JP2002530268A5 - - Google Patents
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- Publication number
- JP2002530268A5 JP2002530268A5 JP2000542326A JP2000542326A JP2002530268A5 JP 2002530268 A5 JP2002530268 A5 JP 2002530268A5 JP 2000542326 A JP2000542326 A JP 2000542326A JP 2000542326 A JP2000542326 A JP 2000542326A JP 2002530268 A5 JP2002530268 A5 JP 2002530268A5
- Authority
- JP
- Japan
- Prior art keywords
- pyrazin
- ethyl
- methyl
- oxamoylpyrrolo
- benzyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP8599798 | 1998-03-31 | ||
| JP10-85997 | 1998-08-31 | ||
| JP10-244735 | 1998-08-31 | ||
| JP24473598 | 1998-08-31 | ||
| PCT/JP1999/001670 WO1999051605A1 (en) | 1998-03-31 | 1999-03-31 | PYRROLO[1,2-a]PYRAZINE sPLA2 INHIBITOR |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2002530268A JP2002530268A (ja) | 2002-09-17 |
| JP2002530268A5 true JP2002530268A5 (https=) | 2009-11-12 |
| JP4412521B2 JP4412521B2 (ja) | 2010-02-10 |
Family
ID=26427020
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2000542326A Expired - Fee Related JP4412521B2 (ja) | 1998-03-31 | 1999-03-31 | ｓＰＬＡ２阻害作用を有するピロロ［１，２−ａ］ピラジン誘導体 |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US6407104B1 (https=) |
| EP (1) | EP1066290A1 (https=) |
| JP (1) | JP4412521B2 (https=) |
| KR (1) | KR20010042307A (https=) |
| CN (1) | CN1303384A (https=) |
| AU (1) | AU3054399A (https=) |
| BR (1) | BR9909345A (https=) |
| CA (1) | CA2326522A1 (https=) |
| HU (1) | HUP0102981A3 (https=) |
| NO (1) | NO20004881L (https=) |
| WO (1) | WO1999051605A1 (https=) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2346334A1 (en) | 1998-10-14 | 2000-04-20 | Shionogi & Co., Ltd. | Composition for treating or preventing ischemia reperfusion injury |
| JP4636521B2 (ja) | 1999-07-19 | 2011-02-23 | 塩野義製薬株式会社 | ｓＰＬＡ２阻害作用を有する三環系化合物 |
| US6787545B1 (en) | 1999-08-23 | 2004-09-07 | Shiongi & Co., Ltd. | Pyrrolotriazine derivatives having spla2-inhibitory activities |
| AU7559600A (en) * | 1999-10-15 | 2001-04-23 | Shionogi & Co., Ltd. | V type and/or x type spla2 inhibitors |
| US6756376B1 (en) | 1999-11-15 | 2004-06-29 | Shionogi & Co., Ltd. | Tricyclic azaindolizine derivatives having an sPLA2-inhibitory activities |
| AU2001267825A1 (en) | 2000-06-29 | 2002-01-08 | Shionogi And Co., Ltd. | Remedies for cirrhosis |
| AU2001267823A1 (en) * | 2000-06-29 | 2002-01-08 | Shionogi And Co., Ltd. | Compounds exhibiting x-type spla2 inhibiting effect |
| AUPQ876400A0 (en) * | 2000-07-14 | 2000-08-03 | University Of Queensland, The | Compositions and method of using them |
| WO2002012249A2 (en) * | 2000-08-04 | 2002-02-14 | Eli Lilly And Company | Substituted pyrrole compounds and their use as spla2 inhibitors |
| TWI314457B (https=) * | 2001-03-19 | 2009-09-11 | Shionogi & Co | |
| US6730694B1 (en) | 2001-07-20 | 2004-05-04 | Eli Lilly And Company | sPLA2 inhibitors |
| DE10155727A1 (de) * | 2001-11-13 | 2003-05-28 | Morphochem Ag | Serin Protease Inhibitoren |
| AUPS282602A0 (en) | 2002-06-07 | 2002-06-27 | Garvan Institute Of Medical Research | Method of inhibiting cell proliferation |
| DK1910384T3 (da) * | 2005-08-04 | 2012-12-17 | Sirtris Pharmaceuticals Inc | Imidazo [2,1-b] thiazol-derivater som sirtuinmodulerende forbindelser |
| CL2008001822A1 (es) * | 2007-06-20 | 2009-03-13 | Sirtris Pharmaceuticals Inc | Compuestos derivados de tiazolo[5,4-b]piridina; composicion farmaceutica que comprende a dichos compuestos; y uso del compuesto en el tratamiento de la resistencia a la insulina, sindrome metabolico, diabetes, entre otras. |
| SG175390A1 (en) | 2009-04-29 | 2011-12-29 | Amarin Corp Plc | Pharmaceutical compositions comprising epa and a cardiovascular agent and methods of using the same |
| CN105622616A (zh) * | 2016-02-25 | 2016-06-01 | 上海雅本化学有限公司 | 一种4-氯吡咯并嘧啶的制备方法 |
| EP4378924A4 (en) * | 2021-09-17 | 2025-09-03 | Mitsui Chemicals Inc | PROCESS FOR PRODUCING A (METH)ACRYLAMIDE COMPOUND |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL109309A (en) * | 1993-04-16 | 2000-06-29 | Lilly Co Eli | 1-H-indole-3-acetic acid hydrazide SPLA2 inhibitors and pharmaceutical compositions containing them |
| IL109311A0 (en) | 1993-04-16 | 1994-07-31 | Lilly Co Eli | 1H-indole-3-acetamide sPla2 inhibitors |
| PL180523B1 (pl) | 1994-04-01 | 2001-02-28 | Eli Lilly & Co | Nowy zwiazek, pochodna 1H-indolo-3-glioksylamidu i srodek farmaceutyczny PL PL PL PL PL PL PL PL PL PL |
| JPH10505584A (ja) | 1994-07-21 | 1998-06-02 | イーライ・リリー・アンド・カンパニー | インドリジンｓＰＬＡ▲下２▼インヒビター |
| US5641800A (en) | 1994-07-21 | 1997-06-24 | Eli Lilly And Company | 1H-indole-1-functional sPLA2 inhibitors |
| US6214876B1 (en) * | 1994-07-21 | 2001-04-10 | Eli Lilly And Company | Indene-1-acetamide sPLA2 inhibitors |
| AU1289797A (en) | 1995-12-13 | 1997-07-03 | Eli Lilly And Company | Naphthyl acetamides as spla2 inhibitors |
| KR19990072111A (ko) | 1995-12-13 | 1999-09-27 | 피터 지. 스트링거 | Spla2 억제제인 나프틸 글리옥스아미드 |
| JP2001503055A (ja) | 1996-10-30 | 2001-03-06 | イーライ・リリー・アンド・カンパニー | 置換三環化合物群 |
| US6353128B1 (en) | 1996-12-03 | 2002-03-05 | Eli Lilly And Company | Phenyl acetamides as sPLA2 inhibitors |
| US5916922A (en) | 1996-12-03 | 1999-06-29 | Eli Lilly And Company | Phenyl glyoxamides as SPLA2 inhibitors |
| ID18983A (id) | 1996-12-04 | 1998-05-28 | Lilly Co Eli | Pirazola sebagai inhibitor sekresi fosfolipase a2 non-pankreas pada manusia |
| US5919774A (en) | 1996-12-10 | 1999-07-06 | Eli Lilly And Company | Pyrroles as sPLA2 inhibitors |
| TW455581B (en) | 1997-06-26 | 2001-09-21 | Lilly Co Eli | Process for preparing 4-substituted-1H-indole-3-glyoxamides |
-
1999
- 1999-03-31 AU AU30543/99A patent/AU3054399A/en not_active Abandoned
- 1999-03-31 CA CA002326522A patent/CA2326522A1/en not_active Abandoned
- 1999-03-31 JP JP2000542326A patent/JP4412521B2/ja not_active Expired - Fee Related
- 1999-03-31 KR KR1020007010855A patent/KR20010042307A/ko not_active Ceased
- 1999-03-31 BR BR9909345-6A patent/BR9909345A/pt not_active IP Right Cessation
- 1999-03-31 US US09/623,591 patent/US6407104B1/en not_active Expired - Fee Related
- 1999-03-31 CN CN99806627A patent/CN1303384A/zh active Pending
- 1999-03-31 HU HU0102981A patent/HUP0102981A3/hu unknown
- 1999-03-31 WO PCT/JP1999/001670 patent/WO1999051605A1/en not_active Ceased
- 1999-03-31 EP EP99912066A patent/EP1066290A1/en not_active Ceased
-
2000
- 2000-09-28 NO NO20004881A patent/NO20004881L/no unknown
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