JP2002535014A5 - - Google Patents
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- JP2002535014A5 JP2002535014A5 JP2000596180A JP2000596180A JP2002535014A5 JP 2002535014 A5 JP2002535014 A5 JP 2002535014A5 JP 2000596180 A JP2000596180 A JP 2000596180A JP 2000596180 A JP2000596180 A JP 2000596180A JP 2002535014 A5 JP2002535014 A5 JP 2002535014A5
- Authority
- JP
- Japan
- Prior art keywords
- seq
- oligonucleotide
- sequence
- combination
- nucleic acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 108091034117 Oligonucleotide Proteins 0.000 description 43
- 108010072866 Prostate-Specific Antigen Proteins 0.000 description 13
- 102100038358 Prostate-specific antigen Human genes 0.000 description 13
- 150000007523 nucleic acids Chemical group 0.000 description 13
- JLCPHMBAVCMARE-UHFFFAOYSA-N [3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-hydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methyl [5-(6-aminopurin-9-yl)-2-(hydroxymethyl)oxolan-3-yl] hydrogen phosphate Polymers Cc1cn(C2CC(OP(O)(=O)OCC3OC(CC3OP(O)(=O)OCC3OC(CC3O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c3nc(N)[nH]c4=O)C(COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3CO)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cc(C)c(=O)[nH]c3=O)n3cc(C)c(=O)[nH]c3=O)n3ccc(N)nc3=O)n3cc(C)c(=O)[nH]c3=O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)O2)c(=O)[nH]c1=O JLCPHMBAVCMARE-UHFFFAOYSA-N 0.000 description 11
- 238000000034 method Methods 0.000 description 11
- 108020004707 nucleic acids Proteins 0.000 description 11
- 102000039446 nucleic acids Human genes 0.000 description 11
- 230000000295 complement effect Effects 0.000 description 8
- 108091032973 (ribonucleotides)n+m Proteins 0.000 description 6
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 description 6
- 239000000523 sample Substances 0.000 description 6
- 108700024394 Exon Proteins 0.000 description 5
- 102100041003 Glutamate carboxypeptidase 2 Human genes 0.000 description 5
- 101000892862 Homo sapiens Glutamate carboxypeptidase 2 Proteins 0.000 description 5
- 108090000623 proteins and genes Proteins 0.000 description 5
- 108020004999 messenger RNA Proteins 0.000 description 3
- 102100038356 Kallikrein-2 Human genes 0.000 description 2
- 101710176220 Kallikrein-2 Proteins 0.000 description 2
- 108091028043 Nucleic acid sequence Proteins 0.000 description 2
- 230000003321 amplification Effects 0.000 description 2
- 238000001514 detection method Methods 0.000 description 2
- 238000003199 nucleic acid amplification method Methods 0.000 description 2
- 238000003556 assay Methods 0.000 description 1
- 239000012472 biological sample Substances 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 239000002773 nucleotide Substances 0.000 description 1
- 125000003729 nucleotide group Chemical group 0.000 description 1
- 210000002307 prostate Anatomy 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US11764099P | 1999-01-28 | 1999-01-28 | |
| US60/117,640 | 1999-01-28 | ||
| PCT/US2000/002270 WO2000044940A2 (en) | 1999-01-28 | 2000-01-28 | Nucleic acid sequences for detecting genetic markers for cancer in a biological sample |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2002535014A JP2002535014A (ja) | 2002-10-22 |
| JP2002535014A5 true JP2002535014A5 (https=) | 2007-03-15 |
| JP4495349B2 JP4495349B2 (ja) | 2010-07-07 |
Family
ID=22374015
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2000596180A Expired - Fee Related JP4495349B2 (ja) | 1999-01-28 | 2000-01-28 | 癌の遺伝マーカーを生物学的サンプルにおいて検出するための核酸配列 |
Country Status (6)
| Country | Link |
|---|---|
| US (5) | US6551778B1 (https=) |
| EP (1) | EP1151142A2 (https=) |
| JP (1) | JP4495349B2 (https=) |
| AU (1) | AU767587B2 (https=) |
| CA (1) | CA2360073C (https=) |
| WO (1) | WO2000044940A2 (https=) |
Families Citing this family (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE69840669D1 (de) | 1997-04-10 | 2009-04-30 | Stichting Katholieke Univ | Pca3, pca3-gene und verfahren zu ihrer verwendung |
| EP1151142A2 (en) * | 1999-01-28 | 2001-11-07 | Gen-Probe Incorporated | Nucleic acid sequences for detecting genetic markers for cancer in a biological sample |
| EP1222266B1 (en) * | 1999-09-29 | 2006-03-29 | Diagnocure Inc. | Pca3 messenger rna in benign and malignant prostate tissues |
| EP1368471A2 (en) * | 2000-11-21 | 2003-12-10 | Diadexus, Inc. | Compositions and methods relating to prostate specific genes and proteins |
| AU2003209127A1 (en) * | 2002-02-11 | 2003-09-04 | Auburn University | High-sensitivity real-time polymerase chain reaction for detection of nucleic acids |
| EP1592809B1 (en) | 2003-02-07 | 2013-04-10 | Diagnocure Inc. | Method to detect prostate cancer in a sample |
| AU2004201842A1 (en) * | 2003-05-01 | 2004-11-18 | Veridex, Llc | Intraoperative lymph node assay |
| CA2491067A1 (en) | 2004-12-24 | 2006-06-24 | Stichting Katholieke Universiteit | Mrna rations in urinary sediments and/or urine as a prognostic marker for prostate cancer |
| US20070130694A1 (en) * | 2005-12-12 | 2007-06-14 | Michaels Emily W | Textile surface modification composition |
| EP3095873B1 (en) | 2006-12-21 | 2018-04-18 | Gen-Probe Incorporated | Methods and compositions for nucleic acid amplification |
| US20110091883A1 (en) * | 2009-02-18 | 2011-04-21 | Helicos Biosciences Corporation | Methods for analyzing minute cellular nucleic acids |
| US9080973B2 (en) * | 2009-04-22 | 2015-07-14 | Wisconsin Alumni Research Foundation | Analyte detection using liquid crystals |
| US8512955B2 (en) | 2009-07-01 | 2013-08-20 | Gen-Probe Incorporated | Methods and compositions for nucleic acid amplification |
| IL243203A (en) * | 2010-07-27 | 2017-04-30 | Genomic Health Inc | Method for using gene expression to determine prognosis of prostate cancer |
| EP2616555B1 (en) | 2010-09-16 | 2017-11-08 | Gen-Probe Incorporated | Capture probes immobilizable via l-nucleotide tail |
| US9255293B2 (en) | 2010-11-01 | 2016-02-09 | Gen-Probe Incorporated | Integrated capture and amplification of target nucleic acid for sequencing |
| US10655165B2 (en) | 2012-02-01 | 2020-05-19 | Gen-Probe Incorporated | Asymmetric hairpin target capture oligomers |
| MY193914A (en) | 2012-03-05 | 2022-11-01 | Oy Arctic Partners Ab | Methods and apparatuses for predicting risk of prostate cancer and prostate gland volume |
| US12326453B2 (en) | 2014-03-28 | 2025-06-10 | Opko Diagnostics, Llc | Compositions and methods for active surveillance of prostate cancer |
| DK3123381T3 (da) | 2014-03-28 | 2023-11-27 | Opko Diagnostics Llc | Sammensætninger og fremgangsmåder relateret til diagnose af prostatacancer |
| WO2016160545A1 (en) | 2015-03-27 | 2016-10-06 | Opko Diagnostics, Llc | Prostate antigen standards and uses thereof |
| EP3448998B1 (en) | 2016-04-27 | 2020-06-03 | Gen-Probe Incorporated | Blood cell lysis reagent |
| CN111518170A (zh) * | 2020-05-09 | 2020-08-11 | 新乡医学院 | 基于fret的psa荧光探针、制备方法及其应用 |
| WO2023175434A1 (en) | 2022-03-15 | 2023-09-21 | Diagenode S.A. | Detection of methylation status of a dna sample |
Family Cites Families (60)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3725010A (en) * | 1971-08-23 | 1973-04-03 | Beckman Instruments Inc | Apparatus for automatically performing chemical processes |
| US5283174A (en) | 1987-09-21 | 1994-02-01 | Gen-Probe, Incorporated | Homogenous protection assay |
| CA2020958C (en) | 1989-07-11 | 2005-01-11 | Daniel L. Kacian | Nucleic acid sequence amplification methods |
| US5851764A (en) * | 1990-10-25 | 1998-12-22 | The Trustees Of Columbia University In The City Of New York | Human prostate tumor inducing gene-1 and uses thereof |
| AU662906B2 (en) | 1991-06-26 | 1995-09-21 | F. Hoffmann-La Roche Ag | Methods for detection of carcinoma metastases by nucleic acid amplification |
| KR100249110B1 (ko) | 1992-05-06 | 2000-04-01 | 다니엘 엘. 캐시앙 | 핵산 서열 증폭 방법, 이에 이용되는 조성물 및 키트 |
| US5786148A (en) | 1996-11-05 | 1998-07-28 | Incyte Pharmaceuticals, Inc. | Polynucleotides encoding a novel prostate-specific kallikrein |
| US5674682A (en) * | 1992-10-29 | 1997-10-07 | Thomas Jefferson University | Nucleic acid primers for detecting micrometastasis of prostate cancer |
| CA2148350A1 (en) | 1992-10-29 | 1994-05-11 | Carlo Croce | Methods of detecting micrometastasis of prostate cancer |
| DE69334071T2 (de) | 1992-11-05 | 2007-10-25 | Sloan-Kettering Institute For Cancer Research | Prostata-spezifisches membranantigen |
| US5516639A (en) | 1993-07-22 | 1996-05-14 | Mayo Foundation For Medical Education And Research | Antibodies specific for human prostate glandular kallkrein |
| US6103237A (en) * | 1993-07-22 | 2000-08-15 | Hybritech Incorporated | Stable variant hK2 polypeptide |
| US6569432B1 (en) * | 1995-02-24 | 2003-05-27 | Sloan-Kettering Institute For Cancer Research | Prostate-specific membrane antigen and uses thereof |
| FR2714062B1 (fr) * | 1993-12-22 | 1996-02-16 | Bio Merieux | Promoteur modifié pour ARN polymérase, sa préparation et ses applications. |
| US5599677A (en) | 1993-12-29 | 1997-02-04 | Abbott Laboratories | Immunoassays for prostate specific antigen |
| CA2187775A1 (en) * | 1994-04-15 | 1995-10-26 | Aaron E. Katz | Method for molecular staging of prostate cancer |
| WO1995030758A1 (en) * | 1994-05-10 | 1995-11-16 | Mayo Foundation For Medical Education And Research | Recombinant hk2 polypeptide |
| WO1996021042A2 (en) | 1995-01-04 | 1996-07-11 | Trustees Of Boston University | Primers for the pcr amplification of metastatic sequences |
| US5698402A (en) | 1995-02-23 | 1997-12-16 | Dianon Systems, Inc. | Methods for diagnosing benign prostatic hyperplasia |
| AU717937B2 (en) * | 1995-02-24 | 2000-04-06 | Sloan-Kettering Institute For Cancer Research | Prostate-specific membrane antigen and uses thereof |
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| GB2302874B (en) * | 1995-06-29 | 1999-11-10 | Orion Yhtymae Oy | Novel proteins |
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| EP0904397A4 (en) | 1996-04-16 | 2003-01-29 | Smithkline Beecham Corp | METHOD FOR DETECTION OF THE PROSTATE SPECIFIC ANTIGEN USED FOR MONITORING AND DIAGNOSING PROSTATE CANCER |
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| CA2218754A1 (en) | 1996-11-15 | 1998-05-15 | Eli Lilly And Company | Recombinant psa expression vectors and assays using the same |
| US6100444A (en) | 1997-02-11 | 2000-08-08 | University Of Rochester Medical Center | Prostate specific regulatory nucleic acid sequences and transgenic non-human animals expressing prostate specific antigen |
| US7033827B2 (en) * | 1997-02-25 | 2006-04-25 | Corixa Corporation | Prostate-specific polynucleotide compositions |
| US6759515B1 (en) * | 1997-02-25 | 2004-07-06 | Corixa Corporation | Compositions and methods for the therapy and diagnosis of prostate cancer |
| US6630305B1 (en) * | 1999-11-12 | 2003-10-07 | Corixa Corporation | Compositions and methods for the therapy and diagnosis of prostate cancer |
| US6620922B1 (en) * | 1997-02-25 | 2003-09-16 | Corixa Corporation | Compositions and methods for the therapy and diagnosis of prostate cancer |
| AU6551398A (en) | 1997-03-11 | 1998-09-29 | Anna C. Ferrari | Method of detecting prostate cancer metastasis |
| WO1998046788A2 (en) * | 1997-04-11 | 1998-10-22 | Micromet Gesellschaft Für Biomedizinische Forschung Mbh | Primers and methods for the detection of disseminated tumor cells |
| CA2286090C (en) | 1997-04-30 | 2013-01-08 | Hybritech Incorporated | Forms of prostate specific antigen and methods for their detection |
| WO1998059073A1 (en) * | 1997-06-20 | 1998-12-30 | Mayo Foundation For Medical Education And Research | Method for detection of breast cancer |
| US5817798A (en) | 1997-09-17 | 1998-10-06 | Abbott Laboratories | Rapid RNA isolation procedure in the presence of a transition metal ion |
| US8101349B2 (en) * | 1997-12-23 | 2012-01-24 | Novartis Vaccines And Diagnostics, Inc. | Gene products differentially expressed in cancerous cells and their methods of use II |
| US20030215803A1 (en) * | 2000-12-07 | 2003-11-20 | Garcia Pablo Dominguez | Human genes and gene expression products isolated from human prostate |
| JP2000069969A (ja) | 1998-08-28 | 2000-03-07 | Hitachi Chem Co Ltd | プライマーＤＮＡ及びこれを用いる前立腺特異抗原をコードするｍＲＮＡの検出方法 |
| EP1151142A2 (en) * | 1999-01-28 | 2001-11-07 | Gen-Probe Incorporated | Nucleic acid sequences for detecting genetic markers for cancer in a biological sample |
| EP1159429A2 (en) * | 1999-02-18 | 2001-12-05 | Compugen Ltd. | Psa and klk-2 splicing variants |
| CA2362885A1 (en) | 1999-03-11 | 2000-09-14 | Mount Sinai Hospital | Human kallikrein-like genes |
| WO2000065067A2 (en) | 1999-04-23 | 2000-11-02 | University Of Washington | Prostate-specific polynucleotides, polypeptides and their methods of use |
| WO2000071711A2 (en) | 1999-05-20 | 2000-11-30 | Fahri Saatcioglu | Differentially expressed genes in prostate cancer |
| WO2001060860A2 (en) * | 2000-02-17 | 2001-08-23 | Millennium Predictive Medicine, Inc. | Genes differentially expressed in human prostate cancer and their use |
| US8017357B2 (en) | 2000-04-07 | 2011-09-13 | Eiken Kagaku Kabushiki Kaisha | Method of amplifying nucleic acid by using double-stranded nucleic acid as template |
| US20020132976A1 (en) | 2000-04-10 | 2002-09-19 | Artur Pedyczak | Immunogenic peptides derived from prostate-specific antigen (PSA) and uses thereof |
| CN100497655C (zh) | 2000-05-01 | 2009-06-10 | 荣研化学株式会社 | 检测核酸合成的反应产物的方法 |
| CN1283807C (zh) | 2001-06-18 | 2006-11-08 | 荣研化学株式会社 | 有效检测双链核酸的方法 |
| JP2005519606A (ja) | 2002-03-14 | 2005-07-07 | エグゾニ・テラピューティック・ソシエテ・アノニム | ヒトカリクレイン−２及びカリクレイン−３のバリアント並びにそれらの使用 |
| US7348142B2 (en) * | 2002-03-29 | 2008-03-25 | Veridex, Lcc | Cancer diagnostic panel |
| EP1592809B1 (en) | 2003-02-07 | 2013-04-10 | Diagnocure Inc. | Method to detect prostate cancer in a sample |
| US20040223885A1 (en) * | 2003-05-06 | 2004-11-11 | Keen Randy E. | Apparatus for the automated synthesis of polynucleotides |
| US20060008468A1 (en) * | 2004-06-17 | 2006-01-12 | Chih-Sheng Chiang | Combinations of tumor-associated antigens in diagnostics for various types of cancers |
-
2000
- 2000-01-28 EP EP00913284A patent/EP1151142A2/en not_active Withdrawn
- 2000-01-28 AU AU34755/00A patent/AU767587B2/en not_active Ceased
- 2000-01-28 WO PCT/US2000/002270 patent/WO2000044940A2/en not_active Ceased
- 2000-01-28 JP JP2000596180A patent/JP4495349B2/ja not_active Expired - Fee Related
- 2000-01-28 US US09/493,491 patent/US6551778B1/en not_active Expired - Lifetime
- 2000-01-28 CA CA2360073A patent/CA2360073C/en not_active Expired - Fee Related
-
2002
- 2002-10-17 US US10/273,707 patent/US6811985B2/en not_active Expired - Lifetime
-
2004
- 2004-10-28 US US10/978,145 patent/US7267956B2/en not_active Expired - Lifetime
-
2007
- 2007-08-13 US US11/838,168 patent/US20080026398A1/en not_active Abandoned
-
2008
- 2008-02-14 US US12/031,489 patent/US20090035773A1/en not_active Abandoned
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