ATE384743T1 - Aminoterminal modifizierte parathyroidhormon (pth) analoge - Google Patents
Aminoterminal modifizierte parathyroidhormon (pth) analogeInfo
- Publication number
- ATE384743T1 ATE384743T1 AT99962819T AT99962819T ATE384743T1 AT E384743 T1 ATE384743 T1 AT E384743T1 AT 99962819 T AT99962819 T AT 99962819T AT 99962819 T AT99962819 T AT 99962819T AT E384743 T1 ATE384743 T1 AT E384743T1
- Authority
- AT
- Austria
- Prior art keywords
- pth
- desamino
- aminoterminal
- analogue
- parathyroid hormone
- Prior art date
Links
- 108090000445 Parathyroid hormone Proteins 0.000 title abstract 3
- 102000003982 Parathyroid hormone Human genes 0.000 title 2
- 239000000199 parathyroid hormone Substances 0.000 title 2
- 229960001319 parathyroid hormone Drugs 0.000 title 2
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 3
- 150000001413 amino acids Chemical group 0.000 abstract 2
- 102100030869 Parathyroid hormone 2 receptor Human genes 0.000 abstract 1
- 101710149426 Parathyroid hormone 2 receptor Proteins 0.000 abstract 1
- 102100032256 Parathyroid hormone/parathyroid hormone-related peptide receptor Human genes 0.000 abstract 1
- 101710180613 Parathyroid hormone/parathyroid hormone-related peptide receptor Proteins 0.000 abstract 1
- 239000012634 fragment Substances 0.000 abstract 1
- 108091002540 human parathyroid hormone (1-31)amide Proteins 0.000 abstract 1
- 102000032129 human parathyroid hormone (1-31)amide Human genes 0.000 abstract 1
- OXZNHYPGOAWYLT-FISSOZIDSA-N ostabolin Chemical compound C([C@H](NC(=O)[C@H](CCSC)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@@H](N)CO)C(C)C)[C@@H](C)CC)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC1N=CN=C1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCSC)C(=O)OC(=O)CC[C@H](NC(=O)[C@@H](NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](N)CCC(O)=O)C(C)C)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CC(C)C)C(=O)NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](N)CCCNC(N)=N)C(C)C)C1C=NC=N1 OXZNHYPGOAWYLT-FISSOZIDSA-N 0.000 abstract 1
- 108010067557 parathyroid hormone (1-34)amide Proteins 0.000 abstract 1
- RRBCHMCWWOHRQL-UMXFMPSGSA-N parathyroid hormone (1-34)amide Chemical compound C([C@H](NC(=O)[C@H](CCSC)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@@H](N)CO)C(C)C)[C@@H](C)CC)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC=1NC=NC=1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC=1NC=NC=1)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC=1C=CC=CC=1)C(N)=O)C1=CN=CN1 RRBCHMCWWOHRQL-UMXFMPSGSA-N 0.000 abstract 1
- 239000000018 receptor agonist Substances 0.000 abstract 1
- 229940044601 receptor agonist Drugs 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 238000006467 substitution reaction Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/635—Parathyroid hormone, i.e. parathormone; Parathyroid hormone-related peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
- A61P3/14—Drugs for disorders of the metabolism for electrolyte homeostasis for calcium homeostasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Endocrinology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Physical Education & Sports Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Rheumatology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Toxicology (AREA)
- Molecular Biology (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US11015298P | 1998-11-25 | 1998-11-25 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE384743T1 true ATE384743T1 (de) | 2008-02-15 |
Family
ID=22331485
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT99962819T ATE384743T1 (de) | 1998-11-25 | 1999-11-23 | Aminoterminal modifizierte parathyroidhormon (pth) analoge |
Country Status (7)
| Country | Link |
|---|---|
| US (2) | US6537965B1 (enExample) |
| EP (1) | EP1175444B1 (enExample) |
| JP (1) | JP2003533167A (enExample) |
| AT (1) | ATE384743T1 (enExample) |
| AU (1) | AU1918300A (enExample) |
| DE (1) | DE69938064T2 (enExample) |
| WO (1) | WO2000031137A1 (enExample) |
Families Citing this family (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP4486256B2 (ja) * | 1998-10-22 | 2010-06-23 | ザ・ジェネラル・ホスピタル・コーポレイション | 副甲状腺ホルモン（ＰＴＨ）および副甲状腺ホルモン関連ペプチド（ＰＴＨｒＰ）の生物活性ペプチドおよびペプチド誘導体 |
| US6417333B1 (en) * | 1998-11-25 | 2002-07-09 | The General Hospital Corporation | Modified human parathyroid hormone |
| WO2000032771A1 (en) * | 1998-11-30 | 2000-06-08 | The General Hospital Corporation | Pth1r and pth3r receptors, methods and uses thereof |
| DE69939275D1 (de) * | 1998-12-31 | 2008-09-18 | Gen Hospital Corp | Peptide, bestehend aus zwei funktionellen PTH-Domänen, die durch ein Linkermolekül verknüpft sind, und Derivate davon |
| US7169567B1 (en) * | 1998-12-31 | 2007-01-30 | The General Hospital Corporation | Screening assay utilizing the PTH receptor |
| US7057012B1 (en) * | 1998-12-31 | 2006-06-06 | The General Hospital Corporation | PTH functional domain conjugate peptides, derivatives thereof and novel tethered ligand-receptor molecules |
| AU7734800A (en) * | 1999-09-29 | 2001-04-30 | General Hospital Corporation, The | Polypeptide derivatives of parathyroid hormone (pth) |
| US6756480B2 (en) | 2000-04-27 | 2004-06-29 | Amgen Inc. | Modulators of receptors for parathyroid hormone and parathyroid hormone-related protein |
| AU2001292905A1 (en) * | 2000-09-19 | 2002-04-02 | Curagen Corporation | Method of identifying osteoregenerative agents using differential gene expression |
| KR100491737B1 (ko) * | 2001-07-20 | 2005-05-27 | 주식회사 한국아이템개발 | 공기 정화 기능의 모기 퇴치기 |
| US7572765B2 (en) | 2001-07-23 | 2009-08-11 | The General Hospital Corporation | Conformationally constrained parathyroid hormone (PTH) analogs |
| DE60233803D1 (de) * | 2001-08-17 | 2009-11-05 | Novartis Ag | 5-cnac zur oralen verabreichung von parathormonfragmenten |
| AU2003239869A1 (en) | 2002-05-23 | 2003-12-12 | Michael Holick | Use of a parathyroid hormone peptide analogs for the treatment of vaginal atrophy |
| US7799757B2 (en) * | 2002-06-13 | 2010-09-21 | Michael Chorev | Analogs of parathyroid hormone and PTH-related protein as bone anabolic agents |
| AU2002951372A0 (en) * | 2002-09-13 | 2002-09-26 | St Vincent's Institute Of Medical Research | Parathyroid hormone-like polypeptides |
| US8088734B2 (en) | 2003-01-21 | 2012-01-03 | Unigene Laboratories Inc. | Oral delivery of peptides |
| AU2003220380A1 (en) * | 2003-03-19 | 2004-11-19 | Bristol-Myers Squibb Company | CONFORMATIONALLY CONSTRAINED PARATHYROID HORMONES WITH Alpha-HELIX STABILIZERS |
| CN1822853A (zh) * | 2003-07-15 | 2006-08-23 | 加拿大国家研究委员会 | 用于治疗特征在于过度增殖皮肤细胞的疾病的人类甲状旁腺激素环状类似物 |
| EP1653985A4 (en) * | 2003-07-17 | 2009-08-05 | Gen Hospital Corp | FORCED PARATHORMON (PTH) ANALOGUE |
| MXPA06013168A (es) * | 2004-05-13 | 2007-05-15 | Johnson & Johnson | Aparato y metodo para el suministro transdermico de agentes de la hormona paratiroidea. |
| CN100566669C (zh) * | 2004-05-13 | 2009-12-09 | 阿尔扎公司 | 甲状旁腺激素药物的透皮释放装置 |
| WO2008019062A2 (en) * | 2006-08-04 | 2008-02-14 | The General Hospital Corporation | Polypeptide derivatives of parathyroid hormone (pth) |
| EP1961765A1 (en) * | 2006-12-08 | 2008-08-27 | Zealand Pharma A/S | Truncated PTH peptides with a cyclic conformation |
| US20090023655A1 (en) * | 2007-04-02 | 2009-01-22 | Louis Luttrell | Biased Ligands for Receptors Such as the PTH Receptor |
| BRPI0814962B8 (pt) * | 2007-08-01 | 2021-05-25 | Chugai Pharmaceutical Co Ltd | métodos in vitro para determinar se um composto candidato é um agonista de longa duração ou de curta duração de um receptor acoplado à proteína g, polipeptídeo, seu uso e composição farmacêutica |
| WO2010111617A2 (en) | 2009-03-27 | 2010-09-30 | Van Andel Research Institute | Parathyroid hormone peptides and parathyroid hormone-related protein peptides and methods of use |
| CN103002906B (zh) | 2010-05-13 | 2017-12-29 | 总医院有限公司 | 甲状旁腺激素类似物及其应用 |
| US11975050B2 (en) | 2018-03-16 | 2024-05-07 | The General Hospital Corporation | Parathyroid hormone polypeptide conjugates and methods of their use |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5896052A (ja) * | 1981-11-30 | 1983-06-07 | Toyo Jozo Co Ltd | 高活性ｈ−ＰＴＨ（１−３４）アミドの製造法 |
| US4423037A (en) * | 1982-05-13 | 1983-12-27 | The General Hospital Corporation | Inhibitors of peptide hormone action |
| JPS59204159A (ja) * | 1983-04-28 | 1984-11-19 | Toyo Jozo Co Ltd | 〔Ｍｅｔ（Ｏ）↑８’↑１↑８〕ｈＰＴＨ−（１−３４）ペプチド |
| IL78342A (en) * | 1985-04-04 | 1991-06-10 | Gen Hospital Corp | Pharmaceutical composition for treatment of osteoporosis in humans comprising a parathyroid hormone or a fragment thereof |
| US5527772A (en) | 1987-10-20 | 1996-06-18 | Holick; Michael F. | Regulation of cell proliferation and differentiation using peptides |
| US5605815A (en) * | 1988-03-14 | 1997-02-25 | Yale University | Nucleic acids encoding and expression of parathyroid hormone-like peptide |
| US5350836A (en) * | 1989-10-12 | 1994-09-27 | Ohio University | Growth hormone antagonists |
| US5814603A (en) * | 1992-06-12 | 1998-09-29 | Affymax Technologies N.V. | Compounds with PTH activity |
| US5589452A (en) * | 1992-07-14 | 1996-12-31 | Syntex (U.S.A.) Inc. | Analogs of parathyroid hormone and parathyroid hormone related peptide: synthesis and use for the treatment of osteoporosis |
| JP4486256B2 (ja) * | 1998-10-22 | 2010-06-23 | ザ・ジェネラル・ホスピタル・コーポレイション | 副甲状腺ホルモン（ＰＴＨ）および副甲状腺ホルモン関連ペプチド（ＰＴＨｒＰ）の生物活性ペプチドおよびペプチド誘導体 |
| US6417333B1 (en) * | 1998-11-25 | 2002-07-09 | The General Hospital Corporation | Modified human parathyroid hormone |
| WO2000032771A1 (en) * | 1998-11-30 | 2000-06-08 | The General Hospital Corporation | Pth1r and pth3r receptors, methods and uses thereof |
-
1999
- 1999-11-23 WO PCT/US1999/027656 patent/WO2000031137A1/en not_active Ceased
- 1999-11-23 DE DE69938064T patent/DE69938064T2/de not_active Expired - Lifetime
- 1999-11-23 EP EP99962819A patent/EP1175444B1/en not_active Expired - Lifetime
- 1999-11-23 US US09/447,800 patent/US6537965B1/en not_active Expired - Fee Related
- 1999-11-23 JP JP2000583963A patent/JP2003533167A/ja active Pending
- 1999-11-23 AT AT99962819T patent/ATE384743T1/de not_active IP Right Cessation
- 1999-11-23 AU AU19183/00A patent/AU1918300A/en not_active Abandoned
-
2003
- 2003-02-11 US US10/361,928 patent/US20030144209A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| AU1918300A (en) | 2000-06-13 |
| US20030144209A1 (en) | 2003-07-31 |
| JP2003533167A (ja) | 2003-11-11 |
| DE69938064D1 (de) | 2008-03-13 |
| EP1175444A1 (en) | 2002-01-30 |
| EP1175444B1 (en) | 2008-01-23 |
| US6537965B1 (en) | 2003-03-25 |
| DE69938064T2 (de) | 2009-01-15 |
| WO2000031137A1 (en) | 2000-06-02 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |