JP2003533167A5 - - Google Patents

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Publication number
JP2003533167A5
JP2003533167A5 JP2000583963A JP2000583963A JP2003533167A5 JP 2003533167 A5 JP2003533167 A5 JP 2003533167A5 JP 2000583963 A JP2000583963 A JP 2000583963A JP 2000583963 A JP2000583963 A JP 2000583963A JP 2003533167 A5 JP2003533167 A5 JP 2003533167A5
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JP
Japan
Prior art keywords
desamino
peptide
ser
composition
hpth
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2000583963A
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English (en)
Japanese (ja)
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JP2003533167A (ja
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Publication date
Application filed filed Critical
Priority claimed from PCT/US1999/027656 external-priority patent/WO2000031137A1/en
Publication of JP2003533167A publication Critical patent/JP2003533167A/ja
Publication of JP2003533167A5 publication Critical patent/JP2003533167A5/ja
Pending legal-status Critical Current

Links

JP2000583963A 1998-11-25 1999-11-23 アミノ末端改変副甲状腺ホルモン(pth)アナログ Pending JP2003533167A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US11015298P 1998-11-25 1998-11-25
US60/110,152 1998-11-25
PCT/US1999/027656 WO2000031137A1 (en) 1998-11-25 1999-11-23 Amino-terminal modified parathyroid hormone (pth) analogs

Publications (2)

Publication Number Publication Date
JP2003533167A JP2003533167A (ja) 2003-11-11
JP2003533167A5 true JP2003533167A5 (enExample) 2007-02-01

Family

ID=22331485

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2000583963A Pending JP2003533167A (ja) 1998-11-25 1999-11-23 アミノ末端改変副甲状腺ホルモン(pth)アナログ

Country Status (7)

Country Link
US (2) US6537965B1 (enExample)
EP (1) EP1175444B1 (enExample)
JP (1) JP2003533167A (enExample)
AT (1) ATE384743T1 (enExample)
AU (1) AU1918300A (enExample)
DE (1) DE69938064T2 (enExample)
WO (1) WO2000031137A1 (enExample)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU1447600A (en) * 1998-10-22 2000-05-08 Thomas J. Gardella Bioactive peptides and peptide derivatives of parathyroid hormone (pth) and parathyroid hormone-related peptide (pthrp)
EP1133560B1 (en) * 1998-11-25 2010-02-17 The General Hospital Corporation Human parathyroid hormone modifications, preparation and use
WO2000032771A1 (en) * 1998-11-30 2000-06-08 The General Hospital Corporation Pth1r and pth3r receptors, methods and uses thereof
ATE308609T1 (de) 1998-12-31 2005-11-15 Gen Hospital Corp Pth rezeptor und testverfahren unter verwendung desselben
US7057012B1 (en) * 1998-12-31 2006-06-06 The General Hospital Corporation PTH functional domain conjugate peptides, derivatives thereof and novel tethered ligand-receptor molecules
WO2000039278A2 (en) * 1998-12-31 2000-07-06 The General Hospital Corporation Pth functional domain conjugate peptides, derivatives thereof and novel tethered ligand-receptor molecules
AU7734800A (en) * 1999-09-29 2001-04-30 General Hospital Corporation, The Polypeptide derivatives of parathyroid hormone (pth)
US6756480B2 (en) 2000-04-27 2004-06-29 Amgen Inc. Modulators of receptors for parathyroid hormone and parathyroid hormone-related protein
AU2001292905A1 (en) * 2000-09-19 2002-04-02 Curagen Corporation Method of identifying osteoregenerative agents using differential gene expression
KR100491737B1 (ko) * 2001-07-20 2005-05-27 주식회사 한국아이템개발 공기 정화 기능의 모기 퇴치기
CA2454275C (en) * 2001-07-23 2012-10-23 The General Hospital Corporation Conformationally constrained parathyroid hormone (pth) analogs
ATE443527T1 (de) * 2001-08-17 2009-10-15 Novartis Pharma Gmbh 5-cnac zur oralen verabreichung von parathormonfragmenten
WO2003099849A2 (en) 2002-05-23 2003-12-04 Michael Holick Use of a parathyroid hormone peptide analogs for the treatment of vaginal atrophy
WO2003105772A2 (en) * 2002-06-13 2003-12-24 Beth Israel Deaconess Medical Center, Inc. Analogs of parathyroid hormone and pth-related protein as bone anabolic agents
AU2002951372A0 (en) * 2002-09-13 2002-09-26 St Vincent's Institute Of Medical Research Parathyroid hormone-like polypeptides
US8088734B2 (en) 2003-01-21 2012-01-03 Unigene Laboratories Inc. Oral delivery of peptides
EP2201960A1 (en) * 2003-03-19 2010-06-30 The General Hospital Corporation Conformationally constrained parathyroid hormones with alpha-helix stabilizers
BRPI0412664A (pt) * 2003-07-15 2006-09-26 Ca Nat Research Council método para tratar uma condição caracterizada por hiperproliferação de células da pele em um indivìduo em risco ou portador dessa condição e utilização de uma quantidade terapeuticamente efetiva de um análogo cìclico de hormÈnio de paratireóide humano (hpth)
JP4871128B2 (ja) * 2003-07-17 2012-02-08 ザ ジェネラル ホスピタル コーポレイション 高次構造的に制約された副甲状腺ホルモン(pth)アナログ
CN100566669C (zh) * 2004-05-13 2009-12-09 阿尔扎公司 甲状旁腺激素药物的透皮释放装置
EP1744683B1 (en) * 2004-05-13 2016-03-16 Alza Corporation Apparatus and method for transdermal delivery of parathyroid hormone agents
US8143374B2 (en) * 2006-08-04 2012-03-27 The General Hospital Corporation Polypeptide derivatives of parathyroid hormone (PTH)
EP1961765A1 (en) * 2006-12-08 2008-08-27 Zealand Pharma A/S Truncated PTH peptides with a cyclic conformation
US20090023655A1 (en) * 2007-04-02 2009-01-22 Louis Luttrell Biased Ligands for Receptors Such as the PTH Receptor
MX353986B (es) 2007-08-01 2017-11-06 Massachusetts Gen Hospital Metodos de analisis y seleccion usando receptores acoplados a proteina g y composiciones relacionadas.
CN102448482A (zh) 2009-03-27 2012-05-09 范安德尔研究所 甲状旁腺素肽和甲状旁腺素相关蛋白肽及使用方法
CN103002906B (zh) 2010-05-13 2017-12-29 总医院有限公司 甲状旁腺激素类似物及其应用
WO2019178462A1 (en) 2018-03-16 2019-09-19 The General Hospital Corporation Parathyroid hormone polypeptide conjugates and methods of their use

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5896052A (ja) * 1981-11-30 1983-06-07 Toyo Jozo Co Ltd 高活性h−PTH(1−34)アミドの製造法
US4423037A (en) * 1982-05-13 1983-12-27 The General Hospital Corporation Inhibitors of peptide hormone action
JPS59204159A (ja) * 1983-04-28 1984-11-19 Toyo Jozo Co Ltd 〔Met(O)↑8’↑1↑8〕hPTH−(1−34)ペプチド
IL78342A (en) * 1985-04-04 1991-06-10 Gen Hospital Corp Pharmaceutical composition for treatment of osteoporosis in humans comprising a parathyroid hormone or a fragment thereof
US5527772A (en) 1987-10-20 1996-06-18 Holick; Michael F. Regulation of cell proliferation and differentiation using peptides
US5605815A (en) * 1988-03-14 1997-02-25 Yale University Nucleic acids encoding and expression of parathyroid hormone-like peptide
US5350836A (en) * 1989-10-12 1994-09-27 Ohio University Growth hormone antagonists
US5814603A (en) * 1992-06-12 1998-09-29 Affymax Technologies N.V. Compounds with PTH activity
US5589452A (en) * 1992-07-14 1996-12-31 Syntex (U.S.A.) Inc. Analogs of parathyroid hormone and parathyroid hormone related peptide: synthesis and use for the treatment of osteoporosis
AU1447600A (en) * 1998-10-22 2000-05-08 Thomas J. Gardella Bioactive peptides and peptide derivatives of parathyroid hormone (pth) and parathyroid hormone-related peptide (pthrp)
EP1133560B1 (en) * 1998-11-25 2010-02-17 The General Hospital Corporation Human parathyroid hormone modifications, preparation and use
WO2000032771A1 (en) * 1998-11-30 2000-06-08 The General Hospital Corporation Pth1r and pth3r receptors, methods and uses thereof

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