JP2003334088A - ヒト由来の新規Ｋｌｏｔｈｏ様タンパク質及びその遺伝子 - Google Patents

ヒト由来の新規Ｋｌｏｔｈｏ様タンパク質及びその遺伝子

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Publication number
JP2003334088A
JP2003334088A JP2002148341A JP2002148341A JP2003334088A JP 2003334088 A JP2003334088 A JP 2003334088A JP 2002148341 A JP2002148341 A JP 2002148341A JP 2002148341 A JP2002148341 A JP 2002148341A JP 2003334088 A JP2003334088 A JP 2003334088A
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Japan
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ala
ser
gly
phe
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Pending
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JP2002148341A
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English (en)
Japanese (ja)
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JP2003334088A5 (enExample
Inventor
Toshiyuki Saito
俊行 齋藤
Akiko Hayashi
昭子 林
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PharmaDesign Inc Japan
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PharmaDesign Inc Japan
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Application filed by PharmaDesign Inc Japan filed Critical PharmaDesign Inc Japan
Priority to JP2002148341A priority Critical patent/JP2003334088A/ja
Publication of JP2003334088A publication Critical patent/JP2003334088A/ja
Publication of JP2003334088A5 publication Critical patent/JP2003334088A5/ja
Pending legal-status Critical Current

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  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
JP2002148341A 2002-05-22 2002-05-22 ヒト由来の新規Ｋｌｏｔｈｏ様タンパク質及びその遺伝子 Pending JP2003334088A (ja)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2002148341A JP2003334088A (ja) 2002-05-22 2002-05-22 ヒト由来の新規Ｋｌｏｔｈｏ様タンパク質及びその遺伝子

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP2002148341A JP2003334088A (ja) 2002-05-22 2002-05-22 ヒト由来の新規Ｋｌｏｔｈｏ様タンパク質及びその遺伝子

Publications (2)

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JP2003334088A true JP2003334088A (ja) 2003-11-25
JP2003334088A5 JP2003334088A5 (enExample) 2005-10-27

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ID=29706244

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JP2002148341A Pending JP2003334088A (ja) 2002-05-22 2002-05-22 ヒト由来の新規Ｋｌｏｔｈｏ様タンパク質及びその遺伝子

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JP (1) JP2003334088A (enExample)

Cited By (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2006158339A (ja) * 2004-12-09 2006-06-22 Kyoto Univ βＫｌｏｔｈｏ遺伝子、Ｃｙｐ７ａ１遺伝子、及びそれらの利用
CN102465182A (zh) * 2010-10-29 2012-05-23 株式会社爱茉莉太平洋 检测皮肤活性物质的检测试剂盒和检测皮肤活性物质的方法
EP2550972A1 (en) * 2007-04-02 2013-01-30 Genentech, Inc. Klotho-beta for use in treating cancer, liver disorders, gallstones, wasting syndrome and obesity-related diseases
US8795985B2 (en) 2009-05-05 2014-08-05 Amgen Inc. FGF 21 polypeptides comprising two or more mutations and uses thereof
US9279013B2 (en) 2008-10-10 2016-03-08 Amgen Inc. FGF-21 mutants comprising polyethylene glycol and uses thereof
US9493530B2 (en) 2009-05-05 2016-11-15 Amgen Inc. FGF21 mutants comprising a mutation at position 98, 171 and/or 180
US9873748B2 (en) 2013-12-23 2018-01-23 Genentech, Inc. Bispecific antibodies binding to beta-klotho and fibroblast growth factor receptor 1
US10093735B2 (en) 2014-01-24 2018-10-09 Ngm Biopharmaceuticals, Inc. Beta-klotho binding proteins
US10800843B2 (en) 2015-07-29 2020-10-13 Ngm Biopharmaceuticals, Inc. Beta klotho-binding proteins
US11072640B2 (en) 2008-06-04 2021-07-27 Amgen Inc. Methods of treating non-alcoholic steatohepatitis using FGF21 mutants

Cited By (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2006158339A (ja) * 2004-12-09 2006-06-22 Kyoto Univ βＫｌｏｔｈｏ遺伝子、Ｃｙｐ７ａ１遺伝子、及びそれらの利用
EP2550972A1 (en) * 2007-04-02 2013-01-30 Genentech, Inc. Klotho-beta for use in treating cancer, liver disorders, gallstones, wasting syndrome and obesity-related diseases
US11072640B2 (en) 2008-06-04 2021-07-27 Amgen Inc. Methods of treating non-alcoholic steatohepatitis using FGF21 mutants
US11840558B2 (en) 2008-06-04 2023-12-12 Amgen Inc. Methods of treating non-alcoholic steatohepatitis using FGF21 mutants
US9279013B2 (en) 2008-10-10 2016-03-08 Amgen Inc. FGF-21 mutants comprising polyethylene glycol and uses thereof
US8795985B2 (en) 2009-05-05 2014-08-05 Amgen Inc. FGF 21 polypeptides comprising two or more mutations and uses thereof
US8835385B2 (en) 2009-05-05 2014-09-16 Amgen Inc. FGF21 polypeptides comprising two or more mutations and uses thereof
US9493530B2 (en) 2009-05-05 2016-11-15 Amgen Inc. FGF21 mutants comprising a mutation at position 98, 171 and/or 180
CN102465182A (zh) * 2010-10-29 2012-05-23 株式会社爱茉莉太平洋 检测皮肤活性物质的检测试剂盒和检测皮肤活性物质的方法
US9884919B2 (en) 2013-12-23 2018-02-06 Genentech, Inc. Methods of treatment with bispecific antibodies binding to beta-klotho and fibroblast growth factor receptor 1
US10246518B2 (en) 2013-12-23 2019-04-02 Genentech, Inc. Nucleic acids encoding bispecific antibodies binding to beta-Klotho and fibroblast growth factor receptor 1
US10882921B2 (en) 2013-12-23 2021-01-05 Genentech, Inc. Host cell comprising nucleic acids encoding bispecific antibodies binding to beta-klotho and fibroblast growth factor receptor 1 and antibody production
US9873748B2 (en) 2013-12-23 2018-01-23 Genentech, Inc. Bispecific antibodies binding to beta-klotho and fibroblast growth factor receptor 1
US10744191B2 (en) 2014-01-24 2020-08-18 Ngm Biopharmaceuticals, Inc. Beta klotho-binding proteins and methods of use thereof
US10093735B2 (en) 2014-01-24 2018-10-09 Ngm Biopharmaceuticals, Inc. Beta-klotho binding proteins
US11596676B2 (en) 2014-01-24 2023-03-07 Ngm Biopharmaceuticals, Inc. Methods of treating nonalcoholic steatohepatitis comprising administering an anti-human beta klotho antibody or binding fragment thereof
US12378312B2 (en) 2014-01-24 2025-08-05 Ngm Biopharmaceuticals, Inc. Polynucleotides encoding human beta klotho antibodies or binding fragments thereof and methods of use thereof
US10800843B2 (en) 2015-07-29 2020-10-13 Ngm Biopharmaceuticals, Inc. Beta klotho-binding proteins
US11667708B2 (en) 2015-07-29 2023-06-06 Ngm Biopharmaceuticals, Inc. Anti-human beta klotho antibody or binding fragment thereof and methods of their use

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