JP2002540280A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2002540280A5 JP2002540280A5 JP2000608692A JP2000608692A JP2002540280A5 JP 2002540280 A5 JP2002540280 A5 JP 2002540280A5 JP 2000608692 A JP2000608692 A JP 2000608692A JP 2000608692 A JP2000608692 A JP 2000608692A JP 2002540280 A5 JP2002540280 A5 JP 2002540280A5
- Authority
- JP
- Japan
- Prior art keywords
- polynucleotide
- nucleoside
- nucleotide
- hydrogen
- labeled
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 125000003729 nucleotide group Chemical group 0.000 claims 50
- 239000002773 nucleotide Substances 0.000 claims 46
- 108091033319 polynucleotide Proteins 0.000 claims 42
- 239000002157 polynucleotide Substances 0.000 claims 42
- 102000040430 polynucleotide Human genes 0.000 claims 42
- 239000002777 nucleoside Substances 0.000 claims 41
- 229910052739 hydrogen Inorganic materials 0.000 claims 35
- 238000000034 method Methods 0.000 claims 34
- 239000001257 hydrogen Substances 0.000 claims 32
- 150000001875 compounds Chemical class 0.000 claims 25
- 150000003833 nucleoside derivatives Chemical class 0.000 claims 22
- 239000007850 fluorescent dye Substances 0.000 claims 19
- 230000000295 complement effect Effects 0.000 claims 18
- 239000001226 triphosphate Substances 0.000 claims 18
- 150000002431 hydrogen Chemical class 0.000 claims 17
- 125000000217 alkyl group Chemical group 0.000 claims 16
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 16
- 235000011178 triphosphate Nutrition 0.000 claims 16
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 15
- 125000003835 nucleoside group Chemical group 0.000 claims 14
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 14
- BDHFUVZGWQCTTF-UHFFFAOYSA-M sulfonate Chemical compound [O-]S(=O)=O BDHFUVZGWQCTTF-UHFFFAOYSA-M 0.000 claims 14
- 125000005647 linker group Chemical group 0.000 claims 12
- UNXRWKVEANCORM-UHFFFAOYSA-N triphosphoric acid Chemical compound OP(O)(=O)OP(O)(=O)OP(O)(O)=O UNXRWKVEANCORM-UHFFFAOYSA-N 0.000 claims 11
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 claims 10
- PXGOKWXKJXAPGV-UHFFFAOYSA-N Fluorine Chemical compound FF PXGOKWXKJXAPGV-UHFFFAOYSA-N 0.000 claims 10
- KDCGOANMDULRCW-UHFFFAOYSA-N Purine Natural products N1=CNC2=NC=NC2=C1 KDCGOANMDULRCW-UHFFFAOYSA-N 0.000 claims 10
- 150000001336 alkenes Chemical class 0.000 claims 10
- 150000001345 alkine derivatives Chemical class 0.000 claims 10
- 125000003118 aryl group Chemical group 0.000 claims 10
- 239000000460 chlorine Substances 0.000 claims 10
- 229910052801 chlorine Inorganic materials 0.000 claims 10
- 125000000753 cycloalkyl group Chemical group 0.000 claims 10
- 229910052731 fluorine Inorganic materials 0.000 claims 10
- 239000011737 fluorine Substances 0.000 claims 10
- 108091034117 Oligonucleotide Proteins 0.000 claims 9
- 150000007942 carboxylates Chemical class 0.000 claims 9
- OPTASPLRGRRNAP-UHFFFAOYSA-N cytosine Chemical group NC=1C=CNC(=O)N=1 OPTASPLRGRRNAP-UHFFFAOYSA-N 0.000 claims 8
- 239000000975 dye Substances 0.000 claims 8
- 229910052760 oxygen Inorganic materials 0.000 claims 8
- 229910052717 sulfur Inorganic materials 0.000 claims 8
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 claims 7
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims 7
- 125000000524 functional group Chemical group 0.000 claims 7
- 239000001301 oxygen Substances 0.000 claims 7
- -1 sulfonate compound Chemical class 0.000 claims 7
- 239000011593 sulfur Substances 0.000 claims 7
- NYHBQMYGNKIUIF-UUOKFMHZSA-N Guanosine Chemical compound C1=NC=2C(=O)NC(N)=NC=2N1[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O NYHBQMYGNKIUIF-UUOKFMHZSA-N 0.000 claims 6
- IQFYYKKMVGJFEH-XLPZGREQSA-N Thymidine Chemical compound O=C1NC(=O)C(C)=CN1[C@@H]1O[C@H](CO)[C@@H](O)C1 IQFYYKKMVGJFEH-XLPZGREQSA-N 0.000 claims 6
- OIRDTQYFTABQOQ-KQYNXXCUSA-N adenosine Chemical compound C1=NC=2C(N)=NC=NC=2N1[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O OIRDTQYFTABQOQ-KQYNXXCUSA-N 0.000 claims 6
- 150000001412 amines Chemical class 0.000 claims 6
- 150000007523 nucleic acids Chemical class 0.000 claims 6
- 125000003545 alkoxy group Chemical group 0.000 claims 5
- 125000005599 alkyl carboxylate group Chemical group 0.000 claims 5
- 150000008052 alkyl sulfonates Chemical class 0.000 claims 5
- 150000001408 amides Chemical class 0.000 claims 5
- 239000003153 chemical reaction reagent Substances 0.000 claims 5
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims 5
- 125000004029 hydroxymethyl group Chemical group [H]OC([H])([H])* 0.000 claims 5
- 238000002372 labelling Methods 0.000 claims 5
- 150000002825 nitriles Chemical class 0.000 claims 5
- 102000039446 nucleic acids Human genes 0.000 claims 5
- 108020004707 nucleic acids Proteins 0.000 claims 5
- 125000000561 purinyl group Chemical group N1=C(N=C2N=CNC2=C1)* 0.000 claims 5
- 239000002719 pyrimidine nucleotide Substances 0.000 claims 5
- 150000003457 sulfones Chemical class 0.000 claims 5
- 125000001140 1,4-phenylene group Chemical group [H]C1=C([H])C([*:2])=C([H])C([H])=C1[*:1] 0.000 claims 4
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims 4
- ISAKRJDGNUQOIC-UHFFFAOYSA-N Uracil Chemical group O=C1C=CNC(=O)N1 ISAKRJDGNUQOIC-UHFFFAOYSA-N 0.000 claims 4
- 229910052799 carbon Inorganic materials 0.000 claims 4
- 229940104302 cytosine Drugs 0.000 claims 4
- 239000002213 purine nucleotide Substances 0.000 claims 4
- 239000002718 pyrimidine nucleoside Substances 0.000 claims 4
- DWRXFEITVBNRMK-UHFFFAOYSA-N Beta-D-1-Arabinofuranosylthymine Natural products O=C1NC(=O)C(C)=CN1C1C(O)C(O)C(CO)O1 DWRXFEITVBNRMK-UHFFFAOYSA-N 0.000 claims 3
- 239000002126 C01EB10 - Adenosine Substances 0.000 claims 3
- MIKUYHXYGGJMLM-GIMIYPNGSA-N Crotonoside Natural products C1=NC2=C(N)NC(=O)N=C2N1[C@H]1O[C@@H](CO)[C@H](O)[C@@H]1O MIKUYHXYGGJMLM-GIMIYPNGSA-N 0.000 claims 3
- NYHBQMYGNKIUIF-UHFFFAOYSA-N D-guanosine Natural products C1=2NC(N)=NC(=O)C=2N=CN1C1OC(CO)C(O)C1O NYHBQMYGNKIUIF-UHFFFAOYSA-N 0.000 claims 3
- OAKJQQAXSVQMHS-UHFFFAOYSA-N Hydrazine Chemical compound NN OAKJQQAXSVQMHS-UHFFFAOYSA-N 0.000 claims 3
- 229960005305 adenosine Drugs 0.000 claims 3
- IQFYYKKMVGJFEH-UHFFFAOYSA-N beta-L-thymidine Natural products O=C1NC(=O)C(C)=CN1C1OC(CO)C(O)C1 IQFYYKKMVGJFEH-UHFFFAOYSA-N 0.000 claims 3
- 229940029575 guanosine Drugs 0.000 claims 3
- 229940104230 thymidine Drugs 0.000 claims 3
- 102000016397 Methyltransferase Human genes 0.000 claims 2
- 108060004795 Methyltransferase Proteins 0.000 claims 2
- CZPWVGJYEJSRLH-UHFFFAOYSA-N Pyrimidine Chemical compound C1=CN=CN=C1 CZPWVGJYEJSRLH-UHFFFAOYSA-N 0.000 claims 2
- 125000003368 amide group Chemical group 0.000 claims 2
- 230000008878 coupling Effects 0.000 claims 2
- 238000010168 coupling process Methods 0.000 claims 2
- 238000005859 coupling reaction Methods 0.000 claims 2
- 230000002255 enzymatic effect Effects 0.000 claims 2
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 2
- 125000000714 pyrimidinyl group Chemical group 0.000 claims 2
- 229940035893 uracil Drugs 0.000 claims 2
- UHDGCWIWMRVCDJ-UHFFFAOYSA-N 1-beta-D-Xylofuranosyl-NH-Cytosine Natural products O=C1N=C(N)C=CN1C1C(O)C(O)C(CO)O1 UHDGCWIWMRVCDJ-UHFFFAOYSA-N 0.000 claims 1
- LOSIULRWFAEMFL-UHFFFAOYSA-N 7-deazaguanine Chemical compound O=C1NC(N)=NC2=C1CC=N2 LOSIULRWFAEMFL-UHFFFAOYSA-N 0.000 claims 1
- UHDGCWIWMRVCDJ-PSQAKQOGSA-N Cytidine Natural products O=C1N=C(N)C=CN1[C@@H]1[C@@H](O)[C@@H](O)[C@H](CO)O1 UHDGCWIWMRVCDJ-PSQAKQOGSA-N 0.000 claims 1
- JJWSNOOGIUMOEE-UHFFFAOYSA-N Monomethylmercury Chemical compound [Hg]C JJWSNOOGIUMOEE-UHFFFAOYSA-N 0.000 claims 1
- 108091028043 Nucleic acid sequence Proteins 0.000 claims 1
- 238000006243 chemical reaction Methods 0.000 claims 1
- 125000001309 chloro group Chemical group Cl* 0.000 claims 1
- UHDGCWIWMRVCDJ-ZAKLUEHWSA-N cytidine Chemical compound O=C1N=C(N)C=CN1[C@H]1[C@H](O)[C@@H](O)[C@H](CO)O1 UHDGCWIWMRVCDJ-ZAKLUEHWSA-N 0.000 claims 1
- 230000001419 dependent effect Effects 0.000 claims 1
- BFMYDTVEBKDAKJ-UHFFFAOYSA-L disodium;(2',7'-dibromo-3',6'-dioxido-3-oxospiro[2-benzofuran-1,9'-xanthene]-4'-yl)mercury;hydrate Chemical compound O.[Na+].[Na+].O1C(=O)C2=CC=CC=C2C21C1=CC(Br)=C([O-])C([Hg])=C1OC1=C2C=C(Br)C([O-])=C1 BFMYDTVEBKDAKJ-UHFFFAOYSA-L 0.000 claims 1
- 238000000295 emission spectrum Methods 0.000 claims 1
- 150000002148 esters Chemical class 0.000 claims 1
- 238000002189 fluorescence spectrum Methods 0.000 claims 1
- 150000004676 glycans Chemical class 0.000 claims 1
- 150000002632 lipids Chemical class 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
- 229920001184 polypeptide Polymers 0.000 claims 1
- 239000005017 polysaccharide Substances 0.000 claims 1
- 229920001282 polysaccharide Polymers 0.000 claims 1
- 102000004196 processed proteins & peptides Human genes 0.000 claims 1
- 108090000765 processed proteins & peptides Proteins 0.000 claims 1
- 102000004169 proteins and genes Human genes 0.000 claims 1
- 108090000623 proteins and genes Proteins 0.000 claims 1
- 150000003212 purines Chemical class 0.000 claims 1
- 239000001022 rhodamine dye Substances 0.000 claims 1
- 239000007787 solid Substances 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US09/277,793 | 1999-03-27 | ||
| US09/277,793 US6080852A (en) | 1996-06-27 | 1999-03-27 | 4,7-dichlororhodamine dyes |
| PCT/US2000/008003 WO2000058406A1 (en) | 1999-03-27 | 2000-03-24 | 4,7-dichlororhodamine dyes useful as molecular probes |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2005321635A Division JP4732130B2 (ja) | 1999-03-27 | 2005-11-04 | 分子プローブとして有用な４，７−ジクロロローダミン色素 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2002540280A JP2002540280A (ja) | 2002-11-26 |
| JP2002540280A5 true JP2002540280A5 (enExample) | 2005-07-21 |
| JP3848838B2 JP3848838B2 (ja) | 2006-11-22 |
Family
ID=23062373
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2000608692A Expired - Lifetime JP3848838B2 (ja) | 1999-03-27 | 2000-03-24 | 分子プローブとして有用な４，７−ジクロロローダミン色素 |
| JP2005321635A Expired - Fee Related JP4732130B2 (ja) | 1999-03-27 | 2005-11-04 | 分子プローブとして有用な４，７−ジクロロローダミン色素 |
| JP2010185648A Withdrawn JP2011016813A (ja) | 1999-03-27 | 2010-08-20 | 分子プローブとして有用な４，７−ジクロロローダミン色素 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2005321635A Expired - Fee Related JP4732130B2 (ja) | 1999-03-27 | 2005-11-04 | 分子プローブとして有用な４，７−ジクロロローダミン色素 |
| JP2010185648A Withdrawn JP2011016813A (ja) | 1999-03-27 | 2010-08-20 | 分子プローブとして有用な４，７−ジクロロローダミン色素 |
Country Status (9)
| Country | Link |
|---|---|
| US (2) | US6080852A (enExample) |
| EP (2) | EP1386946B1 (enExample) |
| JP (3) | JP3848838B2 (enExample) |
| AT (2) | ATE438691T1 (enExample) |
| AU (1) | AU772329B2 (enExample) |
| CA (1) | CA2367868C (enExample) |
| DE (2) | DE60014051T8 (enExample) |
| ES (2) | ES2329562T3 (enExample) |
| WO (1) | WO2000058406A1 (enExample) |
Families Citing this family (71)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6080852A (en) | 1996-06-27 | 2000-06-27 | The Perkin-Elmer Corporation | 4,7-dichlororhodamine dyes |
| US7550570B2 (en) * | 2000-05-25 | 2009-06-23 | Applied Biosystems, Llc. | 4,7-dichlororhodamine dyes labeled polynucleotides |
| US5936087A (en) | 1997-11-25 | 1999-08-10 | The Perkin-Elmer Corporation | Dibenzorhodamine dyes |
| US6583168B1 (en) * | 1997-11-25 | 2003-06-24 | Applera Corporation | Sulfonated diarylrhodamine dyes |
| US6372907B1 (en) * | 1999-11-03 | 2002-04-16 | Apptera Corporation | Water-soluble rhodamine dye peptide conjugates |
| DE60136719D1 (de) * | 2000-08-04 | 2009-01-08 | Molecular Probes Inc | Kondensierte ringe enthaltende 1,2-dihydro-7-hydroxychinolinderivate |
| US7169922B2 (en) * | 2000-08-04 | 2007-01-30 | Invitrogen Corporation | Derivatives of 1,2-dihydro-7-hydroxyquinolines containing fused rings |
| WO2002030944A2 (en) * | 2000-10-11 | 2002-04-18 | Applera Corporation | Fluorescent nucleobase conjugates having anionic linkers |
| US6916492B2 (en) | 2001-03-30 | 2005-07-12 | Council Of Scientific & Industrial Research | Natural nontoxic multicolor fluorescent protein dye from a marine invertebrate, compositions containing the said dye and its uses |
| US6689391B2 (en) | 2001-03-30 | 2004-02-10 | Council Of Scientific & Industrial Research | Natural non-polar fluorescent dye from a non-bioluminescent marine invertebrate, compositions containing the said dye and its uses |
| WO2002079327A1 (en) | 2001-03-30 | 2002-10-10 | Council Of Scientific And Industrial Research | A natural fluorescent dye obtained from a marine invertebrate, compositions containing the said dye and their uses |
| US6887690B2 (en) * | 2001-06-22 | 2005-05-03 | Pe Corporation | Dye-labeled ribonucleotide triphosphates |
| US6764710B2 (en) | 2001-07-18 | 2004-07-20 | Scimed Life Systems, Inc. | Light emitting markers for use with substrates |
| US7052512B2 (en) * | 2001-07-18 | 2006-05-30 | Boston Scientific Scimed, Inc. | Fluorescent dyed lubricant for medical devices |
| US6956122B2 (en) | 2001-09-05 | 2005-10-18 | Council Of Scientific & Industrial Research | Multiple fluorescent natural dye compound from a marine organism |
| US20040171034A1 (en) * | 2002-05-03 | 2004-09-02 | Brian Agnew | Compositions and methods for detection and isolation of phosphorylated molecules |
| US7102005B2 (en) * | 2002-05-03 | 2006-09-05 | Molecular Probes, Inc. | Compositions and methods for detection and isolation of phosphorylated molecules |
| US7445894B2 (en) * | 2002-05-03 | 2008-11-04 | Molecular Probes, Inc. | Compositions and methods for detection and isolation of phosphorylated molecules |
| AU2003229679A1 (en) * | 2002-05-17 | 2003-12-02 | Ciba Specialty Chemicals Holding Inc. | Optical storage media comprising pentacyclic xanthylium dyes |
| CN1653532A (zh) * | 2002-05-17 | 2005-08-10 | 西巴特殊化学品控股有限公司 | 高性能光学存储介质 |
| WO2004025259A2 (en) * | 2002-09-12 | 2004-03-25 | Molecular Probes, Inc. | Site-specific labeling of affinity tags in fusion proteins |
| US20050250214A1 (en) * | 2004-05-05 | 2005-11-10 | Gee Kyle R | Zinc binding compounds and their method of use |
| US7619059B2 (en) | 2003-07-29 | 2009-11-17 | Life Technologies Corporation | Bimolecular optical probes |
| CA2445420A1 (en) | 2003-07-29 | 2005-01-29 | Invitrogen Corporation | Kinase and phosphatase assays |
| US7727752B2 (en) | 2003-07-29 | 2010-06-01 | Life Technologies Corporation | Kinase and phosphatase assays |
| US7271265B2 (en) | 2003-08-11 | 2007-09-18 | Invitrogen Corporation | Cyanine compounds and their application as quenching compounds |
| DE602004025592D1 (de) * | 2003-09-12 | 2010-04-01 | Life Technologies Corp | Anwendungen des Resonanzenergietransfers zwischen Terbium und GFP |
| US7431915B2 (en) | 2003-10-31 | 2008-10-07 | The Regents Of The University Of California | Peptides whose uptake by cells is controllable |
| US20050214807A1 (en) * | 2003-11-19 | 2005-09-29 | Iain Johnson | Environmental sensitive fluorogenic compounds and their application for singlet oxygen and protein detection |
| US7776529B2 (en) | 2003-12-05 | 2010-08-17 | Life Technologies Corporation | Methine-substituted cyanine dye compounds |
| EP2607431B1 (en) * | 2003-12-05 | 2016-08-24 | Life Technologies Corporation | Cyanine dye compounds |
| GB0329161D0 (en) | 2003-12-16 | 2004-01-21 | Precisense As | Reagant for detecting an analyte |
| JP4127204B2 (ja) * | 2003-12-17 | 2008-07-30 | セイコーエプソン株式会社 | 液晶表示装置の製造方法 |
| US20050227309A1 (en) | 2004-01-21 | 2005-10-13 | Corry Schuyler B | Optically-detectable enzyme substrates and their method of use |
| US7344701B2 (en) * | 2004-02-03 | 2008-03-18 | Biosearch Technologies, Inc. | Xanthene dyes |
| US20050186606A1 (en) * | 2004-02-11 | 2005-08-25 | Schroeder Benjamin G. | Methods and compositions for detecting nucleic acids |
| PL1740100T3 (pl) * | 2004-04-13 | 2017-09-29 | Biosearch Technologies, Inc. | Barwniki ksantenowe |
| WO2006023231A2 (en) | 2004-07-27 | 2006-03-02 | Molecular Probes, Inc. | Fluorescent metal ion indicators with large stokes shift |
| JP2008533167A (ja) | 2005-03-15 | 2008-08-21 | アプレラ コーポレイション | 分析物の検出のための、抗体の代替抗原系の使用 |
| JP5306811B2 (ja) | 2005-05-11 | 2013-10-02 | ライフ テクノロジーズ コーポレーション | ２本鎖ｄｎａへの高い選択性を有する蛍光化学物質及びそれらの使用 |
| US20070134685A1 (en) * | 2005-09-06 | 2007-06-14 | Invitrogen Corporation | Control of chemical modification |
| US7521577B2 (en) * | 2006-01-12 | 2009-04-21 | Molecular Probes, Inc. | Heavy metal binding compounds and their method of use |
| US20070196860A1 (en) * | 2006-01-18 | 2007-08-23 | Invitrogen Corporation | Methods for Measuring Real Time Kinase Activity |
| EP2001871B1 (en) * | 2006-03-31 | 2014-07-16 | Applied Biosystems, LLC | Rhodamine-labeled oligonucleotides |
| US8178360B2 (en) * | 2006-05-18 | 2012-05-15 | Illumina Cambridge Limited | Dye compounds and the use of their labelled conjugates |
| NZ575090A (en) | 2006-09-06 | 2012-02-24 | Univ California | Molecular diagnosis and classification of malignant melanoma using RGS1, ARPC2, FN1, SPP1 and WNT-2 polypeptide markers |
| EP2064290B1 (en) | 2006-10-27 | 2013-10-09 | Life Technologies Corporation | Fluorogenic ph sensitive dyes and their method of use |
| US8586743B2 (en) | 2007-01-30 | 2013-11-19 | Life Technologies Corporation | Labeling reagents and methods of their use |
| WO2008151089A2 (en) * | 2007-05-30 | 2008-12-11 | Invitrogen Corporation | Fluorescent phospholipase a2 indicators |
| US8017338B2 (en) * | 2007-11-20 | 2011-09-13 | Life Technologies Corporation | Reversible di-nucleotide terminator sequencing |
| US20090171078A1 (en) * | 2007-11-20 | 2009-07-02 | Applied Biosystems Inc. | Method of sequencing nucleic acids using elaborated nucleotide phosphorotiolate compounds |
| US20090203015A1 (en) * | 2008-02-13 | 2009-08-13 | Celera Corporation | Multiplex assays for hormonal and growth factor receptors, and uses thereof |
| EP2257810B1 (en) | 2008-03-05 | 2013-06-05 | The Regents of the University of California | Molecular diagnosis and classification of malignant melanoma |
| JP2012519170A (ja) | 2009-02-26 | 2012-08-23 | オーエスアイ・ファーマシューティカルズ，エルエルシー | 生体内の腫瘍細胞のｅｍｔステータスをモニターするためのｉｎｓｉｔｕ法 |
| EP2782916B1 (en) | 2011-11-21 | 2018-02-28 | Promega Corporation | Carboxy x rhodamine analogs |
| WO2013082210A1 (en) | 2011-11-29 | 2013-06-06 | Perosphere Inc. | Anticoagulant reversal agents |
| CN102516992A (zh) * | 2011-12-07 | 2012-06-27 | 天津工业大学 | 一种检测Hg2+离子的荧光探针及其合成方法和用途 |
| EP2847165A2 (en) | 2012-04-02 | 2015-03-18 | Yissum Research Development Company of the Hebrew University of Jerusalem Ltd. | Indole, indoline derivatives, compositions comprising them and uses thereof |
| MX366375B (es) | 2013-01-30 | 2019-07-05 | Avelas Biosciences Inc | Moleculas de administracion selectiva y metodos de uso. |
| WO2015041729A2 (en) | 2013-06-03 | 2015-03-26 | The Research Foundation Of State University Of New York | SITE-SPECIFIC ORTHOGONAL LABELING OF THE CARBOXY TERMINUS OF α-TUBULIN IN LIVE CELLS |
| JP6692748B2 (ja) | 2013-09-26 | 2020-05-13 | ナショナル ユニヴァーシティー オブ シンガポール | リゾホスファチジルコリンの足場を利用する組成物及び方法 |
| US10385380B2 (en) | 2014-10-02 | 2019-08-20 | The Regents Of The University Of California | Personalized protease assay to measure protease activity in neoplasms |
| EP3242690B1 (en) | 2015-01-06 | 2020-09-16 | De Haas, Anthony H. | Near-infrared fluorescent surgical dye markers |
| CN107636165A (zh) | 2015-01-12 | 2018-01-26 | 生命科技公司 | 用于核酸文库质量控制和定量的方法、系统和其组合物 |
| KR20200033954A (ko) | 2017-08-02 | 2020-03-30 | 더 리젠츠 오브 더 유니버시티 오브 캘리포니아 | 인간의 신경을 표적화하는 최적화된 펩티드 및 영상 유도된 수술, 진단 및 치료적 전달에서의 이의 용도 |
| JP2022514397A (ja) | 2018-12-20 | 2022-02-10 | ライフ テクノロジーズ コーポレーション | 変更されたローダミン染料及びバイオアッセイにおけるそれらの使用 |
| SG11202106121SA (en) | 2018-12-20 | 2021-07-29 | Life Technologies Corp | Asymmetric rhodamine dye and use thereof in biological assays |
| JP7721399B2 (ja) | 2020-11-26 | 2025-08-12 | キヤノン株式会社 | 新規化合物、及び硫化水素検出用の構造体 |
| US20240207421A1 (en) | 2020-12-04 | 2024-06-27 | Alume Biosciences, Inc. | Nerve targeting peptides and methods of use |
| CN116916971A (zh) | 2021-01-14 | 2023-10-20 | 阿鲁莫生物科学公司 | 用于外科操作中输尿管可视化的方法和组合物 |
| CN117897454A (zh) | 2021-07-21 | 2024-04-16 | 生命技术公司 | 二苯并呫吨猝灭剂、用途和制备方法 |
Family Cites Families (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE47451C (de) | Badische Anilin- und Sodafabrik in Ludwigshafen a. Rh | Neuerung in dem Verfahren zur Darstellung von Farbstoffen aus der Gruppe des Metaamidophenolpbtalelns. (4 | ||
| DE45263C (de) | Badische Anilin- und Sodafabrik in Ludwigshafen a. Rh | Neuerung in dem Verfahren zur Darstellung von Farbstoffen aus der Gruppe des m - Amidophenol - Phtalei'ns | ||
| DE108347C (enExample) | ||||
| BE755141A (fr) | 1969-08-21 | 1971-02-22 | Hoechst Ag | Procede de teinture ou d'impression de matieres textiles a basede polymeres ou de copolymeres de l'acrylonitrile |
| JPS488725B1 (enExample) | 1969-10-08 | 1973-03-17 | ||
| FR2065117A5 (enExample) | 1969-10-08 | 1971-07-23 | Fuji Photo Film Co Ltd | |
| US4318846A (en) | 1979-09-07 | 1982-03-09 | Syva Company | Novel ether substituted fluorescein polyamino acid compounds as fluorescers and quenchers |
| US4622400A (en) | 1983-12-29 | 1986-11-11 | The United States Of America As Represented By The United States Department Of Energy | Preparation of certain m-aminophenols and the use thereof for preparation of laser dyes |
| DE3425631A1 (de) | 1984-07-12 | 1986-01-16 | Basf Ag, 6700 Ludwigshafen | Rhodaminfarbstoffe |
| US4855225A (en) | 1986-02-07 | 1989-08-08 | Applied Biosystems, Inc. | Method of detecting electrophoretically separated oligonucleotides |
| CA1340806C (en) | 1986-07-02 | 1999-11-02 | James Merrill Prober | Method, system and reagents for dna sequencing |
| US4965349A (en) | 1987-12-24 | 1990-10-23 | Applied Biosystems, Inc. | Method of synthesizing oligonucleotides labeled with ammonia-labile groups on solid phase supports |
| EP0333649B1 (de) | 1988-03-01 | 1994-06-08 | Ciba-Geigy Ag | 3-Basisch substituierte 2-Methylfluorane |
| WO1991003476A1 (en) | 1989-09-08 | 1991-03-21 | Applied Biosystems, Inc. | 5- and 6-succinimidylcarboxylate isomers of rhodamine dyes |
| US5366860A (en) * | 1989-09-29 | 1994-11-22 | Applied Biosystems, Inc. | Spectrally resolvable rhodamine dyes for nucleic acid sequence determination |
| US5188934A (en) * | 1989-11-14 | 1993-02-23 | Applied Biosystems, Inc. | 4,7-dichlorofluorescein dyes as molecular probes |
| US5750409A (en) * | 1991-11-18 | 1998-05-12 | Boehringer Mannheim Gmbh | Pentacyclic compounds and their use as absorption or fluorescent dyes |
| US5256799A (en) | 1992-07-14 | 1993-10-26 | The United States Of Americas As Represented By The United States Department Of Energy | Preparation of 6-hydroxyindolines and their use for preparation of novel laser dyes |
| WO1994005688A1 (en) | 1992-09-03 | 1994-03-17 | Applied Biosystems, Inc. | 4,7-dichlorofluorescein dyes as molecular probes |
| US5283336A (en) | 1992-09-08 | 1994-02-01 | The United States Of America As Represented By The United States Department Of Energy | Method for preparation of 7-hydroxy-1,2,3,4-tetrahydroquinoline from 1,2,3,4-tetrahydroquinoline |
| JPH08503604A (ja) | 1992-09-18 | 1996-04-23 | アモコ・コーポレーション | プローブで用いるための緑色蛍光標識ヌクレオチド |
| US6020481A (en) * | 1996-04-01 | 2000-02-01 | The Perkin-Elmer Corporation | Asymmetric benzoxanthene dyes |
| US5847162A (en) | 1996-06-27 | 1998-12-08 | The Perkin Elmer Corporation | 4, 7-Dichlororhodamine dyes |
| US6080852A (en) * | 1996-06-27 | 2000-06-27 | The Perkin-Elmer Corporation | 4,7-dichlororhodamine dyes |
| US6017712A (en) | 1996-06-27 | 2000-01-25 | Lee; Linda | 4,7-dichlororhodamine dyes |
| US5770716A (en) * | 1997-04-10 | 1998-06-23 | The Perkin-Elmer Corporation | Substituted propargylethoxyamido nucleosides, oligonucleotides and methods for using same |
| US5936087A (en) * | 1997-11-25 | 1999-08-10 | The Perkin-Elmer Corporation | Dibenzorhodamine dyes |
-
1999
- 1999-03-27 US US09/277,793 patent/US6080852A/en not_active Expired - Lifetime
-
2000
- 2000-03-24 CA CA002367868A patent/CA2367868C/en not_active Expired - Fee Related
- 2000-03-24 ES ES03025777T patent/ES2329562T3/es not_active Expired - Lifetime
- 2000-03-24 JP JP2000608692A patent/JP3848838B2/ja not_active Expired - Lifetime
- 2000-03-24 WO PCT/US2000/008003 patent/WO2000058406A1/en not_active Ceased
- 2000-03-24 EP EP03025777A patent/EP1386946B1/en not_active Expired - Lifetime
- 2000-03-24 AU AU37732/00A patent/AU772329B2/en not_active Ceased
- 2000-03-24 EP EP00916662A patent/EP1165694B1/en not_active Expired - Lifetime
- 2000-03-24 DE DE60014051T patent/DE60014051T8/de active Active
- 2000-03-24 AT AT03025777T patent/ATE438691T1/de not_active IP Right Cessation
- 2000-03-24 AT AT00916662T patent/ATE277128T1/de not_active IP Right Cessation
- 2000-03-24 DE DE60042706T patent/DE60042706D1/de not_active Expired - Lifetime
- 2000-03-24 ES ES00916662T patent/ES2226801T3/es not_active Expired - Lifetime
- 2000-05-25 US US09/578,920 patent/US6713622B1/en not_active Expired - Lifetime
-
2005
- 2005-11-04 JP JP2005321635A patent/JP4732130B2/ja not_active Expired - Fee Related
-
2010
- 2010-08-20 JP JP2010185648A patent/JP2011016813A/ja not_active Withdrawn
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2002540280A5 (enExample) | ||
| US7001725B2 (en) | Kits employing generalized target-binding e-tag probes | |
| US6818399B2 (en) | Methods employing generalized target-binding e-tag probes | |
| KR0156042B1 (ko) | 적외선 염료로 표지화된 누클레오티드 및 그의 핵산 검출에 있어서의 사용방법 | |
| US7745591B2 (en) | Phosphinoamidite carboxylates and analogs thereof in the synthesis of oligonucleotides having reduced internucleotide charge | |
| JP3566255B2 (ja) | Ｔａｇライブラリー化合物、組成物、キットおよび使用の方法 | |
| US7037654B2 (en) | Methods and compositions for enhancing detection in determinations employing cleavable electrophoretic tag reagents | |
| CN101312985B (zh) | 含有磷酸酯模拟物的多聚核苷酸 | |
| JP4623828B2 (ja) | アミン塩基及びヌクレオシドの構造的類似体 | |
| US20110275124A1 (en) | Reagents for reversibly terminating primer extension | |
| JP2001512131A (ja) | 塩基アナログ | |
| JP2004043819A5 (enExample) | ||
| WO2016182984A1 (en) | Disulfide-linked reversible terminators | |
| JP2006258818A (ja) | 核酸標識化合物 | |
| CA2623042A1 (en) | Labeled nucleotide analogs and uses therefor | |
| JP2010053137A5 (enExample) | ||
| US20040248150A1 (en) | Methods employing oligonucleotide-binding e-tag probes | |
| WO2003042658A2 (en) | Methods and compositions for enhancing detection in determinations employing cleavable electrophoretic tag reagents | |
| WO2021067970A1 (en) | Reversible terminators for dna sequencing and methods of using the same | |
| EP3856753A1 (en) | Disulfide-linked reversible terminators | |
| US7282581B2 (en) | Oligonucleotide labeling reactants based on acyclonucleosides and conjugates derived thereof | |
| CN106459133A (zh) | 用于“z核苷酸”的保护基团及其方法 | |
| US20040210045A1 (en) | Nucleic acid labeling compounds |