JP2003501257A - エーロゾルを生成する方法 - Google Patents
エーロゾルを生成する方法Info
- Publication number
- JP2003501257A JP2003501257A JP2001502989A JP2001502989A JP2003501257A JP 2003501257 A JP2003501257 A JP 2003501257A JP 2001502989 A JP2001502989 A JP 2001502989A JP 2001502989 A JP2001502989 A JP 2001502989A JP 2003501257 A JP2003501257 A JP 2003501257A
- Authority
- JP
- Japan
- Prior art keywords
- liquid
- supply means
- particles
- volume
- flow
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000000443 aerosol Substances 0.000 title claims description 24
- 239000007788 liquid Substances 0.000 claims abstract description 194
- 239000002245 particle Substances 0.000 claims abstract description 70
- 238000000034 method Methods 0.000 claims abstract description 34
- 238000004519 manufacturing process Methods 0.000 claims abstract description 8
- 239000012530 fluid Substances 0.000 claims description 89
- 239000006185 dispersion Substances 0.000 claims description 21
- 230000002269 spontaneous effect Effects 0.000 claims description 5
- 230000003993 interaction Effects 0.000 claims description 2
- 239000007789 gas Substances 0.000 description 38
- 239000000446 fuel Substances 0.000 description 26
- 239000000203 mixture Substances 0.000 description 15
- 230000000694 effects Effects 0.000 description 8
- 238000002474 experimental method Methods 0.000 description 8
- 238000002485 combustion reaction Methods 0.000 description 6
- 239000003814 drug Substances 0.000 description 6
- 229940079593 drug Drugs 0.000 description 6
- 238000011144 upstream manufacturing Methods 0.000 description 6
- 238000000889 atomisation Methods 0.000 description 5
- 238000009826 distribution Methods 0.000 description 5
- 238000012360 testing method Methods 0.000 description 5
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 5
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 4
- 238000013461 design Methods 0.000 description 4
- 238000012377 drug delivery Methods 0.000 description 4
- 238000005516 engineering process Methods 0.000 description 4
- 230000035939 shock Effects 0.000 description 4
- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 description 3
- 230000015556 catabolic process Effects 0.000 description 3
- 238000002347 injection Methods 0.000 description 3
- 239000007924 injection Substances 0.000 description 3
- 239000000463 material Substances 0.000 description 3
- 230000035945 sensitivity Effects 0.000 description 3
- 239000007921 spray Substances 0.000 description 3
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 2
- 239000004215 Carbon black (E152) Substances 0.000 description 2
- 230000001133 acceleration Effects 0.000 description 2
- 230000009471 action Effects 0.000 description 2
- 230000015572 biosynthetic process Effects 0.000 description 2
- 229910052799 carbon Inorganic materials 0.000 description 2
- 230000008859 change Effects 0.000 description 2
- 235000019219 chocolate Nutrition 0.000 description 2
- 150000001875 compounds Chemical class 0.000 description 2
- 238000000354 decomposition reaction Methods 0.000 description 2
- 229930195733 hydrocarbon Natural products 0.000 description 2
- 150000002430 hydrocarbons Chemical class 0.000 description 2
- 239000010410 layer Substances 0.000 description 2
- 210000004072 lung Anatomy 0.000 description 2
- 238000005259 measurement Methods 0.000 description 2
- 230000005499 meniscus Effects 0.000 description 2
- 230000002685 pulmonary effect Effects 0.000 description 2
- 238000004335 scaling law Methods 0.000 description 2
- 238000000926 separation method Methods 0.000 description 2
- 239000007787 solid Substances 0.000 description 2
- 239000000243 solution Substances 0.000 description 2
- 239000012798 spherical particle Substances 0.000 description 2
- 238000012546 transfer Methods 0.000 description 2
- 238000009736 wetting Methods 0.000 description 2
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical group [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 1
- 101100321669 Fagopyrum esculentum FA02 gene Proteins 0.000 description 1
- 229920001213 Polysorbate 20 Polymers 0.000 description 1
- 238000013459 approach Methods 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 230000006835 compression Effects 0.000 description 1
- 238000007906 compression Methods 0.000 description 1
- 230000008878 coupling Effects 0.000 description 1
- 238000010168 coupling process Methods 0.000 description 1
- 238000005859 coupling reaction Methods 0.000 description 1
- 239000008367 deionised water Substances 0.000 description 1
- 229910021641 deionized water Inorganic materials 0.000 description 1
- 239000012153 distilled water Substances 0.000 description 1
- 229940126534 drug product Drugs 0.000 description 1
- 238000004070 electrodeposition Methods 0.000 description 1
- 230000007613 environmental effect Effects 0.000 description 1
- 238000005530 etching Methods 0.000 description 1
- 230000001747 exhibiting effect Effects 0.000 description 1
- 230000002349 favourable effect Effects 0.000 description 1
- 230000004907 flux Effects 0.000 description 1
- 238000007429 general method Methods 0.000 description 1
- 239000007943 implant Substances 0.000 description 1
- 239000011261 inert gas Substances 0.000 description 1
- 238000000691 measurement method Methods 0.000 description 1
- 238000002493 microarray Methods 0.000 description 1
- 238000000386 microscopy Methods 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000005232 molecular self-assembly Methods 0.000 description 1
- 229910052757 nitrogen Inorganic materials 0.000 description 1
- 239000000825 pharmaceutical preparation Substances 0.000 description 1
- 235000010486 polyoxyethylene sorbitan monolaurate Nutrition 0.000 description 1
- 239000000256 polyoxyethylene sorbitan monolaurate Substances 0.000 description 1
- 229920000136 polysorbate Polymers 0.000 description 1
- 229940068977 polysorbate 20 Drugs 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 230000000717 retained effect Effects 0.000 description 1
- 230000002441 reversible effect Effects 0.000 description 1
- 238000001338 self-assembly Methods 0.000 description 1
- 239000002356 single layer Substances 0.000 description 1
- 239000000758 substrate Substances 0.000 description 1
- 239000000375 suspending agent Substances 0.000 description 1
- 238000003786 synthesis reaction Methods 0.000 description 1
- 238000009827 uniform distribution Methods 0.000 description 1
- 239000002699 waste material Substances 0.000 description 1
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B05—SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
- B05B—SPRAYING APPARATUS; ATOMISING APPARATUS; NOZZLES
- B05B7/00—Spraying apparatus for discharge of liquids or other fluent materials from two or more sources, e.g. of liquid and air, of powder and gas
- B05B7/02—Spray pistols; Apparatus for discharge
- B05B7/04—Spray pistols; Apparatus for discharge with arrangements for mixing liquids or other fluent materials before discharge
- B05B7/0416—Spray pistols; Apparatus for discharge with arrangements for mixing liquids or other fluent materials before discharge with arrangements for mixing one gas and one liquid
- B05B7/0441—Spray pistols; Apparatus for discharge with arrangements for mixing liquids or other fluent materials before discharge with arrangements for mixing one gas and one liquid with one inner conduit of liquid surrounded by an external conduit of gas upstream the mixing chamber
- B05B7/0475—Spray pistols; Apparatus for discharge with arrangements for mixing liquids or other fluent materials before discharge with arrangements for mixing one gas and one liquid with one inner conduit of liquid surrounded by an external conduit of gas upstream the mixing chamber with means for deflecting the peripheral gas flow towards the central liquid flow
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B05—SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
- B05B—SPRAYING APPARATUS; ATOMISING APPARATUS; NOZZLES
- B05B7/00—Spraying apparatus for discharge of liquids or other fluent materials from two or more sources, e.g. of liquid and air, of powder and gas
- B05B7/02—Spray pistols; Apparatus for discharge
- B05B7/04—Spray pistols; Apparatus for discharge with arrangements for mixing liquids or other fluent materials before discharge
- B05B7/0416—Spray pistols; Apparatus for discharge with arrangements for mixing liquids or other fluent materials before discharge with arrangements for mixing one gas and one liquid
- B05B7/0483—Spray pistols; Apparatus for discharge with arrangements for mixing liquids or other fluent materials before discharge with arrangements for mixing one gas and one liquid with gas and liquid jets intersecting in the mixing chamber
Landscapes
- Nozzles (AREA)
- Colloid Chemistry (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US13869899P | 1999-06-11 | 1999-06-11 | |
| US60/138,698 | 1999-06-11 | ||
| PCT/US2000/015931 WO2000076673A1 (en) | 1999-06-11 | 2000-06-09 | Method for producing an aerosol |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2003501257A true JP2003501257A (ja) | 2003-01-14 |
| JP2003501257A5 JP2003501257A5 (enExample) | 2007-04-26 |
Family
ID=22483216
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2001502989A Pending JP2003501257A (ja) | 1999-06-11 | 2000-06-09 | エーロゾルを生成する方法 |
Country Status (6)
| Country | Link |
|---|---|
| EP (1) | EP1192009B1 (enExample) |
| JP (1) | JP2003501257A (enExample) |
| AU (1) | AU767486B2 (enExample) |
| CA (1) | CA2374232C (enExample) |
| ES (1) | ES2424713T4 (enExample) |
| WO (1) | WO2000076673A1 (enExample) |
Cited By (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2003093860A (ja) * | 2001-09-25 | 2003-04-02 | Inoac Corp | 流体混合機構 |
| JP2006523142A (ja) * | 2003-04-10 | 2006-10-12 | プレジデント・アンド・フェロウズ・オブ・ハーバード・カレッジ | 流体種の形成および制御 |
| JP2008514414A (ja) * | 2004-09-30 | 2008-05-08 | ウニベルシダ デ セビリャ | 内破性ガス流により液体を空圧式に微粒化するための装置および手順 |
| JP2008538192A (ja) * | 2005-01-17 | 2008-10-16 | ウニベルシダ デ セビリャ | 還流セルを通して流体をミクロ混合するための手順およびデバイス |
| US7600522B2 (en) | 2003-05-22 | 2009-10-13 | Dainippon Screen Mfg. Co., Ltd. | Substrate treatment method and substrate treatment apparatus |
| JP2010075927A (ja) * | 2002-06-28 | 2010-04-08 | President & Fellows Of Harvard College | 流体分散のための方法および装置 |
| US8765485B2 (en) | 2003-08-27 | 2014-07-01 | President And Fellows Of Harvard College | Electronic control of fluidic species |
| US9068699B2 (en) | 2007-04-19 | 2015-06-30 | Brandeis University | Manipulation of fluids, fluid components and reactions in microfluidic systems |
| US9328344B2 (en) | 2006-01-11 | 2016-05-03 | Raindance Technologies, Inc. | Microfluidic devices and methods of use in the formation and control of nanoreactors |
| US9366632B2 (en) | 2010-02-12 | 2016-06-14 | Raindance Technologies, Inc. | Digital analyte analysis |
| US9440232B2 (en) | 2007-02-06 | 2016-09-13 | Raindance Technologies, Inc. | Manipulation of fluids and reactions in microfluidic systems |
| US9562837B2 (en) | 2006-05-11 | 2017-02-07 | Raindance Technologies, Inc. | Systems for handling microfludic droplets |
| US10351905B2 (en) | 2010-02-12 | 2019-07-16 | Bio-Rad Laboratories, Inc. | Digital analyte analysis |
| US10639597B2 (en) | 2006-05-11 | 2020-05-05 | Bio-Rad Laboratories, Inc. | Microfluidic devices |
| US10647981B1 (en) | 2015-09-08 | 2020-05-12 | Bio-Rad Laboratories, Inc. | Nucleic acid library generation methods and compositions |
| US11077415B2 (en) | 2011-02-11 | 2021-08-03 | Bio-Rad Laboratories, Inc. | Methods for forming mixed droplets |
| US11168353B2 (en) | 2011-02-18 | 2021-11-09 | Bio-Rad Laboratories, Inc. | Compositions and methods for molecular labeling |
| US11174509B2 (en) | 2013-12-12 | 2021-11-16 | Bio-Rad Laboratories, Inc. | Distinguishing rare variations in a nucleic acid sequence from a sample |
| US11187702B2 (en) | 2003-03-14 | 2021-11-30 | Bio-Rad Laboratories, Inc. | Enzyme quantification |
| US11254968B2 (en) | 2010-02-12 | 2022-02-22 | Bio-Rad Laboratories, Inc. | Digital analyte analysis |
| US11390917B2 (en) | 2010-02-12 | 2022-07-19 | Bio-Rad Laboratories, Inc. | Digital analyte analysis |
| US11511242B2 (en) | 2008-07-18 | 2022-11-29 | Bio-Rad Laboratories, Inc. | Droplet libraries |
| US11635427B2 (en) | 2010-09-30 | 2023-04-25 | Bio-Rad Laboratories, Inc. | Sandwich assays in droplets |
| US11786872B2 (en) | 2004-10-08 | 2023-10-17 | United Kingdom Research And Innovation | Vitro evolution in microfluidic systems |
| US11898193B2 (en) | 2011-07-20 | 2024-02-13 | Bio-Rad Laboratories, Inc. | Manipulating droplet size |
| US11901041B2 (en) | 2013-10-04 | 2024-02-13 | Bio-Rad Laboratories, Inc. | Digital analysis of nucleic acid modification |
| US12038438B2 (en) | 2008-07-18 | 2024-07-16 | Bio-Rad Laboratories, Inc. | Enzyme quantification |
| US12352673B2 (en) | 2009-03-23 | 2025-07-08 | Bio-Rad Laboratories, Inc. | Manipulation of microfluidic droplets |
Families Citing this family (50)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20060169800A1 (en) * | 1999-06-11 | 2006-08-03 | Aradigm Corporation | Aerosol created by directed flow of fluids and devices and methods for producing same |
| US7575761B2 (en) | 2000-06-30 | 2009-08-18 | Novartis Pharma Ag | Spray drying process control of drying kinetics |
| US7585493B2 (en) | 2001-05-24 | 2009-09-08 | Alexza Pharmaceuticals, Inc. | Thin-film drug delivery article and method of use |
| US20030051728A1 (en) | 2001-06-05 | 2003-03-20 | Lloyd Peter M. | Method and device for delivering a physiologically active compound |
| CA2446904A1 (en) | 2001-05-24 | 2003-04-03 | Alexza Molecular Delivery Corporation | Delivery of drug esters through an inhalation route |
| US20070122353A1 (en) | 2001-05-24 | 2007-05-31 | Hale Ron L | Drug condensation aerosols and kits |
| US7458374B2 (en) | 2002-05-13 | 2008-12-02 | Alexza Pharmaceuticals, Inc. | Method and apparatus for vaporizing a compound |
| US6805853B2 (en) | 2001-11-09 | 2004-10-19 | Alexza Molecular Delivery Corporation | Delivery of diazepam through an inhalation route |
| US7090830B2 (en) | 2001-05-24 | 2006-08-15 | Alexza Pharmaceuticals, Inc. | Drug condensation aerosols and kits |
| US7498019B2 (en) | 2001-05-24 | 2009-03-03 | Alexza Pharmaceuticals, Inc. | Delivery of compounds for the treatment of headache through an inhalation route |
| CA2641760A1 (en) | 2001-05-24 | 2002-11-28 | Alexza Pharmaceuticals, Inc. | Delivery of alprazolam, estazolam, midazolam or triazolam through an inhalation route |
| US6759029B2 (en) | 2001-05-24 | 2004-07-06 | Alexza Molecular Delivery Corporation | Delivery of rizatriptan and zolmitriptan through an inhalation route |
| TW200300696A (en) | 2001-11-01 | 2003-06-16 | Inhale Therapeutic Syst | Spray drying methods and related compositions |
| EP1446102A1 (en) | 2001-11-21 | 2004-08-18 | Alexza Molecular Delivery Corporation | Delivery of caffeine through an inhalation route |
| US9339459B2 (en) | 2003-04-24 | 2016-05-17 | Nektar Therapeutics | Particulate materials |
| US7550133B2 (en) | 2002-11-26 | 2009-06-23 | Alexza Pharmaceuticals, Inc. | Respiratory drug condensation aerosols and methods of making and using them |
| GB0307403D0 (en) | 2003-03-31 | 2003-05-07 | Medical Res Council | Selection by compartmentalised screening |
| GB0307428D0 (en) | 2003-03-31 | 2003-05-07 | Medical Res Council | Compartmentalised combinatorial chemistry |
| US20060078893A1 (en) | 2004-10-12 | 2006-04-13 | Medical Research Council | Compartmentalised combinatorial chemistry by microfluidic control |
| EP1625336B9 (en) | 2003-05-21 | 2012-03-21 | Alexza Pharmaceuticals, Inc. | Use of a layer of solid fuel, method for producing such a layer and associated heating unit |
| US20050221339A1 (en) | 2004-03-31 | 2005-10-06 | Medical Research Council Harvard University | Compartmentalised screening by microfluidic control |
| US7540286B2 (en) | 2004-06-03 | 2009-06-02 | Alexza Pharmaceuticals, Inc. | Multiple dose condensation aerosol devices and methods of forming condensation aerosols |
| US7655470B2 (en) | 2004-10-29 | 2010-02-02 | University Of Chicago | Method for manipulating a plurality of plugs and performing reactions therein in microfluidic systems |
| US9477233B2 (en) | 2004-07-02 | 2016-10-25 | The University Of Chicago | Microfluidic system with a plurality of sequential T-junctions for performing reactions in microdroplets |
| AU2004322756B2 (en) | 2004-08-12 | 2011-04-14 | Alexza Pharmaceuticals, Inc. | Aerosol drug delivery device incorporating percussively activated heat packages |
| ES2265270B1 (es) * | 2005-04-18 | 2008-01-01 | Universidad De Sevilla | Procedimiento y dispositivo para micro-mezclado de fluidos mediante celula de reflujo. |
| EP1861194A2 (en) | 2005-03-04 | 2007-12-05 | The President and Fellows of Harvard College | Method and apparatus for forming multiple emulsions |
| US9012390B2 (en) | 2006-08-07 | 2015-04-21 | Raindance Technologies, Inc. | Fluorocarbon emulsion stabilizing surfactants |
| WO2008112661A2 (en) | 2007-03-09 | 2008-09-18 | Alexza Pharmaceuticals, Inc. | Heating unit for use in a drug delivery device |
| US7776927B2 (en) | 2007-03-28 | 2010-08-17 | President And Fellows Of Harvard College | Emulsions and techniques for formation |
| WO2009129547A1 (en) | 2008-04-18 | 2009-10-22 | The Board Of Trustees Of The University Of Alabama | Meso-scaled combustion system |
| US20100176063A1 (en) * | 2009-01-12 | 2010-07-15 | Yuri Kokotov | Method for coalescence induced liquid-liquid separations and apparatus thereof |
| EP2473263B1 (en) | 2009-09-02 | 2022-11-02 | President and Fellows of Harvard College | Multiple emulsions created using jetting and other techniques |
| WO2011042564A1 (en) | 2009-10-09 | 2011-04-14 | Universite De Strasbourg | Labelled silica-based nanomaterial with enhanced properties and uses thereof |
| EP2517025B1 (en) | 2009-12-23 | 2019-11-27 | Bio-Rad Laboratories, Inc. | Methods for reducing the exchange of molecules between droplets |
| EP2576078B1 (en) | 2010-05-28 | 2018-04-25 | Arizona Board of Regents acting for and on behalf of Arizona State University | Apparatus and methods for a gas dynamic virtual nozzle |
| US20120048963A1 (en) | 2010-08-26 | 2012-03-01 | Alexza Pharmaceuticals, Inc. | Heat Units Using a Solid Fuel Capable of Undergoing an Exothermic Metal Oxidation-Reduction Reaction Propagated without an Igniter |
| WO2012162296A2 (en) | 2011-05-23 | 2012-11-29 | President And Fellows Of Harvard College | Control of emulsions, including multiple emulsions |
| US8841071B2 (en) | 2011-06-02 | 2014-09-23 | Raindance Technologies, Inc. | Sample multiplexing |
| WO2013006661A2 (en) | 2011-07-06 | 2013-01-10 | President And Fellows Of Harvard College | Multiple emulsions and techniques for the formation of multiple emulsions |
| EP2777818A1 (en) | 2013-03-15 | 2014-09-17 | Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. | Method and device of producing an intermittent liquid jet |
| US9821325B2 (en) | 2013-04-30 | 2017-11-21 | Arizona Board Of Regents On Behalf Of Arizona State University | Apparatus and methods for lipidic cubic phase (LCP) injection for membrane protein investigations |
| US11193176B2 (en) | 2013-12-31 | 2021-12-07 | Bio-Rad Laboratories, Inc. | Method for detecting and quantifying latent retroviral RNA species |
| WO2016145075A1 (en) | 2015-03-11 | 2016-09-15 | Alexza Pharmaceuticals, Inc. | Use of antistatic materials in the airway for thermal aerosol condensation process |
| CA2997011A1 (en) | 2015-08-28 | 2017-03-09 | Regents Of The University Of Minnesota | Nozzles and methods of mixing fluid flows |
| ES2663217B1 (es) * | 2016-10-10 | 2019-02-07 | Ingeniatrics Tecnologias S L | Aparato y método para mezclar al menos dos líquidos |
| EP3746138B1 (en) | 2018-02-02 | 2025-12-10 | Alexza Pharmaceuticals, Inc. | Electrical condensation aerosol device |
| JP2021526963A (ja) | 2018-06-14 | 2021-10-11 | リージェンツ オブ ザ ユニバーシティ オブ ミネソタ | 対向流混合装置及び噴霧装置 |
| US10369579B1 (en) | 2018-09-04 | 2019-08-06 | Zyxogen, Llc | Multi-orifice nozzle for droplet atomization |
| CN115228642A (zh) * | 2022-08-02 | 2022-10-25 | 北京航空航天大学 | 小流量分散流雾化喷嘴及低流速雾化器 |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH05138080A (ja) * | 1991-11-25 | 1993-06-01 | Matsushita Electric Ind Co Ltd | 霧化装置 |
| WO1997043048A1 (es) * | 1996-05-13 | 1997-11-20 | Universidad De Sevilla, Vicerrectorado De Investigacion | Procedimiento de atomizacion de liquidos |
| US5884846A (en) * | 1996-09-19 | 1999-03-23 | Tan; Hsiaoming Sherman | Pneumatic concentric nebulizer with adjustable and capillaries |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5868322A (en) * | 1996-01-31 | 1999-02-09 | Hewlett-Packard Company | Apparatus for forming liquid droplets having a mechanically fixed inner microtube |
| AU745904B2 (en) | 1997-12-17 | 2002-04-11 | Universidad De Sevilla | Device and method for creating spherical particles of uniform size |
-
2000
- 2000-06-09 EP EP00938249.0A patent/EP1192009B1/en not_active Expired - Lifetime
- 2000-06-09 ES ES00938249T patent/ES2424713T4/es not_active Expired - Lifetime
- 2000-06-09 AU AU53318/00A patent/AU767486B2/en not_active Ceased
- 2000-06-09 WO PCT/US2000/015931 patent/WO2000076673A1/en not_active Ceased
- 2000-06-09 CA CA2374232A patent/CA2374232C/en not_active Expired - Lifetime
- 2000-06-09 JP JP2001502989A patent/JP2003501257A/ja active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH05138080A (ja) * | 1991-11-25 | 1993-06-01 | Matsushita Electric Ind Co Ltd | 霧化装置 |
| WO1997043048A1 (es) * | 1996-05-13 | 1997-11-20 | Universidad De Sevilla, Vicerrectorado De Investigacion | Procedimiento de atomizacion de liquidos |
| US5884846A (en) * | 1996-09-19 | 1999-03-23 | Tan; Hsiaoming Sherman | Pneumatic concentric nebulizer with adjustable and capillaries |
Cited By (64)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2003093860A (ja) * | 2001-09-25 | 2003-04-02 | Inoac Corp | 流体混合機構 |
| US8986628B2 (en) | 2002-06-28 | 2015-03-24 | President And Fellows Of Harvard College | Method and apparatus for fluid dispersion |
| JP2010075927A (ja) * | 2002-06-28 | 2010-04-08 | President & Fellows Of Harvard College | 流体分散のための方法および装置 |
| US11187702B2 (en) | 2003-03-14 | 2021-11-30 | Bio-Rad Laboratories, Inc. | Enzyme quantification |
| JP2006523142A (ja) * | 2003-04-10 | 2006-10-12 | プレジデント・アンド・フェロウズ・オブ・ハーバード・カレッジ | 流体種の形成および制御 |
| US9038919B2 (en) | 2003-04-10 | 2015-05-26 | President And Fellows Of Harvard College | Formation and control of fluidic species |
| JP2011025243A (ja) * | 2003-04-10 | 2011-02-10 | President & Fellows Of Harvard College | 流体種の形成および制御 |
| US10293341B2 (en) | 2003-04-10 | 2019-05-21 | President And Fellows Of Harvard College | Formation and control of fluidic species |
| JP2014111257A (ja) * | 2003-04-10 | 2014-06-19 | President & Fellows Of Harvard College | 流体種の形成および制御 |
| US11141731B2 (en) | 2003-04-10 | 2021-10-12 | President And Fellows Of Harvard College | Formation and control of fluidic species |
| US20150283546A1 (en) | 2003-04-10 | 2015-10-08 | President And Fellows Of Harvard College | Formation and control of fluidic species |
| US7600522B2 (en) | 2003-05-22 | 2009-10-13 | Dainippon Screen Mfg. Co., Ltd. | Substrate treatment method and substrate treatment apparatus |
| US9878325B2 (en) | 2003-08-27 | 2018-01-30 | President And Fellows Of Harvard College | Electronic control of fluidic species |
| US8765485B2 (en) | 2003-08-27 | 2014-07-01 | President And Fellows Of Harvard College | Electronic control of fluidic species |
| US11383234B2 (en) | 2003-08-27 | 2022-07-12 | President And Fellows Of Harvard College | Electronic control of fluidic species |
| US10625256B2 (en) | 2003-08-27 | 2020-04-21 | President And Fellows Of Harvard College | Electronic control of fluidic species |
| US9789482B2 (en) | 2003-08-27 | 2017-10-17 | President And Fellows Of Harvard College | Methods of introducing a fluid into droplets |
| JP2008514414A (ja) * | 2004-09-30 | 2008-05-08 | ウニベルシダ デ セビリャ | 内破性ガス流により液体を空圧式に微粒化するための装置および手順 |
| US11786872B2 (en) | 2004-10-08 | 2023-10-17 | United Kingdom Research And Innovation | Vitro evolution in microfluidic systems |
| JP2008538192A (ja) * | 2005-01-17 | 2008-10-16 | ウニベルシダ デ セビリャ | 還流セルを通して流体をミクロ混合するための手順およびデバイス |
| JP4875628B2 (ja) * | 2005-01-17 | 2012-02-15 | ウニベルシダ デ セビリャ | 還流セルを通して流体をミクロ混合するための手順およびデバイス |
| US9410151B2 (en) | 2006-01-11 | 2016-08-09 | Raindance Technologies, Inc. | Microfluidic devices and methods of use in the formation and control of nanoreactors |
| US9534216B2 (en) | 2006-01-11 | 2017-01-03 | Raindance Technologies, Inc. | Microfluidic devices and methods of use in the formation and control of nanoreactors |
| US12146134B2 (en) | 2006-01-11 | 2024-11-19 | Bio-Rad Laboratories, Inc. | Microfluidic devices and methods of use in the formation and control of nanoreactors |
| US9328344B2 (en) | 2006-01-11 | 2016-05-03 | Raindance Technologies, Inc. | Microfluidic devices and methods of use in the formation and control of nanoreactors |
| US9562837B2 (en) | 2006-05-11 | 2017-02-07 | Raindance Technologies, Inc. | Systems for handling microfludic droplets |
| US12091710B2 (en) | 2006-05-11 | 2024-09-17 | Bio-Rad Laboratories, Inc. | Systems and methods for handling microfluidic droplets |
| US10639597B2 (en) | 2006-05-11 | 2020-05-05 | Bio-Rad Laboratories, Inc. | Microfluidic devices |
| US11351510B2 (en) | 2006-05-11 | 2022-06-07 | Bio-Rad Laboratories, Inc. | Microfluidic devices |
| US12337287B2 (en) | 2006-05-11 | 2025-06-24 | Bio-Rad Laboratories, Inc. | Microfluidic devices |
| US11819849B2 (en) | 2007-02-06 | 2023-11-21 | Brandeis University | Manipulation of fluids and reactions in microfluidic systems |
| US10603662B2 (en) | 2007-02-06 | 2020-03-31 | Brandeis University | Manipulation of fluids and reactions in microfluidic systems |
| US9440232B2 (en) | 2007-02-06 | 2016-09-13 | Raindance Technologies, Inc. | Manipulation of fluids and reactions in microfluidic systems |
| US10960397B2 (en) | 2007-04-19 | 2021-03-30 | President And Fellows Of Harvard College | Manipulation of fluids, fluid components and reactions in microfluidic systems |
| US9068699B2 (en) | 2007-04-19 | 2015-06-30 | Brandeis University | Manipulation of fluids, fluid components and reactions in microfluidic systems |
| US11224876B2 (en) | 2007-04-19 | 2022-01-18 | Brandeis University | Manipulation of fluids, fluid components and reactions in microfluidic systems |
| US10357772B2 (en) | 2007-04-19 | 2019-07-23 | President And Fellows Of Harvard College | Manipulation of fluids, fluid components and reactions in microfluidic systems |
| US10675626B2 (en) | 2007-04-19 | 2020-06-09 | President And Fellows Of Harvard College | Manipulation of fluids, fluid components and reactions in microfluidic systems |
| US11618024B2 (en) | 2007-04-19 | 2023-04-04 | President And Fellows Of Harvard College | Manipulation of fluids, fluid components and reactions in microfluidic systems |
| US11596908B2 (en) | 2008-07-18 | 2023-03-07 | Bio-Rad Laboratories, Inc. | Droplet libraries |
| US12038438B2 (en) | 2008-07-18 | 2024-07-16 | Bio-Rad Laboratories, Inc. | Enzyme quantification |
| US11511242B2 (en) | 2008-07-18 | 2022-11-29 | Bio-Rad Laboratories, Inc. | Droplet libraries |
| US11534727B2 (en) | 2008-07-18 | 2022-12-27 | Bio-Rad Laboratories, Inc. | Droplet libraries |
| US12352673B2 (en) | 2009-03-23 | 2025-07-08 | Bio-Rad Laboratories, Inc. | Manipulation of microfluidic droplets |
| US11390917B2 (en) | 2010-02-12 | 2022-07-19 | Bio-Rad Laboratories, Inc. | Digital analyte analysis |
| US11254968B2 (en) | 2010-02-12 | 2022-02-22 | Bio-Rad Laboratories, Inc. | Digital analyte analysis |
| US12454718B2 (en) | 2010-02-12 | 2025-10-28 | Bio-Rad Laboratories, Inc. | Digital analyte analysis |
| US9366632B2 (en) | 2010-02-12 | 2016-06-14 | Raindance Technologies, Inc. | Digital analyte analysis |
| US10351905B2 (en) | 2010-02-12 | 2019-07-16 | Bio-Rad Laboratories, Inc. | Digital analyte analysis |
| US10808279B2 (en) | 2010-02-12 | 2020-10-20 | Bio-Rad Laboratories, Inc. | Digital analyte analysis |
| US11635427B2 (en) | 2010-09-30 | 2023-04-25 | Bio-Rad Laboratories, Inc. | Sandwich assays in droplets |
| US11077415B2 (en) | 2011-02-11 | 2021-08-03 | Bio-Rad Laboratories, Inc. | Methods for forming mixed droplets |
| US12140590B2 (en) | 2011-02-18 | 2024-11-12 | Bio-Rad Laboratories, Inc. | Compositions and methods for molecular labeling |
| US11965877B2 (en) | 2011-02-18 | 2024-04-23 | Bio-Rad Laboratories, Inc. | Compositions and methods for molecular labeling |
| US11168353B2 (en) | 2011-02-18 | 2021-11-09 | Bio-Rad Laboratories, Inc. | Compositions and methods for molecular labeling |
| US12140591B2 (en) | 2011-02-18 | 2024-11-12 | Bio-Rad Laboratories, Inc. | Compositions and methods for molecular labeling |
| US11768198B2 (en) | 2011-02-18 | 2023-09-26 | Bio-Rad Laboratories, Inc. | Compositions and methods for molecular labeling |
| US11747327B2 (en) | 2011-02-18 | 2023-09-05 | Bio-Rad Laboratories, Inc. | Compositions and methods for molecular labeling |
| US12461094B2 (en) | 2011-02-18 | 2025-11-04 | Bio-Rad Laboratories, Inc. | Compositions and methods for molecular labeling |
| US11754499B2 (en) | 2011-06-02 | 2023-09-12 | Bio-Rad Laboratories, Inc. | Enzyme quantification |
| US11898193B2 (en) | 2011-07-20 | 2024-02-13 | Bio-Rad Laboratories, Inc. | Manipulating droplet size |
| US11901041B2 (en) | 2013-10-04 | 2024-02-13 | Bio-Rad Laboratories, Inc. | Digital analysis of nucleic acid modification |
| US11174509B2 (en) | 2013-12-12 | 2021-11-16 | Bio-Rad Laboratories, Inc. | Distinguishing rare variations in a nucleic acid sequence from a sample |
| US10647981B1 (en) | 2015-09-08 | 2020-05-12 | Bio-Rad Laboratories, Inc. | Nucleic acid library generation methods and compositions |
Also Published As
| Publication number | Publication date |
|---|---|
| CA2374232C (en) | 2013-08-20 |
| ES2424713T3 (es) | 2013-10-07 |
| AU767486B2 (en) | 2003-11-13 |
| ES2424713T4 (es) | 2014-01-23 |
| EP1192009A1 (en) | 2002-04-03 |
| EP1192009B1 (en) | 2013-05-01 |
| AU5331800A (en) | 2001-01-02 |
| CA2374232A1 (en) | 2000-12-21 |
| EP1192009A4 (en) | 2006-10-18 |
| WO2000076673A1 (en) | 2000-12-21 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2003501257A (ja) | エーロゾルを生成する方法 | |
| US20080053436A1 (en) | Aerosol created by directed flow of fluids and devices and methods for producing same | |
| US8733343B2 (en) | Device and method for creating aerosols for drug delivery | |
| US6357670B2 (en) | Stabilized capillary microjet and devices and methods for producing same | |
| CA2314920C (en) | Device and method for creating aerosols for drug delivery | |
| US6405936B1 (en) | Stabilized capillary microjet and devices and methods for producing same | |
| US6595202B2 (en) | Device and method for creating aerosols for drug delivery | |
| JP2002508250A (ja) | 均一なサイズの球状微粒子を生成するデバイスおよび方法 | |
| JP2002508238A (ja) | 流体のエアレーションのためのデバイスおよび方法 | |
| JP2002508242A (ja) | 燃料噴射ノズルおよびその使用方法 | |
| AU5934602A (en) | Device and method for creating aerosols for drug delivery | |
| AU2006209366A1 (en) | Device and method for creating aerosols for drug delivery |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20070223 |
|
| A621 | Written request for application examination |
Free format text: JAPANESE INTERMEDIATE CODE: A621 Effective date: 20070223 |
|
| A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20091201 |
|
| A02 | Decision of refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A02 Effective date: 20100427 |