JP2003500450A - 陽電子放射断層撮影法のための表皮成長因子受容体に結合する新規化合物 - Google Patents
陽電子放射断層撮影法のための表皮成長因子受容体に結合する新規化合物Info
- Publication number
- JP2003500450A JP2003500450A JP2000620961A JP2000620961A JP2003500450A JP 2003500450 A JP2003500450 A JP 2003500450A JP 2000620961 A JP2000620961 A JP 2000620961A JP 2000620961 A JP2000620961 A JP 2000620961A JP 2003500450 A JP2003500450 A JP 2003500450A
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- compound
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- fluorine
- hydrogen
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
- C07D239/72—Quinazolines; Hydrogenated quinazolines
- C07D239/86—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 4
- C07D239/94—Nitrogen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/041—Heterocyclic compounds
- A61K51/044—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
- A61K51/0459—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having six-membered rings with two nitrogen atoms as the only ring hetero atoms, e.g. piperazine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Physics & Mathematics (AREA)
- Optics & Photonics (AREA)
- Epidemiology (AREA)
- Dermatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Applications Claiming Priority (3)
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| US09/322,979 US6126917A (en) | 1999-06-01 | 1999-06-01 | Epidermal growth factor receptor binding compounds for positron emission tomography |
| US09/322,979 | 1999-06-01 | ||
| PCT/US2000/013749 WO2000072849A1 (en) | 1999-06-01 | 2000-05-19 | Novel epidermal growth factor receptor-binding compounds for positron emission tomography |
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| JP2003500450A true JP2003500450A (ja) | 2003-01-07 |
| JP2003500450A5 JP2003500450A5 (enExample) | 2007-05-10 |
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| US (1) | US6126917A (enExample) |
| EP (1) | EP1180034A4 (enExample) |
| JP (1) | JP2003500450A (enExample) |
| AU (1) | AU4857400A (enExample) |
| CA (1) | CA2375826A1 (enExample) |
| IL (1) | IL146805A0 (enExample) |
| WO (1) | WO2000072849A1 (enExample) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2007191430A (ja) * | 2006-01-19 | 2007-08-02 | Fujifilm Ri Pharma Co Ltd | ４−フェノキシキナゾリン誘導体放射性化合物 |
| JP2011508752A (ja) * | 2008-01-03 | 2011-03-17 | コミッサリア ア ロンネルジー アトミック エ オ ゾンネルジー ザルテルナティーフ | マークされたプリン誘導体の製造方法、該プリン誘導体、およびその使用 |
Families Citing this family (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2002020434A1 (en) * | 2000-09-07 | 2002-03-14 | Wisconsin Alumni Research Foundation | Synthesis of 17f labeled fluoroalkanes |
| US6562319B2 (en) * | 2001-03-12 | 2003-05-13 | Yissum Research Development Company Of The Hebrew University Of Jerusalem | Radiolabeled irreversible inhibitors of epidermal growth factor receptor tyrosine kinase and their use in radioimaging and radiotherapy |
| WO2003065971A2 (en) * | 2001-06-14 | 2003-08-14 | Yissum Research Development Company Of The Hebrew University Of Jerusalem | Non-myeloablative tolerogenic treatment with tyrphostins |
| TW200813014A (en) * | 2002-03-28 | 2008-03-16 | Astrazeneca Ab | Quinazoline derivatives |
| US6924285B2 (en) * | 2002-03-30 | 2005-08-02 | Boehringer Ingelheim Pharma Gmbh & Co. | Bicyclic heterocyclic compounds, pharmaceutical compositions containing these compounds, their use and process for preparing them |
| WO2004006846A2 (en) | 2002-07-15 | 2004-01-22 | Exelixis, Inc. | Receptor-type kinase modulators and methods of use |
| WO2004064718A2 (en) * | 2003-01-23 | 2004-08-05 | T.K. Signal Ltd. | Irreversible inhibitors of egf receptor tyrosine kinases and uses thereof |
| GB0317665D0 (en) * | 2003-07-29 | 2003-09-03 | Astrazeneca Ab | Qinazoline derivatives |
| BRPI0413066A (pt) * | 2003-07-29 | 2006-10-17 | Astrazeneca Ab | derivado de quinazolina, ou um sal farmaceuticamente aceitável, ou um éster farmaceuticamente aceitável do mesmo, da fórmula i, uso e processo para a preparação do mesmo, composto, composição farmacêutica, e, métodos para a produção de um efeito antiproliferativo em um animal de sangue quente, para a prevenção ou tratamento de um tumor, para prover um efeito inibitório de tirosina quinase de egfr seletivo, e para tratar um cáncer em um animal de sangue quente |
| ATE352550T1 (de) * | 2003-09-19 | 2007-02-15 | Astrazeneca Ab | Chinazolinderivate |
| ATE353888T1 (de) * | 2003-09-19 | 2007-03-15 | Astrazeneca Ab | Chinazolinderivate |
| JP2007506716A (ja) * | 2003-09-25 | 2007-03-22 | アストラゼネカ アクチボラグ | キナゾリン誘導体 |
| CA2744997A1 (en) | 2003-09-26 | 2005-04-07 | Exelixis, Inc. | C-met modulators and method of use |
| NO20035682D0 (no) * | 2003-12-18 | 2003-12-18 | Amersham Health As | Optisk avbildning av ösofagkreft og Barretts ösofag |
| NO20035681D0 (no) * | 2003-12-18 | 2003-12-18 | Amersham Health As | Optisk avbildning av lungekreft |
| UY29398A1 (es) * | 2005-02-26 | 2006-10-02 | Astrazeneca Ab | Derivados de quinazolinas, sussales farmacéuticamente aceptables, composiciones que los contienen, procedimientos de preparación y aplicacións. |
| EP1957468A2 (en) * | 2005-09-06 | 2008-08-20 | T.K. Signal Ltd. | Polyalkylene glycol derivatives of 4 - (phenylamino)quinazolines useful as irreversible inhibitors of epidermal growth factor receptor tyrosine kinase |
| EP1921070A1 (de) * | 2006-11-10 | 2008-05-14 | Boehringer Ingelheim Pharma GmbH & Co. KG | Bicyclische Heterocyclen, diese Verbindungen enthaltende Arzneimittel, deren Verwendung und Verfahren zu ihrer Herstelllung |
| EA200901041A1 (ru) * | 2007-02-06 | 2010-02-26 | Бёрингер Ингельхайм Интернациональ Гмбх | Бициклические гетероциклы, содержащие эти соединения лекарственные средства, их применение и способ их получения |
| PL2245026T3 (pl) * | 2008-02-07 | 2013-01-31 | Boehringer Ingelheim Int | Spirocykliczne heterocykle, leki zawierające te związki, ich zastosowanie i sposób ich produkcji |
| ES2444128T3 (es) * | 2008-05-13 | 2014-02-24 | Astrazeneca Ab | Nueva SAL-554 |
| JP5539351B2 (ja) * | 2008-08-08 | 2014-07-02 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | シクロヘキシルオキシ置換ヘテロ環、これらの化合物を含有する医薬、およびそれらを生成するための方法 |
| KR101733773B1 (ko) | 2009-01-16 | 2017-05-10 | 엑셀리시스, 인코포레이티드 | Ｎ-（４-｛〔６，７-비스（메틸옥시）퀴놀린-4-일〕옥시｝페닐）-ｎ＇-（４-플루오로페닐）사이클로프로판-1,1-디카르복사미드의 말산염 및 그 결정형 |
| UA108618C2 (uk) | 2009-08-07 | 2015-05-25 | Застосування c-met-модуляторів в комбінації з темозоломідом та/або променевою терапією для лікування раку | |
| US8753605B2 (en) | 2010-08-31 | 2014-06-17 | The Board Of Trustees Of The Leland Stanford Junior University | Imaging probes, methods of making imaging probes, and methods of imaging |
| CN103254140B (zh) * | 2012-02-17 | 2016-02-17 | 北京师范大学 | 新型18f标记取代喹唑啉类化合物及其制备方法和肿瘤pet显像应用 |
| WO2017122205A1 (en) | 2016-01-13 | 2017-07-20 | Hadasit Medical Research Services And Development Ltd. | Radiolabeled erlotinib analogs and uses thereof |
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| JP2002516823A (ja) * | 1998-05-28 | 2002-06-11 | パーカー ヒューズ インスティテュート | 脳腫瘍の治療のためのキナゾリン |
| JP2002521475A (ja) * | 1998-07-30 | 2002-07-16 | パーカー ヒューズ インスティテュート | 脂質を低下するキナゾリン誘導体 |
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| JPS57144266A (en) * | 1981-03-04 | 1982-09-06 | Sankyo Co Ltd | 4-anilinoquinazoline derivative, its preparation, and analgesic and antiphlogistic agent containing said derivative as active component |
| AU661533B2 (en) * | 1992-01-20 | 1995-07-27 | Astrazeneca Ab | Quinazoline derivatives |
| US5792771A (en) * | 1992-11-13 | 1998-08-11 | Sugen, Inc. | Quinazoline compounds and compositions thereof for the treatment of disease |
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1999
- 1999-06-01 US US09/322,979 patent/US6126917A/en not_active Expired - Lifetime
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2000
- 2000-05-19 AU AU48574/00A patent/AU4857400A/en not_active Abandoned
- 2000-05-19 JP JP2000620961A patent/JP2003500450A/ja active Pending
- 2000-05-19 IL IL14680500A patent/IL146805A0/xx unknown
- 2000-05-19 EP EP00930818A patent/EP1180034A4/en not_active Withdrawn
- 2000-05-19 WO PCT/US2000/013749 patent/WO2000072849A1/en not_active Ceased
- 2000-05-19 CA CA002375826A patent/CA2375826A1/en not_active Abandoned
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| JPH05208911A (ja) * | 1991-06-28 | 1993-08-20 | Imperial Chem Ind Plc <Ici> | 抗癌作用を有する医薬組成物、キナゾリン誘導体及びその製法 |
| JPH0673025A (ja) * | 1992-06-26 | 1994-03-15 | Zeneca Ltd | キナゾリン誘導体、その製造法および該キナゾリン誘導体を含有する抗癌作用を得るための医薬調剤 |
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| US5747498A (en) * | 1996-05-28 | 1998-05-05 | Pfizer Inc. | Alkynyl and azido-substituted 4-anilinoquinazolines |
| WO1998010767A2 (en) * | 1996-09-13 | 1998-03-19 | Sugen, Inc. | Use of quinazoline derivatives for the manufacture of a medicament in the treatment of hyperproliferative skin disorders |
| JP2002516823A (ja) * | 1998-05-28 | 2002-06-11 | パーカー ヒューズ インスティテュート | 脳腫瘍の治療のためのキナゾリン |
| JP2002521475A (ja) * | 1998-07-30 | 2002-07-16 | パーカー ヒューズ インスティテュート | 脂質を低下するキナゾリン誘導体 |
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| JP2002539262A (ja) * | 1999-03-19 | 2002-11-19 | パーカー ヒューズ インスティテュート | キナゾリン化合物製剤および治療におけるその使用 |
| JP2002540103A (ja) * | 1999-03-19 | 2002-11-26 | パーカー ヒューズ インスティテュート | キナゾリン類およびそれらの治療上における使用方法 |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2007191430A (ja) * | 2006-01-19 | 2007-08-02 | Fujifilm Ri Pharma Co Ltd | ４−フェノキシキナゾリン誘導体放射性化合物 |
| JP2011508752A (ja) * | 2008-01-03 | 2011-03-17 | コミッサリア ア ロンネルジー アトミック エ オ ゾンネルジー ザルテルナティーフ | マークされたプリン誘導体の製造方法、該プリン誘導体、およびその使用 |
| US11298432B2 (en) | 2008-01-03 | 2022-04-12 | Commissariat A L'energie Atomique Et Aux Energies Alternatives | Method for preparing a marked purine derivative, said derivative and uses thereof |
Also Published As
| Publication number | Publication date |
|---|---|
| EP1180034A1 (en) | 2002-02-20 |
| EP1180034A4 (en) | 2003-05-14 |
| IL146805A0 (en) | 2002-07-25 |
| US6126917A (en) | 2000-10-03 |
| CA2375826A1 (en) | 2000-12-07 |
| AU4857400A (en) | 2000-12-18 |
| WO2000072849A1 (en) | 2000-12-07 |
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