DE19845402B4 - Mit Heterocyclen substituierte Propanolaminderivate, Verfahren zu deren Herstellung, diese Verbindungen enthaltende Arzneimittel und deren Verwendung - Google Patents

Mit Heterocyclen substituierte Propanolaminderivate, Verfahren zu deren Herstellung, diese Verbindungen enthaltende Arzneimittel und deren Verwendung Download PDF

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Publication number
DE19845402B4
DE19845402B4 DE19845402A DE19845402A DE19845402B4 DE 19845402 B4 DE19845402 B4 DE 19845402B4 DE 19845402 A DE19845402 A DE 19845402A DE 19845402 A DE19845402 A DE 19845402A DE 19845402 B4 DE19845402 B4 DE 19845402B4
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DE
Germany
Prior art keywords
alkyl
phenyl
cooh
cho
coor
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE19845402A
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German (de)
English (en)
Other versions
DE19845402A1 (de
Inventor
Wendelin Dr. Frick
Reinhard Dr. Kirsch
Heiner Dr. Glombik
Hubert Dr. Heuer
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sanofi Aventis Deutschland GmbH
Original Assignee
Aventis Pharma Deutschland GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to DE19845402A priority Critical patent/DE19845402B4/de
Application filed by Aventis Pharma Deutschland GmbH filed Critical Aventis Pharma Deutschland GmbH
Priority to HU0103893A priority patent/HUP0103893A3/hu
Priority to JP2000574523A priority patent/JP2002526539A/ja
Priority to RU2001111815/04A priority patent/RU2219176C2/ru
Priority to CA002346083A priority patent/CA2346083A1/en
Priority to TR2001/00895T priority patent/TR200100895T2/xx
Priority to EP99948790A priority patent/EP1117661B1/de
Priority to PL99347105A priority patent/PL347105A1/xx
Priority to DE59909609T priority patent/DE59909609D1/de
Priority to CNB998116351A priority patent/CN1150185C/zh
Priority to AU61925/99A priority patent/AU760412B2/en
Priority to PCT/EP1999/006932 priority patent/WO2000020410A1/de
Priority to DK99948790T priority patent/DK1117661T3/da
Priority to KR1020017004129A priority patent/KR100611030B1/ko
Priority to ES99948790T priority patent/ES2219065T3/es
Priority to HK02102007.5A priority patent/HK1040249B/zh
Priority to BR9914266-0A priority patent/BR9914266A/pt
Priority to PT99948790T priority patent/PT1117661E/pt
Priority to AT99948790T priority patent/ATE267825T1/de
Priority to US09/407,973 priority patent/US6303639B1/en
Priority to ARP990104958A priority patent/AR021843A1/es
Publication of DE19845402A1 publication Critical patent/DE19845402A1/de
Priority to ZA200102589A priority patent/ZA200102589B/xx
Application granted granted Critical
Publication of DE19845402B4 publication Critical patent/DE19845402B4/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/74—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/79—Acids; Esters
    • C07D213/80—Acids; Esters in position 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Obesity (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Steroid Compounds (AREA)
DE19845402A 1997-04-04 1998-10-02 Mit Heterocyclen substituierte Propanolaminderivate, Verfahren zu deren Herstellung, diese Verbindungen enthaltende Arzneimittel und deren Verwendung Expired - Fee Related DE19845402B4 (de)

Priority Applications (22)

Application Number Priority Date Filing Date Title
DE19845402A DE19845402B4 (de) 1998-10-02 1998-10-02 Mit Heterocyclen substituierte Propanolaminderivate, Verfahren zu deren Herstellung, diese Verbindungen enthaltende Arzneimittel und deren Verwendung
KR1020017004129A KR100611030B1 (ko) 1998-10-02 1999-09-18 헤테로사이클릭 화합물로 치환된 프로판올아민 유도체, 이의 제조방법 및 이들 화합물을 함유하는 약제학적 조성물
RU2001111815/04A RU2219176C2 (ru) 1998-10-02 1999-09-18 Производные 2-аминопиридинов, фармацевтическая композиция на их основе и способ ее получения
CA002346083A CA2346083A1 (en) 1998-10-02 1999-09-18 Propanolamine derivatives substituted with heterocyclic compounds, methods for their production, pharmaceutical compositions containing said compounds and the use thereof
TR2001/00895T TR200100895T2 (tr) 1998-10-02 1999-09-18 Heterosiklik ikameli propanolamin türevleri, üretimi, ilaçları,kullanımı
EP99948790A EP1117661B1 (de) 1998-10-02 1999-09-18 Mit heterocyclen substituierte propanolaminderivate, verfahren zu deren herstellung, diese verbindungen enthaltende arzneimittel und deren verwendung
PL99347105A PL347105A1 (en) 1998-10-02 1999-09-18 Propanolamine derivatives substituted with heterocyclic compounds, methods for their production, pharmaceutical compositions containing said compounds and the use thereof
DE59909609T DE59909609D1 (de) 1998-10-02 1999-09-18 Mit heterocyclen substituierte propanolaminderivate, verfahren zu deren herstellung, diese verbindungen enthaltende arzneimittel und deren verwendung
CNB998116351A CN1150185C (zh) 1998-10-02 1999-09-18 被杂环化合物取代的丙醇胺衍生物、其制备方法、含有所述化合物的药物组合物及其用途
JP2000574523A JP2002526539A (ja) 1998-10-02 1999-09-18 複素環基によって置換されたプロパノールアミン誘導体類、その製造方法、これらの化合物より成る医薬およびその使用
PCT/EP1999/006932 WO2000020410A1 (de) 1998-10-02 1999-09-18 Mit heterocyclen substituierte propanolaminderivate, verfahren zu deren herstellung, diese verbindungen enthaltende arzneimittel und deren verwendung
DK99948790T DK1117661T3 (da) 1998-10-02 1999-09-18 Propanolaminderivater substitueret med heterocycliske grupper, fremgangsmåde til deres fremstilling, farmaceutiske præparater indeholdende disse forbindelser og deres anvendelse
HU0103893A HUP0103893A3 (en) 1998-10-02 1999-09-18 Propanolamine derivatives substituted with heterocyclic compounds, methods for their production, pharmaceutical compositions containing them and use thereof
ES99948790T ES2219065T3 (es) 1998-10-02 1999-09-18 Derivados de propanolamina sustituidos, procedimiento para su preparacion, medicamentos que contienen estos compuestos y su utilizacion.
AU61925/99A AU760412B2 (en) 1997-04-04 1999-09-18 Propanolamine derivatives substituted with heterocyclic compounds, methods for their production, pharmaceutical compositions containing said compounds and the use thereof
BR9914266-0A BR9914266A (pt) 1998-10-02 1999-09-18 Derivados de propanolamina substituìdos por heterociclos, processos para a sua preparação, medicamentos contendo estes compostos e seu emprego
PT99948790T PT1117661E (pt) 1998-10-02 1999-09-18 Derivados de propanolaminas substituidos com heterociclos, procedimento para a sua preparacao, farmacos contendo estes compostos e a sua aplicacao
AT99948790T ATE267825T1 (de) 1998-10-02 1999-09-18 Mit heterocyclen substituierte propanolaminderivate, verfahren zu deren herstellung, diese verbindungen enthaltende arzneimittel und deren verwendung
HK02102007.5A HK1040249B (zh) 1998-10-02 1999-09-18 被雜環化合物取代的丙醇胺衍生物、其製備方法、含有所述化合物的藥物組合物及其用途
US09/407,973 US6303639B1 (en) 1998-10-02 1999-09-29 Propanolamine derivatives substituted by heterocyclic radicals, processes for their preparation, pharmaceuticals comprising these compounds and their use
ARP990104958A AR021843A1 (es) 1998-10-02 1999-09-30 Derivados de propanolamina sustituidos con heterociclos, procedimiento para su preparacion, y su utilizacion.
ZA200102589A ZA200102589B (en) 1998-10-02 2001-03-29 Propanolamine derivatives substituted with heterocyclic compounds, methods for their production, pharmaceutical compositions containing said compounds and the use thereof.

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19845402A DE19845402B4 (de) 1998-10-02 1998-10-02 Mit Heterocyclen substituierte Propanolaminderivate, Verfahren zu deren Herstellung, diese Verbindungen enthaltende Arzneimittel und deren Verwendung

Publications (2)

Publication Number Publication Date
DE19845402A1 DE19845402A1 (de) 2000-04-13
DE19845402B4 true DE19845402B4 (de) 2005-04-07

Family

ID=7883184

Family Applications (2)

Application Number Title Priority Date Filing Date
DE19845402A Expired - Fee Related DE19845402B4 (de) 1997-04-04 1998-10-02 Mit Heterocyclen substituierte Propanolaminderivate, Verfahren zu deren Herstellung, diese Verbindungen enthaltende Arzneimittel und deren Verwendung
DE59909609T Expired - Lifetime DE59909609D1 (de) 1998-10-02 1999-09-18 Mit heterocyclen substituierte propanolaminderivate, verfahren zu deren herstellung, diese verbindungen enthaltende arzneimittel und deren verwendung

Family Applications After (1)

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DE59909609T Expired - Lifetime DE59909609D1 (de) 1998-10-02 1999-09-18 Mit heterocyclen substituierte propanolaminderivate, verfahren zu deren herstellung, diese verbindungen enthaltende arzneimittel und deren verwendung

Country Status (21)

Country Link
US (1) US6303639B1 (https=)
EP (1) EP1117661B1 (https=)
JP (1) JP2002526539A (https=)
KR (1) KR100611030B1 (https=)
CN (1) CN1150185C (https=)
AR (1) AR021843A1 (https=)
AT (1) ATE267825T1 (https=)
AU (1) AU760412B2 (https=)
BR (1) BR9914266A (https=)
CA (1) CA2346083A1 (https=)
DE (2) DE19845402B4 (https=)
DK (1) DK1117661T3 (https=)
ES (1) ES2219065T3 (https=)
HK (1) HK1040249B (https=)
HU (1) HUP0103893A3 (https=)
PL (1) PL347105A1 (https=)
PT (1) PT1117661E (https=)
RU (1) RU2219176C2 (https=)
TR (1) TR200100895T2 (https=)
WO (1) WO2000020410A1 (https=)
ZA (1) ZA200102589B (https=)

Families Citing this family (20)

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DE19845406C2 (de) * 1998-10-02 2001-10-18 Aventis Pharma Gmbh Substituierte 1,3-Diaryl-2-pyridin-2-yl-3-(pyridin-2-ylamino)- propanolderivate, Verfahren zu deren Herstellung, diese Verbindungen enthaltende Arzneimittel und deren Verwendung
AU2002231688A1 (en) 2000-12-21 2002-07-01 Sanofi-Aventis Deutschland Gmbh Diphenyl azetidinone derivatives, method for the production thereof, medicaments containing these compounds, and their use
DE10064402A1 (de) * 2000-12-21 2002-06-27 Aventis Pharma Gmbh Diphenylazetidinonderivate, Verfahren zu deren Herstellung, diese Verbindungen enthaltende Arzneimittel und deren Verwendung
PL366855A1 (en) * 2001-08-22 2005-02-07 Aventis Pharma Deutschland Gmbh Combination preparations of aryl substituted propanolamine derivatives with other active ingredients and the use thereof
US7161008B2 (en) * 2002-05-03 2007-01-09 Sanofi - Aventis Deutschland GmbH Optically active β-aminoketones, optically active 1,3-amino alcohols and processes for preparing them
DE10219987A1 (de) * 2002-05-03 2004-04-08 Aventis Pharma Deutschland Gmbh Optisch aktive β-Aminoketone, optisch aktive 1,3-Aminoalkohole und Verfahren zu deren Herstellung
GB0307918D0 (en) 2003-04-05 2003-05-14 Astrazeneca Ab Therapeutic use
RU2363699C2 (ru) * 2005-02-28 2009-08-10 Джапан Тобакко Инк. Новое производное аминопиридина с ингибиторной активностью в отношении syk.
CA2794018C (en) * 2010-03-24 2016-05-10 Medical University Of South Carolina Compositions and methods for the treatment of degenerative diseases
EP2575821B1 (en) 2010-05-26 2015-08-12 Satiogen Pharmaceuticals, Inc. Bile acid recycling inhibitors and satiogens for treatment of diabetes, obesity, and inflammatory gastrointestinal conditions
CN104023727B (zh) 2011-10-28 2017-04-05 鲁美纳医药公司 用于治疗小儿胆汁淤积性肝病的胆汁酸再循环抑制剂
CA2852957C (en) 2011-10-28 2020-08-04 Lumena Pharmaceuticals, Inc. Bile acid recycling inhibitors for treatment of hypercholemia and cholestatic liver disease
CN105228615A (zh) 2013-03-15 2016-01-06 鲁美纳医药公司 用于治疗巴雷特食管和胃食管返流疾病的胆汁酸再循环抑制剂
US20140275090A1 (en) 2013-03-15 2014-09-18 Lumena Pharmaceuticals, Inc. Bile acid recycling inhibitors for treatment of primary sclerosing cholangitis and inflammatory bowel disease
US11238759B1 (en) 2015-10-29 2022-02-01 Ward-Kraft, Inc. Single ply wristband with printable coating
US11232719B1 (en) 2019-09-04 2022-01-25 Ward-Kraft, Inc. Single ply wristband with printable coating
PL3923943T3 (pl) 2019-02-12 2024-12-09 Mirum Pharmaceuticals, Inc. Zależna od genotypu i dawki odpowiedź na asbti u pacjentów z niedoborem pompy eksportu soli żółciowych
USD988404S1 (en) 2020-02-14 2023-06-06 Rekon, Llc Wristband label form with single strap wristbands
USD941917S1 (en) 2020-02-18 2022-01-25 Ward-Kraft, Inc. Combination wristband label form with extender
USD967253S1 (en) 2020-02-26 2022-10-18 Ward-Kraft, Inc. Wristband form with extender

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0869121A1 (de) * 1997-04-04 1998-10-07 Hoechst Marion Roussel Deutschland GmbH Hypolipidämische Propanolaminderivate

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FI892341A7 (fi) * 1988-06-10 1989-12-11 Hoffmann La Roche Propanoliamiinijohdannaisia
DE19704243A1 (de) * 1997-02-05 1998-08-06 Bayer Ag Neue 2-Amino-substituierte Pyridine

Patent Citations (1)

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Publication number Priority date Publication date Assignee Title
EP0869121A1 (de) * 1997-04-04 1998-10-07 Hoechst Marion Roussel Deutschland GmbH Hypolipidämische Propanolaminderivate

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
MOUTOU,J.L., et.al.: TMSO-Triflate-assisted Addition of Enols to Heteroaromatic Imines or Hydroxyaminal Intermediates. In: Tetrahedron Letters, Vol.35, No.37, 1994, S.6883-6886 *

Also Published As

Publication number Publication date
DK1117661T3 (da) 2004-08-30
US6303639B1 (en) 2001-10-16
HK1040249B (zh) 2005-04-01
JP2002526539A (ja) 2002-08-20
DE59909609D1 (de) 2004-07-01
ZA200102589B (en) 2002-02-27
ES2219065T3 (es) 2004-11-16
PT1117661E (pt) 2004-09-30
HUP0103893A3 (en) 2002-10-28
HUP0103893A2 (hu) 2002-05-29
EP1117661B1 (de) 2004-05-26
CN1321154A (zh) 2001-11-07
ATE267825T1 (de) 2004-06-15
EP1117661A1 (de) 2001-07-25
CA2346083A1 (en) 2000-04-13
DE19845402A1 (de) 2000-04-13
HK1040249A1 (en) 2002-05-31
BR9914266A (pt) 2001-11-06
KR20010103593A (ko) 2001-11-23
TR200100895T2 (tr) 2001-12-21
AU6192599A (en) 2000-04-26
KR100611030B1 (ko) 2006-08-10
CN1150185C (zh) 2004-05-19
RU2219176C2 (ru) 2003-12-20
WO2000020410A1 (de) 2000-04-13
AU760412B2 (en) 2003-05-15
PL347105A1 (en) 2002-03-25
AR021843A1 (es) 2002-08-07

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