JP2002536324A - ソタロールの右旋性及び左旋性異性体の組み合わせを含んでなる医薬組成物 - Google Patents
ソタロールの右旋性及び左旋性異性体の組み合わせを含んでなる医薬組成物Info
- Publication number
- JP2002536324A JP2002536324A JP2000596927A JP2000596927A JP2002536324A JP 2002536324 A JP2002536324 A JP 2002536324A JP 2000596927 A JP2000596927 A JP 2000596927A JP 2000596927 A JP2000596927 A JP 2000596927A JP 2002536324 A JP2002536324 A JP 2002536324A
- Authority
- JP
- Japan
- Prior art keywords
- sotalol
- isomers
- pharmaceutical composition
- combination
- hydrochloride
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
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- 150000003840 hydrochlorides Chemical class 0.000 description 1
- 238000001727 in vivo Methods 0.000 description 1
- 238000001990 intravenous administration Methods 0.000 description 1
- 238000002955 isolation Methods 0.000 description 1
- 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 description 1
- 210000004731 jugular vein Anatomy 0.000 description 1
- VZCYOOQTPOCHFL-UPHRSURJSA-N maleic acid Chemical compound OC(=O)\C=C/C(O)=O VZCYOOQTPOCHFL-UPHRSURJSA-N 0.000 description 1
- 239000011976 maleic acid Substances 0.000 description 1
- 229960002510 mandelic acid Drugs 0.000 description 1
- 238000002483 medication Methods 0.000 description 1
- 238000002844 melting Methods 0.000 description 1
- 230000008018 melting Effects 0.000 description 1
- HNQIVZYLYMDVSB-UHFFFAOYSA-N methanesulfonimidic acid Chemical compound CS(N)(=O)=O HNQIVZYLYMDVSB-UHFFFAOYSA-N 0.000 description 1
- 235000019813 microcrystalline cellulose Nutrition 0.000 description 1
- 239000008108 microcrystalline cellulose Substances 0.000 description 1
- 229940016286 microcrystalline cellulose Drugs 0.000 description 1
- 150000007522 mineralic acids Chemical class 0.000 description 1
- 230000008722 morphological abnormality Effects 0.000 description 1
- 150000007524 organic acids Chemical class 0.000 description 1
- 235000005985 organic acids Nutrition 0.000 description 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 description 1
- 235000013809 polyvinylpolypyrrolidone Nutrition 0.000 description 1
- 229920000523 polyvinylpolypyrrolidone Polymers 0.000 description 1
- 229910000027 potassium carbonate Inorganic materials 0.000 description 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 description 1
- 238000000718 qrs complex Methods 0.000 description 1
- 239000011541 reaction mixture Substances 0.000 description 1
- 230000003252 repetitive effect Effects 0.000 description 1
- 230000000284 resting effect Effects 0.000 description 1
- 230000033764 rhythmic process Effects 0.000 description 1
- 230000002269 spontaneous effect Effects 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
- 230000002194 synthesizing effect Effects 0.000 description 1
- 239000011975 tartaric acid Substances 0.000 description 1
- 235000002906 tartaric acid Nutrition 0.000 description 1
- 229940124597 therapeutic agent Drugs 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 210000003462 vein Anatomy 0.000 description 1
- 230000006815 ventricular dysfunction Effects 0.000 description 1
- 238000005303 weighing Methods 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/18—Sulfonamides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
Landscapes
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Epidemiology (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IN89/CAL/99 | 1999-02-05 | ||
| IN89KO1999 IN188162B (zh) | 1999-02-05 | 1999-02-05 | |
| PCT/IB1999/000322 WO2000045807A1 (en) | 1999-02-05 | 1999-02-22 | Pharmaceutical composition comprising a combination of dextro- and laevo- isomers of sotalol |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| JP2002536324A true JP2002536324A (ja) | 2002-10-29 |
Family
ID=38668683
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2000596927A Pending JP2002536324A (ja) | 1999-02-05 | 1999-02-22 | ソタロールの右旋性及び左旋性異性体の組み合わせを含んでなる医薬組成物 |
Country Status (20)
| Country | Link |
|---|---|
| US (1) | US6281246B2 (zh) |
| EP (1) | EP1146865B9 (zh) |
| JP (1) | JP2002536324A (zh) |
| CN (1) | CN1149987C (zh) |
| AT (1) | ATE241349T1 (zh) |
| AU (1) | AU761521C (zh) |
| BR (1) | BR9915951A (zh) |
| CA (1) | CA2348882C (zh) |
| CZ (1) | CZ20011807A3 (zh) |
| DE (1) | DE69908421T2 (zh) |
| DK (1) | DK1146865T3 (zh) |
| ES (1) | ES2195538T3 (zh) |
| HK (1) | HK1041206B (zh) |
| HU (1) | HU224033B1 (zh) |
| IN (1) | IN188162B (zh) |
| PL (1) | PL351143A1 (zh) |
| PT (1) | PT1146865E (zh) |
| RU (1) | RU2213560C2 (zh) |
| SE (1) | SE1146865T5 (zh) |
| WO (1) | WO2000045807A1 (zh) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20060105044A1 (en) | 2004-05-20 | 2006-05-18 | Singh Bramah N | Sustained release formulations of sotalol |
| SI2024329T1 (sl) * | 2006-05-18 | 2014-01-31 | Dompe' S.P.A. | (2r)-2-((4-sulfonil)aminofenil)propanamidi in farmacevtski sestavki, ki jih vsebujejo |
| CN102329254B (zh) * | 2010-07-12 | 2014-02-05 | 上海奥博生物医药技术有限公司 | 一种制备n-[4-[1-羟基-2-[(1-甲基乙基)胺基]乙基]甲磺酰胺盐酸盐的方法 |
| BE1021328B1 (fr) * | 2014-08-27 | 2015-10-30 | Hyloris Pharmaceuticals SA | Composition pharmaceutique prete a l'emploi |
| BE1021320B1 (fr) * | 2014-08-27 | 2015-10-29 | Hyloris Pharmaceuticals SA | Composition pharmaceutique prete a l'emploi |
| FR3050297A1 (fr) * | 2016-04-13 | 2017-10-20 | Assist Publique - Hopitaux De Paris | Methode de determination de la susceptibilite d'induction d'une torsade de pointes |
| CN109419779B (zh) * | 2017-09-04 | 2021-05-25 | 鲁南制药集团股份有限公司 | 一种盐酸索他洛尔制剂 |
| CN109419780B (zh) * | 2017-09-04 | 2021-05-11 | 张家港市中医医院 | 一种盐酸索他洛尔片剂及其制备方法 |
| CN107982237B (zh) * | 2018-01-17 | 2018-11-23 | 安宁 | 一种盐酸索他洛尔制剂及其制备方法 |
| US10799138B2 (en) | 2018-04-05 | 2020-10-13 | University Of Maryland, Baltimore | Method of administering sotalol IV/switch |
| US11344518B2 (en) | 2018-08-14 | 2022-05-31 | AltaThera Pharmaceuticals LLC | Method of converting atrial fibrillation to normal sinus rhythm and loading oral sotalol in a shortened time frame |
| US11696902B2 (en) | 2018-08-14 | 2023-07-11 | AltaThera Pharmaceuticals, LLC | Method of initiating and escalating sotalol hydrochloride dosing |
| US11610660B1 (en) | 2021-08-20 | 2023-03-21 | AltaThera Pharmaceuticals LLC | Antiarrhythmic drug dosing methods, medical devices, and systems |
| US10512620B1 (en) | 2018-08-14 | 2019-12-24 | AltaThera Pharmaceuticals, LLC | Method of initiating and escalating sotalol hydrochloride dosing |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5089526A (en) * | 1983-05-23 | 1992-02-18 | Bristol-Myers Company | Antiarrhythmic class III process |
| JPH01165569A (ja) * | 1987-12-22 | 1989-06-29 | Mitsui Toatsu Chem Inc | 光学活性なソタロールの製造方法 |
| IES940272A2 (en) * | 1994-02-17 | 1994-11-16 | Russinsky Ltd | "Pharmaceutical Products" |
-
1999
- 1999-02-05 IN IN89KO1999 patent/IN188162B/en unknown
- 1999-02-22 PL PL99351143A patent/PL351143A1/xx not_active IP Right Cessation
- 1999-02-22 BR BR9915951-1A patent/BR9915951A/pt not_active IP Right Cessation
- 1999-02-22 CA CA002348882A patent/CA2348882C/en not_active Expired - Fee Related
- 1999-02-22 AU AU22960/99A patent/AU761521C/en not_active Ceased
- 1999-02-22 ES ES99902781T patent/ES2195538T3/es not_active Expired - Lifetime
- 1999-02-22 DE DE69908421T patent/DE69908421T2/de not_active Expired - Fee Related
- 1999-02-22 JP JP2000596927A patent/JP2002536324A/ja active Pending
- 1999-02-22 PT PT99902781T patent/PT1146865E/pt unknown
- 1999-02-22 CZ CZ20011807A patent/CZ20011807A3/cs unknown
- 1999-02-22 SE SE99902781T patent/SE1146865T5/xx unknown
- 1999-02-22 AT AT99902781T patent/ATE241349T1/de not_active IP Right Cessation
- 1999-02-22 HU HU0104175A patent/HU224033B1/hu active IP Right Grant
- 1999-02-22 CN CNB998136395A patent/CN1149987C/zh not_active Expired - Fee Related
- 1999-02-22 WO PCT/IB1999/000322 patent/WO2000045807A1/en active IP Right Grant
- 1999-02-22 EP EP99902781A patent/EP1146865B9/en not_active Expired - Lifetime
- 1999-02-22 RU RU2001111808/14A patent/RU2213560C2/ru not_active IP Right Cessation
- 1999-02-22 DK DK99902781T patent/DK1146865T3/da active
-
2000
- 2000-12-19 US US09/739,276 patent/US6281246B2/en not_active Expired - Lifetime
-
2002
- 2002-03-26 HK HK02102291.0A patent/HK1041206B/zh not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| US6281246B2 (en) | 2001-08-28 |
| CN1149987C (zh) | 2004-05-19 |
| US20010004643A1 (en) | 2001-06-21 |
| BR9915951A (pt) | 2001-08-21 |
| EP1146865B9 (en) | 2004-03-17 |
| AU761521C (en) | 2004-01-22 |
| WO2000045807A1 (en) | 2000-08-10 |
| EP1146865A1 (en) | 2001-10-24 |
| ATE241349T1 (de) | 2003-06-15 |
| HK1041206A1 (en) | 2002-07-05 |
| HK1041206B (zh) | 2003-10-31 |
| AU761521B2 (en) | 2003-06-05 |
| HUP0104175A2 (hu) | 2002-04-29 |
| CN1328453A (zh) | 2001-12-26 |
| EP1146865B1 (en) | 2003-05-28 |
| DE69908421T2 (de) | 2004-03-18 |
| ES2195538T3 (es) | 2003-12-01 |
| DK1146865T3 (da) | 2003-09-22 |
| CA2348882C (en) | 2004-07-13 |
| HU224033B1 (hu) | 2005-05-30 |
| IN188162B (zh) | 2002-08-31 |
| AU2296099A (en) | 2000-08-25 |
| CA2348882A1 (en) | 2000-08-10 |
| RU2213560C2 (ru) | 2003-10-10 |
| SE1146865T5 (zh) | 2003-11-18 |
| DE69908421D1 (de) | 2003-07-03 |
| PT1146865E (pt) | 2003-08-29 |
| SE1146865T3 (zh) | 2003-09-02 |
| CZ20011807A3 (cs) | 2001-08-15 |
| PL351143A1 (en) | 2003-03-24 |
| HUP0104175A3 (en) | 2002-12-28 |
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