JP2002526516A5 - - Google Patents
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- JP2002526516A5 JP2002526516A5 JP2000574489A JP2000574489A JP2002526516A5 JP 2002526516 A5 JP2002526516 A5 JP 2002526516A5 JP 2000574489 A JP2000574489 A JP 2000574489A JP 2000574489 A JP2000574489 A JP 2000574489A JP 2002526516 A5 JP2002526516 A5 JP 2002526516A5
- Authority
- JP
- Japan
- Prior art keywords
- formula
- alkyl
- carbons
- compound according
- represented
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 125000000217 alkyl group Chemical group 0.000 description 26
- 150000001875 compounds Chemical class 0.000 description 25
- 125000004432 carbon atom Chemical group C* 0.000 description 12
- 150000003839 salts Chemical class 0.000 description 10
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 description 8
- 0 C[C@](C1)([C@]1C=CC(C)=C*)c(cc1)cc2c1C(*)=CC(C)(C)O2 Chemical compound C[C@](C1)([C@]1C=CC(C)=C*)c(cc1)cc2c1C(*)=CC(C)(C)O2 0.000 description 5
- 229910052760 oxygen Inorganic materials 0.000 description 5
- 229910052717 sulfur Inorganic materials 0.000 description 5
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 4
- 125000004123 n-propyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])* 0.000 description 4
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 description 4
- 125000005073 adamantyl group Chemical group C12(CC3CC(CC(C1)C3)C2)* 0.000 description 3
- 125000003342 alkenyl group Chemical group 0.000 description 3
- 125000005037 alkyl phenyl group Chemical group 0.000 description 3
- 125000003118 aryl group Chemical group 0.000 description 3
- 125000000753 cycloalkyl group Chemical group 0.000 description 3
- 125000003709 fluoroalkyl group Chemical group 0.000 description 3
- 125000006570 (C5-C6) heteroaryl group Chemical group 0.000 description 2
- 125000000304 alkynyl group Chemical group 0.000 description 2
- 125000006367 bivalent amino carbonyl group Chemical group [H]N([*:1])C([*:2])=O 0.000 description 2
- 229910052736 halogen Inorganic materials 0.000 description 2
- 150000002367 halogens Chemical class 0.000 description 2
- 125000005842 heteroatom Chemical group 0.000 description 2
- 229910052739 hydrogen Inorganic materials 0.000 description 2
- 239000001257 hydrogen Substances 0.000 description 2
- 125000004435 hydrogen atom Chemical class [H]* 0.000 description 2
- 229910052757 nitrogen Inorganic materials 0.000 description 2
- 125000001424 substituent group Chemical group 0.000 description 2
- 125000000008 (C1-C10) alkyl group Chemical group 0.000 description 1
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 description 1
- 125000002733 (C1-C6) fluoroalkyl group Chemical group 0.000 description 1
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 1
- 125000002252 acyl group Chemical group 0.000 description 1
- 125000005041 acyloxyalkyl group Chemical group 0.000 description 1
- 125000003670 adamantan-2-yl group Chemical group [H]C1([H])C(C2([H])[H])([H])C([H])([H])C3([H])C([*])([H])C1([H])C([H])([H])C2([H])C3([H])[H] 0.000 description 1
- 229910052799 carbon Inorganic materials 0.000 description 1
- 125000001559 cyclopropyl group Chemical group [H]C1([H])C([H])([H])C1([H])* 0.000 description 1
- 125000001072 heteroaryl group Chemical group 0.000 description 1
- 125000005020 hydroxyalkenyl group Chemical group 0.000 description 1
- 125000002768 hydroxyalkyl group Chemical group 0.000 description 1
- 125000005016 hydroxyalkynyl group Chemical group 0.000 description 1
- 125000004464 hydroxyphenyl group Chemical group 0.000 description 1
- 125000000896 monocarboxylic acid group Chemical group 0.000 description 1
- 125000001624 naphthyl group Chemical group 0.000 description 1
- 125000000026 trimethylsilyl group Chemical group [H]C([H])([H])[Si]([*])(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US09/164,950 | 1998-10-01 | ||
| US09/164,950 US6147224A (en) | 1998-10-01 | 1998-10-01 | 2,4-pentadienoic acid derivatives having selective activity for retinoid X (RXR) receptors |
| PCT/US1999/021712 WO2000020370A1 (en) | 1998-10-01 | 1999-09-20 | 2, 4-pentadienoic acid derivatives having selective activity for retinoid x (rxr) receptors |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2002526516A JP2002526516A (ja) | 2002-08-20 |
| JP2002526516A5 true JP2002526516A5 (enExample) | 2007-06-21 |
Family
ID=22596791
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2000574489A Pending JP2002526516A (ja) | 1998-10-01 | 1999-09-20 | レチノイドｘ（ｒｘｒ）受容体に選択的な活性を有する２，４−ペンタジエン酸誘導体 |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US6147224A (enExample) |
| EP (2) | EP1117628B1 (enExample) |
| JP (1) | JP2002526516A (enExample) |
| KR (2) | KR20010075457A (enExample) |
| CN (1) | CN1328538A (enExample) |
| AR (1) | AR020691A1 (enExample) |
| AT (1) | ATE254593T1 (enExample) |
| AU (1) | AU757932B2 (enExample) |
| BR (1) | BR9914256A (enExample) |
| CA (1) | CA2346034A1 (enExample) |
| DE (1) | DE69912973T2 (enExample) |
| ES (1) | ES2207339T3 (enExample) |
| NZ (1) | NZ510528A (enExample) |
| TW (1) | TW580494B (enExample) |
| WO (1) | WO2000020370A1 (enExample) |
| ZA (1) | ZA200102635B (enExample) |
Families Citing this family (31)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6566372B1 (en) * | 1999-08-27 | 2003-05-20 | Ligand Pharmaceuticals Incorporated | Bicyclic androgen and progesterone receptor modulator compounds and methods |
| AU6941200A (en) | 1999-08-27 | 2001-03-26 | Ligand Pharmaceuticals Incorporated | 8-substituted-6-trifluoromethyl-9-pyrido(3,2-g)quinoline compounds as androgen receptor modulators |
| CZ2002711A3 (cs) | 1999-08-27 | 2003-11-12 | Ligand Pharmaceuticals Incorporated | Modulátory androgenních receptorů, způsoby jejich výroby a způsoby jejich použití |
| JP2003529545A (ja) | 1999-09-14 | 2003-10-07 | リガンド・ファーマシューティカルズ・インコーポレイテッド | 改善された薬理学的プロファイルを有するｒｘｒモジュレーター |
| US6906046B2 (en) | 2000-12-22 | 2005-06-14 | Celltech R & D Inc. | Pharmaceutical uses and synthesis of benzobicyclooctanes |
| US6495719B2 (en) | 2001-03-27 | 2002-12-17 | Circagen Pharmaceutical | Histone deacetylase inhibitors |
| US7312247B2 (en) | 2001-03-27 | 2007-12-25 | Errant Gene Therapeutics, Llc | Histone deacetylase inhibitors |
| US7842727B2 (en) | 2001-03-27 | 2010-11-30 | Errant Gene Therapeutics, Llc | Histone deacetylase inhibitors |
| EP1408946A4 (en) * | 2001-03-27 | 2004-06-09 | Circagen Pharmaceutical | HISTONE DEACETYLASE INHIBITORS |
| US8026280B2 (en) | 2001-03-27 | 2011-09-27 | Errant Gene Therapeutics, Llc | Histone deacetylase inhibitors |
| US6388105B1 (en) * | 2001-09-27 | 2002-05-14 | Allergan Sales, Inc. | Benzofuran, indole or benzothiophene 2,4-pentadienoic acid derivatives having selective activity for retinoid X (RXR) receptors |
| US6720423B2 (en) | 2002-04-30 | 2004-04-13 | Allergan, Inc. | Dihydrobenzofuran and dihydrobenzothiophene 2,4-pentadienoic acid derivatives having selective activity for retinoid X (RXR) receptors |
| EP1511477A4 (en) | 2002-05-22 | 2008-04-09 | Errant Gene Therapeutics Llc | HISTONE DEACETYLASE INHIBITORS BASED ON ALPHA-KETO-EPOXYDE COMPOUNDS |
| WO2004046104A2 (en) | 2002-11-20 | 2004-06-03 | Errant Gene Therapeutics, Llc | Treatment of lung cells with histone deacetylase inhibitors |
| US6683092B1 (en) | 2003-04-09 | 2004-01-27 | Allergan, Inc. | [3-(c5-14alkyl-2-oxo-1,2,3,4-tetrahydro-quinolin-6-yl)-3-oxo-propenyl]-phenyl and [3-(c5-14alkyl-2-oxo-1,2,3,4- tetrahydro-quinolin-6-yl)-3-oxo-propenyl]-heteroaryl derivatives having anti-tumor activity |
| US6734193B1 (en) | 2003-06-03 | 2004-05-11 | Allergan, Inc. | (1,2,3,4-tetrahydroquinolin-8-yl)-heptatrienoic acid derivatives having serum glucose reducing activity |
| US6936636B2 (en) * | 2003-06-26 | 2005-08-30 | Allergan, Inc. | 5-[phenyl-tetrahydronaphthalene-2-yl dihydronaphthalen-2-yl and heteroaryl-cyclopropyl]-pentadienoic acid derivatives having serum glucose reducing activity |
| US6887896B1 (en) | 2003-10-29 | 2005-05-03 | Allergan, Inc. | 7-[(7-Alkoxy)-chrom-3-en-6-yl]-heptatrienoic acid and 7-[(3-alkoxy)-5,6-dihydronaphthalen-2-yl]-heptatrienoic acid derivatives having serum glucose reducing activity |
| WO2007041398A2 (en) | 2005-09-30 | 2007-04-12 | Vitae Pharmaceuticals, Inc. | Treatment of cancer with specific rxr agonists |
| US20070185055A1 (en) * | 2006-02-06 | 2007-08-09 | Guang Liang Jiang | Method for treating cachexia with retinoid ligands |
| US10653650B2 (en) | 2011-12-13 | 2020-05-19 | Io Therapeutics, Inc. | Treatment of diseases by concurrently eliciting remyelination effects and immunomodulatory effects using selective RXR agonists |
| MX352727B (es) | 2011-12-13 | 2017-12-06 | Dartmouth College | Tratamiento de trastorno autoinmune al usar agonistas de rxr. |
| JP6492432B2 (ja) * | 2013-07-09 | 2019-04-03 | 東ソー株式会社 | アダマンチル基を有する環状アジン化合物、その製造方法、及びそれを構成成分とする有機電界発光素子 |
| KR102651292B1 (ko) | 2015-10-31 | 2024-03-25 | 아이오 테라퓨틱스, 인크. | Rxr 아고니스트와 갑상선 호르몬의 조합을 사용한 신경계 질환의 치료 |
| DK3426302T3 (da) | 2016-03-10 | 2023-02-27 | Io Therapeutics Inc | Behandling af autoimmunsygdomme med kombinationer af rxr-agonister og skjoldbruskkirtelhormoner |
| KR20180121983A (ko) | 2016-03-10 | 2018-11-09 | 아이오 테라퓨틱스, 인크. | Rxr 작용제 및 갑상선 호르몬의 조합을 사용한 근육 질환의 치료 |
| MX2020003223A (es) | 2017-09-20 | 2020-09-21 | Io Therapeutics Inc | Tratamiento de enfermedades con ésteres de agonistas de rxr selectivos. |
| EP3710027A4 (en) * | 2017-11-17 | 2021-09-29 | IO Therapeutics, Inc. | COMPOUNDS AND SYNTHESIS FOR THE PREPARATION OF RETINOIDS SPECIFIC OF THE RETINOID X-RECEPTOR |
| US10966950B2 (en) | 2019-06-11 | 2021-04-06 | Io Therapeutics, Inc. | Use of an RXR agonist in treating HER2+ cancers |
| MX2024006980A (es) | 2021-12-07 | 2024-07-19 | Io Therapeutics Inc | Uso de un agonista de rxr en el tratamiento de cáncer her2+ resistente a fármacos. |
| KR20240119103A (ko) | 2021-12-07 | 2024-08-06 | 아이오 테라퓨틱스, 인크. | Her2+ 암 치료에서의 rxr 작용제 및 탁산의 용도 |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB8826760D0 (en) * | 1988-11-16 | 1988-12-21 | Wellcome Found | Pesticides |
| AU679171B2 (en) * | 1991-12-18 | 1997-06-26 | Baylor College Of Medicine | Means for the modulation of processes mediated by retinoid receptors and compounds useful therefor |
| PT637297E (pt) * | 1992-04-22 | 2001-01-31 | Ligand Pharm Inc | Compostos com selectividade para os receptores de retinoide x |
| DK0678087T3 (da) * | 1993-01-11 | 1999-09-27 | Ligand Pharm Inc | Forbindelser med selektiv aktivitet til retinoid-X-receptorer og metoder til modulering af processer medieret af retinoid-X |
| US5455265A (en) * | 1993-02-11 | 1995-10-03 | Allergan, Inc. | Method of treatment with compounds having selective agonist-like activity on RXR retinoid receptors |
| MX9700778A (es) * | 1994-08-10 | 1997-05-31 | Hoffmann La Roche | Ligandos del receptor x del acido retinoico. |
| IL116259A (en) * | 1994-12-19 | 2000-07-16 | American Cyanamid Co | Analogs of 9-cis retinoic acid and their use |
| US5543534A (en) * | 1994-12-29 | 1996-08-06 | Allergan | Acetylenes disubstituted with a 5 substituted tetrahydronaphthyl group and with an aryl or heteroaryl groups having retinoid-like biological activity |
| US5648514A (en) * | 1994-12-29 | 1997-07-15 | Allergan | Substituted acetylenes having retinoid-like biological activity |
| US5675033A (en) * | 1995-06-06 | 1997-10-07 | Allergan | 2,4-pentadienoic acid derivatives having retinoid-like biological activity |
| US5776699A (en) * | 1995-09-01 | 1998-07-07 | Allergan, Inc. | Method of identifying negative hormone and/or antagonist activities |
| BR9610875A (pt) * | 1995-10-06 | 1999-07-13 | Ligand Pharm Inc | Modulares rxr seletivos - dimeros e processos para seu uso |
| US5723666A (en) * | 1996-06-21 | 1998-03-03 | Allergan | Oxime substituted tetrahydronaphthalene derivatives having retinoid and/or retinoid antagonist-like biological activity |
| US5728846A (en) * | 1996-12-12 | 1998-03-17 | Allergan | Benzo 1,2-g!-chrom-3-ene and benzo 1,2-g!-thiochrom-3-ene derivatives |
| ES2221371T3 (es) * | 1999-03-08 | 2004-12-16 | Basilea Pharmaceutica Ag | Antagonistas retinoides y el uso de los mismos. |
-
1998
- 1998-10-01 US US09/164,950 patent/US6147224A/en not_active Expired - Fee Related
-
1999
- 1999-09-20 EP EP99970078A patent/EP1117628B1/en not_active Expired - Lifetime
- 1999-09-20 EP EP03025774A patent/EP1388534A3/en not_active Withdrawn
- 1999-09-20 ES ES99970078T patent/ES2207339T3/es not_active Expired - Lifetime
- 1999-09-20 AU AU60513/99A patent/AU757932B2/en not_active Ceased
- 1999-09-20 KR KR1020017004018A patent/KR20010075457A/ko not_active Abandoned
- 1999-09-20 BR BR9914256-2A patent/BR9914256A/pt not_active Application Discontinuation
- 1999-09-20 AT AT99970078T patent/ATE254593T1/de not_active IP Right Cessation
- 1999-09-20 CA CA002346034A patent/CA2346034A1/en not_active Abandoned
- 1999-09-20 JP JP2000574489A patent/JP2002526516A/ja active Pending
- 1999-09-20 WO PCT/US1999/021712 patent/WO2000020370A1/en not_active Ceased
- 1999-09-20 DE DE69912973T patent/DE69912973T2/de not_active Expired - Fee Related
- 1999-09-20 NZ NZ510528A patent/NZ510528A/xx unknown
- 1999-09-20 CN CN99813787A patent/CN1328538A/zh active Pending
- 1999-10-01 AR ARP990104996A patent/AR020691A1/es not_active Application Discontinuation
- 1999-10-12 TW TW088116960A patent/TW580494B/zh not_active IP Right Cessation
-
2001
- 2001-03-30 ZA ZA200102635A patent/ZA200102635B/en unknown
-
2006
- 2006-09-20 KR KR1020060091029A patent/KR20060118367A/ko not_active Ceased
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