AU772329B2 - 4,7-dichlororhodamine dyes useful as molecular probes - Google Patents

4,7-dichlororhodamine dyes useful as molecular probes Download PDF

Info

Publication number
AU772329B2
AU772329B2 AU37732/00A AU3773200A AU772329B2 AU 772329 B2 AU772329 B2 AU 772329B2 AU 37732/00 A AU37732/00 A AU 37732/00A AU 3773200 A AU3773200 A AU 3773200A AU 772329 B2 AU772329 B2 AU 772329B2
Authority
AU
Australia
Prior art keywords
hydrogen
labeled
polynucleotide
nucleoside
tide
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU37732/00A
Other languages
English (en)
Other versions
AU3773200A (en
Inventor
Scott C Benson
Ronald J. Graham
Linda G. Lee
Barnett B. Rosenblum
Sandra L. Spurgeon
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Applied Biosystems LLC
Original Assignee
Applera Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Applera Corp filed Critical Applera Corp
Publication of AU3773200A publication Critical patent/AU3773200A/en
Assigned to APPLERA CORPORATION reassignment APPLERA CORPORATION Alteration of Name(s) of Applicant(s) under S113 Assignors: PE CORPORATION (NY)
Application granted granted Critical
Publication of AU772329B2 publication Critical patent/AU772329B2/en
Assigned to APPLIED BIOSYSTEMS, LLC reassignment APPLIED BIOSYSTEMS, LLC Alteration of Name(s) in Register under S187 Assignors: APPLERA CORPORATION
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Engineering & Computer Science (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Pyrane Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
AU37732/00A 1999-03-27 2000-03-24 4,7-dichlororhodamine dyes useful as molecular probes Ceased AU772329B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US09/277,793 US6080852A (en) 1996-06-27 1999-03-27 4,7-dichlororhodamine dyes
US09/277793 1999-03-27
PCT/US2000/008003 WO2000058406A1 (en) 1999-03-27 2000-03-24 4,7-dichlororhodamine dyes useful as molecular probes

Publications (2)

Publication Number Publication Date
AU3773200A AU3773200A (en) 2000-10-16
AU772329B2 true AU772329B2 (en) 2004-04-22

Family

ID=23062373

Family Applications (1)

Application Number Title Priority Date Filing Date
AU37732/00A Ceased AU772329B2 (en) 1999-03-27 2000-03-24 4,7-dichlororhodamine dyes useful as molecular probes

Country Status (9)

Country Link
US (2) US6080852A (enExample)
EP (2) EP1386946B1 (enExample)
JP (3) JP3848838B2 (enExample)
AT (2) ATE438691T1 (enExample)
AU (1) AU772329B2 (enExample)
CA (1) CA2367868C (enExample)
DE (2) DE60014051T8 (enExample)
ES (2) ES2329562T3 (enExample)
WO (1) WO2000058406A1 (enExample)

Families Citing this family (71)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6080852A (en) 1996-06-27 2000-06-27 The Perkin-Elmer Corporation 4,7-dichlororhodamine dyes
US7550570B2 (en) * 2000-05-25 2009-06-23 Applied Biosystems, Llc. 4,7-dichlororhodamine dyes labeled polynucleotides
US5936087A (en) 1997-11-25 1999-08-10 The Perkin-Elmer Corporation Dibenzorhodamine dyes
US6583168B1 (en) * 1997-11-25 2003-06-24 Applera Corporation Sulfonated diarylrhodamine dyes
US6372907B1 (en) * 1999-11-03 2002-04-16 Apptera Corporation Water-soluble rhodamine dye peptide conjugates
DE60136719D1 (de) * 2000-08-04 2009-01-08 Molecular Probes Inc Kondensierte ringe enthaltende 1,2-dihydro-7-hydroxychinolinderivate
US7169922B2 (en) * 2000-08-04 2007-01-30 Invitrogen Corporation Derivatives of 1,2-dihydro-7-hydroxyquinolines containing fused rings
WO2002030944A2 (en) * 2000-10-11 2002-04-18 Applera Corporation Fluorescent nucleobase conjugates having anionic linkers
US6916492B2 (en) 2001-03-30 2005-07-12 Council Of Scientific & Industrial Research Natural nontoxic multicolor fluorescent protein dye from a marine invertebrate, compositions containing the said dye and its uses
US6689391B2 (en) 2001-03-30 2004-02-10 Council Of Scientific & Industrial Research Natural non-polar fluorescent dye from a non-bioluminescent marine invertebrate, compositions containing the said dye and its uses
WO2002079327A1 (en) 2001-03-30 2002-10-10 Council Of Scientific And Industrial Research A natural fluorescent dye obtained from a marine invertebrate, compositions containing the said dye and their uses
US6887690B2 (en) * 2001-06-22 2005-05-03 Pe Corporation Dye-labeled ribonucleotide triphosphates
US6764710B2 (en) 2001-07-18 2004-07-20 Scimed Life Systems, Inc. Light emitting markers for use with substrates
US7052512B2 (en) * 2001-07-18 2006-05-30 Boston Scientific Scimed, Inc. Fluorescent dyed lubricant for medical devices
US6956122B2 (en) 2001-09-05 2005-10-18 Council Of Scientific & Industrial Research Multiple fluorescent natural dye compound from a marine organism
US20040171034A1 (en) * 2002-05-03 2004-09-02 Brian Agnew Compositions and methods for detection and isolation of phosphorylated molecules
US7102005B2 (en) * 2002-05-03 2006-09-05 Molecular Probes, Inc. Compositions and methods for detection and isolation of phosphorylated molecules
US7445894B2 (en) * 2002-05-03 2008-11-04 Molecular Probes, Inc. Compositions and methods for detection and isolation of phosphorylated molecules
AU2003229679A1 (en) * 2002-05-17 2003-12-02 Ciba Specialty Chemicals Holding Inc. Optical storage media comprising pentacyclic xanthylium dyes
CN1653532A (zh) * 2002-05-17 2005-08-10 西巴特殊化学品控股有限公司 高性能光学存储介质
WO2004025259A2 (en) * 2002-09-12 2004-03-25 Molecular Probes, Inc. Site-specific labeling of affinity tags in fusion proteins
US20050250214A1 (en) * 2004-05-05 2005-11-10 Gee Kyle R Zinc binding compounds and their method of use
US7619059B2 (en) 2003-07-29 2009-11-17 Life Technologies Corporation Bimolecular optical probes
CA2445420A1 (en) 2003-07-29 2005-01-29 Invitrogen Corporation Kinase and phosphatase assays
US7727752B2 (en) 2003-07-29 2010-06-01 Life Technologies Corporation Kinase and phosphatase assays
US7271265B2 (en) 2003-08-11 2007-09-18 Invitrogen Corporation Cyanine compounds and their application as quenching compounds
DE602004025592D1 (de) * 2003-09-12 2010-04-01 Life Technologies Corp Anwendungen des Resonanzenergietransfers zwischen Terbium und GFP
US7431915B2 (en) 2003-10-31 2008-10-07 The Regents Of The University Of California Peptides whose uptake by cells is controllable
US20050214807A1 (en) * 2003-11-19 2005-09-29 Iain Johnson Environmental sensitive fluorogenic compounds and their application for singlet oxygen and protein detection
US7776529B2 (en) 2003-12-05 2010-08-17 Life Technologies Corporation Methine-substituted cyanine dye compounds
EP2607431B1 (en) * 2003-12-05 2016-08-24 Life Technologies Corporation Cyanine dye compounds
GB0329161D0 (en) 2003-12-16 2004-01-21 Precisense As Reagant for detecting an analyte
JP4127204B2 (ja) * 2003-12-17 2008-07-30 セイコーエプソン株式会社 液晶表示装置の製造方法
US20050227309A1 (en) 2004-01-21 2005-10-13 Corry Schuyler B Optically-detectable enzyme substrates and their method of use
US7344701B2 (en) * 2004-02-03 2008-03-18 Biosearch Technologies, Inc. Xanthene dyes
US20050186606A1 (en) * 2004-02-11 2005-08-25 Schroeder Benjamin G. Methods and compositions for detecting nucleic acids
PL1740100T3 (pl) * 2004-04-13 2017-09-29 Biosearch Technologies, Inc. Barwniki ksantenowe
WO2006023231A2 (en) 2004-07-27 2006-03-02 Molecular Probes, Inc. Fluorescent metal ion indicators with large stokes shift
JP2008533167A (ja) 2005-03-15 2008-08-21 アプレラ コーポレイション 分析物の検出のための、抗体の代替抗原系の使用
JP5306811B2 (ja) 2005-05-11 2013-10-02 ライフ テクノロジーズ コーポレーション ２本鎖ｄｎａへの高い選択性を有する蛍光化学物質及びそれらの使用
US20070134685A1 (en) * 2005-09-06 2007-06-14 Invitrogen Corporation Control of chemical modification
US7521577B2 (en) * 2006-01-12 2009-04-21 Molecular Probes, Inc. Heavy metal binding compounds and their method of use
US20070196860A1 (en) * 2006-01-18 2007-08-23 Invitrogen Corporation Methods for Measuring Real Time Kinase Activity
EP2001871B1 (en) * 2006-03-31 2014-07-16 Applied Biosystems, LLC Rhodamine-labeled oligonucleotides
US8178360B2 (en) * 2006-05-18 2012-05-15 Illumina Cambridge Limited Dye compounds and the use of their labelled conjugates
NZ575090A (en) 2006-09-06 2012-02-24 Univ California Molecular diagnosis and classification of malignant melanoma using RGS1, ARPC2, FN1, SPP1 and WNT-2 polypeptide markers
EP2064290B1 (en) 2006-10-27 2013-10-09 Life Technologies Corporation Fluorogenic ph sensitive dyes and their method of use
US8586743B2 (en) 2007-01-30 2013-11-19 Life Technologies Corporation Labeling reagents and methods of their use
WO2008151089A2 (en) * 2007-05-30 2008-12-11 Invitrogen Corporation Fluorescent phospholipase a2 indicators
US8017338B2 (en) * 2007-11-20 2011-09-13 Life Technologies Corporation Reversible di-nucleotide terminator sequencing
US20090171078A1 (en) * 2007-11-20 2009-07-02 Applied Biosystems Inc. Method of sequencing nucleic acids using elaborated nucleotide phosphorotiolate compounds
US20090203015A1 (en) * 2008-02-13 2009-08-13 Celera Corporation Multiplex assays for hormonal and growth factor receptors, and uses thereof
EP2257810B1 (en) 2008-03-05 2013-06-05 The Regents of the University of California Molecular diagnosis and classification of malignant melanoma
JP2012519170A (ja) 2009-02-26 2012-08-23 オーエスアイ・ファーマシューティカルズ，エルエルシー 生体内の腫瘍細胞のｅｍｔステータスをモニターするためのｉｎｓｉｔｕ法
EP2782916B1 (en) 2011-11-21 2018-02-28 Promega Corporation Carboxy x rhodamine analogs
WO2013082210A1 (en) 2011-11-29 2013-06-06 Perosphere Inc. Anticoagulant reversal agents
CN102516992A (zh) * 2011-12-07 2012-06-27 天津工业大学 一种检测Hg2+离子的荧光探针及其合成方法和用途
EP2847165A2 (en) 2012-04-02 2015-03-18 Yissum Research Development Company of the Hebrew University of Jerusalem Ltd. Indole, indoline derivatives, compositions comprising them and uses thereof
MX366375B (es) 2013-01-30 2019-07-05 Avelas Biosciences Inc Moleculas de administracion selectiva y metodos de uso.
WO2015041729A2 (en) 2013-06-03 2015-03-26 The Research Foundation Of State University Of New York SITE-SPECIFIC ORTHOGONAL LABELING OF THE CARBOXY TERMINUS OF α-TUBULIN IN LIVE CELLS
JP6692748B2 (ja) 2013-09-26 2020-05-13 ナショナル ユニヴァーシティー オブ シンガポール リゾホスファチジルコリンの足場を利用する組成物及び方法
US10385380B2 (en) 2014-10-02 2019-08-20 The Regents Of The University Of California Personalized protease assay to measure protease activity in neoplasms
EP3242690B1 (en) 2015-01-06 2020-09-16 De Haas, Anthony H. Near-infrared fluorescent surgical dye markers
CN107636165A (zh) 2015-01-12 2018-01-26 生命科技公司 用于核酸文库质量控制和定量的方法、系统和其组合物
KR20200033954A (ko) 2017-08-02 2020-03-30 더 리젠츠 오브 더 유니버시티 오브 캘리포니아 인간의 신경을 표적화하는 최적화된 펩티드 및 영상 유도된 수술, 진단 및 치료적 전달에서의 이의 용도
JP2022514397A (ja) 2018-12-20 2022-02-10 ライフ テクノロジーズ コーポレーション 変更されたローダミン染料及びバイオアッセイにおけるそれらの使用
SG11202106121SA (en) 2018-12-20 2021-07-29 Life Technologies Corp Asymmetric rhodamine dye and use thereof in biological assays
JP7721399B2 (ja) 2020-11-26 2025-08-12 キヤノン株式会社 新規化合物、及び硫化水素検出用の構造体
US20240207421A1 (en) 2020-12-04 2024-06-27 Alume Biosciences, Inc. Nerve targeting peptides and methods of use
CN116916971A (zh) 2021-01-14 2023-10-20 阿鲁莫生物科学公司 用于外科操作中输尿管可视化的方法和组合物
CN117897454A (zh) 2021-07-21 2024-04-16 生命技术公司 二苯并呫吨猝灭剂、用途和制备方法

Family Cites Families (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE47451C (de) Badische Anilin- und Sodafabrik in Ludwigshafen a. Rh Neuerung in dem Verfahren zur Darstellung von Farbstoffen aus der Gruppe des Metaamidophenolpbtalelns. (4
DE45263C (de) Badische Anilin- und Sodafabrik in Ludwigshafen a. Rh Neuerung in dem Verfahren zur Darstellung von Farbstoffen aus der Gruppe des m - Amidophenol - Phtalei'ns
DE108347C (enExample)
BE755141A (fr) 1969-08-21 1971-02-22 Hoechst Ag Procede de teinture ou d'impression de matieres textiles a basede polymeres ou de copolymeres de l'acrylonitrile
JPS488725B1 (enExample) 1969-10-08 1973-03-17
FR2065117A5 (enExample) 1969-10-08 1971-07-23 Fuji Photo Film Co Ltd
US4318846A (en) 1979-09-07 1982-03-09 Syva Company Novel ether substituted fluorescein polyamino acid compounds as fluorescers and quenchers
US4622400A (en) 1983-12-29 1986-11-11 The United States Of America As Represented By The United States Department Of Energy Preparation of certain m-aminophenols and the use thereof for preparation of laser dyes
DE3425631A1 (de) 1984-07-12 1986-01-16 Basf Ag, 6700 Ludwigshafen Rhodaminfarbstoffe
US4855225A (en) 1986-02-07 1989-08-08 Applied Biosystems, Inc. Method of detecting electrophoretically separated oligonucleotides
CA1340806C (en) 1986-07-02 1999-11-02 James Merrill Prober Method, system and reagents for dna sequencing
US4965349A (en) 1987-12-24 1990-10-23 Applied Biosystems, Inc. Method of synthesizing oligonucleotides labeled with ammonia-labile groups on solid phase supports
EP0333649B1 (de) 1988-03-01 1994-06-08 Ciba-Geigy Ag 3-Basisch substituierte 2-Methylfluorane
WO1991003476A1 (en) 1989-09-08 1991-03-21 Applied Biosystems, Inc. 5- and 6-succinimidylcarboxylate isomers of rhodamine dyes
US5366860A (en) * 1989-09-29 1994-11-22 Applied Biosystems, Inc. Spectrally resolvable rhodamine dyes for nucleic acid sequence determination
US5188934A (en) * 1989-11-14 1993-02-23 Applied Biosystems, Inc. 4,7-dichlorofluorescein dyes as molecular probes
US5750409A (en) * 1991-11-18 1998-05-12 Boehringer Mannheim Gmbh Pentacyclic compounds and their use as absorption or fluorescent dyes
US5256799A (en) 1992-07-14 1993-10-26 The United States Of Americas As Represented By The United States Department Of Energy Preparation of 6-hydroxyindolines and their use for preparation of novel laser dyes
WO1994005688A1 (en) 1992-09-03 1994-03-17 Applied Biosystems, Inc. 4,7-dichlorofluorescein dyes as molecular probes
US5283336A (en) 1992-09-08 1994-02-01 The United States Of America As Represented By The United States Department Of Energy Method for preparation of 7-hydroxy-1,2,3,4-tetrahydroquinoline from 1,2,3,4-tetrahydroquinoline
JPH08503604A (ja) 1992-09-18 1996-04-23 アモコ・コーポレーション プローブで用いるための緑色蛍光標識ヌクレオチド
US6020481A (en) * 1996-04-01 2000-02-01 The Perkin-Elmer Corporation Asymmetric benzoxanthene dyes
US5847162A (en) 1996-06-27 1998-12-08 The Perkin Elmer Corporation 4, 7-Dichlororhodamine dyes
US6080852A (en) * 1996-06-27 2000-06-27 The Perkin-Elmer Corporation 4,7-dichlororhodamine dyes
US6017712A (en) 1996-06-27 2000-01-25 Lee; Linda 4,7-dichlororhodamine dyes
US5770716A (en) * 1997-04-10 1998-06-23 The Perkin-Elmer Corporation Substituted propargylethoxyamido nucleosides, oligonucleotides and methods for using same
US5936087A (en) * 1997-11-25 1999-08-10 The Perkin-Elmer Corporation Dibenzorhodamine dyes

Also Published As

Publication number Publication date
DE60014051T8 (de) 2006-04-27
WO2000058406A1 (en) 2000-10-05
EP1165694B1 (en) 2004-09-22
DE60014051D1 (de) 2004-10-28
JP3848838B2 (ja) 2006-11-22
CA2367868C (en) 2007-06-19
EP1386946B1 (en) 2009-08-05
JP2006151973A (ja) 2006-06-15
ES2226801T3 (es) 2005-04-01
EP1165694A1 (en) 2002-01-02
EP1386946A1 (en) 2004-02-04
AU3773200A (en) 2000-10-16
CA2367868A1 (en) 2000-10-05
ATE438691T1 (de) 2009-08-15
JP2002540280A (ja) 2002-11-26
ATE277128T1 (de) 2004-10-15
JP2011016813A (ja) 2011-01-27
JP4732130B2 (ja) 2011-07-27
US6080852A (en) 2000-06-27
ES2329562T3 (es) 2009-11-27
DE60014051T2 (de) 2006-02-23
US6713622B1 (en) 2004-03-30
DE60042706D1 (de) 2009-09-17

Similar Documents

Publication Publication Date Title
AU772329B2 (en) 4,7-dichlororhodamine dyes useful as molecular probes
AU709209B2 (en) 4,7-dichlororhodamine dyes
US6017712A (en) 4,7-dichlororhodamine dyes
EP0940450B1 (en) Energy transfer dyes with enhanced fluorescence
US5863727A (en) Energy transfer dyes with enhanced fluorescence
AU707242B2 (en) Asymmetric benzoxanthene dyes
US6849745B2 (en) Energy transfer dyes with enhanced fluorescence
EP1212457B1 (en) Uv excitable fluorescent energy transfer dyes
US20090093623A1 (en) 4,7-dichlororhodamine dyes
CA2297589C (en) Energy transfer dyes with enhanced fluorescence

Legal Events

Date Code Title Description
PC1 Assignment before grant (sect. 113)

Owner name: APPLERA CORPORATION

Free format text: THE FORMER OWNER WAS: PE CORPORATION (NY)

FGA Letters patent sealed or granted (standard patent)
MK14 Patent ceased section 143(a) (annual fees not paid) or expired