JP2002526539A5 - - Google Patents
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- Publication number
- JP2002526539A5 JP2002526539A5 JP2000574523A JP2000574523A JP2002526539A5 JP 2002526539 A5 JP2002526539 A5 JP 2002526539A5 JP 2000574523 A JP2000574523 A JP 2000574523A JP 2000574523 A JP2000574523 A JP 2000574523A JP 2002526539 A5 JP2002526539 A5 JP 2002526539A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- phenyl
- pyridyl
- fluorine
- cooh
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 description 19
- 125000004076 pyridyl group Chemical group 0.000 description 18
- PXGOKWXKJXAPGV-UHFFFAOYSA-N Fluorine Chemical compound FF PXGOKWXKJXAPGV-UHFFFAOYSA-N 0.000 description 14
- 229910052731 fluorine Inorganic materials 0.000 description 14
- 239000011737 fluorine Substances 0.000 description 14
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 description 12
- 229910052801 chlorine Inorganic materials 0.000 description 10
- 239000000460 chlorine Substances 0.000 description 10
- WKBOTKDWSSQWDR-UHFFFAOYSA-N Bromine atom Chemical compound [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 description 9
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 description 9
- GDTBXPJZTBHREO-UHFFFAOYSA-N bromine Substances BrBr GDTBXPJZTBHREO-UHFFFAOYSA-N 0.000 description 9
- 229910052794 bromium Inorganic materials 0.000 description 9
- 125000000217 alkyl group Chemical group 0.000 description 7
- PNDPGZBMCMUPRI-UHFFFAOYSA-N iodine Chemical compound II PNDPGZBMCMUPRI-UHFFFAOYSA-N 0.000 description 7
- 125000001072 heteroaryl group Chemical group 0.000 description 6
- 229910052739 hydrogen Inorganic materials 0.000 description 6
- 239000001257 hydrogen Substances 0.000 description 6
- 125000001041 indolyl group Chemical group 0.000 description 6
- 125000000842 isoxazolyl group Chemical group 0.000 description 6
- 125000002971 oxazolyl group Chemical group 0.000 description 6
- 125000000714 pyrimidinyl group Chemical group 0.000 description 6
- 125000000335 thiazolyl group Chemical group 0.000 description 6
- 125000001544 thienyl group Chemical group 0.000 description 6
- 125000003118 aryl group Chemical group 0.000 description 5
- 125000004435 hydrogen atom Chemical group [H]* 0.000 description 5
- 125000002883 imidazolyl group Chemical group 0.000 description 5
- -1 quinoyl Chemical group 0.000 description 5
- 125000001425 triazolyl group Chemical group 0.000 description 5
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 description 4
- 150000001875 compounds Chemical class 0.000 description 4
- 125000000332 coumarinyl group Chemical group O1C(=O)C(=CC2=CC=CC=C12)* 0.000 description 4
- 125000002541 furyl group Chemical group 0.000 description 4
- 150000002431 hydrogen Chemical class 0.000 description 4
- 125000001786 isothiazolyl group Chemical group 0.000 description 4
- 125000005545 phthalimidyl group Chemical group 0.000 description 4
- 125000004193 piperazinyl group Chemical group 0.000 description 4
- 125000003831 tetrazolyl group Chemical group 0.000 description 4
- 125000004209 (C1-C8) alkyl group Chemical group 0.000 description 3
- 150000003839 salts Chemical class 0.000 description 3
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 description 2
- 239000003814 drug Substances 0.000 description 2
- 125000005493 quinolyl group Chemical group 0.000 description 2
- 125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 description 1
- ZIODHUMVFOUCOM-UHFFFAOYSA-N 4,5,6,7-tetrahydro-1,2-benzoxazole Chemical compound C1CCCC2=C1C=NO2 ZIODHUMVFOUCOM-UHFFFAOYSA-N 0.000 description 1
- 208000031226 Hyperlipidaemia Diseases 0.000 description 1
- 125000005605 benzo group Chemical group 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19845402A DE19845402B4 (de) | 1998-10-02 | 1998-10-02 | Mit Heterocyclen substituierte Propanolaminderivate, Verfahren zu deren Herstellung, diese Verbindungen enthaltende Arzneimittel und deren Verwendung |
| DE19845402.3 | 1998-10-02 | ||
| PCT/EP1999/006932 WO2000020410A1 (de) | 1998-10-02 | 1999-09-18 | Mit heterocyclen substituierte propanolaminderivate, verfahren zu deren herstellung, diese verbindungen enthaltende arzneimittel und deren verwendung |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2002526539A JP2002526539A (ja) | 2002-08-20 |
| JP2002526539A5 true JP2002526539A5 (https=) | 2006-09-14 |
Family
ID=7883184
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2000574523A Pending JP2002526539A (ja) | 1998-10-02 | 1999-09-18 | 複素環基によって置換されたプロパノールアミン誘導体類、その製造方法、これらの化合物より成る医薬およびその使用 |
Country Status (21)
| Country | Link |
|---|---|
| US (1) | US6303639B1 (https=) |
| EP (1) | EP1117661B1 (https=) |
| JP (1) | JP2002526539A (https=) |
| KR (1) | KR100611030B1 (https=) |
| CN (1) | CN1150185C (https=) |
| AR (1) | AR021843A1 (https=) |
| AT (1) | ATE267825T1 (https=) |
| AU (1) | AU760412B2 (https=) |
| BR (1) | BR9914266A (https=) |
| CA (1) | CA2346083A1 (https=) |
| DE (2) | DE19845402B4 (https=) |
| DK (1) | DK1117661T3 (https=) |
| ES (1) | ES2219065T3 (https=) |
| HK (1) | HK1040249B (https=) |
| HU (1) | HUP0103893A3 (https=) |
| PL (1) | PL347105A1 (https=) |
| PT (1) | PT1117661E (https=) |
| RU (1) | RU2219176C2 (https=) |
| TR (1) | TR200100895T2 (https=) |
| WO (1) | WO2000020410A1 (https=) |
| ZA (1) | ZA200102589B (https=) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE19845406C2 (de) * | 1998-10-02 | 2001-10-18 | Aventis Pharma Gmbh | Substituierte 1,3-Diaryl-2-pyridin-2-yl-3-(pyridin-2-ylamino)- propanolderivate, Verfahren zu deren Herstellung, diese Verbindungen enthaltende Arzneimittel und deren Verwendung |
| MXPA03005019A (es) | 2000-12-21 | 2003-09-25 | Avantis Pharma Deutschland Gmb | Derivados de difenilazetidinonas, metodo para su produccion farmacos que contienen estos compuestos y su uso. |
| DE10064402A1 (de) * | 2000-12-21 | 2002-06-27 | Aventis Pharma Gmbh | Diphenylazetidinonderivate, Verfahren zu deren Herstellung, diese Verbindungen enthaltende Arzneimittel und deren Verwendung |
| EP1420826A2 (de) * | 2001-08-22 | 2004-05-26 | Aventis Pharma Deutschland GmbH | Kombinationspräparate von arylsubstituierten propanolaminderivaten mit weiteren wirkstoffen und deren verwendung |
| DE10219987A1 (de) * | 2002-05-03 | 2004-04-08 | Aventis Pharma Deutschland Gmbh | Optisch aktive β-Aminoketone, optisch aktive 1,3-Aminoalkohole und Verfahren zu deren Herstellung |
| US7161008B2 (en) * | 2002-05-03 | 2007-01-09 | Sanofi - Aventis Deutschland GmbH | Optically active β-aminoketones, optically active 1,3-amino alcohols and processes for preparing them |
| GB0307918D0 (en) | 2003-04-05 | 2003-05-14 | Astrazeneca Ab | Therapeutic use |
| RU2363699C2 (ru) * | 2005-02-28 | 2009-08-10 | Джапан Тобакко Инк. | Новое производное аминопиридина с ингибиторной активностью в отношении syk. |
| AU2011232347B2 (en) * | 2010-03-24 | 2015-08-06 | Musc Foundation For Research Development | Compositions and methods for the treatment of degenerative diseases |
| ES2552657T3 (es) | 2010-05-26 | 2015-12-01 | Satiogen Pharmaceuticals, Inc. | Inhibidores del reciclado de ácidos biliares y saciógenos para el tratamiento de diabetes, obesidad, y afecciones gastrointestinales inflamatorias |
| US20130108573A1 (en) | 2011-10-28 | 2013-05-02 | Lumena Pharmaceuticals, Inc. | Bile Acid Recycling Inhibitors for Treatment of Hypercholemia and Cholestatic Liver Disease |
| AU2012328526B2 (en) | 2011-10-28 | 2017-05-25 | Shire Human Genetic Therapies, Inc. | Bile acid recycling inhibitors for treatment of pediatric cholestatic liver diseases |
| AU2014229050A1 (en) | 2013-03-15 | 2015-10-22 | Lumena Pharmaceuticals Llc | Bile acid recycling inhibitors for treatment of Barrett's esophagus and gastroesophageal reflux disease |
| CA2907230A1 (en) | 2013-03-15 | 2014-09-18 | Lumena Pharmaceuticals, Inc. | Bile acid recycling inhibitors for treatment of primary sclerosing cholangitis and inflammatory bowel disease |
| US11238759B1 (en) | 2015-10-29 | 2022-02-01 | Ward-Kraft, Inc. | Single ply wristband with printable coating |
| US11232719B1 (en) | 2019-09-04 | 2022-01-25 | Ward-Kraft, Inc. | Single ply wristband with printable coating |
| EP3923943B1 (en) | 2019-02-12 | 2024-07-31 | Mirum Pharmaceuticals, Inc. | Genotype and dose-dependent response to an asbti in patients with bile salt export pump deficiency |
| USD988404S1 (en) | 2020-02-14 | 2023-06-06 | Rekon, Llc | Wristband label form with single strap wristbands |
| USD941917S1 (en) | 2020-02-18 | 2022-01-25 | Ward-Kraft, Inc. | Combination wristband label form with extender |
| USD967253S1 (en) | 2020-02-26 | 2022-10-18 | Ward-Kraft, Inc. | Wristband form with extender |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SU1194273A3 (ru) * | 1981-02-09 | 1985-11-23 | Пфайзер Инк (Фирма) | Способ получени пирбутерола или его аналогов |
| FI892341L (fi) * | 1988-06-10 | 1989-12-11 | Hoffmann La Roche | Propanolaminderivat. |
| DE19704243A1 (de) * | 1997-02-05 | 1998-08-06 | Bayer Ag | Neue 2-Amino-substituierte Pyridine |
| EP0869121B1 (de) * | 1997-04-04 | 2004-06-09 | Aventis Pharma Deutschland GmbH | Hypolipidämische Propanolaminderivate |
-
1998
- 1998-10-02 DE DE19845402A patent/DE19845402B4/de not_active Expired - Fee Related
-
1999
- 1999-09-18 ES ES99948790T patent/ES2219065T3/es not_active Expired - Lifetime
- 1999-09-18 BR BR9914266-0A patent/BR9914266A/pt not_active Application Discontinuation
- 1999-09-18 PT PT99948790T patent/PT1117661E/pt unknown
- 1999-09-18 HU HU0103893A patent/HUP0103893A3/hu unknown
- 1999-09-18 RU RU2001111815/04A patent/RU2219176C2/ru not_active IP Right Cessation
- 1999-09-18 CN CNB998116351A patent/CN1150185C/zh not_active Expired - Fee Related
- 1999-09-18 JP JP2000574523A patent/JP2002526539A/ja active Pending
- 1999-09-18 EP EP99948790A patent/EP1117661B1/de not_active Expired - Lifetime
- 1999-09-18 CA CA002346083A patent/CA2346083A1/en not_active Abandoned
- 1999-09-18 WO PCT/EP1999/006932 patent/WO2000020410A1/de not_active Ceased
- 1999-09-18 AU AU61925/99A patent/AU760412B2/en not_active Ceased
- 1999-09-18 DE DE59909609T patent/DE59909609D1/de not_active Expired - Lifetime
- 1999-09-18 AT AT99948790T patent/ATE267825T1/de not_active IP Right Cessation
- 1999-09-18 PL PL99347105A patent/PL347105A1/xx not_active Application Discontinuation
- 1999-09-18 HK HK02102007.5A patent/HK1040249B/zh not_active IP Right Cessation
- 1999-09-18 KR KR1020017004129A patent/KR100611030B1/ko not_active Expired - Fee Related
- 1999-09-18 TR TR2001/00895T patent/TR200100895T2/xx unknown
- 1999-09-18 DK DK99948790T patent/DK1117661T3/da active
- 1999-09-29 US US09/407,973 patent/US6303639B1/en not_active Expired - Lifetime
- 1999-09-30 AR ARP990104958A patent/AR021843A1/es unknown
-
2001
- 2001-03-29 ZA ZA200102589A patent/ZA200102589B/xx unknown
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