JP2002531421A5 - - Google Patents
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- Publication number
- JP2002531421A5 JP2002531421A5 JP2000584928A JP2000584928A JP2002531421A5 JP 2002531421 A5 JP2002531421 A5 JP 2002531421A5 JP 2000584928 A JP2000584928 A JP 2000584928A JP 2000584928 A JP2000584928 A JP 2000584928A JP 2002531421 A5 JP2002531421 A5 JP 2002531421A5
- Authority
- JP
- Japan
- Prior art keywords
- hapten
- carrier
- conjugate
- antibody
- complex
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000003814 drug Substances 0.000 description 7
- 238000000034 method Methods 0.000 description 6
- 229960005486 vaccine Drugs 0.000 description 6
- 239000012634 fragment Substances 0.000 description 5
- 206010057852 Nicotine dependence Diseases 0.000 description 4
- 208000025569 Tobacco Use disease Diseases 0.000 description 4
- 239000002671 adjuvant Substances 0.000 description 4
- SNICXCGAKADSCV-UHFFFAOYSA-N nicotine Chemical compound CN1CCCC1C1=CC=CN=C1 SNICXCGAKADSCV-UHFFFAOYSA-N 0.000 description 3
- SNICXCGAKADSCV-JTQLQIEISA-N (-)-Nicotine Chemical group CN1CCC[C@H]1C1=CC=CN=C1 SNICXCGAKADSCV-JTQLQIEISA-N 0.000 description 2
- 102000014914 Carrier Proteins Human genes 0.000 description 2
- 108010078791 Carrier Proteins Proteins 0.000 description 2
- 150000001875 compounds Chemical class 0.000 description 2
- 239000011159 matrix material Substances 0.000 description 2
- 229960002715 nicotine Drugs 0.000 description 2
- 239000000546 pharmaceutical excipient Substances 0.000 description 2
- 0 CN1C*CC1 Chemical compound CN1C*CC1 0.000 description 1
- 241000124008 Mammalia Species 0.000 description 1
- 229940024606 amino acid Drugs 0.000 description 1
- 150000001413 amino acids Chemical class 0.000 description 1
- JUJWROOIHBZHMG-UHFFFAOYSA-N c1ccncc1 Chemical compound c1ccncc1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 description 1
- 229950006073 cotinine Drugs 0.000 description 1
- 230000003053 immunization Effects 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 229920002643 polyglutamic acid Polymers 0.000 description 1
- 239000007858 starting material Substances 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US09/201,800 | 1998-12-01 | ||
| US09/201,800 US6232082B1 (en) | 1998-12-01 | 1998-12-01 | Hapten-carrier conjugates for treating and preventing nicotine addiction |
| PCT/US1999/028272 WO2000032239A1 (en) | 1998-12-01 | 1999-12-01 | Hapten-carrier conjugates for treating and preventing nicotine addiction |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010264835A Division JP2011079849A (ja) | 1998-12-01 | 2010-11-29 | ニコチン中毒の治療及び予防のためのハプテン−キャリア複合体 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2002531421A JP2002531421A (ja) | 2002-09-24 |
| JP2002531421A5 true JP2002531421A5 (https=) | 2007-01-18 |
| JP4971542B2 JP4971542B2 (ja) | 2012-07-11 |
Family
ID=22747358
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2000584928A Expired - Fee Related JP4971542B2 (ja) | 1998-12-01 | 1999-12-01 | ニコチン中毒の治療及び予防のためのハプテン−キャリア複合体 |
| JP2010264835A Pending JP2011079849A (ja) | 1998-12-01 | 2010-11-29 | ニコチン中毒の治療及び予防のためのハプテン−キャリア複合体 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010264835A Pending JP2011079849A (ja) | 1998-12-01 | 2010-11-29 | ニコチン中毒の治療及び予防のためのハプテン−キャリア複合体 |
Country Status (26)
| Country | Link |
|---|---|
| US (7) | US6232082B1 (https=) |
| EP (3) | EP1512414A1 (https=) |
| JP (2) | JP4971542B2 (https=) |
| KR (1) | KR100656836B1 (https=) |
| CN (2) | CN100586481C (https=) |
| AT (1) | ATE279211T1 (https=) |
| AU (1) | AU763001B2 (https=) |
| BR (1) | BR9915852A (https=) |
| CA (1) | CA2352765C (https=) |
| DE (1) | DE69921178T2 (https=) |
| DK (1) | DK1135166T3 (https=) |
| EA (1) | EA004956B1 (https=) |
| ES (1) | ES2229800T3 (https=) |
| HK (2) | HK1042428B (https=) |
| HU (1) | HUP0104365A3 (https=) |
| IL (2) | IL143474A0 (https=) |
| ME (1) | MEP34208A (https=) |
| MX (1) | MXPA01005511A (https=) |
| NO (1) | NO331998B1 (https=) |
| NZ (1) | NZ512103A (https=) |
| PL (1) | PL199253B1 (https=) |
| PT (1) | PT1135166E (https=) |
| RS (1) | RS51273B (https=) |
| TR (1) | TR200102411T2 (https=) |
| WO (1) | WO2000032239A1 (https=) |
| ZA (1) | ZA200104477B (https=) |
Families Citing this family (74)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20020032316A1 (en) * | 1995-03-31 | 2002-03-14 | Cantab Pharmaceuticals Research Limited | Hapten-carrier conjugates for use in drug-abuse therapy and methods for preparation of same |
| US6232082B1 (en) * | 1998-12-01 | 2001-05-15 | Nabi | Hapten-carrier conjugates for treating and preventing nicotine addiction |
| WO2002058635A2 (en) * | 2001-01-26 | 2002-08-01 | The Scripps Research Institute | Nicotine immunogens and antibodies and uses thereof |
| SE521512C2 (sv) * | 2001-06-25 | 2003-11-11 | Niconovum Ab | Anordning för administrering av en substans till främre delen av en individs munhåla |
| US20030148260A1 (en) * | 2001-08-07 | 2003-08-07 | Bernard Levin | Method of diagnosing colorectal adenomas and cancer using proton maggnetic resonance spectroscopy |
| US20050089524A1 (en) * | 2002-03-01 | 2005-04-28 | Sanderson Sam D. | Compositions and compounds for use as molecular adjuvant for a nicotine vaccine |
| NZ537003A (en) * | 2002-07-18 | 2008-03-28 | Cytos Biotechnology Ag | Hapten-carrier conjugates comprising virus like particles and uses thereof |
| US20040115244A1 (en) * | 2002-12-17 | 2004-06-17 | Holgate Eric Jamison | Methods and compositions for nicotine replacement therapy |
| ES2285233T3 (es) | 2002-12-20 | 2007-11-16 | Niconovum Ab | Un material en particulas que contiene nicotina y celulosa microcristalina fisicamente y quimicamente estable. |
| WO2005040338A2 (en) * | 2003-05-21 | 2005-05-06 | The Scripps Research Institute | Constrained alkaloid immunogens and antibodies and uses thereof |
| GB0313916D0 (en) | 2003-06-16 | 2003-07-23 | Glaxosmithkline Biolog Sa | Vaccine composition |
| US7220842B2 (en) * | 2004-04-05 | 2007-05-22 | Dade Behring Inc. | Immunoassays for buprenorphine and norbuprenorphine |
| US7678551B2 (en) * | 2004-10-25 | 2010-03-16 | Seradyn, Inc. | Immunoassays for lamotrigine |
| US9492400B2 (en) | 2004-11-04 | 2016-11-15 | Massachusetts Institute Of Technology | Coated controlled release polymer particles as efficient oral delivery vehicles for biopharmaceuticals |
| US20060252107A1 (en) * | 2005-02-22 | 2006-11-09 | Acucela, Inc. | Compositions and methods for diagnosing and treating retinal diseases |
| EP1963308A4 (en) * | 2005-11-28 | 2010-12-15 | Nabi Biopharmaceuticals | METHOD FOR PRODUCING A NICOTINE HAPTEN |
| US20070134169A1 (en) * | 2005-12-11 | 2007-06-14 | Rabinoff Michael D | Methods for smoking cessation or alcohol cessation or other addiction cessation |
| US9267937B2 (en) | 2005-12-15 | 2016-02-23 | Massachusetts Institute Of Technology | System for screening particles |
| WO2007100755A1 (en) * | 2006-02-27 | 2007-09-07 | Nabi Biopharmaceuticals | Method for decreasing the toxic effects of nicotine on fetuses in pregnant women |
| US9402809B2 (en) | 2006-03-16 | 2016-08-02 | Niconovum Usa, Inc. | Snuff composition |
| ES2776100T3 (es) * | 2006-03-31 | 2020-07-29 | Massachusetts Inst Technology | Sistema para el suministro dirigido de agentes terapéuticos |
| EP1849780A1 (en) * | 2006-04-21 | 2007-10-31 | De Staat der Nederlanden, vert. door de minister van VWS | Vaccine against nicotine addiction |
| EP1854478A1 (en) * | 2006-05-12 | 2007-11-14 | Cytos Biotechnology AG | Nicotine-carrier vaccine formulation |
| US8367113B2 (en) | 2006-05-15 | 2013-02-05 | Massachusetts Institute Of Technology | Polymers for functional particles |
| US20110052697A1 (en) * | 2006-05-17 | 2011-03-03 | Gwangju Institute Of Science & Technology | Aptamer-Directed Drug Delivery |
| WO2007150030A2 (en) * | 2006-06-23 | 2007-12-27 | Massachusetts Institute Of Technology | Microfluidic synthesis of organic nanoparticles |
| US20100144845A1 (en) * | 2006-08-04 | 2010-06-10 | Massachusetts Institute Of Technology | Oligonucleotide systems for targeted intracellular delivery |
| US9217129B2 (en) | 2007-02-09 | 2015-12-22 | Massachusetts Institute Of Technology | Oscillating cell culture bioreactor |
| WO2008124634A1 (en) * | 2007-04-04 | 2008-10-16 | Massachusetts Institute Of Technology | Polymer-encapsulated reverse micelles |
| WO2008124632A1 (en) * | 2007-04-04 | 2008-10-16 | Massachusetts Institute Of Technology | Amphiphilic compound assisted nanoparticles for targeted delivery |
| EP2630966B1 (en) | 2007-10-12 | 2017-04-19 | Massachusetts Institute of Technology | Vaccine nanotechnology |
| EP2222702B1 (en) * | 2007-11-29 | 2016-01-13 | Cytos Biotechnology AG | Human monoclonal nicotine specific antibodies |
| EP2065398A1 (en) * | 2007-11-29 | 2009-06-03 | Cytos Biotechnology AG | Human monoclonal nicotine specific antibodies |
| US20110086063A1 (en) * | 2008-06-04 | 2011-04-14 | Cornell University | Vaccines for prevention and treatment of addiction |
| JP2011524521A (ja) * | 2008-06-13 | 2011-09-01 | ナビ バイオファーマシューティカルズ | 喫煙停止キットおよび方法 |
| US20110182918A1 (en) * | 2008-06-13 | 2011-07-28 | Nabi Biopharmaceuticals | Personalized drug treatment and smoking cessation kit and method |
| JP2011530497A (ja) * | 2008-08-08 | 2011-12-22 | ノバルティス アーゲー | ニコチン由来ハプテンの調製方法 |
| US8343497B2 (en) | 2008-10-12 | 2013-01-01 | The Brigham And Women's Hospital, Inc. | Targeting of antigen presenting cells with immunonanotherapeutics |
| US8343498B2 (en) | 2008-10-12 | 2013-01-01 | Massachusetts Institute Of Technology | Adjuvant incorporation in immunonanotherapeutics |
| US8277812B2 (en) | 2008-10-12 | 2012-10-02 | Massachusetts Institute Of Technology | Immunonanotherapeutics that provide IgG humoral response without T-cell antigen |
| US8591905B2 (en) | 2008-10-12 | 2013-11-26 | The Brigham And Women's Hospital, Inc. | Nicotine immunonanotherapeutics |
| US8552165B2 (en) * | 2008-12-09 | 2013-10-08 | Heather Davis | Immunostimulatory oligonucleotides |
| HUE027823T2 (hu) | 2008-12-09 | 2016-11-28 | Coley Pharm Group Inc | Immunstimuláló oligonukleotidok |
| US20110064750A1 (en) * | 2009-07-31 | 2011-03-17 | Nabi Biopharmaceuticals | Method and kit for treating nicotine addiction |
| CN107617110A (zh) * | 2009-08-26 | 2018-01-23 | 西莱克塔生物科技公司 | 诱导t细胞辅助的组合物 |
| EP2477974A2 (en) * | 2009-09-14 | 2012-07-25 | The Scripps Research Institute | Nicotine haptens, immunoconjugates and their uses |
| US20110182831A1 (en) * | 2010-01-25 | 2011-07-28 | Aradigm Corporation | Systems and methods used in conjunction with nicotine vaccines for effecting cessation of tobacco use |
| ES2887335T3 (es) | 2010-03-17 | 2021-12-22 | Univ Cornell | Vacuna contra las drogas de abuso basada en adenovirus alterado |
| WO2011123042A1 (en) * | 2010-04-01 | 2011-10-06 | Independent Pharmaceutica Ab | Vaccination procedure and products for use therein |
| GB201006324D0 (en) | 2010-04-15 | 2010-06-02 | Glaxosmithkline Biolog Sa | Vaccine |
| AU2011258165B2 (en) | 2010-05-26 | 2016-11-17 | Selecta Biosciences, Inc. | Dose selection of adjuvanted synthetic nanocarriers |
| TWI578997B (zh) | 2010-06-04 | 2017-04-21 | 輝瑞疫苗有限責任公司 | 用於預防或治療菸鹼成癮之共軛體 |
| WO2012061717A1 (en) | 2010-11-05 | 2012-05-10 | Selecta Biosciences, Inc. | Modified nicotinic compounds and related methods |
| WO2012099717A1 (en) * | 2011-01-04 | 2012-07-26 | National Jewish Health | Leukotrienes and asthma exacerbation risk |
| CN103826657A (zh) | 2011-04-04 | 2014-05-28 | 衣阿华大学研究基金会 | 改进疫苗免疫原性的方法 |
| JP2014521687A (ja) | 2011-07-29 | 2014-08-28 | セレクタ バイオサイエンシーズ インコーポレーテッド | 体液性および細胞傷害性ｔリンパ球（ｃｔｌ）免疫応答を生成する合成ナノキャリア |
| WO2013130393A1 (en) | 2012-02-28 | 2013-09-06 | Cornell University | Aav-directed persistent expression of an anti-nicotine antibody gene for smoking cessation |
| US10004811B2 (en) * | 2012-04-13 | 2018-06-26 | Cornell University | Development of a highly efficient second generation nicotine-conjugate vaccine to treat nicotine addiction |
| TWI600905B (zh) * | 2012-09-21 | 2017-10-01 | 國立臺灣師範大學 | 聚合半抗原成為免疫原的技術方法 |
| US9303013B2 (en) | 2014-05-16 | 2016-04-05 | Pfizer Inc. | Conjugates and associated methods of producing them for the prevention or treatment of nicotine addiction |
| US20170107275A1 (en) * | 2014-05-19 | 2017-04-20 | The Scripps Research Institute | Enantiopure haptens for nicotine vaccine development |
| CN104402992B (zh) * | 2014-11-28 | 2018-09-18 | 杭州安旭科技有限公司 | 一种合成大麻抗原的合成方法及合成大麻抗原的应用 |
| EP3247380A1 (en) * | 2015-01-20 | 2017-11-29 | Universiteit Antwerpen | Neuregulin in the treatment of fibrotic disorders |
| CN106496309A (zh) * | 2016-11-24 | 2017-03-15 | 北京开景基因技术有限公司 | 微球抗原及其制备方法以及抗可替宁抗体的制备方法 |
| AU2018283973B2 (en) | 2017-06-11 | 2025-04-24 | Molecular Express, Inc. | Methods and compositions for substance use disorder vaccine formulations and uses thereof |
| US11440970B2 (en) | 2017-08-15 | 2022-09-13 | Antidote Therapeutics, Inc. | Nicotine-binding antibodies |
| CN108362891B (zh) * | 2017-12-27 | 2020-09-25 | 北京勤邦生物技术有限公司 | 一种泼尼松的磁免疫化学发光检测试剂盒及其应用 |
| US11333372B2 (en) | 2018-03-09 | 2022-05-17 | Scot Matthew Duncan | Energy recovery high efficiency dehumidification system |
| US12571547B2 (en) | 2018-03-09 | 2026-03-10 | Heds Holdings Llc | Hybrid geothermal, air source, water source systems |
| EP3801594A1 (en) * | 2018-06-06 | 2021-04-14 | Antidote Therapeutics, Inc. | Methods for improving circulation and treating cardiovascular disease |
| KR102237349B1 (ko) | 2019-10-23 | 2021-04-07 | 한국과학기술연구원 | 니코틴 중독 또는 금단 증상 예방 또는 치료용 약학 조성물 |
| US20220265601A1 (en) * | 2021-02-10 | 2022-08-25 | David Alan Heldreth, JR. | Methods of use and formulations of allosteric modulators of the serotonin, dopamine and other receptor systems for medical, recreational, religious, research and other uses. |
| CN115583992B (zh) * | 2022-11-02 | 2026-02-17 | 江南大学 | 一种氧化还原响应的载体蛋白及其在制备疫苗中的应用 |
| CN116747315A (zh) * | 2023-06-20 | 2023-09-15 | 中国科学院长春应用化学研究所 | 高dar值的抗体-免疫调节药物偶联物及其制备方法和应用 |
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-
1998
- 1998-12-01 US US09/201,800 patent/US6232082B1/en not_active Expired - Fee Related
-
1999
- 1999-12-01 AU AU20335/00A patent/AU763001B2/en not_active Ceased
- 1999-12-01 CA CA2352765A patent/CA2352765C/en not_active Expired - Fee Related
- 1999-12-01 ME MEP-342/08A patent/MEP34208A/xx unknown
- 1999-12-01 KR KR1020017006805A patent/KR100656836B1/ko not_active Expired - Fee Related
- 1999-12-01 ES ES99964009T patent/ES2229800T3/es not_active Expired - Lifetime
- 1999-12-01 BR BR9915852-3A patent/BR9915852A/pt not_active IP Right Cessation
- 1999-12-01 IL IL14347499A patent/IL143474A0/xx active IP Right Grant
- 1999-12-01 EA EA200100610A patent/EA004956B1/ru not_active IP Right Cessation
- 1999-12-01 EP EP04024278A patent/EP1512414A1/en not_active Withdrawn
- 1999-12-01 HK HK02102329.6A patent/HK1042428B/en not_active IP Right Cessation
- 1999-12-01 CN CN200510092438A patent/CN100586481C/zh not_active Expired - Fee Related
- 1999-12-01 HU HU0104365A patent/HUP0104365A3/hu unknown
- 1999-12-01 EP EP10179154A patent/EP2324855A1/en not_active Withdrawn
- 1999-12-01 TR TR2001/02411T patent/TR200102411T2/xx unknown
- 1999-12-01 PL PL349012A patent/PL199253B1/pl not_active IP Right Cessation
- 1999-12-01 MX MXPA01005511A patent/MXPA01005511A/es not_active IP Right Cessation
- 1999-12-01 DK DK99964009T patent/DK1135166T3/da active
- 1999-12-01 CN CNB998139564A patent/CN1220521C/zh not_active Expired - Fee Related
- 1999-12-01 NZ NZ512103A patent/NZ512103A/en not_active IP Right Cessation
- 1999-12-01 JP JP2000584928A patent/JP4971542B2/ja not_active Expired - Fee Related
- 1999-12-01 EP EP99964009A patent/EP1135166B9/en not_active Revoked
- 1999-12-01 DE DE69921178T patent/DE69921178T2/de not_active Expired - Lifetime
- 1999-12-01 PT PT99964009T patent/PT1135166E/pt unknown
- 1999-12-01 RS YUP-396/01A patent/RS51273B/sr unknown
- 1999-12-01 AT AT99964009T patent/ATE279211T1/de active
- 1999-12-01 WO PCT/US1999/028272 patent/WO2000032239A1/en not_active Ceased
- 1999-12-01 HK HK02104914.3A patent/HK1043061B/zh not_active IP Right Cessation
-
2001
- 2001-02-16 US US09/784,139 patent/US6518031B2/en not_active Expired - Fee Related
- 2001-05-25 NO NO20012589A patent/NO331998B1/no not_active IP Right Cessation
- 2001-05-31 IL IL143474A patent/IL143474A/en not_active IP Right Cessation
- 2001-05-31 ZA ZA200104477A patent/ZA200104477B/xx unknown
-
2002
- 2002-12-30 US US10/330,676 patent/US6773891B2/en not_active Expired - Fee Related
-
2004
- 2004-08-03 US US10/909,841 patent/US7247502B2/en not_active Expired - Fee Related
-
2007
- 2007-07-20 US US11/780,742 patent/US7776620B2/en not_active Expired - Fee Related
-
2010
- 2010-07-14 US US12/836,165 patent/US8026109B2/en not_active Expired - Fee Related
- 2010-11-29 JP JP2010264835A patent/JP2011079849A/ja active Pending
-
2011
- 2011-05-13 US US13/107,460 patent/US20110217320A1/en not_active Abandoned
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