JP2002530111A5 - - Google Patents
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- Publication number
- JP2002530111A5 JP2002530111A5 JP2000584075A JP2000584075A JP2002530111A5 JP 2002530111 A5 JP2002530111 A5 JP 2002530111A5 JP 2000584075 A JP2000584075 A JP 2000584075A JP 2000584075 A JP2000584075 A JP 2000584075A JP 2002530111 A5 JP2002530111 A5 JP 2002530111A5
- Authority
- JP
- Japan
- Prior art keywords
- amino acids
- peptide
- composition
- embedded image
- hpth
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 150000001413 amino acids Chemical class 0.000 description 32
- 108090000765 processed proteins & peptides Proteins 0.000 description 32
- 239000000203 mixture Substances 0.000 description 21
- 239000012634 fragment Substances 0.000 description 8
- 210000000988 bone and bone Anatomy 0.000 description 7
- 210000004027 cell Anatomy 0.000 description 6
- 150000003839 salts Chemical class 0.000 description 6
- 102000053602 DNA Human genes 0.000 description 4
- 208000001132 Osteoporosis Diseases 0.000 description 4
- 108020004511 Recombinant DNA Proteins 0.000 description 4
- 239000003937 drug carrier Substances 0.000 description 4
- 108700000288 parathyroid hormone (1-28) Proteins 0.000 description 4
- 125000003275 alpha amino acid group Chemical group 0.000 description 2
- 230000001580 bacterial effect Effects 0.000 description 2
- 238000000034 method Methods 0.000 description 2
- 108020004707 nucleic acids Proteins 0.000 description 2
- 102000039446 nucleic acids Human genes 0.000 description 2
- 150000007523 nucleic acids Chemical class 0.000 description 2
- 239000008194 pharmaceutical composition Substances 0.000 description 2
- 108091033319 polynucleotide Proteins 0.000 description 2
- 102000040430 polynucleotide Human genes 0.000 description 2
- 239000002157 polynucleotide Substances 0.000 description 2
- 208000006386 Bone Resorption Diseases 0.000 description 1
- 241000124008 Mammalia Species 0.000 description 1
- 206010039984 Senile osteoporosis Diseases 0.000 description 1
- 230000010072 bone remodeling Effects 0.000 description 1
- 230000024279 bone resorption Effects 0.000 description 1
- 210000003527 eukaryotic cell Anatomy 0.000 description 1
- 239000007850 fluorescent dye Substances 0.000 description 1
- 230000002538 fungal effect Effects 0.000 description 1
- 238000001727 in vivo Methods 0.000 description 1
- 210000004962 mammalian cell Anatomy 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 230000011164 ossification Effects 0.000 description 1
- 238000007911 parenteral administration Methods 0.000 description 1
- 208000001685 postmenopausal osteoporosis Diseases 0.000 description 1
- 102000004196 processed proteins & peptides Human genes 0.000 description 1
- 210000001236 prokaryotic cell Anatomy 0.000 description 1
- 238000007920 subcutaneous administration Methods 0.000 description 1
- 230000003612 virological effect Effects 0.000 description 1
- 210000005253 yeast cell Anatomy 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US10993898P | 1998-11-25 | 1998-11-25 | |
| US60/109,938 | 1998-11-25 | ||
| PCT/US1999/027863 WO2000031266A1 (en) | 1998-11-25 | 1999-11-24 | Human parathyroid hormone modifications, preparation and use |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2002530111A JP2002530111A (ja) | 2002-09-17 |
| JP2002530111A5 true JP2002530111A5 (enExample) | 2007-01-25 |
| JP4486258B2 JP4486258B2 (ja) | 2010-06-23 |
Family
ID=22330386
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2000584075A Expired - Fee Related JP4486258B2 (ja) | 1998-11-25 | 1999-11-24 | ヒト副甲状腺ホルモンの改変、調製および使用 |
Country Status (7)
| Country | Link |
|---|---|
| US (3) | US6417333B1 (enExample) |
| EP (1) | EP1133560B1 (enExample) |
| JP (1) | JP4486258B2 (enExample) |
| AT (1) | ATE458054T1 (enExample) |
| AU (1) | AU1633200A (enExample) |
| DE (1) | DE69942035D1 (enExample) |
| WO (1) | WO2000031266A1 (enExample) |
Families Citing this family (32)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6417133B1 (en) * | 1998-02-25 | 2002-07-09 | Monsanto Technology Llc | Deeply reduced oxidation catalyst and its use for catalyzing liquid phase oxidation reactions |
| AU1447600A (en) * | 1998-10-22 | 2000-05-08 | Thomas J. Gardella | Bioactive peptides and peptide derivatives of parathyroid hormone (pth) and parathyroid hormone-related peptide (pthrp) |
| DE69942035D1 (de) * | 1998-11-25 | 2010-04-01 | Gen Hospital Corp | Menschliches parathyroidhormon, modifikationen, herstellung und verwendung |
| WO2000031137A1 (en) * | 1998-11-25 | 2000-06-02 | The General Hospital Corporation | Amino-terminal modified parathyroid hormone (pth) analogs |
| AU4217299A (en) * | 1998-11-30 | 2000-06-19 | General Hospital Corporation, The | Pth1r and pth3r receptors, methods and uses thereof |
| EP1612263A1 (en) * | 1998-12-31 | 2006-01-04 | The General Hospital Corporation | PTH receptor and screening assay utilizing the same |
| US7057012B1 (en) * | 1998-12-31 | 2006-06-06 | The General Hospital Corporation | PTH functional domain conjugate peptides, derivatives thereof and novel tethered ligand-receptor molecules |
| EP1147133B1 (en) * | 1998-12-31 | 2008-08-06 | The General Hospital Corporation | Peptides consisting of two PTH functional domains fused by a linker molecule, and derivatives thereof |
| WO2001023521A2 (en) | 1999-09-29 | 2001-04-05 | The General Hospital Corporation | Polypeptide derivatives of parathyroid hormone (pth) |
| ES2316354T3 (es) * | 1999-09-29 | 2009-04-16 | The General Hospital Corporation | Derivados polipeptidos de la hormona paratiroidea (pth). |
| US7022815B1 (en) | 1999-09-29 | 2006-04-04 | The General Hospital Corporation | Polypeptide derivatives of parathyroid hormone (PTH) |
| US6756480B2 (en) * | 2000-04-27 | 2004-06-29 | Amgen Inc. | Modulators of receptors for parathyroid hormone and parathyroid hormone-related protein |
| US20050124537A1 (en) * | 2000-04-27 | 2005-06-09 | Amgen Inc. | Modulators of receptors for parathyroid hormone and parathyroid hormone-related protein |
| KR100491737B1 (ko) * | 2001-07-20 | 2005-05-27 | 주식회사 한국아이템개발 | 공기 정화 기능의 모기 퇴치기 |
| US7572765B2 (en) | 2001-07-23 | 2009-08-11 | The General Hospital Corporation | Conformationally constrained parathyroid hormone (PTH) analogs |
| WO2003048665A1 (en) | 2001-12-03 | 2003-06-12 | Massachusetts Institute Of Technology | Microscale lyophilization and drying methods for the stabilization of molecules |
| AU2003278766A1 (en) | 2002-09-04 | 2004-03-29 | Microchips, Inc. | Method and device for the controlled delivery of parathyroid hormone |
| AU2002951372A0 (en) * | 2002-09-13 | 2002-09-26 | St Vincent's Institute Of Medical Research | Parathyroid hormone-like polypeptides |
| EP1567178A4 (en) * | 2002-11-01 | 2009-07-15 | Amgen Inc | MODULATORS OF RECEPTORS FOR NEUTRAL THERAPY HORMONE AND SIDE-HORSE HORMONE-RELATED PROTEINS |
| AU2003220380A1 (en) * | 2003-03-19 | 2004-11-19 | Bristol-Myers Squibb Company | CONFORMATIONALLY CONSTRAINED PARATHYROID HORMONES WITH Alpha-HELIX STABILIZERS |
| JP4871128B2 (ja) * | 2003-07-17 | 2012-02-08 | ザ ジェネラル ホスピタル コーポレイション | 高次構造的に制約された副甲状腺ホルモン（ｐｔｈ）アナログ |
| US7488316B2 (en) | 2005-01-25 | 2009-02-10 | Microchips, Inc. | Control of drug release by transient modification of local microenvironments |
| EP2054077A4 (en) * | 2006-08-04 | 2010-10-13 | Gen Hospital Corp | POLYPEPTIDE DERIVATIVES OF PARATHYROID HORMONE (PTH) |
| EP1961765A1 (en) * | 2006-12-08 | 2008-08-27 | Zealand Pharma A/S | Truncated PTH peptides with a cyclic conformation |
| BRPI0814962B8 (pt) | 2007-08-01 | 2021-05-25 | Chugai Pharmaceutical Co Ltd | métodos in vitro para determinar se um composto candidato é um agonista de longa duração ou de curta duração de um receptor acoplado à proteína g, polipeptídeo, seu uso e composição farmacêutica |
| US8563513B2 (en) | 2009-03-27 | 2013-10-22 | Van Andel Research Institute | Parathyroid hormone peptides and parathyroid hormone-related protein peptides and methods of use |
| US9492508B2 (en) | 2010-05-13 | 2016-11-15 | The General Hospital Corporation | Parathyroid hormone analogs and uses thereof |
| US9757388B2 (en) | 2011-05-13 | 2017-09-12 | Acerus Pharmaceuticals Srl | Intranasal methods of treating women for anorgasmia with 0.6% and 0.72% testosterone gels |
| US20130040923A1 (en) | 2011-05-13 | 2013-02-14 | Trimel Pharmaceuticals Corporation | Intranasal lower dosage strength testosterone gel formulations and use thereof for treating anorgasmia or hypoactive sexual desire disorder |
| US20130045958A1 (en) | 2011-05-13 | 2013-02-21 | Trimel Pharmaceuticals Corporation | Intranasal 0.15% and 0.24% testosterone gel formulations and use thereof for treating anorgasmia or hypoactive sexual desire disorder |
| US11744838B2 (en) | 2013-03-15 | 2023-09-05 | Acerus Biopharma Inc. | Methods of treating hypogonadism with transnasal testosterone bio-adhesive gel formulations in male with allergic rhinitis, and methods for preventing an allergic rhinitis event |
| EP3765061A4 (en) | 2018-03-16 | 2022-01-26 | The General Hospital Corporation | PARATHORMON-POLYPEPTIDE CONJUGATES AND METHODS OF USE |
Family Cites Families (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1991005050A1 (en) * | 1989-09-29 | 1991-04-18 | Her Majesty In Right Of Canada As Represented By The National Research Council Of Canada | Synthesis of mature human parathyroid hormone |
| US5350836A (en) * | 1989-10-12 | 1994-09-27 | Ohio University | Growth hormone antagonists |
| AU672790B2 (en) | 1992-07-15 | 1996-10-17 | Novartis Ag | Variants of parathyroid hormone and its fragments |
| US5556940A (en) * | 1994-06-20 | 1996-09-17 | National Research Council Of Canada | Parathyroid hormone analogues for the treatment of osteoporosis |
| CA2178894A1 (en) * | 1995-06-15 | 1996-12-16 | Tsunehiko Fukuda | Parathyroid hormone derivatives and their use |
| JP4122061B2 (ja) * | 1996-08-02 | 2008-07-23 | ナショナル リサーチ カウンシル オブ カナダ | 骨粗鬆症の治寮のための副甲状腺ホルモン類似体 |
| EP1030658A1 (en) * | 1997-10-14 | 2000-08-30 | Eli Lilly And Company | Method of building and maintaining bone |
| AU1447600A (en) | 1998-10-22 | 2000-05-08 | Thomas J. Gardella | Bioactive peptides and peptide derivatives of parathyroid hormone (pth) and parathyroid hormone-related peptide (pthrp) |
| WO2000031137A1 (en) * | 1998-11-25 | 2000-06-02 | The General Hospital Corporation | Amino-terminal modified parathyroid hormone (pth) analogs |
| DE69942035D1 (de) * | 1998-11-25 | 2010-04-01 | Gen Hospital Corp | Menschliches parathyroidhormon, modifikationen, herstellung und verwendung |
| AU4217299A (en) | 1998-11-30 | 2000-06-19 | General Hospital Corporation, The | Pth1r and pth3r receptors, methods and uses thereof |
| EP1147133B1 (en) | 1998-12-31 | 2008-08-06 | The General Hospital Corporation | Peptides consisting of two PTH functional domains fused by a linker molecule, and derivatives thereof |
| EP1612263A1 (en) | 1998-12-31 | 2006-01-04 | The General Hospital Corporation | PTH receptor and screening assay utilizing the same |
| ES2316354T3 (es) | 1999-09-29 | 2009-04-16 | The General Hospital Corporation | Derivados polipeptidos de la hormona paratiroidea (pth). |
| US7572765B2 (en) | 2001-07-23 | 2009-08-11 | The General Hospital Corporation | Conformationally constrained parathyroid hormone (PTH) analogs |
| US7521528B2 (en) | 2003-01-24 | 2009-04-21 | The General Hospital Corporation | Conformationally constrained parathyroid hormone (PTH) analogs with lactam bridges |
| AU2003220380A1 (en) | 2003-03-19 | 2004-11-19 | Bristol-Myers Squibb Company | CONFORMATIONALLY CONSTRAINED PARATHYROID HORMONES WITH Alpha-HELIX STABILIZERS |
| JP4871128B2 (ja) | 2003-07-17 | 2012-02-08 | ザ ジェネラル ホスピタル コーポレイション | 高次構造的に制約された副甲状腺ホルモン（ｐｔｈ）アナログ |
-
1999
- 1999-11-24 DE DE69942035T patent/DE69942035D1/de not_active Expired - Lifetime
- 1999-11-24 US US09/448,867 patent/US6417333B1/en not_active Expired - Lifetime
- 1999-11-24 AU AU16332/00A patent/AU1633200A/en not_active Abandoned
- 1999-11-24 WO PCT/US1999/027863 patent/WO2000031266A1/en not_active Ceased
- 1999-11-24 EP EP99959086A patent/EP1133560B1/en not_active Expired - Lifetime
- 1999-11-24 AT AT99959086T patent/ATE458054T1/de not_active IP Right Cessation
- 1999-11-24 JP JP2000584075A patent/JP4486258B2/ja not_active Expired - Fee Related
-
2002
- 2002-05-30 US US10/157,076 patent/US6803213B2/en not_active Expired - Fee Related
-
2004
- 2004-10-07 US US10/959,605 patent/US7479478B2/en not_active Expired - Fee Related
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