JP2002534507A5 - - Google Patents
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- Publication number
- JP2002534507A5 JP2002534507A5 JP2000593587A JP2000593587A JP2002534507A5 JP 2002534507 A5 JP2002534507 A5 JP 2002534507A5 JP 2000593587 A JP2000593587 A JP 2000593587A JP 2000593587 A JP2000593587 A JP 2000593587A JP 2002534507 A5 JP2002534507 A5 JP 2002534507A5
- Authority
- JP
- Japan
- Prior art keywords
- hydrogen
- alkoxy
- alkyl
- compound
- oxides
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- -1 nitro, cyano, amino, aminocarbonyl Chemical group 0.000 description 38
- 229910052739 hydrogen Inorganic materials 0.000 description 22
- 239000001257 hydrogen Substances 0.000 description 22
- 125000003545 alkoxy group Chemical group 0.000 description 21
- 150000001875 compounds Chemical class 0.000 description 15
- 125000000217 alkyl group Chemical group 0.000 description 13
- 150000002431 hydrogen Chemical class 0.000 description 13
- 150000001204 N-oxides Chemical class 0.000 description 12
- 150000003839 salts Chemical class 0.000 description 12
- 125000002887 hydroxy group Chemical group [H]O* 0.000 description 7
- 229910052736 halogen Inorganic materials 0.000 description 6
- 125000004435 hydrogen atom Chemical group [H]* 0.000 description 6
- 150000002367 halogens Chemical group 0.000 description 5
- 125000004453 alkoxycarbonyl group Chemical group 0.000 description 4
- 125000002619 bicyclic group Chemical group 0.000 description 4
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 description 4
- 125000000000 cycloalkoxy group Chemical group 0.000 description 4
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 description 4
- 125000006168 tricyclic group Chemical group 0.000 description 4
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 3
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 description 3
- 125000005196 alkyl carbonyloxy group Chemical group 0.000 description 3
- 125000002178 anthracenyl group Chemical group C1(=CC=CC2=CC3=CC=CC=C3C=C12)* 0.000 description 3
- 125000000499 benzofuranyl group Chemical group O1C(=CC2=C1C=CC=C2)* 0.000 description 3
- 125000004541 benzoxazolyl group Chemical group O1C(=NC2=C1C=CC=C2)* 0.000 description 3
- 125000000259 cinnolinyl group Chemical group N1=NC(=CC2=CC=CC=C12)* 0.000 description 3
- 125000003983 fluorenyl group Chemical group C1(=CC=CC=2C3=CC=CC=C3CC12)* 0.000 description 3
- 125000003392 indanyl group Chemical group C1(CCC2=CC=CC=C12)* 0.000 description 3
- 125000003453 indazolyl group Chemical group N1N=C(C2=C1C=CC=C2)* 0.000 description 3
- 125000001041 indolyl group Chemical group 0.000 description 3
- 125000005956 isoquinolyl group Chemical group 0.000 description 3
- 125000001624 naphthyl group Chemical group 0.000 description 3
- 125000004592 phthalazinyl group Chemical group C1(=NN=CC2=CC=CC=C12)* 0.000 description 3
- 125000002294 quinazolinyl group Chemical group N1=C(N=CC2=CC=CC=C12)* 0.000 description 3
- 125000005493 quinolyl group Chemical group 0.000 description 3
- 125000001567 quinoxalinyl group Chemical group N1=C(C=NC2=CC=CC=C12)* 0.000 description 3
- 125000001622 2-naphthyl group Chemical group [H]C1=C([H])C([H])=C2C([H])=C(*)C([H])=C([H])C2=C1[H] 0.000 description 2
- 125000004550 quinolin-6-yl group Chemical group N1=CC=CC2=CC(=CC=C12)* 0.000 description 2
- KLJIPLWGNJQJRM-UHFFFAOYSA-N 2-phenylcyclohexan-1-amine Chemical compound NC1CCCCC1C1=CC=CC=C1 KLJIPLWGNJQJRM-UHFFFAOYSA-N 0.000 description 1
- 125000004466 alkoxycarbonylamino group Chemical group 0.000 description 1
- 125000004457 alkyl amino carbonyl group Chemical group 0.000 description 1
- 125000003282 alkyl amino group Chemical group 0.000 description 1
- 125000004448 alkyl carbonyl group Chemical group 0.000 description 1
- 125000002947 alkylene group Chemical group 0.000 description 1
- 125000005530 alkylenedioxy group Chemical group 0.000 description 1
- 125000005605 benzo group Chemical group 0.000 description 1
- 125000005708 carbonyloxy group Chemical group [*:2]OC([*:1])=O 0.000 description 1
- 125000003016 chromanyl group Chemical group O1C(CCC2=CC=CC=C12)* 0.000 description 1
- 125000000597 dioxinyl group Chemical group 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 125000005842 heteroatom Chemical group 0.000 description 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 description 1
- 230000003287 optical effect Effects 0.000 description 1
- 239000000546 pharmaceutical excipient Substances 0.000 description 1
- 125000001792 phenanthrenyl group Chemical group C1(=CC=CC=2C3=CC=CC=C3C=CC12)* 0.000 description 1
- 239000007858 starting material Substances 0.000 description 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP99100705.5 | 1999-01-15 | ||
| EP99100705 | 1999-01-15 | ||
| PCT/EP2000/000152 WO2000042019A1 (en) | 1999-01-15 | 2000-01-12 | 6-arylphenanthridines with pde-iv inhibiting activity |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2002534507A JP2002534507A (ja) | 2002-10-15 |
| JP2002534507A5 true JP2002534507A5 (https=) | 2007-03-01 |
Family
ID=8237353
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2000593587A Withdrawn JP2002534507A (ja) | 1999-01-15 | 2000-01-12 | 新規６−アリールフェナントリジン |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US6479505B1 (https=) |
| EP (1) | EP1147088B1 (https=) |
| JP (1) | JP2002534507A (https=) |
| AT (1) | ATE315029T1 (https=) |
| AU (1) | AU2289400A (https=) |
| CA (1) | CA2359416A1 (https=) |
| CY (1) | CY1105427T1 (https=) |
| DE (1) | DE60025327T2 (https=) |
| DK (1) | DK1147088T3 (https=) |
| ES (1) | ES2255483T3 (https=) |
| PT (1) | PT1147088E (https=) |
| SI (1) | SI1147088T1 (https=) |
| WO (1) | WO2000042019A1 (https=) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TR200501553T2 (tr) * | 1999-01-15 | 2005-06-21 | Altana Pharma Ag | PDE-IV inhibe edici aktivitesi olan fenilfenantridinler |
| ES2236288T3 (es) | 2000-07-14 | 2005-07-16 | Altana Pharma Ag | 6-heteroarilfenantridinas. |
| CN1293074C (zh) * | 2001-04-18 | 2007-01-03 | 奥索-麦克尼尔药品公司 | 具有pde抑制活性的芳基茚并吡啶 |
| US6958328B2 (en) | 2001-04-18 | 2005-10-25 | Ortho-Mcneil Pharmaceutical, Inc | Arylindenopyridines and related therapeutic and prophylactic methods |
| US6903109B2 (en) | 2001-04-18 | 2005-06-07 | Ortho-Muniel Pharmaceutical, Inc. | Arylindenopyridines and related therapeutic and prophylactic methods |
| US20040127510A1 (en) | 2002-04-16 | 2004-07-01 | Heintzelman Geoffrey R. | Arylindenopyridines and arylindenopyrimidines and related therapeutic and prophylactic methods |
| CA2495597A1 (en) * | 2002-08-17 | 2004-03-04 | Altana Pharma Ag | Novel phenanthridines |
| ATE353217T1 (de) | 2002-08-29 | 2007-02-15 | Altana Pharma Ag | 3-hydroxy-6-phenylphenanthridine als pde-4 inhibitoren |
| ES2449741T3 (es) | 2004-01-23 | 2014-03-21 | Mitsui Chemicals Agro, Inc. | 3-(Dihidro(tetrahidro)isoquinolin-1-il)quinolinas |
| CA2556086C (en) | 2004-02-18 | 2014-04-01 | Altana Pharma Ag | Novel guanidinyl-substituted hydroxy-6-phenylphenenthridines as effective phosphodiesterase (pde) 4 inhibitors |
| PL2589599T4 (pl) * | 2004-03-03 | 2015-06-30 | Takeda Gmbh | Nowe hydroksy-6-heteroarylofenantrydyny i ich zastosowanie jako inhibitorów PDE4 |
| US20080167316A1 (en) * | 2005-03-02 | 2008-07-10 | Altana Pharma Ag | 6-Heteroaryl-1,2,3,4,4A, 10B-Hexahydrophenanthridines as Pde4-Inhibitors for the Treatment of Inflammatory Disorders |
| PL1856093T3 (pl) * | 2005-03-02 | 2010-05-31 | Takeda Gmbh | Chlorowodorek (2R,4aR,10bR)-6-(2,6-dimetoksy-pirydyn-3-ylo)-9-etoksy-8-metoksy-1,2,3,4,4a,10b-heksahydrofenantrydyn-2-olu |
| US8568967B2 (en) | 2005-05-17 | 2013-10-29 | Taiho Pharmaceutical Co., Ltd. | Method for diagnosis of severity and prediction of recurrence in eosinophilic inflammatory disease |
| NO340563B1 (no) * | 2016-09-05 | 2017-05-15 | Takeda Gmbh | Nye salter av 6-heterocyklylsubstituerte heksahydrofenantridinderivater |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BR9707233A (pt) | 1996-01-31 | 1999-07-20 | Byk Gulden Lomberg Chem Fab | Fenantridinas |
| US6127378A (en) | 1996-03-26 | 2000-10-03 | Byk Gulden Lomberg Chemische Fabrik Gmbh | Phenanthridines substituted in the 6 position |
| SI0889886T1 (en) * | 1996-03-26 | 2003-02-28 | Altana Pharma Ag | Novel phenanthridines substituted in the 6 position |
| PT998460E (pt) | 1997-07-25 | 2004-07-30 | Altana Pharma Ag | Novos derivados de tetrazole |
| JP2001510827A (ja) | 1997-07-25 | 2001-08-07 | ビイク グルデン ロンベルク ヒエーミツシエ フアブリーク ゲゼルシヤフト ミツト ベシユレンクテル ハフツング | 置換６−フェニルフェナントリジン |
-
2000
- 2000-01-12 WO PCT/EP2000/000152 patent/WO2000042019A1/en not_active Ceased
- 2000-01-12 SI SI200030823T patent/SI1147088T1/sl unknown
- 2000-01-12 PT PT00901530T patent/PT1147088E/pt unknown
- 2000-01-12 US US09/889,143 patent/US6479505B1/en not_active Expired - Fee Related
- 2000-01-12 AU AU22894/00A patent/AU2289400A/en not_active Abandoned
- 2000-01-12 ES ES00901530T patent/ES2255483T3/es not_active Expired - Lifetime
- 2000-01-12 DK DK00901530T patent/DK1147088T3/da active
- 2000-01-12 CA CA002359416A patent/CA2359416A1/en not_active Abandoned
- 2000-01-12 EP EP00901530A patent/EP1147088B1/en not_active Expired - Lifetime
- 2000-01-12 DE DE60025327T patent/DE60025327T2/de not_active Expired - Fee Related
- 2000-01-12 JP JP2000593587A patent/JP2002534507A/ja not_active Withdrawn
- 2000-01-12 AT AT00901530T patent/ATE315029T1/de not_active IP Right Cessation
-
2006
- 2006-03-13 CY CY20061100351T patent/CY1105427T1/el unknown
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