JP2002524523A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2002524523A5 JP2002524523A5 JP2000569823A JP2000569823A JP2002524523A5 JP 2002524523 A5 JP2002524523 A5 JP 2002524523A5 JP 2000569823 A JP2000569823 A JP 2000569823A JP 2000569823 A JP2000569823 A JP 2000569823A JP 2002524523 A5 JP2002524523 A5 JP 2002524523A5
- Authority
- JP
- Japan
- Prior art keywords
- dendrimer
- terminated
- acid
- terminal
- pharmaceutical composition
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 239000000412 dendrimer Substances 0.000 description 54
- 229920000736 dendritic polymer Polymers 0.000 description 54
- 239000008194 pharmaceutical composition Substances 0.000 description 14
- 239000002253 acid Substances 0.000 description 8
- KXDAEFPNCMNJSK-UHFFFAOYSA-N Benzamide Chemical compound NC(=O)C1=CC=CC=C1 KXDAEFPNCMNJSK-UHFFFAOYSA-N 0.000 description 6
- 125000000217 alkyl group Chemical group 0.000 description 6
- 150000001875 compounds Chemical class 0.000 description 6
- -1 alkyl sulfonic acid Chemical compound 0.000 description 5
- NBIIXXVUZAFLBC-UHFFFAOYSA-N Phosphoric acid Chemical compound OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 description 4
- 125000003118 aryl group Chemical group 0.000 description 4
- 150000001768 cations Chemical class 0.000 description 4
- 229910052739 hydrogen Inorganic materials 0.000 description 4
- UMGDCJDMYOKAJW-UHFFFAOYSA-N aminothiocarboxamide Chemical group NC(N)=S UMGDCJDMYOKAJW-UHFFFAOYSA-N 0.000 description 3
- 150000001450 anions Chemical class 0.000 description 3
- 125000000896 monocarboxylic acid group Chemical group 0.000 description 3
- 230000001629 suppression Effects 0.000 description 3
- UHBGYFCCKRAEHA-UHFFFAOYSA-N P-toluamide Chemical compound CC1=CC=C(C(N)=O)C=C1 UHBGYFCCKRAEHA-UHFFFAOYSA-N 0.000 description 2
- ABLZXFCXXLZCGV-UHFFFAOYSA-N Phosphorous acid Chemical compound OP(O)=O ABLZXFCXXLZCGV-UHFFFAOYSA-N 0.000 description 2
- XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical group NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 description 2
- OOEZTTCJYIGGPQ-UHFFFAOYSA-N [4-(carbamothioylamino)phenyl] dihydrogen phosphate Chemical compound NC(=S)NC1=CC=C(OP(O)(O)=O)C=C1 OOEZTTCJYIGGPQ-UHFFFAOYSA-N 0.000 description 2
- 229910000147 aluminium phosphate Inorganic materials 0.000 description 2
- 125000003710 aryl alkyl group Chemical group 0.000 description 2
- SQVRNKJHWKZAKO-UHFFFAOYSA-N beta-N-Acetyl-D-neuraminic acid Natural products CC(=O)NC1C(O)CC(O)(C(O)=O)OC1C(O)C(O)CO SQVRNKJHWKZAKO-UHFFFAOYSA-N 0.000 description 2
- 239000003814 drug Substances 0.000 description 2
- BQINXKOTJQCISL-GRCPKETISA-N keto-neuraminic acid Chemical compound OC(=O)C(=O)C[C@H](O)[C@@H](N)[C@@H](O)[C@H](O)[C@H](O)CO BQINXKOTJQCISL-GRCPKETISA-N 0.000 description 2
- 229920000962 poly(amidoamine) Polymers 0.000 description 2
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 description 2
- 108090000765 processed proteins & peptides Proteins 0.000 description 2
- 102000004196 processed proteins & peptides Human genes 0.000 description 2
- 230000000069 prophylactic effect Effects 0.000 description 2
- SQVRNKJHWKZAKO-OQPLDHBCSA-N sialic acid Chemical compound CC(=O)N[C@@H]1[C@@H](O)C[C@@](O)(C(O)=O)OC1[C@H](O)[C@H](O)CO SQVRNKJHWKZAKO-OQPLDHBCSA-N 0.000 description 2
- 230000001225 therapeutic effect Effects 0.000 description 2
- 231100000331 toxic Toxicity 0.000 description 2
- 230000002588 toxic effect Effects 0.000 description 2
- 239000003440 toxic substance Substances 0.000 description 2
- 231100000765 toxin Toxicity 0.000 description 2
- 239000003053 toxin Substances 0.000 description 2
- 108700012359 toxins Proteins 0.000 description 2
- MDAXKAUIABOHTD-UHFFFAOYSA-N 1,4,8,11-tetraazacyclotetradecane Chemical compound C1CNCCNCCCNCCNC1 MDAXKAUIABOHTD-UHFFFAOYSA-N 0.000 description 1
- DVZWMDIRFMBWSC-UHFFFAOYSA-N 2-[(4-amino-4-oxobutanoyl)amino]ethanesulfonic acid Chemical compound NC(=O)CCC(=O)NCCS(O)(=O)=O DVZWMDIRFMBWSC-UHFFFAOYSA-N 0.000 description 1
- QPVSSARHYZXAPM-UHFFFAOYSA-N 2-amino-2-oxoethanesulfonic acid Chemical compound NC(=O)CS(O)(=O)=O QPVSSARHYZXAPM-UHFFFAOYSA-N 0.000 description 1
- KHMVPPUPOGJSFK-UHFFFAOYSA-N 4-(carbamothioylamino)benzenesulfonic acid Chemical compound NC(=S)NC1=CC=C(S(O)(=O)=O)C=C1 KHMVPPUPOGJSFK-UHFFFAOYSA-N 0.000 description 1
- DZQZJJXVAMIPNR-UHFFFAOYSA-N 4-(carbamothioylamino)naphthalene-1-sulfonic acid Chemical compound C1=CC=C2C(NC(=S)N)=CC=C(S(O)(=O)=O)C2=C1 DZQZJJXVAMIPNR-UHFFFAOYSA-N 0.000 description 1
- MFBPZROATHHERV-UHFFFAOYSA-N 4-(carbamothioylamino)naphthalene-2,7-disulfonic acid Chemical compound OS(=O)(=O)C1=CC=C2C(NC(=S)N)=CC(S(O)(=O)=O)=CC2=C1 MFBPZROATHHERV-UHFFFAOYSA-N 0.000 description 1
- XJJDJRSMXUUIKJ-UHFFFAOYSA-N 4-(carbamoylamino)benzenesulfonic acid Chemical compound NC(=O)NC1=CC=C(S(O)(=O)=O)C=C1 XJJDJRSMXUUIKJ-UHFFFAOYSA-N 0.000 description 1
- NILHACLJODBATD-UHFFFAOYSA-N 4-(propanoylamino)benzenesulfonic acid Chemical compound CCC(=O)NC1=CC=C(S(O)(=O)=O)C=C1 NILHACLJODBATD-UHFFFAOYSA-N 0.000 description 1
- BCFOOQRXUXKJCL-UHFFFAOYSA-N 4-amino-4-oxo-2-sulfobutanoic acid Chemical compound NC(=O)CC(C(O)=O)S(O)(=O)=O BCFOOQRXUXKJCL-UHFFFAOYSA-N 0.000 description 1
- ALYNCZNDIQEVRV-UHFFFAOYSA-N 4-aminobenzoic acid Chemical compound NC1=CC=C(C(O)=O)C=C1 ALYNCZNDIQEVRV-UHFFFAOYSA-N 0.000 description 1
- VHHHYFRIANJFAT-UHFFFAOYSA-N 5-(carbamothioylamino)benzene-1,3-dicarboxylic acid Chemical compound NC(=S)NC1=CC(C(O)=O)=CC(C(O)=O)=C1 VHHHYFRIANJFAT-UHFFFAOYSA-N 0.000 description 1
- KIQNQOQMGFSEMM-UHFFFAOYSA-N 5-(carbamothioylamino)benzene-1,3-disulfonic acid Chemical compound NC(=S)NC1=CC(S(O)(=O)=O)=CC(S(O)(=O)=O)=C1 KIQNQOQMGFSEMM-UHFFFAOYSA-N 0.000 description 1
- NDWQMRYDEZSGEF-UHFFFAOYSA-N 8-(carbamothioylamino)naphthalene-1,3,6-trisulfonic acid Chemical compound OS(=O)(=O)C1=CC(S(O)(=O)=O)=C2C(NC(=S)N)=CC(S(O)(=O)=O)=CC2=C1 NDWQMRYDEZSGEF-UHFFFAOYSA-N 0.000 description 1
- QGZKDVFQNNGYKY-UHFFFAOYSA-N Ammonia Chemical group N QGZKDVFQNNGYKY-UHFFFAOYSA-N 0.000 description 1
- 241000894006 Bacteria Species 0.000 description 1
- LSNNMFCWUKXFEE-UHFFFAOYSA-M Bisulfite Chemical compound OS([O-])=O LSNNMFCWUKXFEE-UHFFFAOYSA-M 0.000 description 1
- ZOXJGFHDIHLPTG-UHFFFAOYSA-N Boron Chemical compound [B] ZOXJGFHDIHLPTG-UHFFFAOYSA-N 0.000 description 1
- 241000233866 Fungi Species 0.000 description 1
- ISWSIDIOOBJBQZ-UHFFFAOYSA-N Phenol Chemical compound OC1=CC=CC=C1 ISWSIDIOOBJBQZ-UHFFFAOYSA-N 0.000 description 1
- 108010039918 Polylysine Proteins 0.000 description 1
- 241000700605 Viruses Species 0.000 description 1
- MSMXAJVUGSDTNQ-UHFFFAOYSA-N [4-(carbamothioylamino)-7-phosphononaphthalen-1-yl]phosphonic acid Chemical compound OP(=O)(O)C1=CC=C2C(NC(=S)N)=CC=C(P(O)(O)=O)C2=C1 MSMXAJVUGSDTNQ-UHFFFAOYSA-N 0.000 description 1
- JDFHYYZTUNBHCA-UHFFFAOYSA-N [4-(carbamothioylamino)phenyl]methylphosphonic acid Chemical compound NC(=S)NC1=CC=C(CP(O)(O)=O)C=C1 JDFHYYZTUNBHCA-UHFFFAOYSA-N 0.000 description 1
- GDBQRUMLUQFAPB-UHFFFAOYSA-N [4-(carbamothioylamino)phenyl]phosphonic acid Chemical compound NC(=S)NC1=CC=C(P(O)(O)=O)C=C1 GDBQRUMLUQFAPB-UHFFFAOYSA-N 0.000 description 1
- JRROFPKPQONCSD-UHFFFAOYSA-N [4-[carbamothioyl(ethyl)amino]phenyl]methylphosphonic acid Chemical compound CCN(C(N)=S)C1=CC=C(CP(O)(O)=O)C=C1 JRROFPKPQONCSD-UHFFFAOYSA-N 0.000 description 1
- 125000000738 acetamido group Chemical group [H]C([H])([H])C(=O)N([H])[*] 0.000 description 1
- 230000002378 acidificating effect Effects 0.000 description 1
- 150000001408 amides Chemical group 0.000 description 1
- 125000000909 amidinium group Chemical group 0.000 description 1
- 150000001412 amines Chemical class 0.000 description 1
- 125000000129 anionic group Chemical group 0.000 description 1
- 229910052796 boron Inorganic materials 0.000 description 1
- ZADPBFCGQRWHPN-UHFFFAOYSA-N boronic acid Chemical compound OBO ZADPBFCGQRWHPN-UHFFFAOYSA-N 0.000 description 1
- DNSISZSEWVHGLH-UHFFFAOYSA-N butanamide Chemical compound CCCC(N)=O DNSISZSEWVHGLH-UHFFFAOYSA-N 0.000 description 1
- UKYZWASSXSSTCI-UHFFFAOYSA-N c1cc[nH+]cc1.CCCCCCCCCCCCC([NH-])=O Chemical compound c1cc[nH+]cc1.CCCCCCCCCCCCC([NH-])=O UKYZWASSXSSTCI-UHFFFAOYSA-N 0.000 description 1
- 150000001732 carboxylic acid derivatives Chemical class 0.000 description 1
- 125000002091 cationic group Chemical group 0.000 description 1
- 239000003085 diluting agent Substances 0.000 description 1
- MGHPNCMVUAKAIE-UHFFFAOYSA-N diphenylmethanamine Chemical group C=1C=CC=CC=1C(N)C1=CC=CC=C1 MGHPNCMVUAKAIE-UHFFFAOYSA-N 0.000 description 1
- 239000003937 drug carrier Substances 0.000 description 1
- 125000003916 ethylene diamine group Chemical group 0.000 description 1
- GNBHRKFJIUUOQI-UHFFFAOYSA-N fluorescein Chemical compound O1C(=O)C2=CC=CC=C2C21C1=CC=C(O)C=C1OC1=CC(O)=CC=C21 GNBHRKFJIUUOQI-UHFFFAOYSA-N 0.000 description 1
- 125000002795 guanidino group Chemical group C(N)(=N)N* 0.000 description 1
- 125000000623 heterocyclic group Chemical group 0.000 description 1
- 239000001257 hydrogen Substances 0.000 description 1
- 125000004435 hydrogen atom Chemical class [H]* 0.000 description 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 description 1
- 208000015181 infectious disease Diseases 0.000 description 1
- 230000005764 inhibitory process Effects 0.000 description 1
- 229920000831 ionic polymer Polymers 0.000 description 1
- 150000002500 ions Chemical class 0.000 description 1
- 125000005647 linker group Chemical group 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 1
- CERZMXAJYMMUDR-UHFFFAOYSA-N neuraminic acid Natural products NC1C(O)CC(O)(C(O)=O)OC1C(O)C(O)CO CERZMXAJYMMUDR-UHFFFAOYSA-N 0.000 description 1
- LTHCSWBWNVGEFE-UHFFFAOYSA-N octanamide Chemical compound CCCCCCCC(N)=O LTHCSWBWNVGEFE-UHFFFAOYSA-N 0.000 description 1
- 229910052760 oxygen Inorganic materials 0.000 description 1
- 231100000614 poison Toxicity 0.000 description 1
- 229920000333 poly(propyleneimine) Polymers 0.000 description 1
- 229920000656 polylysine Polymers 0.000 description 1
- JUJWROOIHBZHMG-UHFFFAOYSA-O pyridinium Chemical compound C1=CC=[NH+]C=C1 JUJWROOIHBZHMG-UHFFFAOYSA-O 0.000 description 1
- 229910052717 sulfur Inorganic materials 0.000 description 1
- 125000003396 thiol group Chemical group [H]S* 0.000 description 1
- 231100000167 toxic agent Toxicity 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| AUPP5843A AUPP584398A0 (en) | 1998-09-14 | 1998-09-14 | Inhibition of toxic materials or substances |
| AU5843 | 1998-09-14 | ||
| PCT/AU1999/000762 WO2000015239A1 (fr) | 1998-09-14 | 1999-09-13 | Inhibition de matieres ou de substances toxiques au moyen de dendrimeres |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2002524523A JP2002524523A (ja) | 2002-08-06 |
| JP2002524523A5 true JP2002524523A5 (fr) | 2006-11-16 |
Family
ID=3810065
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2000569823A Withdrawn JP2002524523A (ja) | 1998-09-14 | 1999-09-13 | デンドリマーを用いる毒性物質の抑制 |
Country Status (9)
| Country | Link |
|---|---|
| EP (1) | EP1113805A4 (fr) |
| JP (1) | JP2002524523A (fr) |
| KR (1) | KR20010075089A (fr) |
| CN (1) | CN1323215A (fr) |
| AU (1) | AUPP584398A0 (fr) |
| BR (1) | BR9913718A (fr) |
| CA (1) | CA2343205A1 (fr) |
| NZ (1) | NZ510376A (fr) |
| WO (1) | WO2000015239A1 (fr) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6720355B2 (en) | 1997-02-21 | 2004-04-13 | The Regents Of The University Of California | Sodium dodecyl sulfate compositions for inactivating prions |
| AUPP584298A0 (en) * | 1998-09-14 | 1998-10-08 | Starpharma Limited | Antimicrobial and antiparasitic agents |
| EP1187622A4 (fr) * | 1999-06-01 | 2005-06-22 | Univ California | Technique de sterilisation |
| KR100413532B1 (ko) * | 2001-02-14 | 2003-12-31 | 학교법인 포항공과대학교 | 폴리아민이 말단에 치환된 덴드리머 및 그 제조방법 |
| AUPR412901A0 (en) * | 2001-03-30 | 2001-05-03 | Starpharma Limited | Agents for the prevention and treatment of sexually transmitted disease s - II |
| AUPR412801A0 (en) | 2001-03-30 | 2001-05-03 | Starpharma Limited | Agent for the prevention and treatment of sexually transmitted disease s - I |
| WO2004072153A1 (fr) * | 2003-02-13 | 2004-08-26 | National Center For Scientific Research 'demokritos' | Dendrimeres multifonctionnels et polymeres hyperramifies pour des systemes d'administration de medicaments et des systemes de distribution de genes |
| CN1296711C (zh) * | 2004-05-14 | 2007-01-24 | 沈阳迈迪生物医学技术有限公司 | 乳腺癌的Her－2免疫组织化学诊断试剂盒 |
| ES2562055T3 (es) * | 2005-10-18 | 2016-03-02 | Starpharma Pty Limited | Sistema de administración de una composición dendrimérica microbicida |
| WO2007082331A1 (fr) | 2006-01-20 | 2007-07-26 | Starpharma Pty Limited | Macromolecule modifiee |
| JP5322918B2 (ja) * | 2006-03-22 | 2013-10-23 | スターファーマ・プロプライエタリー・リミテッド | 避妊用組成物 |
| JP4949206B2 (ja) * | 2007-11-09 | 2012-06-06 | 独立行政法人科学技術振興機構 | 生体分子修飾のためのポリイオンデンドリマー |
| JP4767295B2 (ja) * | 2008-07-17 | 2011-09-07 | 独立行政法人科学技術振興機構 | シトクロムｃ捕捉型アポトーシス抑制剤 |
| CN102743411A (zh) * | 2012-07-25 | 2012-10-24 | 中国人民解放军第四军医大学 | 聚酰胺胺型树枝状大分子在制备预防或治疗脓毒血症的药物中的应用 |
| CN105524285B (zh) * | 2014-10-21 | 2018-06-15 | 浙江大学 | 含硫脲树枝状大分子和含硫脲超支化聚合物及其制备方法和应用 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5914095A (en) * | 1989-04-07 | 1999-06-22 | Salutar, Inc. | Polychelants containg amide bonds |
| US5364613A (en) * | 1989-04-07 | 1994-11-15 | Sieving Paul F | Polychelants containing macrocyclic chelant moieties |
| JPH10501665A (ja) * | 1994-06-15 | 1998-02-10 | フィリップス エレクトロニクス ネムローゼ フェンノートシャップ | 低電源電圧に関して同相除去をする差動増幅器 |
-
1998
- 1998-09-14 AU AUPP5843A patent/AUPP584398A0/en not_active Abandoned
-
1999
- 1999-09-13 NZ NZ510376A patent/NZ510376A/xx unknown
- 1999-09-13 CN CN99812271A patent/CN1323215A/zh active Pending
- 1999-09-13 WO PCT/AU1999/000762 patent/WO2000015239A1/fr not_active Application Discontinuation
- 1999-09-13 BR BR9913718-6A patent/BR9913718A/pt not_active IP Right Cessation
- 1999-09-13 EP EP99945772A patent/EP1113805A4/fr not_active Withdrawn
- 1999-09-13 JP JP2000569823A patent/JP2002524523A/ja not_active Withdrawn
- 1999-09-13 CA CA002343205A patent/CA2343205A1/fr not_active Abandoned
- 1999-09-13 KR KR1020017003255A patent/KR20010075089A/ko not_active Application Discontinuation
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2002524524A5 (fr) | ||
| JP2002524523A5 (fr) | ||
| Mintzer et al. | Biomedical applications of dendrimers: a tutorial | |
| CA2343113A1 (fr) | Compositions antimicrobiennes et antiparasitaires a base de dendrimere anionique ou cationique | |
| CN1134486C (zh) | 抗病毒树枝状体 | |
| JP4082517B2 (ja) | ポリアミノ酸誘導体及びケラチン繊維のトリートメント用組成物におけるそれらの用途 | |
| CA1321346C (fr) | Imagerie rmn obtenue avec des sels de metaux polyvalents de poly (acide-alkylene-amino) alcanes | |
| AU698752B2 (en) | Process for removing bile salts from a patient and alkylated compositions therefor | |
| US8642659B2 (en) | Hair treatment product and hair after-treatment product containing ether guanidines as active substances, for protecting from damage caused by chemical treatment and for repairing already damaged hair | |
| JP5571952B2 (ja) | 毛髪直接付着性ポリマーを含む毛髪処理用組成物 | |
| SZYMAŃSKI et al. | Nanotechnology in pharmaceutical and biomedical applications: Dendrimers | |
| JP2001507378A (ja) | 医用画像用新ポリマー性造影薬 | |
| JPH08502530A (ja) | ポリアルキレンオキシドに基づくｍｒ像形成組成物 | |
| JP2010529214A (ja) | カチオン性基及び疎水性基により官能基化したポリグルタミン酸及びその応用、特にはその治療への応用 | |
| JP2009528439A5 (fr) | ||
| WO2007099660A1 (fr) | complexe de micelles polymeres contenant de l'acide nucleique | |
| JPH09512264A (ja) | デンドリマー状化合物 | |
| DE60214713D1 (de) | Arylborsäuren für die behandlung von fettsucht | |
| JP2020063250A (ja) | ピロリドン誘導体、オリゴマー及びポリマー | |
| RU2012124266A (ru) | Хелаты марганца и их применение в качестве контрастных агентов в магнитно-резонансной визуализации (mpb) | |
| JP2002527474A5 (ja) | 躁病および双極性障害の治療のための医薬 | |
| EP0731797A1 (fr) | Chelates paramagnetiques utilises dans le diagnostic par resonance magnetique | |
| KR101041985B1 (ko) | 핵산 전달용 고분자의 제조방법 및 상기 고분자를 함유하는 핵산 전달용 조성물 | |
| US20120269895A1 (en) | Dendritic pic micelles with bioactive proteins | |
| JP2008510683A5 (fr) |