US6586617B1
(en)
*
|
1999-04-28 |
2003-07-01 |
Sumitomo Chemical Takeda Agro Company, Limited |
Sulfonamide derivatives
|
JP2001026506A
(ja)
*
|
1999-04-28 |
2001-01-30 |
Takeda Chem Ind Ltd |
スルホンアミド誘導体
|
US6503949B1
(en)
*
|
1999-05-17 |
2003-01-07 |
Noro Nordisk A/S |
Glucagon antagonists/inverse agonists
|
CA2423933A1
(en)
|
2000-10-17 |
2002-04-25 |
Applied Research Systems Ars Holding N.V. |
Pharmaceutically active sulfanilide derivatives
|
US6657070B2
(en)
|
2000-12-13 |
2003-12-02 |
Wyeth |
Production of chirally pure α-amino acids and N-sulfonyl α-amino acids
|
MXPA03005255A
(es)
|
2000-12-13 |
2004-10-14 |
Wyeth Corp |
Inhibidores de produccion de beta-amiloide de sulfonamida heterociclica.
|
GB0108592D0
(en)
|
2001-04-05 |
2001-05-23 |
Merck Sharp & Dohme |
Therapeutic agents
|
GB0108591D0
(en)
|
2001-04-05 |
2001-05-23 |
Merck Sharp & Dohme |
Therapeutic agents
|
EP1435955A2
(en)
*
|
2001-05-05 |
2004-07-14 |
SmithKline Beecham P.L.C. |
N-aroyl cyclic amine derivatives as orexin receptor antagonists
|
GB0115862D0
(en)
*
|
2001-06-28 |
2001-08-22 |
Smithkline Beecham Plc |
Compounds
|
AR035260A1
(es)
*
|
2001-08-03 |
2004-05-05 |
Schering Corp |
Derivados de piperidina amino sustituidas, composiciones farmaceuticas y el uso de dichos derivados para la preparacion de medicamentos como inhibidores de la gama secretasa, y para el tratamiento de la enfermedad de alzheimer
|
EP1492765B1
(en)
|
2001-08-03 |
2011-07-06 |
Schering Corporation |
Novel gamma secretase inhibitors
|
GB0120347D0
(en)
|
2001-08-21 |
2001-10-17 |
Merck Sharp & Dohme |
Therapeutic agents
|
SI1465861T1
(sl)
*
|
2001-12-20 |
2009-12-31 |
Bristol Myers Squibb Co |
Alfa-(n-sulfonamido)acetamidni derivati kot beta-amiloid inhibitorji
|
TWI330176B
(en)
|
2001-12-27 |
2010-09-11 |
Daiichi Seiyaku Co |
Inhibitor against the production and secretion of amyloid protein
|
DE10201392A1
(de)
*
|
2002-01-16 |
2003-07-31 |
Bayer Ag |
Phenylsulfoxide und-sulfone
|
BR0311767A
(pt)
*
|
2002-06-11 |
2005-03-08 |
Wyeth Corp |
Compostos inibidores de sulfonamida substituìda da produção de beta amilóide, suas composições e usos
|
US6989399B2
(en)
|
2002-08-01 |
2006-01-24 |
Bristol-Myers Squibb Company |
Antiamyloid phenylsulfonamides: N-alkanol derivatives
|
GB0223038D0
(en)
|
2002-10-04 |
2002-11-13 |
Merck Sharp & Dohme |
Therapeutic compounds
|
GB0223039D0
(en)
|
2002-10-04 |
2002-11-13 |
Merck Sharp & Dohme |
Therapeutic compounds
|
GB0223040D0
(en)
*
|
2002-10-04 |
2002-11-13 |
Merck Sharp & Dohme |
Therapeutic compounds
|
WO2004033418A2
(en)
|
2002-10-11 |
2004-04-22 |
Actelion Pharmaceuticals Ltd. |
Sulfonylamino-acetic derivatives and their use as orexin receptor antagonists
|
US7521481B2
(en)
|
2003-02-27 |
2009-04-21 |
Mclaurin Joanne |
Methods of preventing, treating and diagnosing disorders of protein aggregation
|
WO2004080952A1
(de)
*
|
2003-03-10 |
2004-09-23 |
Bayer Healthcare Ag |
Phenylsulfonamid-derivate zur behandlung der alzheimerschen krankheit
|
NZ542468A
(en)
|
2003-03-31 |
2009-01-31 |
Wyeth Corp |
Fluoro- and trifluoroalkyl-containing heterocyclic sulfonamide inhibitors of beta amyloid production and derivatives thereof
|
MXPA05010937A
(es)
*
|
2003-04-14 |
2005-11-25 |
Inst For Pharm Discovery Inc |
Derivados de fenilalanina n-(1,3-tiazol-2-il)amino)carbonil)fenil)sulfonil) y compuestos relacionados para el tratamiento de diabetes.
|
CA2525124A1
(en)
|
2003-05-13 |
2004-11-25 |
Schering Corporation |
Bridged n-arylsulfonylpiperidines as gamma-secretase inhibitors
|
DE602004011767T2
(de)
|
2003-05-16 |
2009-02-19 |
Merck Sharp & Dohme Ltd., Hoddesdon |
Cyclohexylsulfone als gamma-sekretase-inhibitoren
|
JP2007516938A
(ja)
*
|
2003-06-23 |
2007-06-28 |
ニューロケム (インターナショナル) リミテッド |
アミロイド関連疾患を治療するための方法および組成物
|
KR20060066057A
(ko)
|
2003-06-30 |
2006-06-15 |
다이이찌 세이야꾸 가부시기가이샤 |
복소환 메틸 설폰 유도체
|
AR045218A1
(es)
|
2003-08-08 |
2005-10-19 |
Schering Corp |
Aminas ciclicas inhibidoras de bace-1 que poseen una benzamida sustituyente; composiciones farmaceuticas que las contienen y su uso en la fabricacion de medicamentos para tratar enfermedades cognitivas o neurodegenerativas.
|
ES2308247T3
(es)
|
2003-08-08 |
2008-12-01 |
Schering Corporation |
Aminas ciclicas inhibidoras de bace-1 que tienen un sustituyente heterociclico.
|
GB0323258D0
(en)
|
2003-10-04 |
2003-11-05 |
Merck Sharp & Dohme |
Therapeutic compounds
|
EP1680406A1
(en)
*
|
2003-10-29 |
2006-07-19 |
Elan Pharmaceuticals, Inc. |
N-substituted benzene sulfonamides
|
WO2005073198A1
(en)
|
2004-01-16 |
2005-08-11 |
Wyeth |
Heterocyclic sulfonamide inhibitors of beta amyloid production containing an azole
|
JP2007528405A
(ja)
*
|
2004-03-11 |
2007-10-11 |
イーラン ファーマスーティカルズ、インコーポレイテッド |
N−置換ベンゼンスルホンアミド
|
MXPA06011414A
(es)
|
2004-03-31 |
2007-04-20 |
Johnson & Johnson |
Compuestos heterociclicos sin imidazol como ligandos del receptor de h3 histamina.
|
EP2261218B1
(en)
|
2004-05-26 |
2013-04-03 |
Eisai R&D Management Co., Ltd. |
Imidazole compound for use as an intermediate in the production of cinnamide compounds
|
MX2007000040A
(es)
|
2004-06-30 |
2007-03-07 |
Schering Corp |
N-arilsulfonilaminas heterociclicas sustituidas como inhibidores de gamma-secretasas.
|
US7803802B2
(en)
|
2004-07-22 |
2010-09-28 |
Schering Corporation |
Substituted amide beta secretase inhibitors
|
ES2338904T3
(es)
|
2004-10-26 |
2010-05-13 |
EISAI R&D MANAGEMENT CO., LTD. |
Forma amorfa de compuestos de cinamida.
|
TW200630327A
(en)
*
|
2004-10-28 |
2006-09-01 |
Inst For Pharm Discovery Inc |
Substituted phenylalkanoic acids
|
CA2595173A1
(en)
|
2005-01-18 |
2006-07-27 |
Elan Pharmaceuticals, Inc. |
N-substituted heterocyclic sulfonamides
|
WO2006080043A2
(en)
|
2005-01-27 |
2006-08-03 |
Alma Mater Studiorum- Universita' Di Bologna |
Organic compounds useful for the treatment of alzheimer's disease, their use and method of preparation
|
KR20070116865A
(ko)
*
|
2005-04-08 |
2007-12-11 |
다이이찌 산쿄 가부시키가이샤 |
피리딜메틸설폰 유도체
|
MY144960A
(en)
|
2005-11-24 |
2011-11-30 |
Eisai R&D Man Co Ltd |
Morpholine type cinnamide compound
|
TWI370130B
(en)
|
2005-11-24 |
2012-08-11 |
Eisai R&D Man Co Ltd |
Two cyclic cinnamide compound
|
RU2448964C2
(ru)
|
2006-01-20 |
2012-04-27 |
Шеринг Корпорейшн |
КАРБОЦИКЛИЧЕСКИЕ И ГЕТЕРОЦИКЛИЧЕСКИЕ АРИЛСУЛЬФОНЫ, ИХ ПРИМЕНЕНИЕ И ФАРМАЦЕВТИЧЕСКАЯ КОМПОЗИЦИЯ НА ИХ ОСНОВЕ, ОБЛАДАЮЩАЯ СВОЙСТВАМИ ИНГИБИТОРА γ-СЕКРЕТАЗЫ
|
US20080045499A1
(en)
*
|
2006-02-06 |
2008-02-21 |
Elan Pharmaceuticals, Inc. |
Preferential Inhibition of Presenilin-1
|
US9567396B2
(en)
|
2006-03-07 |
2017-02-14 |
Evonik Degussa Gmbh |
Notch inhibition in the prevention of vein graft failure
|
US8133857B2
(en)
*
|
2006-03-07 |
2012-03-13 |
The Brigham and Women's FHospital, Inc. |
NOTCH inhibition in the treatment of atherosclerosis
|
TWI378091B
(en)
|
2006-03-09 |
2012-12-01 |
Eisai R&D Man Co Ltd |
Multi-cyclic cinnamide derivatives
|
CN101460453B
(zh)
|
2006-04-11 |
2012-10-03 |
埃科特莱茵药品有限公司 |
磺酰胺化合物
|
AU2007256931B2
(en)
|
2006-05-30 |
2013-01-24 |
Janssen Pharmaceutica N.V. |
Substituted pyridyl amide compounds as modulators of the histamine H3 receptor
|
US7737141B2
(en)
|
2006-07-28 |
2010-06-15 |
Eisai R&D Management Co., Ltd. |
Prodrug of cinnamide compound
|
TW200817319A
(en)
|
2006-08-10 |
2008-04-16 |
Astellas Pharma Inc |
Sulfonamide compound or salt thereof
|
WO2008061247A2
(en)
*
|
2006-11-16 |
2008-05-22 |
The Regent Of The University Of California |
Benzenesulfonanilide compound inhibitors of urea transporters
|
AU2008215948A1
(en)
|
2007-02-12 |
2008-08-21 |
Merck & Co., Inc. |
Piperazine derivatives for treatment of AD and related conditions
|
US8664411B2
(en)
|
2007-07-05 |
2014-03-04 |
Merck Sharp & Dohme Corp. |
Tetrahydropyranochromene gamma secretase inhibitors
|
PE20090447A1
(es)
|
2007-07-17 |
2009-04-18 |
Schering Corp |
Bencensulfonil-cromano, tiocromano, tetrahidronaftaleno e inhibidores relacionados de la gamma secretasa
|
EP2559693B1
(en)
|
2007-08-31 |
2014-11-26 |
Eisai R&D Management Co., Ltd. |
Polycyclic compound
|
US7935815B2
(en)
|
2007-08-31 |
2011-05-03 |
Eisai R&D Management Co., Ltd. |
Imidazoyl pyridine compounds and salts thereof
|
TW200920362A
(en)
|
2007-09-11 |
2009-05-16 |
Daiichi Sankyo Co Ltd |
Alkylsulfone derivatives
|
US8084477B2
(en)
|
2007-10-31 |
2011-12-27 |
Bristol-Myers Squibb Company |
Alpha-(N-sulfonamido)acetamide compound as an inhibitor of beta amyloid peptide production
|
US8093276B2
(en)
|
2007-10-31 |
2012-01-10 |
Bristol-Myers Squibb Company |
Alpha-(N-sulfonamido)acetamide compound as an inhibitor of beta amyloid peptide production
|
NZ584998A
(en)
|
2007-11-20 |
2012-08-31 |
Janssen Pharmaceutica Nv |
Cycloalkyloxy-and heterocycloalkyloxypyridine compounds as modulators of the histamine h3 receptor
|
US8354446B2
(en)
|
2007-12-21 |
2013-01-15 |
Ligand Pharmaceuticals Incorporated |
Selective androgen receptor modulators (SARMs) and uses thereof
|
WO2009120783A1
(en)
*
|
2008-03-25 |
2009-10-01 |
The Johns Hopkins University |
High affinity inhibitors of hepatitis c virus ns3/4a protease
|
US8461389B2
(en)
|
2008-04-18 |
2013-06-11 |
University College Dublin, National University Of Ireland, Dublin |
Psycho-pharmaceuticals
|
JP2011523633A
(ja)
*
|
2008-05-08 |
2011-08-18 |
ブリストル−マイヤーズ スクイブ カンパニー |
2−アリールグリシンアミド誘導体
|
GB0812969D0
(en)
|
2008-07-15 |
2008-08-20 |
Sentinel Oncology Ltd |
Pharmaceutical compounds
|
TW201020247A
(en)
*
|
2008-11-06 |
2010-06-01 |
Gruenenthal Gmbh |
Substituierte disulfonamide
|
US8044077B2
(en)
|
2009-03-19 |
2011-10-25 |
Bristol-Myers Squibb Company |
Alpha-(N-sulfonamido)acetamide compounds incorporating deuterium as inhibitors of beta amyloid peptide production
|
US7977362B2
(en)
|
2009-03-20 |
2011-07-12 |
Bristol-Myers Squibb Company |
Alpha-(N-benzenesulfonamido)cycloalkyl derivatives
|
US8252821B2
(en)
|
2009-04-14 |
2012-08-28 |
Bristol-Myers Squibb Company |
Bioavailable capsule compositions of amorphous alpha-(N-sulfonamido)acetamide compound
|
CN102459251B
(zh)
|
2009-05-14 |
2015-05-20 |
詹森药业有限公司 |
作为白三烯a4水解酶的调节剂的具有两个稠合双环杂芳基部分的化合物
|
EP2493497A4
(en)
|
2009-11-01 |
2013-07-24 |
Brigham & Womens Hospital |
INHIBITION OF NOTCH FOR THE TREATMENT AND PREVENTION OF OBESITY AND METABOLIC SYNDROME
|
CN103193691B
(zh)
*
|
2012-01-06 |
2017-08-25 |
中国科学院上海药物研究所 |
磺胺类化合物、药物组合物及其制法和应用
|
JP6134338B2
(ja)
*
|
2012-02-29 |
2017-05-24 |
バルーク エス.ブルームバーグ インスティテュート |
B型肝炎ウイルス共有結合閉環状dna形成の阻害剤およびそれらの使用方法
|
WO2013192078A1
(en)
|
2012-06-22 |
2013-12-27 |
Temple University - Of The Commonwealth System Of Higher Education |
Synthetic pgpg analogs, methods of preparation and methods of use
|
BR112015006737A2
(pt)
*
|
2012-09-27 |
2017-07-04 |
Hoffmann La Roche |
compostos de sulfonamida substituídos
|
EP2981522A4
(en)
|
2013-04-05 |
2016-08-31 |
Salk Inst For Biological Studi |
ANTAGONISTS OF PPAR
|
EP3613418A1
(en)
|
2014-01-17 |
2020-02-26 |
Ligand Pharmaceuticals, Inc. |
Methods and compositions for modulating hormone levels
|
EP2932966A1
(en)
|
2014-04-16 |
2015-10-21 |
Novartis AG |
Gamma secretase inhibitors for treating respiratory diseases
|
CN104151277A
(zh)
*
|
2014-06-30 |
2014-11-19 |
北京万全德众医药生物技术有限公司 |
盐酸决奈达隆一种氧化杂质的制备方法
|
WO2016057322A1
(en)
|
2014-10-08 |
2016-04-14 |
Salk Institute For Biological Studies |
Ppar agonists and methods of use thereof
|
US20170360726A1
(en)
*
|
2014-12-05 |
2017-12-21 |
Aquinnah Pharmaceuticals, Inc. |
Compounds, compositions and methods of use
|
CN106466313A
(zh)
*
|
2015-08-18 |
2017-03-01 |
中国科学院上海药物研究所 |
一类磺酰胺基取代的酰胺类衍生物在制备用于治疗阿尔茨海默病的药物中的用途
|
CN108349904B
(zh)
|
2015-10-07 |
2021-08-31 |
米托布里奇公司 |
Ppar激动剂、化合物、药物组合物及其使用方法
|
CA3019014A1
(en)
|
2016-04-13 |
2017-10-19 |
Mitobridge, Inc. |
Ppar agonists, compounds, pharmaceutical compositions, and methods of use thereof
|
AU2019207491A1
(en)
|
2018-01-10 |
2020-07-30 |
Cura Therapeutics, Llc |
Pharmaceutical compositions comprising phenylsulfonamides, and their therapeutic applications
|
WO2020016377A1
(en)
|
2018-07-19 |
2020-01-23 |
INSERM (Institut National de la Santé et de la Recherche Médicale) |
Combination for treating cancer
|
WO2021007474A1
(en)
*
|
2019-07-11 |
2021-01-14 |
Cura Therapeutics, Llc |
Phenyl compounds and pharmaceutical compositions thereof, and their therapeutic applications
|
CN112457687B
(zh)
*
|
2019-09-06 |
2022-10-25 |
台湾永光化学工业股份有限公司 |
新颖反应性染料
|
WO2022101481A1
(en)
|
2020-11-16 |
2022-05-19 |
INSERM (Institut National de la Santé et de la Recherche Médicale) |
Methods and compositions for predicting and treating uveal melanoma
|