JP2002522462A5 - - Google Patents
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- Publication number
- JP2002522462A5 JP2002522462A5 JP2000564574A JP2000564574A JP2002522462A5 JP 2002522462 A5 JP2002522462 A5 JP 2002522462A5 JP 2000564574 A JP2000564574 A JP 2000564574A JP 2000564574 A JP2000564574 A JP 2000564574A JP 2002522462 A5 JP2002522462 A5 JP 2002522462A5
- Authority
- JP
- Japan
- Prior art keywords
- group
- hydrogen
- lower alkoxy
- pharmaceutically acceptable
- acetoxy
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 125000003545 alkoxy group Chemical group 0.000 description 22
- 229910052739 hydrogen Inorganic materials 0.000 description 22
- 239000001257 hydrogen Substances 0.000 description 22
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 description 11
- 125000000217 alkyl group Chemical group 0.000 description 11
- 125000005605 benzo group Chemical group 0.000 description 11
- 229910052736 halogen Inorganic materials 0.000 description 11
- 150000002367 halogens Chemical class 0.000 description 11
- 150000002431 hydrogen Chemical class 0.000 description 11
- -1 hydroxy, acetoxy Chemical group 0.000 description 11
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 description 11
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 description 11
- 150000001875 compounds Chemical class 0.000 description 10
- 150000003839 salts Chemical class 0.000 description 8
- 230000009787 cardiac fibrosis Effects 0.000 description 4
- 239000003937 drug carrier Substances 0.000 description 4
- LVASCWIMLIKXLA-LSDHHAIUSA-N halofuginone Chemical compound O[C@@H]1CCCN[C@H]1CC(=O)CN1C(=O)C2=CC(Cl)=C(Br)C=C2N=C1 LVASCWIMLIKXLA-LSDHHAIUSA-N 0.000 description 3
- 229950010152 halofuginone Drugs 0.000 description 3
- 239000003814 drug Substances 0.000 description 2
- 238000004519 manufacturing process Methods 0.000 description 2
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 238000011282 treatment Methods 0.000 description 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IL12579098 | 1998-08-13 | ||
| US13714599P | 1999-06-01 | 1999-06-01 | |
| US125790 | 1999-06-01 | ||
| US60/137,145 | 1999-06-01 | ||
| PCT/IL1999/000440 WO2000009070A2 (en) | 1998-08-13 | 1999-08-13 | Inhibition of pathogenic processes related to tissue trauma |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2002522462A JP2002522462A (ja) | 2002-07-23 |
| JP2002522462A5 true JP2002522462A5 (enExample) | 2006-10-05 |
Family
ID=26323693
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2000564574A Pending JP2002522462A (ja) | 1998-08-13 | 1999-08-13 | 組織外傷に関連した病原プロセスの阻害 |
Country Status (8)
| Country | Link |
|---|---|
| EP (1) | EP1109559B1 (enExample) |
| JP (1) | JP2002522462A (enExample) |
| AT (1) | ATE307586T1 (enExample) |
| AU (1) | AU756437B2 (enExample) |
| CA (1) | CA2340176A1 (enExample) |
| DE (1) | DE69927987T2 (enExample) |
| ES (1) | ES2255286T3 (enExample) |
| WO (1) | WO2000009070A2 (enExample) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL143366A0 (en) * | 2001-05-24 | 2002-04-21 | Harasit Medical Res Services & | Treatment of renal fibrosis |
| EP1558261A4 (en) * | 2002-10-31 | 2008-06-04 | Israel State | CHINAZOLINONE COMPOSITIONS TO REGULATE GENE EXPRESSION IN CONNECTION WITH PATHOLOGICAL PROCESSES |
| RU2243778C2 (ru) * | 2003-02-18 | 2005-01-10 | Московский городской научно-исследовательский институт скорой помощи им. Н.В. Склифосовского | Способ лечения последствий травматического и интраоперационного повреждения тканей у больных с политравмой |
| WO2007120606A2 (en) | 2006-04-10 | 2007-10-25 | President And Fellows Of Harvard College | Methods for modulating formation and progression of cellulite |
| CA2711743C (en) | 2007-01-21 | 2015-04-07 | Agricultural Research Organization | Quinazolinone derivatives for treating or preventing skeletal muscle fibrosis |
| CA2737219C (en) | 2008-08-11 | 2017-02-28 | Tracy Keller | Halofuginone analogs for inhibition of trna synthetases and uses thereof |
| WO2012108538A1 (ja) | 2011-02-10 | 2012-08-16 | 国立大学法人 長崎大学 | 急性肺損傷診断方法 |
| AU2013207796B2 (en) | 2012-01-13 | 2017-04-27 | President And Fellows Of Harvard College | Halofuginol derivatives and their use in cosmetic and pharmaceutical compositions |
| US11708353B2 (en) | 2018-06-08 | 2023-07-25 | The General Hospital Corporation | Inhibitors of prolyl-tRNA-synthetase |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3320124A (en) * | 1964-07-20 | 1967-05-16 | American Cyanamid Co | Method for treating coccidiosis with quinazolinones |
| DE2934069A1 (de) * | 1979-08-23 | 1981-03-12 | Hoechst Ag, 6000 Frankfurt | Mittel gegen theileriosen und seine verwendung. |
| JPH08510251A (ja) * | 1993-05-07 | 1996-10-29 | ビー マーゴリン、ソロモン | 線維症の病変の修復と予防のための組成物および方法 |
| CA2113229C (en) * | 1994-01-11 | 1999-04-20 | Mark Pines | Anti-fibrotic quinazolinone-containing compositions and methods for the use thereof |
| IL110831A (en) * | 1994-08-31 | 1998-12-27 | Hadasit Med Res Service | Pharmaceutical compositions containing quinazolinone derivatives for preventing restenosis |
| JPH0971586A (ja) * | 1995-09-07 | 1997-03-18 | Yamanouchi Pharmaceut Co Ltd | 新規な二環性縮合イミダゾール誘導体 |
| AU3667397A (en) * | 1996-07-03 | 1998-01-21 | Alain Colige | Recombinant n-proteinase, and the production, methods and uses thereof |
| PT930876E (pt) * | 1996-07-22 | 2005-01-31 | Renovo Ltd | Utilizacao de moduladores da funcao esteroide sexual para tratar feridas e desordens fibroticas |
| EP0941108B1 (en) * | 1996-12-04 | 2002-10-16 | Renovo Limited | Wound healing and treatment of fibrosis |
| US5852024A (en) * | 1997-02-11 | 1998-12-22 | Hadasit | Treatment and prevention of adhesions |
| US6028075A (en) * | 1997-02-11 | 2000-02-22 | Pines; Mark | Quinazolinone containing pharmaceutical compositions for prevention of neovascularization and for treating malignancies |
| DE19951702A1 (de) * | 1999-10-27 | 2001-05-03 | Aventis Pharma Gmbh | Verwendung von 2-Amino-3,4-dihydro-chinazolinen zur Herstellung eines Medikaments zur Behandlung oder Prophylaxe von durch ischämischen Zuständen bewirkten Krankheiten |
-
1999
- 1999-08-13 WO PCT/IL1999/000440 patent/WO2000009070A2/en not_active Ceased
- 1999-08-13 ES ES99936952T patent/ES2255286T3/es not_active Expired - Lifetime
- 1999-08-13 JP JP2000564574A patent/JP2002522462A/ja active Pending
- 1999-08-13 DE DE69927987T patent/DE69927987T2/de not_active Expired - Fee Related
- 1999-08-13 AT AT99936952T patent/ATE307586T1/de not_active IP Right Cessation
- 1999-08-13 AU AU51914/99A patent/AU756437B2/en not_active Ceased
- 1999-08-13 CA CA002340176A patent/CA2340176A1/en not_active Abandoned
- 1999-08-13 EP EP99936952A patent/EP1109559B1/en not_active Expired - Lifetime
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