JP2002541215A5 - - Google Patents
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- Publication number
- JP2002541215A5 JP2002541215A5 JP2000610520A JP2000610520A JP2002541215A5 JP 2002541215 A5 JP2002541215 A5 JP 2002541215A5 JP 2000610520 A JP2000610520 A JP 2000610520A JP 2000610520 A JP2000610520 A JP 2000610520A JP 2002541215 A5 JP2002541215 A5 JP 2002541215A5
- Authority
- JP
- Japan
- Prior art keywords
- gabapentin
- pain
- reagent
- sodium channel
- pregabalin
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
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- 208000002193 Pain Diseases 0.000 description 67
- 239000003153 chemical reaction reagent Substances 0.000 description 66
- 150000001875 compounds Chemical class 0.000 description 58
- 239000003195 sodium channel blocking agent Substances 0.000 description 57
- 229960002870 gabapentin Drugs 0.000 description 55
- 208000000094 Chronic Pain Diseases 0.000 description 40
- AYXYPKUFHZROOJ-ZETCQYMHSA-N pregabalin Chemical compound CC(C)C[C@H](CN)CC(O)=O AYXYPKUFHZROOJ-ZETCQYMHSA-N 0.000 description 38
- 229960001233 pregabalin Drugs 0.000 description 38
- 150000003839 salts Chemical class 0.000 description 35
- 229940125794 sodium channel blocker Drugs 0.000 description 35
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- 239000008194 pharmaceutical composition Substances 0.000 description 27
- 238000000034 method Methods 0.000 description 25
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- 150000002431 hydrogen Chemical class 0.000 description 23
- 206010010904 Convulsion Diseases 0.000 description 22
- 108091006146 Channels Proteins 0.000 description 21
- 125000003118 aryl group Chemical group 0.000 description 19
- 125000000217 alkyl group Chemical group 0.000 description 18
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- 125000002768 hydroxyalkyl group Chemical group 0.000 description 13
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-
2000
- 2000-04-10 DE DE60022333T patent/DE60022333T2/de not_active Expired - Lifetime
- 2000-04-10 EP EP00923183A patent/EP1169060B1/en not_active Expired - Lifetime
- 2000-04-10 WO PCT/US2000/009387 patent/WO2000061188A1/en not_active Ceased
- 2000-04-10 CA CA002370030A patent/CA2370030C/en not_active Expired - Fee Related
- 2000-04-10 DK DK00923183T patent/DK1169060T3/da active
- 2000-04-10 JP JP2000610520A patent/JP2002541215A/ja active Pending
- 2000-04-10 AT AT00923183T patent/ATE303162T1/de active
- 2000-04-10 AU AU43349/00A patent/AU4334900A/en not_active Abandoned
-
2001
- 2001-10-05 US US09/971,007 patent/US20020037926A1/en not_active Abandoned
-
2003
- 2003-08-21 US US10/644,783 patent/US7393872B2/en not_active Expired - Lifetime
-
2008
- 2008-06-13 US US12/138,568 patent/US20080318932A1/en not_active Abandoned
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