JP2010053137A5 - - Google Patents
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- JP2010053137A5 JP2010053137A5 JP2009272932A JP2009272932A JP2010053137A5 JP 2010053137 A5 JP2010053137 A5 JP 2010053137A5 JP 2009272932 A JP2009272932 A JP 2009272932A JP 2009272932 A JP2009272932 A JP 2009272932A JP 2010053137 A5 JP2010053137 A5 JP 2010053137A5
- Authority
- JP
- Japan
- Prior art keywords
- substituted
- dye
- saturated
- carbon atoms
- sulfonate
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 239000000975 dye Substances 0.000 claims 121
- 125000005647 linker group Chemical group 0.000 claims 90
- ZUOUZKKEUPVFJK-UHFFFAOYSA-N diphenyl Chemical compound C1=CC=CC=C1C1=CC=CC=C1 ZUOUZKKEUPVFJK-UHFFFAOYSA-N 0.000 claims 84
- -1 phenoxy, phenyl Chemical group 0.000 claims 81
- 125000004432 carbon atom Chemical group C* 0.000 claims 72
- 229920006395 saturated elastomer Polymers 0.000 claims 72
- 125000000623 heterocyclic group Chemical group 0.000 claims 58
- 150000001875 compounds Chemical class 0.000 claims 54
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims 50
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 50
- 239000002773 nucleotide Substances 0.000 claims 46
- 125000003729 nucleotide group Chemical group 0.000 claims 46
- BDHFUVZGWQCTTF-UHFFFAOYSA-M sulfonate Chemical compound [O-]S(=O)=O BDHFUVZGWQCTTF-UHFFFAOYSA-M 0.000 claims 46
- 108091033319 polynucleotide Proteins 0.000 claims 44
- 102000040430 polynucleotide Human genes 0.000 claims 44
- 239000002157 polynucleotide Substances 0.000 claims 44
- 235000010290 biphenyl Nutrition 0.000 claims 42
- 239000004305 biphenyl Substances 0.000 claims 42
- 238000000034 method Methods 0.000 claims 42
- 125000001624 naphthyl group Chemical class 0.000 claims 42
- 125000000753 cycloalkyl group Chemical group 0.000 claims 38
- 125000004122 cyclic group Chemical group 0.000 claims 34
- 150000002430 hydrocarbons Chemical class 0.000 claims 34
- QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 claims 32
- 229930195733 hydrocarbon Natural products 0.000 claims 32
- 150000007942 carboxylates Chemical class 0.000 claims 28
- 229910052739 hydrogen Inorganic materials 0.000 claims 26
- 239000001257 hydrogen Substances 0.000 claims 26
- 239000004215 Carbon black (E152) Substances 0.000 claims 24
- 150000002431 hydrogen Chemical class 0.000 claims 24
- 125000006413 ring segment Chemical group 0.000 claims 22
- 125000004429 atom Chemical group 0.000 claims 20
- 229910019142 PO4 Inorganic materials 0.000 claims 16
- 125000003545 alkoxy group Chemical group 0.000 claims 16
- 150000001408 amides Chemical class 0.000 claims 16
- 150000001412 amines Chemical group 0.000 claims 16
- 150000002118 epoxides Chemical class 0.000 claims 16
- 230000005284 excitation Effects 0.000 claims 16
- 150000002825 nitriles Chemical class 0.000 claims 16
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 claims 16
- 239000010452 phosphate Substances 0.000 claims 16
- UEZVMMHDMIWARA-UHFFFAOYSA-M phosphonate Chemical compound [O-]P(=O)=O UEZVMMHDMIWARA-UHFFFAOYSA-M 0.000 claims 16
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 16
- 239000000523 sample Substances 0.000 claims 15
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims 12
- KDTZBYPBMTXCSO-UHFFFAOYSA-N 2-phenoxyphenol Chemical class OC1=CC=CC=C1OC1=CC=CC=C1 KDTZBYPBMTXCSO-UHFFFAOYSA-N 0.000 claims 8
- QGZKDVFQNNGYKY-UHFFFAOYSA-O Ammonium Chemical compound [NH4+] QGZKDVFQNNGYKY-UHFFFAOYSA-O 0.000 claims 8
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 claims 8
- PXGOKWXKJXAPGV-UHFFFAOYSA-N Fluorine Chemical compound FF PXGOKWXKJXAPGV-UHFFFAOYSA-N 0.000 claims 8
- OAKJQQAXSVQMHS-UHFFFAOYSA-N Hydrazine Chemical compound NN OAKJQQAXSVQMHS-UHFFFAOYSA-N 0.000 claims 8
- PEEHTFAAVSWFBL-UHFFFAOYSA-N Maleimide Chemical compound O=C1NC(=O)C=C1 PEEHTFAAVSWFBL-UHFFFAOYSA-N 0.000 claims 8
- 125000000066 S-methyl group Chemical group [H]C([H])([H])S* 0.000 claims 8
- 125000005360 alkyl sulfoxide group Chemical group 0.000 claims 8
- 125000003118 aryl group Chemical group 0.000 claims 8
- 125000005362 aryl sulfone group Chemical group 0.000 claims 8
- 125000005361 aryl sulfoxide group Chemical group 0.000 claims 8
- 125000005110 aryl thio group Chemical group 0.000 claims 8
- 150000001540 azides Chemical class 0.000 claims 8
- 229910052801 chlorine Inorganic materials 0.000 claims 8
- 239000000460 chlorine Substances 0.000 claims 8
- 150000002148 esters Chemical class 0.000 claims 8
- 229910052731 fluorine Inorganic materials 0.000 claims 8
- 239000011737 fluorine Substances 0.000 claims 8
- 125000002485 formyl group Chemical class [H]C(*)=O 0.000 claims 8
- 150000004820 halides Chemical class 0.000 claims 8
- 125000005179 haloacetyl group Chemical group 0.000 claims 8
- 125000001475 halogen functional group Chemical group 0.000 claims 8
- 125000002887 hydroxy group Chemical class [H]O* 0.000 claims 8
- 125000004029 hydroxymethyl group Chemical group [H]OC([H])([H])* 0.000 claims 8
- PGLTVOMIXTUURA-UHFFFAOYSA-N iodoacetamide Chemical class NC(=O)CI PGLTVOMIXTUURA-UHFFFAOYSA-N 0.000 claims 8
- 150000002540 isothiocyanates Chemical class 0.000 claims 8
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 claims 8
- 150000008300 phosphoramidites Chemical class 0.000 claims 8
- 150000003141 primary amines Chemical class 0.000 claims 8
- DNPUPQAMUUREAN-UHFFFAOYSA-O pyridin-1-ium-1,4-diamine Chemical group NC1=CC=[N+](C=C1)N DNPUPQAMUUREAN-UHFFFAOYSA-O 0.000 claims 8
- 150000003335 secondary amines Chemical class 0.000 claims 8
- 229940124530 sulfonamide Drugs 0.000 claims 8
- 150000003456 sulfonamides Chemical class 0.000 claims 8
- 150000003457 sulfones Chemical class 0.000 claims 8
- YBBRCQOCSYXUOC-UHFFFAOYSA-N sulfuryl dichloride Chemical compound ClS(Cl)(=O)=O YBBRCQOCSYXUOC-UHFFFAOYSA-N 0.000 claims 8
- 150000003573 thiols Chemical class 0.000 claims 8
- 125000003944 tolyl group Chemical group 0.000 claims 8
- 229920003169 water-soluble polymer Polymers 0.000 claims 8
- 238000000137 annealing Methods 0.000 claims 4
- GNBHRKFJIUUOQI-UHFFFAOYSA-N fluorescein Chemical compound O1C(=O)C2=CC=CC=C2C21C1=CC=C(O)C=C1OC1=CC(O)=CC=C21 GNBHRKFJIUUOQI-UHFFFAOYSA-N 0.000 claims 4
- 125000000843 phenylene group Chemical group C1(=C(C=CC=C1)*)* 0.000 claims 4
- 125000001424 substituent group Chemical group 0.000 claims 4
- 239000000203 mixture Substances 0.000 claims 3
- YOSZEPWSVKKQOV-UHFFFAOYSA-N 12h-benzo[a]phenoxazine Chemical compound C1=CC=CC2=C3NC4=CC=CC=C4OC3=CC=C21 YOSZEPWSVKKQOV-UHFFFAOYSA-N 0.000 claims 2
- IHXWECHPYNPJRR-UHFFFAOYSA-N 3-hydroxycyclobut-2-en-1-one Chemical compound OC1=CC(=O)C1 IHXWECHPYNPJRR-UHFFFAOYSA-N 0.000 claims 2
- 102000004190 Enzymes Human genes 0.000 claims 2
- 108090000790 Enzymes Proteins 0.000 claims 2
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 2
- 102000003960 Ligases Human genes 0.000 claims 2
- 108090000364 Ligases Proteins 0.000 claims 2
- CZPWVGJYEJSRLH-UHFFFAOYSA-N Pyrimidine Chemical compound C1=CN=CN=C1 CZPWVGJYEJSRLH-UHFFFAOYSA-N 0.000 claims 2
- 230000003321 amplification Effects 0.000 claims 2
- 150000001721 carbon Chemical class 0.000 claims 2
- VILAVOFMIJHSJA-UHFFFAOYSA-N dicarbon monoxide Chemical group [C]=C=O VILAVOFMIJHSJA-UHFFFAOYSA-N 0.000 claims 2
- 239000007850 fluorescent dye Substances 0.000 claims 2
- 125000000524 functional group Chemical group 0.000 claims 2
- 238000003199 nucleic acid amplification method Methods 0.000 claims 2
- 229910052760 oxygen Inorganic materials 0.000 claims 2
- IEQIEDJGQAUEQZ-UHFFFAOYSA-N phthalocyanine Chemical compound N1C(N=C2C3=CC=CC=C3C(N=C3C4=CC=CC=C4C(=N4)N3)=N2)=C(C=CC=C2)C2=C1N=C1C2=CC=CC=C2C4=N1 IEQIEDJGQAUEQZ-UHFFFAOYSA-N 0.000 claims 2
- 125000004219 purine nucleobase group Chemical group 0.000 claims 2
- PYWVYCXTNDRMGF-UHFFFAOYSA-N rhodamine B Chemical compound [Cl-].C=12C=CC(=[N+](CC)CC)C=C2OC2=CC(N(CC)CC)=CC=C2C=1C1=CC=CC=C1C(O)=O PYWVYCXTNDRMGF-UHFFFAOYSA-N 0.000 claims 2
- 239000001022 rhodamine dye Substances 0.000 claims 2
- 229910052717 sulfur Inorganic materials 0.000 claims 2
- ANRHNWWPFJCPAZ-UHFFFAOYSA-M thionine Chemical group [Cl-].C1=CC(N)=CC2=[S+]C3=CC(N)=CC=C3N=C21 ANRHNWWPFJCPAZ-UHFFFAOYSA-M 0.000 claims 2
- XKKCQTLDIPIRQD-JGVFFNPUSA-N 1-[(2r,5s)-5-(hydroxymethyl)oxolan-2-yl]-5-methylpyrimidine-2,4-dione Chemical group O=C1NC(=O)C(C)=CN1[C@@H]1O[C@H](CO)CC1 XKKCQTLDIPIRQD-JGVFFNPUSA-N 0.000 claims 1
- WVXRAFOPTSTNLL-NKWVEPMBSA-N 2',3'-dideoxyadenosine Chemical group C1=NC=2C(N)=NC=NC=2N1[C@H]1CC[C@@H](CO)O1 WVXRAFOPTSTNLL-NKWVEPMBSA-N 0.000 claims 1
- OCLZPNCLRLDXJC-NTSWFWBYSA-N 2-amino-9-[(2r,5s)-5-(hydroxymethyl)oxolan-2-yl]-3h-purin-6-one Chemical group C1=2NC(N)=NC(=O)C=2N=CN1[C@H]1CC[C@@H](CO)O1 OCLZPNCLRLDXJC-NTSWFWBYSA-N 0.000 claims 1
- 108091034117 Oligonucleotide Proteins 0.000 claims 1
- WREGKURFCTUGRC-POYBYMJQSA-N Zalcitabine Chemical group O=C1N=C(N)C=CN1[C@@H]1O[C@H](CO)CC1 WREGKURFCTUGRC-POYBYMJQSA-N 0.000 claims 1
- 230000000295 complement effect Effects 0.000 claims 1
- BFMYDTVEBKDAKJ-UHFFFAOYSA-L disodium;(2',7'-dibromo-3',6'-dioxido-3-oxospiro[2-benzofuran-1,9'-xanthene]-4'-yl)mercury;hydrate Chemical compound O.[Na+].[Na+].O1C(=O)C2=CC=CC=C2C21C1=CC(Br)=C([O-])C([Hg])=C1OC1=C2C=C(Br)C([O-])=C1 BFMYDTVEBKDAKJ-UHFFFAOYSA-L 0.000 claims 1
- 238000001962 electrophoresis Methods 0.000 claims 1
- 238000001917 fluorescence detection Methods 0.000 claims 1
- 238000002189 fluorescence spectrum Methods 0.000 claims 1
- 238000009396 hybridization Methods 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 239000000178 monomer Substances 0.000 claims 1
- YCWSUKQGVSGXJO-NTUHNPAUSA-N nifuroxazide Chemical group C1=CC(O)=CC=C1C(=O)N\N=C\C1=CC=C([N+]([O-])=O)O1 YCWSUKQGVSGXJO-NTUHNPAUSA-N 0.000 claims 1
- 102000039446 nucleic acids Human genes 0.000 claims 1
- 108020004707 nucleic acids Proteins 0.000 claims 1
- 150000007523 nucleic acids Chemical class 0.000 claims 1
- 238000012163 sequencing technique Methods 0.000 claims 1
- 239000007790 solid phase Substances 0.000 claims 1
- 238000001228 spectrum Methods 0.000 claims 1
- 229960000523 zalcitabine Drugs 0.000 claims 1
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US09/724,855 US6583168B1 (en) | 1997-11-25 | 2000-11-28 | Sulfonated diarylrhodamine dyes |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2002546764A Division JP4486781B2 (ja) | 2000-11-28 | 2001-11-27 | 蛍光標識としてのスルホン化ジアリールローダミン色素 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2010053137A JP2010053137A (ja) | 2010-03-11 |
| JP2010053137A5 true JP2010053137A5 (enExample) | 2010-08-19 |
Family
ID=24912198
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2002546764A Expired - Fee Related JP4486781B2 (ja) | 2000-11-28 | 2001-11-27 | 蛍光標識としてのスルホン化ジアリールローダミン色素 |
| JP2008335693A Withdrawn JP2009108098A (ja) | 2000-11-28 | 2008-12-29 | 蛍光標識としてのスルホン化ジアリールローダミン色素 |
| JP2009272932A Withdrawn JP2010053137A (ja) | 2000-11-28 | 2009-11-30 | 蛍光標識としてのスルホン化ジアリールローダミン色素 |
| JP2010161112A Pending JP2010285625A (ja) | 2000-11-28 | 2010-07-15 | 蛍光標識としてのスルホン化ジアリールローダミン色素 |
Family Applications Before (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2002546764A Expired - Fee Related JP4486781B2 (ja) | 2000-11-28 | 2001-11-27 | 蛍光標識としてのスルホン化ジアリールローダミン色素 |
| JP2008335693A Withdrawn JP2009108098A (ja) | 2000-11-28 | 2008-12-29 | 蛍光標識としてのスルホン化ジアリールローダミン色素 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010161112A Pending JP2010285625A (ja) | 2000-11-28 | 2010-07-15 | 蛍光標識としてのスルホン化ジアリールローダミン色素 |
Country Status (6)
| Country | Link |
|---|---|
| US (2) | US6583168B1 (enExample) |
| EP (3) | EP1339798A2 (enExample) |
| JP (4) | JP4486781B2 (enExample) |
| AU (1) | AU2002219896A1 (enExample) |
| CA (1) | CA2429816A1 (enExample) |
| WO (1) | WO2002044416A2 (enExample) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5936087A (en) * | 1997-11-25 | 1999-08-10 | The Perkin-Elmer Corporation | Dibenzorhodamine dyes |
| WO2000071559A1 (en) * | 1999-05-24 | 2000-11-30 | Invitrogen Corporation | Method for deblocking of labeled oligonucleotides |
| US6979530B2 (en) * | 2001-05-21 | 2005-12-27 | Applera Corporation | Peptide conjugates and fluorescence detection methods for intracellular caspase assay |
| CA2490961A1 (en) * | 2002-07-01 | 2004-01-08 | Guava Technologies, Inc. | Fluorescent dyes, energy transfer couples and methods |
| US20050186606A1 (en) * | 2004-02-11 | 2005-08-25 | Schroeder Benjamin G. | Methods and compositions for detecting nucleic acids |
| US7767834B2 (en) * | 2004-08-13 | 2010-08-03 | Elitech Holding B.V. | Phosphonylated fluorescent dyes and conjugates |
| ES2461858T3 (es) * | 2004-08-13 | 2014-05-21 | Epoch Biosciences, Inc. | Colorantes fluorescentes de fosfonato y conjugados |
| CA2581174A1 (en) * | 2004-09-16 | 2006-03-30 | Applera Corporation | Fluorescent dye compounds, conjugates and uses thereof |
| EP2001871B1 (en) * | 2006-03-31 | 2014-07-16 | Applied Biosystems, LLC | Rhodamine-labeled oligonucleotides |
| US8178360B2 (en) * | 2006-05-18 | 2012-05-15 | Illumina Cambridge Limited | Dye compounds and the use of their labelled conjugates |
| GB0611405D0 (en) | 2006-06-09 | 2006-07-19 | Univ Belfast | FKBP-L: A novel inhibitor of angiogenesis |
| KR101117722B1 (ko) * | 2009-08-28 | 2012-03-07 | 삼성모바일디스플레이주식회사 | 유기 발광 소자 |
| KR101193182B1 (ko) * | 2009-09-02 | 2012-10-19 | 삼성디스플레이 주식회사 | 유기 발광 소자 |
| DE102010042634A1 (de) | 2010-10-19 | 2012-04-19 | Atto-Tec Gmbh | Neue Amin-substituierte tricyclische Fluoreszenzfarbstoffe |
| EP2782916B1 (en) | 2011-11-21 | 2018-02-28 | Promega Corporation | Carboxy x rhodamine analogs |
| JP5729491B2 (ja) * | 2012-01-24 | 2015-06-03 | 株式会社島津製作所 | 有機系太陽電池用色素材料の分析方法及び精製方法 |
| EP2942352A4 (en) * | 2013-01-07 | 2016-09-07 | Univ Tokyo | ASYMMETRIC SI-RHODAMINE AND RHODOL SYNTHESIS |
| JP6815603B2 (ja) * | 2016-11-22 | 2021-01-20 | スガイ化学工業株式会社 | ジナフトチオフェン誘導体及びその製造方法 |
| JP2018090535A (ja) * | 2016-12-02 | 2018-06-14 | 国立大学法人 東京大学 | 近赤外蛍光カルシウムプローブ |
| JP2018090536A (ja) * | 2016-12-02 | 2018-06-14 | 国立大学法人 東京大学 | 近赤外蛍光レシオ型プローブ |
| CN109111421B (zh) * | 2018-10-12 | 2022-04-22 | 湖南科技大学 | 一种氧杂蒽类荧光探针及其制备方法和应用 |
Family Cites Families (52)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4230558A (en) | 1978-10-02 | 1980-10-28 | Coulter Electronics, Inc. | Single drop separator |
| JPS55141460A (en) * | 1979-04-20 | 1980-11-05 | Agency Of Ind Science & Technol | Preparation of sulfanilic acid and naphthionic acid |
| US4458066A (en) | 1980-02-29 | 1984-07-03 | University Patents, Inc. | Process for preparing polynucleotides |
| US4415732A (en) | 1981-03-27 | 1983-11-15 | University Patents, Inc. | Phosphoramidite compounds and processes |
| US4973679A (en) | 1981-03-27 | 1990-11-27 | University Patents, Inc. | Process for oligonucleo tide synthesis using phosphormidite intermediates |
| US4711955A (en) | 1981-04-17 | 1987-12-08 | Yale University | Modified nucleotides and methods of preparing and using same |
| US4883750A (en) | 1984-12-13 | 1989-11-28 | Applied Biosystems, Inc. | Detection of specific sequences in nucleic acids |
| US4757141A (en) | 1985-08-26 | 1988-07-12 | Applied Biosystems, Incorporated | Amino-derivatized phosphite and phosphate linking agents, phosphoramidite precursors, and useful conjugates thereof |
| US4855225A (en) | 1986-02-07 | 1989-08-08 | Applied Biosystems, Inc. | Method of detecting electrophoretically separated oligonucleotides |
| US4811218A (en) | 1986-06-02 | 1989-03-07 | Applied Biosystems, Inc. | Real time scanning electrophoresis apparatus for DNA sequencing |
| US5151507A (en) | 1986-07-02 | 1992-09-29 | E. I. Du Pont De Nemours And Company | Alkynylamino-nucleotides |
| DE3821454A1 (de) | 1987-06-24 | 1989-02-09 | Hitachi Ltd | Verfahren zur aufbereitung gebrauchter elektrophorese-gele fuer die wiederverwendung |
| US5231191A (en) | 1987-12-24 | 1993-07-27 | Applied Biosystems, Inc. | Rhodamine phosphoramidite compounds |
| US5047524A (en) | 1988-12-21 | 1991-09-10 | Applied Biosystems, Inc. | Automated system for polynucleotide synthesis and purification |
| US5262530A (en) | 1988-12-21 | 1993-11-16 | Applied Biosystems, Inc. | Automated system for polynucleotide synthesis and purification |
| US5141813A (en) | 1989-08-28 | 1992-08-25 | Clontech Laboratories, Inc. | Multifunctional controlled pore glass reagent for solid phase oligonucleotide synthesis |
| US5366860A (en) | 1989-09-29 | 1994-11-22 | Applied Biosystems, Inc. | Spectrally resolvable rhodamine dyes for nucleic acid sequence determination |
| US5091652A (en) | 1990-01-12 | 1992-02-25 | The Regents Of The University Of California | Laser excited confocal microscope fluorescence scanner and method |
| US5274240A (en) | 1990-01-12 | 1993-12-28 | The Regents Of The University Of California | Capillary array confocal fluorescence scanner and method |
| US5405975A (en) * | 1993-03-29 | 1995-04-11 | Molecular Probes, Inc. | Fluorescent ion-selective diaryldiaza crown ether conjugates |
| US5210015A (en) | 1990-08-06 | 1993-05-11 | Hoffman-La Roche Inc. | Homogeneous assay system using the nuclease activity of a nucleic acid polymerase |
| GB9024176D0 (en) * | 1990-11-07 | 1990-12-19 | Medical Res Council | Photolabile compounds,their synthesis and use as fluorophores |
| DE4137934A1 (de) * | 1991-11-18 | 1993-05-19 | Boehringer Mannheim Gmbh | Neue pentacyklische verbindungen und ihre verwendung als absorptions- oder fluoreszenzfarbstoffe |
| US5750409A (en) | 1991-11-18 | 1998-05-12 | Boehringer Mannheim Gmbh | Pentacyclic compounds and their use as absorption or fluorescent dyes |
| DE69322266T2 (de) | 1992-04-03 | 1999-06-02 | Perkin-Elmer Corp., Foster City, Calif. | Proben zusammensetzung und verfahren |
| WO1994005688A1 (en) | 1992-09-03 | 1994-03-17 | Applied Biosystems, Inc. | 4,7-dichlorofluorescein dyes as molecular probes |
| US5538848A (en) | 1994-11-16 | 1996-07-23 | Applied Biosystems Division, Perkin-Elmer Corp. | Method for detecting nucleic acid amplification using self-quenching fluorescence probe |
| WO1995016910A1 (en) | 1993-12-17 | 1995-06-22 | Perkin-Elmer Corporation | Uncharged polymers for separation of biomolecules by capillary electrophoresis |
| US5654419A (en) | 1994-02-01 | 1997-08-05 | The Regents Of The University Of California | Fluorescent labels and their use in separations |
| US5543026A (en) | 1994-02-07 | 1996-08-06 | The Perkin-Elmer Corporation | Real-time scanning fluorescence electrophoresis apparatus for the analysis of polynucleotide fragments |
| US5605809A (en) | 1994-10-28 | 1997-02-25 | Oncoimmunin, Inc. | Compositions for the detection of proteases in biological samples and methods of use thereof |
| US5912340A (en) | 1995-10-04 | 1999-06-15 | Epoch Pharmaceuticals, Inc. | Selective binding complementary oligonucleotides |
| US5736626A (en) | 1996-01-29 | 1998-04-07 | The Perkin-Elmer Corporation | Solid support reagents for the direct synthesis of 3'-labeled polynucleotides |
| US6020481A (en) * | 1996-04-01 | 2000-02-01 | The Perkin-Elmer Corporation | Asymmetric benzoxanthene dyes |
| US5945526A (en) | 1996-05-03 | 1999-08-31 | Perkin-Elmer Corporation | Energy transfer dyes with enhanced fluorescence |
| US5800996A (en) | 1996-05-03 | 1998-09-01 | The Perkin Elmer Corporation | Energy transfer dyes with enchanced fluorescence |
| US6080852A (en) * | 1996-06-27 | 2000-06-27 | The Perkin-Elmer Corporation | 4,7-dichlororhodamine dyes |
| US5821356A (en) | 1996-08-12 | 1998-10-13 | The Perkin Elmer Corporation | Propargylethoxyamino nucleotides |
| US6043060A (en) | 1996-11-18 | 2000-03-28 | Imanishi; Takeshi | Nucleotide analogues |
| JP3756313B2 (ja) | 1997-03-07 | 2006-03-15 | 武 今西 | 新規ビシクロヌクレオシド及びオリゴヌクレオチド類縁体 |
| US5770716A (en) | 1997-04-10 | 1998-06-23 | The Perkin-Elmer Corporation | Substituted propargylethoxyamido nucleosides, oligonucleotides and methods for using same |
| KR100414936B1 (ko) | 1997-09-12 | 2004-01-13 | 엑시콘 에이/에스 | 이환 및 삼환 뉴클레오시드, 뉴클레오타이드 및올리고뉴클레오타이드 동족체 |
| US6130101A (en) | 1997-09-23 | 2000-10-10 | Molecular Probes, Inc. | Sulfonated xanthene derivatives |
| US6008379A (en) * | 1997-10-01 | 1999-12-28 | The Perkin-Elmer Corporation | Aromatic-substituted xanthene dyes |
| US5936087A (en) * | 1997-11-25 | 1999-08-10 | The Perkin-Elmer Corporation | Dibenzorhodamine dyes |
| US6080868A (en) * | 1998-01-23 | 2000-06-27 | The Perkin-Elmer Corporation | Nitro-substituted non-fluorescent asymmetric cyanine dye compounds |
| US6096875A (en) | 1998-05-29 | 2000-08-01 | The Perlein-Elmer Corporation | Nucleotide compounds including a rigid linker |
| US5948648A (en) | 1998-05-29 | 1999-09-07 | Khan; Shaheer H. | Nucleotide compounds including a rigid linker |
| CA2335359C (en) * | 1999-04-23 | 2007-07-17 | Molecular Probes, Inc. | Xanthene dyes and their application as luminescence quenching compounds |
| DE19923168A1 (de) * | 1999-05-20 | 2000-11-23 | Roche Diagnostics Gmbh | Neue Fluoreszenzfarbstoffe und ihre Verwendung als Fluoreszenzmarker |
| US6248884B1 (en) * | 1999-06-03 | 2001-06-19 | The Perkin-Elmer Corporation | Extended rhodamine compounds useful as fluorescent labels |
| WO2002030944A2 (en) * | 2000-10-11 | 2002-04-18 | Applera Corporation | Fluorescent nucleobase conjugates having anionic linkers |
-
2000
- 2000-11-28 US US09/724,855 patent/US6583168B1/en not_active Expired - Lifetime
-
2001
- 2001-11-27 JP JP2002546764A patent/JP4486781B2/ja not_active Expired - Fee Related
- 2001-11-27 EP EP01998658A patent/EP1339798A2/en not_active Ceased
- 2001-11-27 WO PCT/US2001/044475 patent/WO2002044416A2/en not_active Ceased
- 2001-11-27 CA CA002429816A patent/CA2429816A1/en not_active Abandoned
- 2001-11-27 AU AU2002219896A patent/AU2002219896A1/en not_active Abandoned
- 2001-11-27 EP EP09016130A patent/EP2221347A1/en not_active Withdrawn
- 2001-11-27 EP EP09016135A patent/EP2179996A1/en not_active Withdrawn
-
2003
- 2003-06-24 US US10/602,974 patent/US7018431B2/en not_active Expired - Lifetime
-
2008
- 2008-12-29 JP JP2008335693A patent/JP2009108098A/ja not_active Withdrawn
-
2009
- 2009-11-30 JP JP2009272932A patent/JP2010053137A/ja not_active Withdrawn
-
2010
- 2010-07-15 JP JP2010161112A patent/JP2010285625A/ja active Pending
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