JP2002531091A - Ｐｔｈ１ｒおよびｐｔｈ３ｒレセプター - Google Patents
Ｐｔｈ１ｒおよびｐｔｈ３ｒレセプターInfo
- Publication number
- JP2002531091A JP2002531091A JP2000585406A JP2000585406A JP2002531091A JP 2002531091 A JP2002531091 A JP 2002531091A JP 2000585406 A JP2000585406 A JP 2000585406A JP 2000585406 A JP2000585406 A JP 2000585406A JP 2002531091 A JP2002531091 A JP 2002531091A
- Authority
- JP
- Japan
- Prior art keywords
- amino acid
- receptor
- pth1r
- seq
- pth3r
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
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- 238000002415 sodium dodecyl sulfate polyacrylamide gel electrophoresis Methods 0.000 description 1
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- 230000003381 solubilizing effect Effects 0.000 description 1
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- GKLVYJBZJHMRIY-UHFFFAOYSA-N technetium atom Chemical compound [Tc] GKLVYJBZJHMRIY-UHFFFAOYSA-N 0.000 description 1
- 229960002180 tetracycline Drugs 0.000 description 1
- 229930101283 tetracycline Natural products 0.000 description 1
- 235000019364 tetracycline Nutrition 0.000 description 1
- 150000003522 tetracyclines Chemical class 0.000 description 1
- 229940126585 therapeutic drug Drugs 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 229940104230 thymidine Drugs 0.000 description 1
- 230000036346 tooth eruption Effects 0.000 description 1
- 238000010361 transduction Methods 0.000 description 1
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- 230000009466 transformation Effects 0.000 description 1
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- 239000013638 trimer Substances 0.000 description 1
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- 102000003298 tumor necrosis factor receptor Human genes 0.000 description 1
- 239000000717 tumor promoter Substances 0.000 description 1
- 230000007306 turnover Effects 0.000 description 1
- 241000701161 unidentified adenovirus Species 0.000 description 1
- 241001529453 unidentified herpesvirus Species 0.000 description 1
- OGWKCGZFUXNPDA-XQKSVPLYSA-N vincristine Chemical compound C([N@]1C[C@@H](C[C@]2(C(=O)OC)C=3C(=CC4=C([C@]56[C@H]([C@@]([C@H](OC(C)=O)[C@]7(CC)C=CCN([C@H]67)CC5)(O)C(=O)OC)N4C=O)C=3)OC)C[C@@](C1)(O)CC)CC1=C2NC2=CC=CC=C12 OGWKCGZFUXNPDA-XQKSVPLYSA-N 0.000 description 1
- 229960004528 vincristine Drugs 0.000 description 1
- OGWKCGZFUXNPDA-UHFFFAOYSA-N vincristine Natural products C1C(CC)(O)CC(CC2(C(=O)OC)C=3C(=CC4=C(C56C(C(C(OC(C)=O)C7(CC)C=CCN(C67)CC5)(O)C(=O)OC)N4C=O)C=3)OC)CN1CCC1=C2NC2=CC=CC=C12 OGWKCGZFUXNPDA-UHFFFAOYSA-N 0.000 description 1
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/461—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from fish
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/18—Drugs for disorders of the endocrine system of the parathyroid hormones
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/72—Receptors; Cell surface antigens; Cell surface determinants for hormones
- C07K14/723—G protein coupled receptor, e.g. TSHR-thyrotropin-receptor, LH/hCG receptor, FSH receptor
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Zoology (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Toxicology (AREA)
- Endocrinology (AREA)
- Immunology (AREA)
- Cell Biology (AREA)
- Diabetes (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US11046798P | 1998-11-30 | 1998-11-30 | |
| US60/110,467 | 1998-11-30 | ||
| PCT/US1999/028207 WO2000032775A1 (en) | 1998-11-30 | 1999-11-30 | Pth1r and pth3r receptors |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2002531091A true JP2002531091A (ja) | 2002-09-24 |
| JP2002531091A5 JP2002531091A5 (https=) | 2006-11-24 |
Family
ID=22333168
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2000585406A Pending JP2002531091A (ja) | 1998-11-30 | 1999-11-30 | Ｐｔｈ１ｒおよびｐｔｈ３ｒレセプター |
Country Status (5)
| Country | Link |
|---|---|
| US (3) | US6541220B1 (https=) |
| EP (1) | EP1135489A1 (https=) |
| JP (1) | JP2002531091A (https=) |
| AU (2) | AU4217299A (https=) |
| WO (2) | WO2000032771A1 (https=) |
Families Citing this family (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP4486256B2 (ja) * | 1998-10-22 | 2010-06-23 | ザ・ジェネラル・ホスピタル・コーポレイション | 副甲状腺ホルモン（ＰＴＨ）および副甲状腺ホルモン関連ペプチド（ＰＴＨｒＰ）の生物活性ペプチドおよびペプチド誘導体 |
| DE69938064T2 (de) * | 1998-11-25 | 2009-01-15 | The General Hospital Corp., Boston | Aminoterminal modifizierte parathyroidhormon (pth) analoge |
| WO2000031266A1 (en) * | 1998-11-25 | 2000-06-02 | The General Hospital Corporation | Human parathyroid hormone modifications, preparation and use |
| AU4217299A (en) * | 1998-11-30 | 2000-06-19 | General Hospital Corporation, The | Pth1r and pth3r receptors, methods and uses thereof |
| US7057012B1 (en) * | 1998-12-31 | 2006-06-06 | The General Hospital Corporation | PTH functional domain conjugate peptides, derivatives thereof and novel tethered ligand-receptor molecules |
| ATE308609T1 (de) * | 1998-12-31 | 2005-11-15 | Gen Hospital Corp | Pth rezeptor und testverfahren unter verwendung desselben |
| DE69939275D1 (de) * | 1998-12-31 | 2008-09-18 | Gen Hospital Corp | Peptide, bestehend aus zwei funktionellen PTH-Domänen, die durch ein Linkermolekül verknüpft sind, und Derivate davon |
| WO2001023521A2 (en) * | 1999-09-29 | 2001-04-05 | The General Hospital Corporation | Polypeptide derivatives of parathyroid hormone (pth) |
| US6756480B2 (en) * | 2000-04-27 | 2004-06-29 | Amgen Inc. | Modulators of receptors for parathyroid hormone and parathyroid hormone-related protein |
| KR100491737B1 (ko) * | 2001-07-20 | 2005-05-27 | 주식회사 한국아이템개발 | 공기 정화 기능의 모기 퇴치기 |
| AU2002339843B2 (en) | 2001-07-23 | 2007-12-06 | The General Hospital Corporation | Conformationally constrained parathyroid hormone (PTH) analogs |
| AU2002951372A0 (en) * | 2002-09-13 | 2002-09-26 | St Vincent's Institute Of Medical Research | Parathyroid hormone-like polypeptides |
| US7795220B2 (en) * | 2003-03-19 | 2010-09-14 | The General Hospital Corporation | Conformationally constrained parathyroid hormones with alpha-helix stabilizers |
| JP4871128B2 (ja) * | 2003-07-17 | 2012-02-08 | ザ ジェネラル ホスピタル コーポレイション | 高次構造的に制約された副甲状腺ホルモン（ｐｔｈ）アナログ |
| US20060068426A1 (en) * | 2004-08-20 | 2006-03-30 | Tam James P | Cyclic peptides and antibodies thereof |
| WO2008019062A2 (en) * | 2006-08-04 | 2008-02-14 | The General Hospital Corporation | Polypeptide derivatives of parathyroid hormone (pth) |
| EP1961765A1 (en) * | 2006-12-08 | 2008-08-27 | Zealand Pharma A/S | Truncated PTH peptides with a cyclic conformation |
| CN104072606B (zh) * | 2007-08-01 | 2017-09-22 | 总医院有限公司 | 利用g蛋白偶联受体和相关组合物的筛选方法 |
| US20110256557A1 (en) * | 2008-10-31 | 2011-10-20 | Discoverybiomed, Inc. | Identifying parathyroid hormone agonists and antagonists |
| MX358161B (es) | 2010-05-13 | 2018-08-06 | The General Hospital Corp Star | Analogos de hormona paratiroidea y usos para los mismos. |
| CN109803680B (zh) * | 2016-08-01 | 2024-05-17 | 佐马美国有限公司 | 甲状旁腺激素受体1(pth1r)抗体和其用途 |
| US11975050B2 (en) | 2018-03-16 | 2024-05-07 | The General Hospital Corporation | Parathyroid hormone polypeptide conjugates and methods of their use |
| WO2022235929A1 (en) * | 2021-05-05 | 2022-11-10 | Radius Pharmaceuticals, Inc. | Animal model having homologous recombination of mouse pth1 receptor |
| CN114874325B (zh) * | 2022-06-01 | 2023-02-14 | 南京医科大学 | 抗人pth1r胞外区阻断型单域抗体及其应用 |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4423037A (en) | 1982-05-13 | 1983-12-27 | The General Hospital Corporation | Inhibitors of peptide hormone action |
| US5010010A (en) | 1986-10-22 | 1991-04-23 | Selmer-Sande, A.S. | Production of human parathyroid hormone from microorganisms |
| US5462856A (en) | 1990-07-19 | 1995-10-31 | Bunsen Rush Laboratories, Inc. | Methods for identifying chemicals that act as agonists or antagonists for receptors and other proteins involved in signal transduction via pathways that utilize G-proteins |
| DE69233472T2 (de) * | 1991-04-05 | 2006-02-09 | The General Hospital Corp., Charlestown | Parathormonrezeptor und dafür codierende DNA |
| US5208041A (en) | 1991-05-23 | 1993-05-04 | Allelix Biopharmaceuticals Inc. | Essentially pure human parathyroid hormone |
| RU2112515C1 (ru) | 1991-12-17 | 1998-06-10 | Проктер энд Гэмбл Фармасьютикалз, Инк. | Способ лечения остеопороза |
| US5814603A (en) | 1992-06-12 | 1998-09-29 | Affymax Technologies N.V. | Compounds with PTH activity |
| US5589452A (en) | 1992-07-14 | 1996-12-31 | Syntex (U.S.A.) Inc. | Analogs of parathyroid hormone and parathyroid hormone related peptide: synthesis and use for the treatment of osteoporosis |
| US5496801A (en) | 1993-12-23 | 1996-03-05 | Allelix Biopharmaceuticals Inc. | Parathyroid hormone formulation |
| JP4486256B2 (ja) * | 1998-10-22 | 2010-06-23 | ザ・ジェネラル・ホスピタル・コーポレイション | 副甲状腺ホルモン（ＰＴＨ）および副甲状腺ホルモン関連ペプチド（ＰＴＨｒＰ）の生物活性ペプチドおよびペプチド誘導体 |
| WO2000031266A1 (en) * | 1998-11-25 | 2000-06-02 | The General Hospital Corporation | Human parathyroid hormone modifications, preparation and use |
| DE69938064T2 (de) * | 1998-11-25 | 2009-01-15 | The General Hospital Corp., Boston | Aminoterminal modifizierte parathyroidhormon (pth) analoge |
| AU4217299A (en) * | 1998-11-30 | 2000-06-19 | General Hospital Corporation, The | Pth1r and pth3r receptors, methods and uses thereof |
| ATE412670T1 (de) | 1999-09-29 | 2008-11-15 | Gen Hospital Corp | Parathyroid hormon (pth) polypeptidderivate |
-
1999
- 1999-05-28 AU AU42172/99A patent/AU4217299A/en not_active Abandoned
- 1999-05-28 WO PCT/US1999/011883 patent/WO2000032771A1/en not_active Ceased
- 1999-11-30 JP JP2000585406A patent/JP2002531091A/ja active Pending
- 1999-11-30 US US09/449,632 patent/US6541220B1/en not_active Expired - Fee Related
- 1999-11-30 WO PCT/US1999/028207 patent/WO2000032775A1/en not_active Ceased
- 1999-11-30 AU AU19260/00A patent/AU1926000A/en not_active Abandoned
- 1999-11-30 EP EP99962914A patent/EP1135489A1/en not_active Withdrawn
-
2003
- 2003-02-25 US US10/372,095 patent/US7078487B2/en not_active Expired - Fee Related
-
2006
- 2006-05-25 US US11/440,090 patent/US20060228353A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| EP1135489A1 (en) | 2001-09-26 |
| US6541220B1 (en) | 2003-04-01 |
| AU1926000A (en) | 2000-06-19 |
| AU4217299A (en) | 2000-06-19 |
| WO2000032771A1 (en) | 2000-06-08 |
| WO2000032775A9 (en) | 2001-03-29 |
| WO2000032775A1 (en) | 2000-06-08 |
| US20060228353A1 (en) | 2006-10-12 |
| US7078487B2 (en) | 2006-07-18 |
| US20030162256A1 (en) | 2003-08-28 |
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