JP2002521334A - 置換ベンズイミダゾール抗ウィルス剤 - Google Patents

置換ベンズイミダゾール抗ウィルス剤

Info

Publication number
JP2002521334A
JP2002521334A JP2000560893A JP2000560893A JP2002521334A JP 2002521334 A JP2002521334 A JP 2002521334A JP 2000560893 A JP2000560893 A JP 2000560893A JP 2000560893 A JP2000560893 A JP 2000560893A JP 2002521334 A JP2002521334 A JP 2002521334A
Authority
JP
Japan
Prior art keywords
alkyl
ylmethyl
embedded image
benzimidazol
compound
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
JP2000560893A
Other languages
English (en)
Japanese (ja)
Other versions
JP2002521334A5 (https=
Inventor
クオ ロング ユー
リタ リー シヴィエロ
マーク アール クリスタル
キャスリーン エフ カドー
ニコラス エイ ミーンウェル
Original Assignee
ブリストルーマイヤーズ スクイブ カンパニー
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by ブリストルーマイヤーズ スクイブ カンパニー filed Critical ブリストルーマイヤーズ スクイブ カンパニー
Publication of JP2002521334A publication Critical patent/JP2002521334A/ja
Publication of JP2002521334A5 publication Critical patent/JP2002521334A5/ja
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Virology (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
JP2000560893A 1998-07-20 1999-07-20 置換ベンズイミダゾール抗ウィルス剤 Abandoned JP2002521334A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US9338798P 1998-07-20 1998-07-20
US60/093,387 1998-07-20
PCT/US1999/012398 WO2000004900A1 (en) 1998-07-20 1999-07-20 Substituted benzimidazole antiviral agents

Publications (2)

Publication Number Publication Date
JP2002521334A true JP2002521334A (ja) 2002-07-16
JP2002521334A5 JP2002521334A5 (https=) 2006-08-17

Family

ID=22238648

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2000560893A Abandoned JP2002521334A (ja) 1998-07-20 1999-07-20 置換ベンズイミダゾール抗ウィルス剤

Country Status (6)

Country Link
US (2) US6908936B2 (https=)
EP (1) EP1098644A1 (https=)
JP (1) JP2002521334A (https=)
AU (1) AU741946B2 (https=)
CA (1) CA2338147A1 (https=)
WO (1) WO2000004900A1 (https=)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2008528564A (ja) * 2005-01-31 2008-07-31 アロウ セラピューティクス リミテッド 抗ウイルス剤としてのキナゾリン誘導体
JP2011503136A (ja) * 2007-11-15 2011-01-27 エフ．ホフマン−ラ ロシュ アーゲー ベンゾイミダゾール誘導体及びｆｘｒアゴニストとしてのその使用
JP2020532494A (ja) * 2017-07-20 2020-11-12 アールイーヴァイラル リミテッド 医薬化合物

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2215670T3 (es) 1999-06-28 2004-10-16 Janssen Pharmaceutica N.V. Inhibidores de la replicacion del virus sincitial respiratorio.
ES2338098T3 (es) * 2000-05-03 2010-05-04 Medimmune, Llc Terapia de combinacion de enfermedades respiratorias usando anticuerpos y agentes antiinflamatorios.
US6489338B2 (en) 2000-06-13 2002-12-03 Bristol-Myers Squibb Company Imidazopyridine and imidazopyrimidine antiviral agents
US6506738B1 (en) 2000-09-27 2003-01-14 Bristol-Myers Squibb Company Benzimidazolone antiviral agents
US6774134B2 (en) 2000-12-20 2004-08-10 Bristol-Myers Squibb Company Heterocyclic substituted 2-methyl-benzimidazole antiviral agents
US20040096451A1 (en) * 2002-07-25 2004-05-20 Young James F. Methods of treating and preventing RSV, hMPV, and PIV using anti-RSV, anti-hMPV, and anti-PIV antibodies
US7030150B2 (en) 2001-05-11 2006-04-18 Trimeris, Inc. Benzimidazole compounds and antiviral uses thereof
US6919331B2 (en) * 2001-12-10 2005-07-19 Bristol-Myers Squibb Company Substituted 2-methyl-benzimidazole respiratory syncytial virus antiviral agents
US7157471B2 (en) * 2003-08-25 2007-01-02 Boehringer Ingelheim International Gmbh Haloalkyl- and piperidine-substituted benzimidazole-derivatives
US7323567B2 (en) 2003-10-30 2008-01-29 Boehringer Ingelheim (Canada) Ltd. RSV polymerase inhibitors
GB0406282D0 (en) * 2004-03-19 2004-04-21 Arrow Therapeutics Ltd Therapeutic compounds
GB0406280D0 (en) * 2004-03-19 2004-04-21 Arrow Therapeutics Ltd Chemical compounds
BRPI0520554A2 (pt) 2005-09-19 2009-06-13 Arrow Therapeutics Ltd uso de uma benzodiazepina ou um sal farmaceuticamente aceitável do mesmo, método para tratar ou prevenir uma infecção por hcv em um paciente, derivado de benzodiazepina ou um sal famaceuticamente aceitável do mesmo, e, composição farmacêutica
GB0520475D0 (en) * 2005-10-07 2005-11-16 Arrow Therapeutics Ltd Chemical compounds
WO2007080401A1 (en) * 2006-01-11 2007-07-19 Arrow Therapeutics Limited Triazoloanilinopyrimidine derivatives for use as antiviral agents
ES2424214T3 (es) 2007-08-27 2013-09-30 Siga Technologies, Inc. Medicamentos antivirales para el tratamiento de una infección por Arenavirus
RU2407738C1 (ru) * 2009-07-03 2010-12-27 Общество с ограниченной ответственностью "Интеллектуальный Диалог" Противовирусный активный компонент, фармацевтическая композиция, лекарственное средство, способ лечения вирусных заболеваний
US9850251B2 (en) 2013-12-10 2017-12-26 Shandong Danhong Pharmaceutical Co., Ltd. Imidazole derivative used as antiviral agent and use therof in preparation of medicament
ES2821649T3 (es) 2015-06-08 2021-04-27 Shangdong Danhong Pharmaceutical Co Ltd Método para preparar derivados de imidazol e intermedios de los mismos y formas cristalinas
CN105820156A (zh) * 2016-04-21 2016-08-03 广东工业大学 苯并三氮唑基苯并咪唑啉及其制备方法和应用

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3394141A (en) 1965-11-12 1968-07-23 Fabio Sparatore Z-benzyaminobenzimidazoles
US4324794A (en) * 1980-08-26 1982-04-13 Research Triangle Institute Inhibition of respiratory syncytial virus-induced cell fusion by amidino compounds
FI75816C (fi) 1981-02-06 1988-08-08 Ucb Sa Foerfarande foer framstaellning av terapeutiskt aktiv 2-/4-(difenylmetyl)-1-piperazinyl/-aettiksyror eller dess amid.
US5066656A (en) * 1989-11-01 1991-11-19 Janssen Pharmaceutica N.V. Pharmacologically active (6,7-dihydro-5H-pyrrolo[1,2-c]imidazol-5-yl)- and (5,6,7,8-tetrahydroimidazo[1,5-a]pyridin-5-yl) substituted 1H-benzotriazole derivatives
US5256668A (en) 1993-03-17 1993-10-26 American Home Products Corporation Aminopyrimidine derivatives as antiviral agents for respiratory syncytial virus
CA2197393A1 (en) 1996-02-13 1997-08-14 Yakov Gluzman (Deceased) Triazine containing anionic compounds useful as antiviral agents
US6919331B2 (en) * 2001-12-10 2005-07-19 Bristol-Myers Squibb Company Substituted 2-methyl-benzimidazole respiratory syncytial virus antiviral agents

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2008528564A (ja) * 2005-01-31 2008-07-31 アロウ セラピューティクス リミテッド 抗ウイルス剤としてのキナゾリン誘導体
JP2011503136A (ja) * 2007-11-15 2011-01-27 エフ．ホフマン−ラ ロシュ アーゲー ベンゾイミダゾール誘導体及びｆｘｒアゴニストとしてのその使用
JP2020532494A (ja) * 2017-07-20 2020-11-12 アールイーヴァイラル リミテッド 医薬化合物

Also Published As

Publication number Publication date
WO2000004900A1 (en) 2000-02-03
AU5080999A (en) 2000-02-14
US20030139450A1 (en) 2003-07-24
US6908936B2 (en) 2005-06-21
US20050038085A1 (en) 2005-02-17
CA2338147A1 (en) 2000-02-03
AU741946B2 (en) 2001-12-13
EP1098644A1 (en) 2001-05-16
US7030140B2 (en) 2006-04-18

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