NO20003723L - Triazol- og imidazolderivater - Google Patents
Triazol- og imidazolderivaterInfo
- Publication number
- NO20003723L NO20003723L NO20003723A NO20003723A NO20003723L NO 20003723 L NO20003723 L NO 20003723L NO 20003723 A NO20003723 A NO 20003723A NO 20003723 A NO20003723 A NO 20003723A NO 20003723 L NO20003723 L NO 20003723L
- Authority
- NO
- Norway
- Prior art keywords
- lower alkyl
- pyridin
- hydroxy
- phenyl
- hydrogen
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/04—Drugs for disorders of the muscular or neuromuscular system for myasthenia gravis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/10—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing aromatic rings
Abstract
Foreliggende oppfinnelse angår forbindelser med den generelle formel R1 hvor R1 - R4 betyr uavhengig hydrogen, -CF3> -OCF3, OCHF2, -OCH2F, lavere alkyl, lavere alkoksy, halogen, hydroksy, fenyl, benzyl, amino, nitro, pyrrol-1-yl, lavere alkyl-sulfonyl, lavere alkyl-sulfanyl, cyano eller benzyloksy; eller R2 og R3 kan være sammen -0-(CH2)2-O-, -0-CH2-0-, -0-(CH2)2-, -(CH2)3- eller -CH=CH-CH=CH-; X betyr-N=,-N(R8)-eller-CH=; Y betyr -N=, =N-, -N(R8)- eller -CH=; hvor en av X eller Y har å være nitrogen; R5 betyr gruppen v hvor R6 og R7 betyr uavhengig av hverandre hydrogen, lavere alkyl, -C(0)-lavere alkyl, hydroksy-lavere alkyl, lavere alkenyl, -C(O)CH2OH eller R6 og R7 kan være sammen med the N-atom -(CH2)n-, -(CH2)2-O-(CH2)2-, -CH2-CH=CH-CH2,-CH2-CH[OC(0)CH3]-(CH2)2, -CH2-CH[NHC(O)CH3]-(CH2)2, -O-(CH2)3-, -CH2-CH(OCH3)-(CH2)2-, -CH2-CH(halogen)-(CH2)2-, -(CH2)2-CH(0- fenyl)-(CH2)2-, -(CH2)2-N(CHO)-(CH2)2-, -(CH2)2-N(COCH3HCH2)2-, -CH2-CH(OH> (CH2)3-, -(CH2)2-CH(OH)-(CH2)2- eller -(CH2)2-N(benzyl)-CH:)2-; n betyr 3 til 5; og R8 betyr hydrogen, lavere alkyl, lavere alkenyl, lavere alkinyl, -(CH2)m-O-lavere alkyl, -(CH2)m-OH, -(CH2)m-CHF2, -(CH2)m-CH2F, -(CH2)m-C(O)-lavere alkyl, -(CH2)m-C(0)0- lavere alkyl, -(CH2)m-CH(OH)-lavere alkyl, -(CH2)m-CH(OH)-(CH2)mOH, -(CH2)m-C6H5, hvilken fenylring eventuelt er substituert med lavere alkyl, lavere alkoksy eller hydroksy, -(CH2)m-C(=CH2)-lavere alkyl, -(CH2)m-cykloalkyl) -(CH2)m-CN, -(CH2)m-pyridin-4-yl, -(CH2)m-pyridin-3-yl eller -(CH2)m-pyridin-2-yl; m betyr O til 4; og deres farmasøytisk godtagbare syreaddisjonssalter. Disse forbindelser kan anvendes for behandling av sykdommer beslektet med NMDA reseptor-subtype selektive blokkeringsmidler.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP99114313 | 1999-07-21 |
Publications (2)
Publication Number | Publication Date |
---|---|
NO20003723D0 NO20003723D0 (no) | 2000-07-20 |
NO20003723L true NO20003723L (no) | 2001-01-22 |
Family
ID=8238635
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NO20003723A NO20003723L (no) | 1999-07-21 | 2000-07-20 | Triazol- og imidazolderivater |
Country Status (29)
Country | Link |
---|---|
US (1) | US6265426B1 (no) |
EP (1) | EP1070708B1 (no) |
JP (1) | JP3628946B2 (no) |
KR (1) | KR100383776B1 (no) |
CN (1) | CN1148357C (no) |
AR (1) | AR024790A1 (no) |
AT (1) | ATE257827T1 (no) |
AU (1) | AU773463B2 (no) |
BR (1) | BR0003075A (no) |
CA (1) | CA2314009C (no) |
CO (1) | CO5190713A1 (no) |
DE (1) | DE60007697T2 (no) |
DK (1) | DK1070708T3 (no) |
ES (1) | ES2211420T3 (no) |
HR (1) | HRP20000482A2 (no) |
HU (1) | HUP0002792A3 (no) |
ID (1) | ID26599A (no) |
IL (1) | IL137328A0 (no) |
MA (1) | MA26747A1 (no) |
MX (1) | MXPA00007069A (no) |
NO (1) | NO20003723L (no) |
NZ (1) | NZ505766A (no) |
PE (1) | PE20010349A1 (no) |
PL (1) | PL341616A1 (no) |
PT (1) | PT1070708E (no) |
SG (1) | SG98422A1 (no) |
TR (1) | TR200002097A3 (no) |
UY (1) | UY26253A1 (no) |
ZA (1) | ZA200003680B (no) |
Families Citing this family (28)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5962490A (en) * | 1987-09-25 | 1999-10-05 | Texas Biotechnology Corporation | Thienyl-, furyl- and pyrrolyl-sulfonamides and derivatives thereof that modulate the activity of endothelin |
US6610723B2 (en) | 2001-01-29 | 2003-08-26 | Hoffmann-La Roche Inc. | Imidazole derivatives |
CA2440284A1 (en) * | 2001-03-08 | 2002-09-19 | Emory University | Ph-dependent nmda receptor antagonists |
US6951875B2 (en) | 2001-10-29 | 2005-10-04 | Hoffmann-La Roche Inc. | Conjugated aromatic compounds with a pyridine substituent |
US7005432B2 (en) * | 2002-05-16 | 2006-02-28 | Hoffman-La Roche Inc. | Substituted imidazol-pyridazine derivatives |
WO2003105771A2 (en) | 2002-06-17 | 2003-12-24 | Merck & Co., Inc. | 1-((5-aryl-1,2,4-oxadiazol-3-yl)benzyl)azetidine-3-carboxylates and 1-((5-aryl-1,2,4-oxadiazol-3-yl)benzyl)pyrrolidine-3-carboxylates as edg receptor agonists |
JP2006515276A (ja) * | 2002-10-22 | 2006-05-25 | オスコテック株式会社 | 骨粗鬆症の予防及び治療効果を有するフラン誘導体並びにこれを含む薬学的組成物 |
US7084145B2 (en) * | 2002-10-25 | 2006-08-01 | Pfizer Inc. | Triazole compounds useful in therapy |
CA2514363A1 (en) * | 2003-02-12 | 2004-08-26 | Transtech Pharma, Inc. | Substituted azole derivatives as therapeutic agents |
GB0303503D0 (en) * | 2003-02-14 | 2003-03-19 | Novartis Ag | Organic compounds |
GB0315111D0 (en) | 2003-06-27 | 2003-07-30 | Cancer Rec Tech Ltd | Substituted 5-membered ring compounds and their use |
BRPI0417928A (pt) * | 2003-12-22 | 2007-04-17 | Merck & Co Inc | composto, composição farmacêutica, métodos para o tratamento ou a prevenção de uma condição mediada pelo receptor de bradicinina b1, e de dor em um mamìfero, e, uso de um composto |
ZA200605526B (en) * | 2004-02-12 | 2007-11-28 | Transtech Pharma Inc | Substituted azole derivatives, compositions and methods of use |
WO2007089857A2 (en) | 2006-01-30 | 2007-08-09 | Transtech Pharma, Inc. | Substituted imidazole derivatives and their use as ptpase inhibitors |
JO3019B1 (ar) * | 2006-04-19 | 2016-09-05 | Janssen Pharmaceutica Nv | ثلاثي مستبدل 4،2،1-ثلاثي زولات |
KR101567608B1 (ko) | 2007-02-08 | 2015-11-09 | 신타 파마슈티칼스 코프. | 암과 같은 증식성 질환의 치료에 유용한 트라이아졸 화합물 |
LT2430921T (lt) | 2007-04-03 | 2017-09-25 | E. I. Du Pont De Nemours And Company | Pakeistieji benzeno fungicidai |
WO2008131148A1 (en) * | 2007-04-19 | 2008-10-30 | The Trustees Of The University Of Pennsylvania | Diphenyl-heteroaryl derivatives and their use for binding and imaging amyloid plaques |
US8420680B2 (en) | 2007-06-29 | 2013-04-16 | Emory University | NMDA receptor antagonists for neuroprotection |
JO2784B1 (en) * | 2007-10-18 | 2014-03-15 | شركة جانسين فارماسوتيكا ان. في | 5,3,1 - Triazole substitute derivative |
CN101827836B (zh) | 2007-10-18 | 2014-02-19 | 詹森药业有限公司 | 三取代的1,2,4-三唑化合物 |
MY152486A (en) | 2008-03-19 | 2014-10-15 | Janssen Pharmaceutica Nv | Trisubstituted 1,2,4 - triazoles as nicotinic acetylcholine receptor modulators |
EP2254580A1 (en) * | 2008-03-27 | 2010-12-01 | EVOTEC Neurosciences GmbH | Methods for treating disorders using nmda nr2b-subtype selective antagonist |
WO2009135944A1 (en) | 2008-05-09 | 2009-11-12 | Janssen Pharmaceutica Nv | Trisubstituted pyrazoles as acetylcholine receptor modulators |
RU2532394C1 (ru) * | 2013-10-29 | 2014-11-10 | Общество с ограниченной ответственностью "Научно-производственное объединение "Фарматрон" (НПО "Фарматрон") | ПРИМЕНЕНИЕ БРОМИДА 1-β-ФЕНИЛЭТИЛ)-4-АМИНО-1,2,4-ТРИАЗОЛИЯ (ГИПЕРТРИЛ) КАК АКТИВНОЙ ОСНОВЫ ЛЕКАРСТВЕННЫХ СРЕДСТВ ДЛЯ КОРРЕКЦИИ НАРУШЕНИЙ ФУНКЦИОНИРОВАНИЯ НИТРОКСИДЕРГИЧЕСКОЙ СИСТЕМЫ ОРГАНОВ-МИШЕНЕЙ ПРИ ГОМОЦИСТЕИНЕМИИ И ОСТРЫХ НАРУШЕНИЯХ МОЗГОВОГО КРОВООБРАЩЕНИЯ |
EP3185684A1 (en) * | 2014-08-29 | 2017-07-05 | E. I. du Pont de Nemours and Company | Herbicidal triazoles |
KR102512548B1 (ko) | 2017-12-22 | 2023-03-22 | 삼성디스플레이 주식회사 | 유기 전계 발광 소자 및 유기 전계 발광 소자용 함질소 화합물 |
US11912670B1 (en) | 2023-10-25 | 2024-02-27 | King Faisal University | Ethyl 4-(5-(3-fluorophenyl)-4-phenyl-4H-1,2,4-triazol-3-ylthio)butanoate as an antimicrobial compound |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB1579352A (en) * | 1977-05-06 | 1980-11-19 | Lepetit Spa | 3,5-disubstituted-1h-1,2,4-triazoles |
DE19643037A1 (de) * | 1996-10-18 | 1998-04-23 | Boehringer Ingelheim Kg | Neue Oxadiazole, Verfahren zu ihrer Herstellung sowie deren Verwendung als Arzneimittel |
PL337887A1 (en) * | 1997-07-03 | 2000-09-11 | Neurogen Corp | Some diarylimidazole derivatives, novel class of specific npy ligands |
IT1300055B1 (it) * | 1998-04-17 | 2000-04-05 | Boehringer Ingelheim Italia | Eterocicli con anello a 5 termini difenil-sostituiti loro procedimento di preparazione e loro impiego come farmici |
US7487474B2 (en) | 2003-01-02 | 2009-02-03 | Pdf Solutions, Inc. | Designing an integrated circuit to improve yield using a variant design element |
-
2000
- 2000-07-13 AT AT00114183T patent/ATE257827T1/de not_active IP Right Cessation
- 2000-07-13 DE DE60007697T patent/DE60007697T2/de not_active Expired - Fee Related
- 2000-07-13 DK DK00114183T patent/DK1070708T3/da active
- 2000-07-13 PT PT00114183T patent/PT1070708E/pt unknown
- 2000-07-13 ES ES00114183T patent/ES2211420T3/es not_active Expired - Lifetime
- 2000-07-13 EP EP00114183A patent/EP1070708B1/en not_active Expired - Lifetime
- 2000-07-17 NZ NZ505766A patent/NZ505766A/en unknown
- 2000-07-17 CA CA002314009A patent/CA2314009C/en not_active Expired - Fee Related
- 2000-07-17 PE PE2000000707A patent/PE20010349A1/es not_active Application Discontinuation
- 2000-07-17 IL IL13732800A patent/IL137328A0/xx unknown
- 2000-07-17 AU AU48651/00A patent/AU773463B2/en not_active Ceased
- 2000-07-18 SG SG200003981A patent/SG98422A1/en unknown
- 2000-07-19 MX MXPA00007069A patent/MXPA00007069A/es unknown
- 2000-07-19 MA MA26026A patent/MA26747A1/fr unknown
- 2000-07-19 TR TR2000/02097A patent/TR200002097A3/tr unknown
- 2000-07-19 CO CO00054541A patent/CO5190713A1/es not_active Application Discontinuation
- 2000-07-19 US US09/619,518 patent/US6265426B1/en not_active Expired - Fee Related
- 2000-07-19 ID IDP20000607D patent/ID26599A/id unknown
- 2000-07-19 AR ARP000103702A patent/AR024790A1/es active IP Right Grant
- 2000-07-20 HR HR20000482A patent/HRP20000482A2/hr not_active Application Discontinuation
- 2000-07-20 CN CNB001201816A patent/CN1148357C/zh not_active Expired - Fee Related
- 2000-07-20 ZA ZA200003680A patent/ZA200003680B/xx unknown
- 2000-07-20 HU HU0002792A patent/HUP0002792A3/hu unknown
- 2000-07-20 UY UY26253A patent/UY26253A1/es not_active Application Discontinuation
- 2000-07-20 KR KR10-2000-0041592A patent/KR100383776B1/ko not_active IP Right Cessation
- 2000-07-20 NO NO20003723A patent/NO20003723L/no unknown
- 2000-07-21 PL PL00341616A patent/PL341616A1/xx not_active Application Discontinuation
- 2000-07-21 BR BR0003075-9A patent/BR0003075A/pt not_active Application Discontinuation
- 2000-07-21 JP JP2000220748A patent/JP3628946B2/ja not_active Expired - Fee Related
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
NO20003723L (no) | Triazol- og imidazolderivater | |
JP2018524298A5 (no) | ||
RU2014105624A (ru) | Соединения индазола, способ их применения и фармацевтическая композиция | |
AU2134402A (en) | Antiviral agents | |
WO2001064639A3 (en) | Pde iv inhibiting amides, compositions and pharmaceutical use | |
CA2404464A1 (en) | Pyrrolidine and piperidine derivatives and their use for the treatment of neurodegenerative disorders | |
PA8550201A1 (es) | Analogos de prostaglandina | |
JP2008534453A5 (no) | ||
RU2010126056A (ru) | Органические соединения | |
MXPA05012247A (es) | Derivados de bencimidazol nuevos. | |
CA2332087A1 (en) | Aryl substituted azabenzimidazoles and their use in the treatment of hiv and aids related diseases | |
PE20010541A1 (es) | Uso de una composicion de benzimidazol para tratar el cancer | |
BRPI0409959A (pt) | uso de derivados de azetidinacarboxamida em terapia | |
DE60323743D1 (en) | N-(substituierte benzyl)-8-hydroxy-1,6-naphthyridin-7- carbonsäureamide als hiv-integrase-hemmer | |
HK1066535A1 (en) | Hetero-bicyclic crf antagonists | |
RU2441021C2 (ru) | Лизобактинамиды | |
RU2000104870A (ru) | Производные фталазина и терапевтические средства для эректильной дисфункции | |
RU98119076A (ru) | Производные 2-(3h)-оксазолона и их применение в качестве ингибиторов сох-2 | |
JP2004534758A5 (no) | ||
JP2001519413A5 (no) | ||
IL160082A0 (en) | Quinoline derivatives and use thereof as antitumor agents | |
TW200505882A (en) | Benzothiazole derivatives | |
CA2523253A1 (en) | Methyl indoles and methyl pyrrolopyridines as alpha-1 adrenergic agonists | |
TNSN00015A1 (fr) | Nouveaux sels de morpholinobenzamide | |
GB0019008D0 (en) | Therapeutic compounds |