JP2002522462A - 組織外傷に関連した病原プロセスの阻害 - Google Patents

組織外傷に関連した病原プロセスの阻害

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Publication number
JP2002522462A
JP2002522462A JP2000564574A JP2000564574A JP2002522462A JP 2002522462 A JP2002522462 A JP 2002522462A JP 2000564574 A JP2000564574 A JP 2000564574A JP 2000564574 A JP2000564574 A JP 2000564574A JP 2002522462 A JP2002522462 A JP 2002522462A
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JP
Japan
Prior art keywords
group
expression
halofuginone
collagen
inhibition
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2000564574A
Other languages
English (en)
Japanese (ja)
Other versions
JP2002522462A5 (enExample
Inventor
パインズ、マーク
ブロダフスキー、イスラエル
ナーグラ、アーノン
ハズーム、エリ
Original Assignee
ハダシット・メディカル・リサーチ・サービシイズ・アンド・ディベロプメント・カンパニー・リミテッド
アグリカルチュラル リサーチ オーガナイゼーション
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Filing date
Publication date
Application filed by ハダシット・メディカル・リサーチ・サービシイズ・アンド・ディベロプメント・カンパニー・リミテッド, アグリカルチュラル リサーチ オーガナイゼーション filed Critical ハダシット・メディカル・リサーチ・サービシイズ・アンド・ディベロプメント・カンパニー・リミテッド
Publication of JP2002522462A publication Critical patent/JP2002522462A/ja
Publication of JP2002522462A5 publication Critical patent/JP2002522462A5/ja
Pending legal-status Critical Current

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • A61P17/02Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system

Landscapes

  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Epidemiology (AREA)
  • Dermatology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
JP2000564574A 1998-08-13 1999-08-13 組織外傷に関連した病原プロセスの阻害 Pending JP2002522462A (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
IL12579098 1998-08-13
US13714599P 1999-06-01 1999-06-01
US125790 1999-06-01
US60/137,145 1999-06-01
PCT/IL1999/000440 WO2000009070A2 (en) 1998-08-13 1999-08-13 Inhibition of pathogenic processes related to tissue trauma

Publications (2)

Publication Number Publication Date
JP2002522462A true JP2002522462A (ja) 2002-07-23
JP2002522462A5 JP2002522462A5 (enExample) 2006-10-05

Family

ID=26323693

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2000564574A Pending JP2002522462A (ja) 1998-08-13 1999-08-13 組織外傷に関連した病原プロセスの阻害

Country Status (8)

Country Link
EP (1) EP1109559B1 (enExample)
JP (1) JP2002522462A (enExample)
AT (1) ATE307586T1 (enExample)
AU (1) AU756437B2 (enExample)
CA (1) CA2340176A1 (enExample)
DE (1) DE69927987T2 (enExample)
ES (1) ES2255286T3 (enExample)
WO (1) WO2000009070A2 (enExample)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2006504769A (ja) * 2002-10-31 2006-02-09 ステート オブ イスラエル、ミニストリー オブ アグリカルチャー 病理学的プロセスに関する遺伝子発現を制御するためのキナゾリノン組成物
WO2012108538A1 (ja) 2011-02-10 2012-08-16 国立大学法人 長崎大学 急性肺損傷診断方法

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL143366A0 (en) * 2001-05-24 2002-04-21 Harasit Medical Res Services & Treatment of renal fibrosis
RU2243778C2 (ru) * 2003-02-18 2005-01-10 Московский городской научно-исследовательский институт скорой помощи им. Н.В. Склифосовского Способ лечения последствий травматического и интраоперационного повреждения тканей у больных с политравмой
EP2010136B1 (en) * 2006-04-10 2012-09-12 The President and Fellows of Harvard College Methods for modulating formation and progression of cellulite
EP2114409B1 (en) 2007-01-21 2013-11-20 Agricultural Research Organization Composition and method for treating or preventing skeletal muscle fibrosis
CN102177152A (zh) 2008-08-11 2011-09-07 哈佛大学校长及研究员协会 用于抑制tRNA合成酶的卤夫酮(halofuginone)类似物和其用途
US10155742B2 (en) 2012-01-13 2018-12-18 President And Fellows Of Harvard College Halofuginol derivatives and their use in cosmetic and pharmaceutical compositions
US11708353B2 (en) 2018-06-08 2023-07-25 The General Hospital Corporation Inhibitors of prolyl-tRNA-synthetase

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5449678A (en) * 1994-01-11 1995-09-12 Agricultural Research Organization, Ministry Of Agriculture Anti-fibrotic quinazolinone-containing compositions and methods for the use thereof
WO1996006616A1 (en) * 1994-08-31 1996-03-07 Davidson, Clifford, M. Quinazolinone pharmaceuticals and use thereof
JPH08510251A (ja) * 1993-05-07 1996-10-29 ビー マーゴリン、ソロモン 線維症の病変の修復と予防のための組成物および方法
WO1998000555A1 (en) * 1996-07-03 1998-01-08 Prockop Darwin J Recombinant n-proteinase, and the production, methods and uses thereof
WO1998003180A2 (en) * 1996-07-22 1998-01-29 The Victoria University Of Manchester Use of sex steroids function modulators to treat wounds and fibrotic disorders
WO1998024465A1 (en) * 1996-12-04 1998-06-11 The Victoria University Of Manchester Wound healing and treatment of fibrosis

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3320124A (en) * 1964-07-20 1967-05-16 American Cyanamid Co Method for treating coccidiosis with quinazolinones
DE2934069A1 (de) * 1979-08-23 1981-03-12 Hoechst Ag, 6000 Frankfurt Mittel gegen theileriosen und seine verwendung.
JPH0971586A (ja) * 1995-09-07 1997-03-18 Yamanouchi Pharmaceut Co Ltd 新規な二環性縮合イミダゾール誘導体
US6028075A (en) * 1997-02-11 2000-02-22 Pines; Mark Quinazolinone containing pharmaceutical compositions for prevention of neovascularization and for treating malignancies
US5852024A (en) * 1997-02-11 1998-12-22 Hadasit Treatment and prevention of adhesions
DE19951702A1 (de) * 1999-10-27 2001-05-03 Aventis Pharma Gmbh Verwendung von 2-Amino-3,4-dihydro-chinazolinen zur Herstellung eines Medikaments zur Behandlung oder Prophylaxe von durch ischämischen Zuständen bewirkten Krankheiten

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH08510251A (ja) * 1993-05-07 1996-10-29 ビー マーゴリン、ソロモン 線維症の病変の修復と予防のための組成物および方法
US5449678A (en) * 1994-01-11 1995-09-12 Agricultural Research Organization, Ministry Of Agriculture Anti-fibrotic quinazolinone-containing compositions and methods for the use thereof
WO1996006616A1 (en) * 1994-08-31 1996-03-07 Davidson, Clifford, M. Quinazolinone pharmaceuticals and use thereof
WO1998000555A1 (en) * 1996-07-03 1998-01-08 Prockop Darwin J Recombinant n-proteinase, and the production, methods and uses thereof
WO1998003180A2 (en) * 1996-07-22 1998-01-29 The Victoria University Of Manchester Use of sex steroids function modulators to treat wounds and fibrotic disorders
WO1998024465A1 (en) * 1996-12-04 1998-06-11 The Victoria University Of Manchester Wound healing and treatment of fibrosis

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
JPN6009052372, PINES,M. et al, "Halofuginone, a specific inhibitor of collagen type I synthesis, prevents dimethylnitrosamine−induce", J Hepatol, 1997, Vol.27, No.2, p.391−8 *
JPN6009052374, NAGLER,A. et al, "Reduction in pulmonary fibrosis in vivo by halofuginone", Am J Respir Crit Care Med, 1996, Vol.154, No.4 Pt 1, p.1082−6 *

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2006504769A (ja) * 2002-10-31 2006-02-09 ステート オブ イスラエル、ミニストリー オブ アグリカルチャー 病理学的プロセスに関する遺伝子発現を制御するためのキナゾリノン組成物
WO2012108538A1 (ja) 2011-02-10 2012-08-16 国立大学法人 長崎大学 急性肺損傷診断方法

Also Published As

Publication number Publication date
WO2000009070A3 (en) 2000-10-19
WO2000009070A2 (en) 2000-02-24
EP1109559B1 (en) 2005-10-26
EP1109559A2 (en) 2001-06-27
DE69927987D1 (de) 2005-12-01
ATE307586T1 (de) 2005-11-15
ES2255286T3 (es) 2006-06-16
DE69927987T2 (de) 2006-11-09
AU756437B2 (en) 2003-01-16
CA2340176A1 (en) 2000-02-24
EP1109559A4 (en) 2002-05-08
AU5191499A (en) 2000-03-06

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