JP2002531091A5 - - Google Patents
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- Publication number
- JP2002531091A5 JP2002531091A5 JP2000585406A JP2000585406A JP2002531091A5 JP 2002531091 A5 JP2002531091 A5 JP 2002531091A5 JP 2000585406 A JP2000585406 A JP 2000585406A JP 2000585406 A JP2000585406 A JP 2000585406A JP 2002531091 A5 JP2002531091 A5 JP 2002531091A5
- Authority
- JP
- Japan
- Prior art keywords
- leu
- pth1r
- receptor
- val
- pth3r
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US11046798P | 1998-11-30 | 1998-11-30 | |
| US60/110,467 | 1998-11-30 | ||
| PCT/US1999/028207 WO2000032775A1 (en) | 1998-11-30 | 1999-11-30 | Pth1r and pth3r receptors |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2002531091A JP2002531091A (ja) | 2002-09-24 |
| JP2002531091A5 true JP2002531091A5 (https=) | 2006-11-24 |
Family
ID=22333168
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2000585406A Pending JP2002531091A (ja) | 1998-11-30 | 1999-11-30 | Ｐｔｈ１ｒおよびｐｔｈ３ｒレセプター |
Country Status (5)
| Country | Link |
|---|---|
| US (3) | US6541220B1 (https=) |
| EP (1) | EP1135489A1 (https=) |
| JP (1) | JP2002531091A (https=) |
| AU (2) | AU4217299A (https=) |
| WO (2) | WO2000032771A1 (https=) |
Families Citing this family (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU1447600A (en) * | 1998-10-22 | 2000-05-08 | Thomas J. Gardella | Bioactive peptides and peptide derivatives of parathyroid hormone (pth) and parathyroid hormone-related peptide (pthrp) |
| DE69942035D1 (de) * | 1998-11-25 | 2010-04-01 | Gen Hospital Corp | Menschliches parathyroidhormon, modifikationen, herstellung und verwendung |
| US6537965B1 (en) * | 1998-11-25 | 2003-03-25 | The General Hospital Corporation | Amino-terminal modified parathyroid hormone (PTH) analogs |
| AU4217299A (en) * | 1998-11-30 | 2000-06-19 | General Hospital Corporation, The | Pth1r and pth3r receptors, methods and uses thereof |
| US7057012B1 (en) * | 1998-12-31 | 2006-06-06 | The General Hospital Corporation | PTH functional domain conjugate peptides, derivatives thereof and novel tethered ligand-receptor molecules |
| DE69939275D1 (de) * | 1998-12-31 | 2008-09-18 | Gen Hospital Corp | Peptide, bestehend aus zwei funktionellen PTH-Domänen, die durch ein Linkermolekül verknüpft sind, und Derivate davon |
| EP1141237B1 (en) | 1998-12-31 | 2005-11-02 | The General Hospital Corporation | Pth receptor and screening assay utilizing the same |
| AU7734800A (en) * | 1999-09-29 | 2001-04-30 | General Hospital Corporation, The | Polypeptide derivatives of parathyroid hormone (pth) |
| US6756480B2 (en) * | 2000-04-27 | 2004-06-29 | Amgen Inc. | Modulators of receptors for parathyroid hormone and parathyroid hormone-related protein |
| KR100491737B1 (ko) * | 2001-07-20 | 2005-05-27 | 주식회사 한국아이템개발 | 공기 정화 기능의 모기 퇴치기 |
| CA2454275C (en) | 2001-07-23 | 2012-10-23 | The General Hospital Corporation | Conformationally constrained parathyroid hormone (pth) analogs |
| AU2002951372A0 (en) * | 2002-09-13 | 2002-09-26 | St Vincent's Institute Of Medical Research | Parathyroid hormone-like polypeptides |
| US7795220B2 (en) * | 2003-03-19 | 2010-09-14 | The General Hospital Corporation | Conformationally constrained parathyroid hormones with alpha-helix stabilizers |
| WO2005009358A2 (en) * | 2003-07-17 | 2005-02-03 | The General Hospital Corporation | Conformationally constrained parathyroid hormone (pth) analogs |
| US20060068426A1 (en) * | 2004-08-20 | 2006-03-30 | Tam James P | Cyclic peptides and antibodies thereof |
| EP2054077A4 (en) * | 2006-08-04 | 2010-10-13 | Gen Hospital Corp | POLYPEPTIDE DERIVATIVES OF PARATHYROID HORMONE (PTH) |
| EP1961765A1 (en) * | 2006-12-08 | 2008-08-27 | Zealand Pharma A/S | Truncated PTH peptides with a cyclic conformation |
| AU2008282805B2 (en) | 2007-08-01 | 2014-05-01 | Chugai Pharmaceutical Co., Ltd. | Screening methods using G-protein coupled receptors and related compositions |
| US20110256557A1 (en) * | 2008-10-31 | 2011-10-20 | Discoverybiomed, Inc. | Identifying parathyroid hormone agonists and antagonists |
| WO2011143406A2 (en) | 2010-05-13 | 2011-11-17 | The General Hospital Corporation | Parathyroid hormone analogs and uses thereof |
| WO2018026748A1 (en) * | 2016-08-01 | 2018-02-08 | Xoma (Us) Llc | Parathyroid hormone receptor 1 (pth1r) antibodies and uses thereof |
| WO2019178462A1 (en) | 2018-03-16 | 2019-09-19 | The General Hospital Corporation | Parathyroid hormone polypeptide conjugates and methods of their use |
| US20240374761A1 (en) * | 2021-05-05 | 2024-11-14 | Radius Pharmaceuticals, Inc. | Animal model having homologous recombination of mouse pth1 receptor |
| CN114874325B (zh) * | 2022-06-01 | 2023-02-14 | 南京医科大学 | 抗人pth1r胞外区阻断型单域抗体及其应用 |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4423037A (en) | 1982-05-13 | 1983-12-27 | The General Hospital Corporation | Inhibitors of peptide hormone action |
| US5010010A (en) | 1986-10-22 | 1991-04-23 | Selmer-Sande, A.S. | Production of human parathyroid hormone from microorganisms |
| US5462856A (en) | 1990-07-19 | 1995-10-31 | Bunsen Rush Laboratories, Inc. | Methods for identifying chemicals that act as agonists or antagonists for receptors and other proteins involved in signal transduction via pathways that utilize G-proteins |
| ATE287898T1 (de) * | 1991-04-05 | 2005-02-15 | Gen Hospital Corp | Parathyroid-hormon-rezeptor und seine kodierende dna |
| US5208041A (en) | 1991-05-23 | 1993-05-04 | Allelix Biopharmaceuticals Inc. | Essentially pure human parathyroid hormone |
| JPH07502507A (ja) | 1991-12-17 | 1995-03-16 | プロクター、エンド、ギャンブル、ファーマスーティカルズ、インコーポレーテッド | ビスホスホネート類及び副甲状腺ホルモンを用いた骨粗鬆症の治療方法 |
| US5814603A (en) | 1992-06-12 | 1998-09-29 | Affymax Technologies N.V. | Compounds with PTH activity |
| US5589452A (en) | 1992-07-14 | 1996-12-31 | Syntex (U.S.A.) Inc. | Analogs of parathyroid hormone and parathyroid hormone related peptide: synthesis and use for the treatment of osteoporosis |
| US5496801A (en) | 1993-12-23 | 1996-03-05 | Allelix Biopharmaceuticals Inc. | Parathyroid hormone formulation |
| AU1447600A (en) * | 1998-10-22 | 2000-05-08 | Thomas J. Gardella | Bioactive peptides and peptide derivatives of parathyroid hormone (pth) and parathyroid hormone-related peptide (pthrp) |
| DE69942035D1 (de) * | 1998-11-25 | 2010-04-01 | Gen Hospital Corp | Menschliches parathyroidhormon, modifikationen, herstellung und verwendung |
| US6537965B1 (en) * | 1998-11-25 | 2003-03-25 | The General Hospital Corporation | Amino-terminal modified parathyroid hormone (PTH) analogs |
| AU4217299A (en) * | 1998-11-30 | 2000-06-19 | General Hospital Corporation, The | Pth1r and pth3r receptors, methods and uses thereof |
| DE60040678D1 (en) | 1999-09-29 | 2008-12-11 | Gen Hospital Corp | Parathyroid hormon (pth) polypeptidderivate |
-
1999
- 1999-05-28 AU AU42172/99A patent/AU4217299A/en not_active Abandoned
- 1999-05-28 WO PCT/US1999/011883 patent/WO2000032771A1/en not_active Ceased
- 1999-11-30 WO PCT/US1999/028207 patent/WO2000032775A1/en not_active Ceased
- 1999-11-30 EP EP99962914A patent/EP1135489A1/en not_active Withdrawn
- 1999-11-30 JP JP2000585406A patent/JP2002531091A/ja active Pending
- 1999-11-30 AU AU19260/00A patent/AU1926000A/en not_active Abandoned
- 1999-11-30 US US09/449,632 patent/US6541220B1/en not_active Expired - Fee Related
-
2003
- 2003-02-25 US US10/372,095 patent/US7078487B2/en not_active Expired - Fee Related
-
2006
- 2006-05-25 US US11/440,090 patent/US20060228353A1/en not_active Abandoned
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