko Curna, Llc | Treatment of insulin gene (ins) related diseases by inhibition of natural antisense transcript to an insulin gene (ins) |
| US9044493B2 (en) | 2009-08-11 | 2015-06-02 | Curna, Inc. | Treatment of Adiponectin related diseases by inhibition of natural antisense transcript to an Adiponectin |
| CN102482670B (zh) | 2009-08-21 | 2018-06-15 | 库尔纳公司 | 通过抑制‘hsp70-相互作用蛋白的c末端’(chip)的天然反义转录物而治疗chip相关疾病 |
| CN102482671B (zh) | 2009-08-25 | 2017-12-01 | 库尔纳公司 | 通过抑制‘含有iq模体的gtp酶激活蛋白’(iqgap)的天然反义转录物而治疗iqgap相关疾病 |
| NO2480669T3 (enExample) | 2009-09-25 | 2018-04-07 | ||
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| CA2782366A1 (en) | 2009-12-16 | 2011-07-14 | Opko Curna, Llc | Treatment of membrane bound transcription factor peptidase, site 1 (mbtps1) related diseases by inhibition of natural antisense transcript to mbtps1 |
| EP2515947B1 (en) | 2009-12-23 | 2021-10-06 | CuRNA, Inc. | Treatment of uncoupling protein 2 (ucp2) related diseases by inhibition of natural antisense transcript to ucp2 |
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| RU2612161C2 (ru) | 2010-01-06 | 2017-03-02 | Курна, Инк. | Лечение заболеваний, связанных с геном развития поджелудочной железы, путем ингибирования природного антисмыслового транскрипта к гену развития поджелудочной железы |
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2000
- 2000-02-25 NZ NZ513757A patent/NZ513757A/xx not_active IP Right Cessation
- 2000-02-25 ES ES00914710T patent/ES2300257T3/es not_active Expired - Lifetime
- 2000-02-25 WO PCT/US2000/004875 patent/WO2000049937A2/en not_active Ceased
- 2000-02-25 EP EP00914710A patent/EP1163254B1/en not_active Expired - Lifetime
- 2000-02-25 CA CA2371814A patent/CA2371814C/en not_active Expired - Fee Related
- 2000-02-25 DE DE60037938T patent/DE60037938T2/de not_active Expired - Lifetime
- 2000-02-25 JP JP2000600553A patent/JP4785252B2/ja not_active Expired - Fee Related
- 2000-02-25 CA CA2850318A patent/CA2850318A1/en not_active Abandoned
- 2000-02-25 DK DK00914710T patent/DK1163254T3/da active
- 2000-02-25 HU HU0200093A patent/HU227190B1/hu not_active IP Right Cessation
- 2000-02-25 AU AU36064/00A patent/AU767133B2/en not_active Ceased
- 2000-02-25 KR KR1020077004243A patent/KR100820266B1/ko not_active Expired - Fee Related
- 2000-02-25 AT AT00914710T patent/ATE385237T1/de active
- 2000-02-25 US US09/913,325 patent/US7534773B1/en not_active Expired - Fee Related
- 2000-02-25 KR KR1020017010946A patent/KR100768109B1/ko not_active Expired - Fee Related
- 2000-02-25 IL IL14497500A patent/IL144975A0/xx active IP Right Grant
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2001
- 2001-08-19 IL IL144975A patent/IL144975A/en not_active IP Right Cessation
- 2001-08-21 NO NO20014058A patent/NO330799B1/no not_active IP Right Cessation
- 2001-08-30 US US09/944,326 patent/US7368436B2/en not_active Expired - Fee Related
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2006
- 2006-03-06 US US11/276,581 patent/US7592323B1/en not_active Expired - Fee Related
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2007
- 2007-10-19 US US11/875,226 patent/US7732422B2/en not_active Expired - Fee Related
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2010
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2012
- 2012-05-04 US US13/464,670 patent/US8536149B2/en not_active Expired - Fee Related
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