MA26747A1 - Composes inhibiteurs de recepteurs de nmda, leurs utilisations dans le traitement de troubles neuronaux et leurs preparations - Google Patents

Composes inhibiteurs de recepteurs de nmda, leurs utilisations dans le traitement de troubles neuronaux et leurs preparations

Info

Publication number
MA26747A1
MA26747A1 MA26026A MA26026A MA26747A1 MA 26747 A1 MA26747 A1 MA 26747A1 MA 26026 A MA26026 A MA 26026A MA 26026 A MA26026 A MA 26026A MA 26747 A1 MA26747 A1 MA 26747A1
Authority
MA
Morocco
Prior art keywords
treatment
preparations
nmda receptor
inhibitor compounds
receptor inhibitor
Prior art date
Application number
MA26026A
Other languages
English (en)
Inventor
Alexander Alanine
Neidhart Marie-Paule Heitz
Emmanuel Pinard
Rene Wyler
Bernd Buettelmann
Georg Jaeschke
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of MA26747A1 publication Critical patent/MA26747A1/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A61P21/04—Drugs for disorders of the muscular or neuromuscular system for myasthenia gravis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/10—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing aromatic rings

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Neurology (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Psychiatry (AREA)
  • Psychology (AREA)
  • Hospice & Palliative Care (AREA)
  • Pain & Pain Management (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

LA PRÉSENTE INVENTION A TRAIT à DES COMPOSÉS DE FORMILE GÉNÉRALE : LEURS SELS D'ADDITION D'ACIDE ACCEPTABLES SUR LE PLAN PHARMACEUTIQUE. ON PEUT UTILISER CES COMPOSÉS POUR LE TRAITEMENT DE MALADIES APPARENTÉES AUX INHIBITEURS SÉLECTIFS DE SOUS -TYPE DE RECEPTEURS DE MMDA.
MA26026A 1999-07-21 2000-07-19 Composes inhibiteurs de recepteurs de nmda, leurs utilisations dans le traitement de troubles neuronaux et leurs preparations MA26747A1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP99114313 1999-07-21

Publications (1)

Publication Number Publication Date
MA26747A1 true MA26747A1 (fr) 2004-12-20

Family

ID=8238635

Family Applications (1)

Application Number Title Priority Date Filing Date
MA26026A MA26747A1 (fr) 1999-07-21 2000-07-19 Composes inhibiteurs de recepteurs de nmda, leurs utilisations dans le traitement de troubles neuronaux et leurs preparations

Country Status (29)

Country Link
US (1) US6265426B1 (fr)
EP (1) EP1070708B1 (fr)
JP (1) JP3628946B2 (fr)
KR (1) KR100383776B1 (fr)
CN (1) CN1148357C (fr)
AR (1) AR024790A1 (fr)
AT (1) ATE257827T1 (fr)
AU (1) AU773463B2 (fr)
BR (1) BR0003075A (fr)
CA (1) CA2314009C (fr)
CO (1) CO5190713A1 (fr)
DE (1) DE60007697T2 (fr)
DK (1) DK1070708T3 (fr)
ES (1) ES2211420T3 (fr)
HR (1) HRP20000482A2 (fr)
HU (1) HUP0002792A3 (fr)
ID (1) ID26599A (fr)
IL (1) IL137328A0 (fr)
MA (1) MA26747A1 (fr)
MX (1) MXPA00007069A (fr)
NO (1) NO20003723L (fr)
NZ (1) NZ505766A (fr)
PE (1) PE20010349A1 (fr)
PL (1) PL341616A1 (fr)
PT (1) PT1070708E (fr)
SG (1) SG98422A1 (fr)
TR (1) TR200002097A3 (fr)
UY (1) UY26253A1 (fr)
ZA (1) ZA200003680B (fr)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5962490A (en) * 1987-09-25 1999-10-05 Texas Biotechnology Corporation Thienyl-, furyl- and pyrrolyl-sulfonamides and derivatives thereof that modulate the activity of endothelin
US6610723B2 (en) 2001-01-29 2003-08-26 Hoffmann-La Roche Inc. Imidazole derivatives
EP1436258A4 (fr) 2001-03-08 2005-03-23 Univ Emory Antagonistes du recepteur nmda dependant du ph
US6951875B2 (en) 2001-10-29 2005-10-04 Hoffmann-La Roche Inc. Conjugated aromatic compounds with a pyridine substituent
US7005432B2 (en) * 2002-05-16 2006-02-28 Hoffman-La Roche Inc. Substituted imidazol-pyridazine derivatives
US7199142B2 (en) 2002-06-17 2007-04-03 Merck & Co., Inc. 1-((5-aryl-1,2,4-oxadiazol-3-yl) benzyl)azetidine-3-carboxylates and 1-((5-aryl-1,2,4-oxadiazol-3-yl)benzyl) pyrrolidine-3-carboxylates as edg receptor agonists
US20060004088A1 (en) * 2002-10-22 2006-01-05 Oct Inc. Furan derivatives for preventing and curing osteoporosis and pharmaceutical compositions containing the same
US7084145B2 (en) * 2002-10-25 2006-08-01 Pfizer Inc. Triazole compounds useful in therapy
EP1594847A2 (fr) * 2003-02-12 2005-11-16 Transtech Pharma, Inc. Utilisation de derives d'azoles substitues en tant qu'agents therapeutiques
GB0303503D0 (en) * 2003-02-14 2003-03-19 Novartis Ag Organic compounds
GB0315111D0 (en) * 2003-06-27 2003-07-30 Cancer Rec Tech Ltd Substituted 5-membered ring compounds and their use
AU2004309357B2 (en) * 2003-12-22 2010-10-07 Merck Sharp & Dohme Corp. Alpha-hydroxy amides as bradykinin antagonists or inverse agonists
EP1730118A1 (fr) * 2004-02-12 2006-12-13 Transtech Pharma, Inc. Derives d'azole substitues, compositions, et procedes d'utilisation
CN101374835B (zh) * 2006-01-30 2012-04-25 转化技术制药公司 作为PTPase抑制剂的取代的咪唑衍生物、组合物和使用方法
JO3019B1 (ar) 2006-04-19 2016-09-05 Janssen Pharmaceutica Nv ثلاثي مستبدل 4،2،1-ثلاثي زولات
BRPI0807219A2 (pt) 2007-02-08 2015-05-26 Synta Pharmaceuticals Corp Composto de tiazol que modulam a atividade de hsp90
EP2532240A3 (fr) * 2007-04-03 2013-03-13 E. I. du Pont de Nemours and Company Fongicides de benzène substitués
EP2144507A4 (fr) * 2007-04-19 2010-05-26 Univ Pennsylvania Dérivés de diphényl-hétéroaryle et leur utilisation pour la liaison et l'imagerie de plaques amyloïdes
CN101815518B (zh) * 2007-06-29 2013-01-09 埃莫里大学 用于神经保护的nmda受体拮抗剂
JO2784B1 (en) 2007-10-18 2014-03-15 شركة جانسين فارماسوتيكا ان. في 5,3,1 - Triazole substitute derivative
MX2010004177A (es) 2007-10-18 2010-05-03 Janssen Pharmaceutica Nv 1,2,4-triazoles trisustituidos.
KR101564303B1 (ko) 2008-03-19 2015-11-06 얀센 파마슈티카 엔.브이. 니코틴성 아세틸콜린 수용체 조절제로서의 삼치환된 1,2,4-트리아졸
MX2010009649A (es) * 2008-03-27 2010-12-17 Evotecv Neurosciences Gmbh Metodos para tratar trastornos utilizando un antagonista selectivo del subtipo nr2b de nmda.
CL2009001125A1 (es) 2008-05-09 2011-02-11 Janssen Pharmaceutica Nv Compuestos derivados de pirazol trisustituido, moduladores alostericos positivos de los receptores ach nicotinicos; composicion farmaceutica que los comprende; proceso de preparacion de la composicion; y su uso en el tratamiento de enfermedades de snc o inflamatorias.
RU2532394C1 (ru) * 2013-10-29 2014-11-10 Общество с ограниченной ответственностью "Научно-производственное объединение "Фарматрон" (НПО "Фарматрон") ПРИМЕНЕНИЕ БРОМИДА 1-β-ФЕНИЛЭТИЛ)-4-АМИНО-1,2,4-ТРИАЗОЛИЯ (ГИПЕРТРИЛ) КАК АКТИВНОЙ ОСНОВЫ ЛЕКАРСТВЕННЫХ СРЕДСТВ ДЛЯ КОРРЕКЦИИ НАРУШЕНИЙ ФУНКЦИОНИРОВАНИЯ НИТРОКСИДЕРГИЧЕСКОЙ СИСТЕМЫ ОРГАНОВ-МИШЕНЕЙ ПРИ ГОМОЦИСТЕИНЕМИИ И ОСТРЫХ НАРУШЕНИЯХ МОЗГОВОГО КРОВООБРАЩЕНИЯ
CN106659159A (zh) * 2014-08-29 2017-05-10 杜邦公司 除草三唑
KR102512548B1 (ko) 2017-12-22 2023-03-22 삼성디스플레이 주식회사 유기 전계 발광 소자 및 유기 전계 발광 소자용 함질소 화합물
US12065411B1 (en) * 2023-10-23 2024-08-20 King Faisal University Methyl 4-((5-(3-fluorophenyl)-4-phenyl-4H-1,2,4-triazol-3-ylthio)methyl)benzoate as an antimicrobial compound
US11912670B1 (en) 2023-10-25 2024-02-27 King Faisal University Ethyl 4-(5-(3-fluorophenyl)-4-phenyl-4H-1,2,4-triazol-3-ylthio)butanoate as an antimicrobial compound

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1579352A (en) * 1977-05-06 1980-11-19 Lepetit Spa 3,5-disubstituted-1h-1,2,4-triazoles
DE19643037A1 (de) * 1996-10-18 1998-04-23 Boehringer Ingelheim Kg Neue Oxadiazole, Verfahren zu ihrer Herstellung sowie deren Verwendung als Arzneimittel
BR9810651A (pt) * 1997-07-03 2000-10-03 Neurogen Corp Certos derivados de diarilimidazol; uma nova classe de ligantes npy especìficos
IT1300055B1 (it) * 1998-04-17 2000-04-05 Boehringer Ingelheim Italia Eterocicli con anello a 5 termini difenil-sostituiti loro procedimento di preparazione e loro impiego come farmici
EP1579352A2 (fr) 2003-01-02 2005-09-28 PDF Solutions, Inc. Amelioration du rendement

Also Published As

Publication number Publication date
AR024790A1 (es) 2002-10-23
HU0002792D0 (en) 2000-09-28
IL137328A0 (en) 2001-07-24
DE60007697D1 (de) 2004-02-19
US6265426B1 (en) 2001-07-24
DK1070708T3 (da) 2004-05-10
UY26253A1 (es) 2000-10-31
DE60007697T2 (de) 2004-12-09
NZ505766A (en) 2002-03-28
AU4865100A (en) 2001-01-25
SG98422A1 (en) 2003-09-19
ZA200003680B (en) 2001-01-22
TR200002097A2 (tr) 2001-02-21
MXPA00007069A (es) 2002-04-24
ATE257827T1 (de) 2004-01-15
ID26599A (id) 2001-01-25
CA2314009A1 (fr) 2001-01-21
HUP0002792A3 (en) 2002-10-28
PT1070708E (pt) 2004-05-31
JP2001064263A (ja) 2001-03-13
HRP20000482A2 (en) 2001-06-30
CN1281852A (zh) 2001-01-31
EP1070708B1 (fr) 2004-01-14
BR0003075A (pt) 2001-03-13
NO20003723D0 (no) 2000-07-20
EP1070708A1 (fr) 2001-01-24
PL341616A1 (en) 2001-01-29
CA2314009C (fr) 2008-09-30
NO20003723L (no) 2001-01-22
HUP0002792A2 (hu) 2001-09-28
CO5190713A1 (es) 2002-08-29
CN1148357C (zh) 2004-05-05
KR20010049825A (ko) 2001-06-15
JP3628946B2 (ja) 2005-03-16
KR100383776B1 (ko) 2003-05-12
TR200002097A3 (tr) 2001-02-21
AU773463B2 (en) 2004-05-27
PE20010349A1 (es) 2001-03-26
ES2211420T3 (es) 2004-07-16

Similar Documents

Publication Publication Date Title
MA26747A1 (fr) Composes inhibiteurs de recepteurs de nmda, leurs utilisations dans le traitement de troubles neuronaux et leurs preparations
MA27647A1 (fr) Antagonistes de ccr5 utiles comme agents therapeutiques
TNSN97193A1 (fr) Amides inhibiteurs de secretion de apo b/mtp, procede pour leur preparation et compositions pharmaceutiques les contenant.
TR200000129T2 (tr) Yepyeni spiroazabisiklik heterosiklik bileşikler.
TNSN97110A1 (fr) Derives de 2-(2-oxo-ethylidene)-imidazolidine-4-one, procede pour leur preparation et compositions pharmaceutiques les contenant
ES2233931T3 (es) Fenilacetato y derivados, solos o en combinacion con otros compuestos, contra estados neoplasicos y otros trastornos.
MA25809A1 (fr) Derives d'arylmethylamine pour usage comme inhibiteurs de tryptase
TNSN99126A1 (fr) Pyrrolopyrimidines nouvelles, procede pour leur preparation et compositions pharmaceutiques les contenant
TNSN98154A1 (fr) Derives de 2-aminopyridine nouveaux et compositions pharmaceutiques les contenant
MA27509A1 (fr) Formulations a liberation prolongee contenant de la lamotrigine
MX9603520A (es) Derivados del acido hidroxamico y acido carboxilico, procesos para su preparacion y su uso.
MA30412B1 (fr) Composés Pharmaceutiques
BR9609413A (pt) Formulações de dieta e farmacêuticas para a profilaxia e o tratamento de distúrbios gastrintestinais
MA26723A1 (fr) Acides oxamiques nouveaux, procede pour leur preparation et compositions pharmaceutiques les contenant
MA26700A1 (fr) FORMULATIONS PHARMACEUTIQUES D'INHIBITEURS DE PDE-5 DE GMPc à LIBERATION CONTROLEE, ET PROCEDE POUR LEUR PREPARATION.
TNSN98083A1 (fr) Derives de 6-0 methylerythromycine a, procede pour leur preparation et compositions pharmaceutiques les contenant.
NZ331452A (en) use of 2-(4-indolyl-1-piperazinyl)alkylene-N-(2-pyridyl)-cyclohexane- carboxamide derivatives in treating central nervous system disorders
TNSN04168A1 (fr) Derives de thiazole et d'oxazole qui modulent l'activite de ppar
TNSN99031A1 (fr) Composes heterocycliques nouveaux inhibiteurs de romatases, procede pour leur preparation et compositions pharmaceutiques les contenant
TNSN00231A1 (fr) Forme cristalline de 4-carboxyamino-2-substitue-1,2,3,4- tetrahydroquinoleine, et compositions la contenant
EE04700B1 (et) Segamisest sõltumatud toimeainet aeglustatult vabastavad mitmeosalised ravimvormid ja nende valmistamismeetodid
NO20000093L (no) (+)-Norcisaprid nyttig for 5-HT3 og 5-HT4-medierte forstyrrelser
MA26741A1 (fr) Suspensions de ziprasidone nouvelles et procede pour leur preparation.
TNSN00106A1 (fr) Composition pharmaceutique nouvelle comprenant un inhibiteur de nos, et procede pour sa preparation
CA2203310A1 (fr) Comprime matriciel permettant la liberation prolongee du sel de sodium de tianeptine apres administration par voie orale