JP2003321369A5 - - Google Patents
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- JP2003321369A5 JP2003321369A5 JP2002132205A JP2002132205A JP2003321369A5 JP 2003321369 A5 JP2003321369 A5 JP 2003321369A5 JP 2002132205 A JP2002132205 A JP 2002132205A JP 2002132205 A JP2002132205 A JP 2002132205A JP 2003321369 A5 JP2003321369 A5 JP 2003321369A5
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- Prior art keywords
- acid
- compound
- orally administered
- administered composition
- group
- Prior art date
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- 150000001875 compounds Chemical class 0.000 claims description 59
- 239000000203 mixture Substances 0.000 claims description 35
- 239000002253 acid Substances 0.000 claims description 30
- -1 aromatic hydrocarbon ester Chemical class 0.000 claims description 13
- 125000004432 carbon atom Chemical group C* 0.000 claims description 13
- 150000003839 salts Chemical class 0.000 claims description 12
- SZJHUSHDSGMAPF-KSXWWTRBSA-N (1r,2s,4ar,6ar,6as,6br,8ar,10s,12ar,14bs)-2-acetyloxy-10-hydroxy-1,2,6a,6b,9,9,12a-heptamethyl-1,3,4,5,6,6a,7,8,8a,10,11,12,13,14b-tetradecahydropicene-4a-carboxylic acid Chemical compound C([C@@]12C)C[C@H](O)C(C)(C)[C@@H]1CC[C@]1(C)[C@@H]2CC=C2[C@@H]3[C@@H](C)[C@](OC(C)=O)(C)CC[C@]3(C(O)=O)CC[C@]21C SZJHUSHDSGMAPF-KSXWWTRBSA-N 0.000 claims description 10
- 239000003814 drug Substances 0.000 claims description 5
- VBLIMTVKFVIDFU-PAZRJNPVSA-N (1r,2r,4as,6as,6as,6br,8as,10r,12s,12ar,14bs)-1,10,12-trihydroxy-1,2,6a,6b,9,9,12a-heptamethyl-11-oxo-3,4,5,6,6a,7,8,8a,10,12,13,14b-dodecahydro-2h-picene-4a-carboxylic acid Chemical compound O[C@@H]1C(=O)[C@H](O)C(C)(C)[C@@H]2CC[C@@]3(C)[C@]4(C)CC[C@@]5(C(O)=O)CC[C@@H](C)[C@](O)(C)[C@H]5C4=CC[C@@H]3[C@]21C VBLIMTVKFVIDFU-PAZRJNPVSA-N 0.000 claims description 4
- VBLIMTVKFVIDFU-UHFFFAOYSA-N 1beta-Hydroxy-2-oxopomolic acid Natural products OC1C(=O)C(O)C(C)(C)C2CCC3(C)C4(C)CCC5(C(O)=O)CCC(C)C(O)(C)C5C4=CCC3C21C VBLIMTVKFVIDFU-UHFFFAOYSA-N 0.000 claims description 4
- 125000004122 cyclic group Chemical group 0.000 claims description 4
- WCGUUGGRBIKTOS-GPOJBZKASA-N (3beta)-3-hydroxyurs-12-en-28-oic acid Chemical compound C1C[C@H](O)C(C)(C)[C@@H]2CC[C@@]3(C)[C@]4(C)CC[C@@]5(C(O)=O)CC[C@@H](C)[C@H](C)[C@H]5C4=CC[C@@H]3[C@]21C WCGUUGGRBIKTOS-GPOJBZKASA-N 0.000 claims description 3
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- FFMVHFPLIIYYNC-UHFFFAOYSA-N 2alpha,3alpha,23-trihydroxy-12,20(30)-ursadien-28-oic acid Natural products CC12CC(O)C(O)C(C)(CO)C1CCC1(C)C2CC=C2C3C(C)C(=C)CCC3(C(O)=O)CCC21C FFMVHFPLIIYYNC-UHFFFAOYSA-N 0.000 claims description 3
- IKIYIAJFBKHTIG-AAKXVVKBSA-N Camaldulensic acid Natural products O=C(O)[C@@]12[C@@H]([C@@H](C)[C@H](CO)CC1)C=1[C@](C)([C@@]3(C)[C@H]([C@@H](OC)C=1)[C@]1(C)[C@H](C(C)(C)[C@@H](O)CC1)CC3)CC2 IKIYIAJFBKHTIG-AAKXVVKBSA-N 0.000 claims description 3
- 206010012438 Dermatitis atopic Diseases 0.000 claims description 3
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- FFMVHFPLIIYYNC-QXIFDOFRSA-N actinidic acid Chemical compound C([C@@]12C)[C@@H](O)[C@H](O)[C@@](C)(CO)[C@@H]1CC[C@]1(C)[C@@H]2CC=C2[C@@H]3[C@@H](C)C(=C)CC[C@]3(C(O)=O)CC[C@]21C FFMVHFPLIIYYNC-QXIFDOFRSA-N 0.000 claims description 3
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- PLSAJKYPRJGMHO-UHFFFAOYSA-N ursolic acid Natural products CC1CCC2(CCC3(C)C(C=CC4C5(C)CCC(O)C(C)(C)C5CCC34C)C2C1C)C(=O)O PLSAJKYPRJGMHO-UHFFFAOYSA-N 0.000 claims description 3
- GHYOCDFICYLMRF-UTIIJYGPSA-N (2S,3R)-N-[(2S)-3-(cyclopenten-1-yl)-1-[(2R)-2-methyloxiran-2-yl]-1-oxopropan-2-yl]-3-hydroxy-3-(4-methoxyphenyl)-2-[[(2S)-2-[(2-morpholin-4-ylacetyl)amino]propanoyl]amino]propanamide Chemical compound C1(=CCCC1)C[C@@H](C(=O)[C@@]1(OC1)C)NC([C@H]([C@@H](C1=CC=C(C=C1)OC)O)NC([C@H](C)NC(CN1CCOCC1)=O)=O)=O GHYOCDFICYLMRF-UTIIJYGPSA-N 0.000 claims description 2
- QFLWZFQWSBQYPS-AWRAUJHKSA-N (3S)-3-[[(2S)-2-[[(2S)-2-[5-[(3aS,6aR)-2-oxo-1,3,3a,4,6,6a-hexahydrothieno[3,4-d]imidazol-4-yl]pentanoylamino]-3-methylbutanoyl]amino]-3-(4-hydroxyphenyl)propanoyl]amino]-4-[1-bis(4-chlorophenoxy)phosphorylbutylamino]-4-oxobutanoic acid Chemical compound CCCC(NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)CCCCC1SC[C@@H]2NC(=O)N[C@H]12)C(C)C)P(=O)(Oc1ccc(Cl)cc1)Oc1ccc(Cl)cc1 QFLWZFQWSBQYPS-AWRAUJHKSA-N 0.000 claims description 2
- 229910052768 actinide Inorganic materials 0.000 claims description 2
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- 125000005907 alkyl ester group Chemical group 0.000 claims description 2
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- ZLVXBBHTMQJRSX-VMGNSXQWSA-N jdtic Chemical compound C1([C@]2(C)CCN(C[C@@H]2C)C[C@H](C(C)C)NC(=O)[C@@H]2NCC3=CC(O)=CC=C3C2)=CC=CC(O)=C1 ZLVXBBHTMQJRSX-VMGNSXQWSA-N 0.000 claims description 2
- 229930183710 Ilexgenin Natural products 0.000 claims 1
- 229940011658 asiatic acid Drugs 0.000 claims 1
- LBGFKBYMNRAMFC-PYSQTNCISA-N asiatic acid Natural products C[C@@H]1CC[C@@]2(CC[C@]3(C)C(=CC[C@@H]4[C@@]5(C)C[C@@H](O)[C@H](O)[C@@](C)(CO)[C@@H]5CC[C@@]34C)[C@]2(C)[C@H]1C)C(=O)O LBGFKBYMNRAMFC-PYSQTNCISA-N 0.000 claims 1
- CLXOLTFMHAXJST-UHFFFAOYSA-N esculentic acid Natural products C12CC=C3C4CC(C)(C(O)=O)CCC4(C(O)=O)CCC3(C)C1(C)CCC1C2(C)CCC(O)C1(CO)C CLXOLTFMHAXJST-UHFFFAOYSA-N 0.000 claims 1
- YHGVYECWZWIVJC-TVZJSHMMSA-N primulagenin A Chemical compound C1C[C@H](O)C(C)(C)[C@@H]2CC[C@@]3(C)[C@]4(C)C[C@@H](O)[C@@]5(CO)CCC(C)(C)C[C@H]5C4=CC[C@@H]3[C@]21C YHGVYECWZWIVJC-TVZJSHMMSA-N 0.000 claims 1
- XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 description 9
- 239000003795 chemical substances by application Substances 0.000 description 8
- 125000002887 hydroxy group Chemical group [H]O* 0.000 description 8
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- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 4
- ZMANZCXQSJIPKH-UHFFFAOYSA-N Triethylamine Chemical class CCN(CC)CC ZMANZCXQSJIPKH-UHFFFAOYSA-N 0.000 description 4
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 description 4
- WWZKQHOCKIZLMA-UHFFFAOYSA-N octanoic acid Chemical compound CCCCCCCC(O)=O WWZKQHOCKIZLMA-UHFFFAOYSA-N 0.000 description 4
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- 238000000622 liquid--liquid extraction Methods 0.000 description 2
- HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 description 2
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- LNAZSHAWQACDHT-XIYTZBAFSA-N (2r,3r,4s,5r,6s)-4,5-dimethoxy-2-(methoxymethyl)-3-[(2s,3r,4s,5r,6r)-3,4,5-trimethoxy-6-(methoxymethyl)oxan-2-yl]oxy-6-[(2r,3r,4s,5r,6r)-4,5,6-trimethoxy-2-(methoxymethyl)oxan-3-yl]oxyoxane Chemical compound CO[C@@H]1[C@@H](OC)[C@H](OC)[C@@H](COC)O[C@H]1O[C@H]1[C@H](OC)[C@@H](OC)[C@H](O[C@H]2[C@@H]([C@@H](OC)[C@H](OC)O[C@@H]2COC)OC)O[C@@H]1COC LNAZSHAWQACDHT-XIYTZBAFSA-N 0.000 description 1
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Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2002132205A JP4179795B2 (ja) | 2002-05-08 | 2002-05-08 | ストレス緩和用の経口投与組成物 |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2002132205A JP4179795B2 (ja) | 2002-05-08 | 2002-05-08 | ストレス緩和用の経口投与組成物 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2003321369A JP2003321369A (ja) | 2003-11-11 |
| JP2003321369A5 true JP2003321369A5 (https=) | 2005-05-26 |
| JP4179795B2 JP4179795B2 (ja) | 2008-11-12 |
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| Application Number | Title | Priority Date | Filing Date |
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| JP2002132205A Expired - Fee Related JP4179795B2 (ja) | 2002-05-08 | 2002-05-08 | ストレス緩和用の経口投与組成物 |
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| JP (1) | JP4179795B2 (https=) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2009234926A (ja) * | 2008-03-25 | 2009-10-15 | Kinji Ishida | 副腎肥大抑制剤及びそれを含有する飼料組成物又は治療用組成物 |
| JP2009234924A (ja) * | 2008-03-25 | 2009-10-15 | Kinji Ishida | 免疫回復剤及びそれを含有する飼料組成物 |
| JP2015189691A (ja) * | 2014-03-27 | 2015-11-02 | 公益財団法人東洋食品研究所 | Ｇｐｄｈ活性抑制剤 |
| CN104961790B (zh) * | 2015-05-18 | 2019-03-26 | 中国人民解放军海军医学研究所 | 积雪草酸衍生物、其制备方法及其在制备抗抑郁药物中的应用 |
| CN105218615B (zh) * | 2015-09-23 | 2017-03-29 | 云南植物药业有限公司 | 一种天然新化合物及其制备和应用 |
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