JP2003500406A - 光学活性を誘発する７−ピロリジン置換体を持った光学活性のキノリンカルボン酸誘導体及びその製造方法 - Google Patents

光学活性を誘発する７−ピロリジン置換体を持った光学活性のキノリンカルボン酸誘導体及びその製造方法

Info

Publication number
JP2003500406A
JP2003500406A JP2000619797A JP2000619797A JP2003500406A JP 2003500406 A JP2003500406 A JP 2003500406A JP 2000619797 A JP2000619797 A JP 2000619797A JP 2000619797 A JP2000619797 A JP 2000619797A JP 2003500406 A JP2003500406 A JP 2003500406A
Authority
JP
Japan
Prior art keywords
formula
compound
optically active
acid
reaction
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
JP2000619797A
Other languages
English (en)
Japanese (ja)
Other versions
JP2003500406A5 (https=
Inventor
サン ジュン ヨン
ヤン ホー チュン
チ ウー リー
ジン ソー リー
ナム ドー キム
ヨン ホー ジン
ワン ジン ソン
イク ホー キム
ウォン ヨン ヤン
ドン ラク チョイ
ジュン ハン シン
Original Assignee
ドン ワ ファーマシューティカルズ インダストリー コーポレーティッド リミテッド
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from KR1020000024657A external-priority patent/KR20010029698A/ko
Application filed by ドン ワ ファーマシューティカルズ インダストリー コーポレーティッド リミテッド filed Critical ドン ワ ファーマシューティカルズ インダストリー コーポレーティッド リミテッド
Publication of JP2003500406A publication Critical patent/JP2003500406A/ja
Publication of JP2003500406A5 publication Critical patent/JP2003500406A5/ja
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/10—Spiro-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Communicable Diseases (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pyrrole Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
JP2000619797A 1999-05-20 2000-05-18 光学活性を誘発する７−ピロリジン置換体を持った光学活性のキノリンカルボン酸誘導体及びその製造方法 Withdrawn JP2003500406A (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
KR19990018158 1999-05-20
KR1999/18158 1999-05-20
KR1020000024657A KR20010029698A (ko) 1999-05-20 2000-05-09 광학활성을 유발하는 7-피롤리딘 치환체를 갖는광학활성의 퀴놀린 카르복실산 유도체 및 그의 제조방법
KR2000/24657 2000-05-09
PCT/KR2000/000487 WO2000071541A1 (en) 1999-05-20 2000-05-18 Optically active quinoline carboxylic acid derivatives having 7-pyrrolidine substitutes causing optical activity and a process for preparing thereof

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2006084397A Division JP5276255B2 (ja) 1999-05-20 2006-03-27 光学活性を誘発する７−ピロリジン置換体を持った光学活性のキノリンカルボン酸誘導体及びその製造方法

Publications (2)

Publication Number Publication Date
JP2003500406A true JP2003500406A (ja) 2003-01-07
JP2003500406A5 JP2003500406A5 (https=) 2006-01-05

Family

ID=37040873

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2000619797A Withdrawn JP2003500406A (ja) 1999-05-20 2000-05-18 光学活性を誘発する７−ピロリジン置換体を持った光学活性のキノリンカルボン酸誘導体及びその製造方法
JP2006084397A Expired - Lifetime JP5276255B2 (ja) 1999-05-20 2006-03-27 光学活性を誘発する７−ピロリジン置換体を持った光学活性のキノリンカルボン酸誘導体及びその製造方法

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2006084397A Expired - Lifetime JP5276255B2 (ja) 1999-05-20 2006-03-27 光学活性を誘発する７−ピロリジン置換体を持った光学活性のキノリンカルボン酸誘導体及びその製造方法

Country Status (11)

Country Link
US (2) US6649763B1 (https=)
EP (1) EP1187835B1 (https=)
JP (2) JP2003500406A (https=)
KR (1) KR100497942B1 (https=)
CN (1) CN1142164C (https=)
AT (1) ATE382047T1 (https=)
AU (1) AU757272B2 (https=)
CA (1) CA2374767C (https=)
DE (1) DE60037587T2 (https=)
ES (1) ES2296618T3 (https=)
WO (1) WO2000071541A1 (https=)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2013500251A (ja) * 2009-07-27 2013-01-07 アリメド インコーポレーテッド Ｒ−７−（３−アミノメチル−４−メトキシイミノ−３−メチル−ピロリジン−１−イル）−１−シクロプロピル−６−フルオロ−４−オキソ−１，４−ジヒドロ−［１，８］ナフチリジン−３−カルボキシル酸ｌ−アスパラギン酸塩、その製造方法及びこれを含む抗菌用薬学的組成物

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6589978B2 (en) * 2000-06-30 2003-07-08 Hoffman-La Roche Inc. 1-sulfonyl pyrrolidine derivatives
WO2006099167A1 (en) * 2005-03-10 2006-09-21 Theravance, Inc. Biphenyl compounds useful as muscarinic receptor antagonists
US7902227B2 (en) 2007-07-27 2011-03-08 Janssen Pharmaceutica Nv. C-7 isoxazolinyl quinolone / naphthyridine derivatives useful as antibacterial agents
CN101353348A (zh) * 2008-07-28 2009-01-28 南京明生医药技术有限公司 7-[4-(胺甲基)-4-氟-3-(烷氧亚氨基)吡咯烷-1-基]取代的喹啉羧酸衍生物及其制备方法
KR20220135949A (ko) 2021-03-31 2022-10-07 주식회사 이큐인베스트먼트 차트 유사도 분석을 이용한 주식 거래 인공신경망 장치 및 방법

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0541086A1 (en) * 1991-11-08 1993-05-12 Kaken Pharmaceutical Co., Ltd. Antibacterial 6-fluoro-quinolones having an oxime group on the substituent in position 7
DK0688772T3 (da) * 1994-06-16 1999-11-01 Lg Chemical Ltd Quinolincarboxylsyrederivater med 7-(4-aminomethyl-3-oxim)-pyrrolidinsubstituenter og fremgangsmåde til deres fremstilling
IT234996Y1 (it) 1994-06-22 2000-03-31 Bocchiotti Soc Ind Elettrotec Imballaggio per profilati metallici.
DE4422237A1 (de) * 1994-06-24 1996-01-04 Gruenenthal Gmbh Verwendung von Lactamverbindungen als pharmazeutische Wirkstoffe
KR0174373B1 (ko) * 1995-08-03 1999-02-18 성재갑 7-(4-아미노메틸-4-알킬-3-알킬옥심)피롤리딘 치환체를 갖는 신규 퀴놀린 카르복실산 유도체 및 그의 제조방법
KR100566346B1 (ko) * 1997-06-26 2006-11-10 동화약품공업주식회사 퀴놀론카르복실산 유도체

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2013500251A (ja) * 2009-07-27 2013-01-07 アリメド インコーポレーテッド Ｒ−７−（３−アミノメチル−４−メトキシイミノ−３−メチル−ピロリジン−１−イル）−１−シクロプロピル−６−フルオロ−４−オキソ−１，４−ジヒドロ−［１，８］ナフチリジン−３−カルボキシル酸ｌ−アスパラギン酸塩、その製造方法及びこれを含む抗菌用薬学的組成物

Also Published As

Publication number Publication date
DE60037587T2 (de) 2008-04-30
CN1358185A (zh) 2002-07-10
JP2006232842A (ja) 2006-09-07
US6649763B1 (en) 2003-11-18
EP1187835A4 (en) 2003-01-29
US6753430B2 (en) 2004-06-22
AU4620900A (en) 2000-12-12
DE60037587D1 (de) 2008-02-07
EP1187835A1 (en) 2002-03-20
US20040029915A1 (en) 2004-02-12
WO2000071541A1 (en) 2000-11-30
ES2296618T3 (es) 2008-05-01
ATE382047T1 (de) 2008-01-15
CA2374767C (en) 2007-05-15
JP5276255B2 (ja) 2013-08-28
CA2374767A1 (en) 2000-11-30
KR20020002461A (ko) 2002-01-09
EP1187835B1 (en) 2007-12-26
KR100497942B1 (ko) 2005-06-29
CN1142164C (zh) 2004-03-17
AU757272B2 (en) 2003-02-13

Similar Documents

Publication Publication Date Title
JP3463939B2 (ja) ヘリコバクター・ピロリ感染及び関連する胃十二指腸疾患の処置のための７−（２−オキサ−５，８−ジアザビシクロ［４．３．０］ノニ−８−イル）−キノロンカルボン酸及びナフチリドンカルボン酸誘導体の使用
JP2002527434A (ja) キノリン誘導体および抗菌剤としてその使用
CS246065B2 (en) Method of new 7-substituted cyclic aminonaphthyridine-,quinoline-and benzoxazinecarboxylic acids production
JPH0798819B2 (ja) 置換架橋ジアザビシクロアルキルキノロンカルボン酸
JP2628541B2 (ja) ３−アルキル−３−アミノメチルピロリジン類
CA3173787A1 (en) Expanded dosage regimens for integrin inhibitors
KR100566346B1 (ko) 퀴놀론카르복실산 유도체
JP5276255B2 (ja) 光学活性を誘発する７−ピロリジン置換体を持った光学活性のキノリンカルボン酸誘導体及びその製造方法
JP2817907B2 (ja) 抗菌剤製造用の中間体
WO1996022988A1 (en) Quinolinecarboxylic acid derivatives
WO1994014794A1 (fr) Derive d'acide 8-methoxyquinolonecarboxylique
JP2848538B2 (ja) ２環性アミノ基で置換されたピリドンカルボン酸誘導体、そのエステルおよびその塩ならびにこれらの中間体たる２環性アミン
JPWO1995021163A1 (ja) ２環性アミノ基で置換されたピリドンカルボン酸誘導体、そのエステルおよびその塩ならびにこれらの中間体たる２環性アミン
KR20010029698A (ko) 광학활성을 유발하는 7-피롤리딘 치환체를 갖는광학활성의 퀴놀린 카르복실산 유도체 및 그의 제조방법
RU2088581C1 (ru) Производные азетидина или их фармацевтически приемлемые соли, способ их получения и композиция, проявляющая противомикробное действие на их основе
JPH07188230A (ja) １−（２−フルオロシクロプロピル）−キノロンカルボン酸および１−（２−フルオロシクロプロピル）−ナフチリドンカルボン酸誘導体
JPH05345777A (ja) ７−（４，４−ジアルキル−３−アミノ置換ピロリジニル）キノロン−３−カルボン酸誘導体
WO1994014813A1 (en) Novel quinolone derivatives and processes for preparing the same
JPH1112278A (ja) ピリドンカルボン酸誘導体、そのエステルまたはこれらの塩
KR20030081762A (ko) 플루오로피롤리딘 치환체를 포함하는 퀴놀린 카르복실산유도체 및 그의 제조방법
JP2001181281A (ja) 抗菌剤として有用なキノロン誘導体
CN1175251A (zh) 有双环氨基取代的吡啶酮羧酸衍生物，其酯及盐,以及可用作其中间体的双环类胺
JP2003104988A (ja) 抗菌剤として有用なキノロン誘導体
JPH07278139A (ja) 新規なキノロンカルボン酸誘導体およびその製造法
JPWO1996001260A1 (ja) ピリドンカルボン酸誘導体、そのエステルおよびその塩ならびにこれらの合成中間体

Legal Events

Date Code Title Description
A977 Report on retrieval

Free format text: JAPANESE INTERMEDIATE CODE: A971007

Effective date: 20050628

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20050803

A524 Written submission of copy of amendment under article 19 pct

Free format text: JAPANESE INTERMEDIATE CODE: A524

Effective date: 20051102

A02 Decision of refusal

Free format text: JAPANESE INTERMEDIATE CODE: A02

Effective date: 20051209

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20060327

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20060313

A911 Transfer to examiner for re-examination before appeal (zenchi)

Free format text: JAPANESE INTERMEDIATE CODE: A911

Effective date: 20060511

A912 Re-examination (zenchi) completed and case transferred to appeal board

Free format text: JAPANESE INTERMEDIATE CODE: A912

Effective date: 20060630

RD04 Notification of resignation of power of attorney

Free format text: JAPANESE INTERMEDIATE CODE: A7424

Effective date: 20070308

A761 Written withdrawal of application

Free format text: JAPANESE INTERMEDIATE CODE: A761

Effective date: 20070425