JP2002521334A - 置換ベンズイミダゾール抗ウィルス剤 - Google Patents

置換ベンズイミダゾール抗ウィルス剤

Info

Publication number
JP2002521334A
JP2002521334A JP2000560893A JP2000560893A JP2002521334A JP 2002521334 A JP2002521334 A JP 2002521334A JP 2000560893 A JP2000560893 A JP 2000560893A JP 2000560893 A JP2000560893 A JP 2000560893A JP 2002521334 A JP2002521334 A JP 2002521334A
Authority
JP
Japan
Prior art keywords
alkyl
ylmethyl
embedded image
benzimidazol
compound
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
JP2000560893A
Other languages
English (en)
Japanese (ja)
Other versions
JP2002521334A5 (https=
Inventor
クオ ロング ユー
リタ リー シヴィエロ
マーク アール クリスタル
キャスリーン エフ カドー
ニコラス エイ ミーンウェル
Original Assignee
ブリストルーマイヤーズ スクイブ カンパニー
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by ブリストルーマイヤーズ スクイブ カンパニー filed Critical ブリストルーマイヤーズ スクイブ カンパニー
Publication of JP2002521334A publication Critical patent/JP2002521334A/ja
Publication of JP2002521334A5 publication Critical patent/JP2002521334A5/ja
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Virology (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
JP2000560893A 1998-07-20 1999-07-20 置換ベンズイミダゾール抗ウィルス剤 Abandoned JP2002521334A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US9338798P 1998-07-20 1998-07-20
US60/093,387 1998-07-20
PCT/US1999/012398 WO2000004900A1 (en) 1998-07-20 1999-07-20 Substituted benzimidazole antiviral agents

Publications (2)

Publication Number Publication Date
JP2002521334A true JP2002521334A (ja) 2002-07-16
JP2002521334A5 JP2002521334A5 (https=) 2006-08-17

Family

ID=22238648

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2000560893A Abandoned JP2002521334A (ja) 1998-07-20 1999-07-20 置換ベンズイミダゾール抗ウィルス剤

Country Status (6)

Country Link
US (2) US6908936B2 (https=)
EP (1) EP1098644A1 (https=)
JP (1) JP2002521334A (https=)
AU (1) AU741946B2 (https=)
CA (1) CA2338147A1 (https=)
WO (1) WO2000004900A1 (https=)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2008528564A (ja) * 2005-01-31 2008-07-31 アロウ セラピューティクス リミテッド 抗ウイルス剤としてのキナゾリン誘導体
JP2011503136A (ja) * 2007-11-15 2011-01-27 エフ．ホフマン−ラ ロシュ アーゲー ベンゾイミダゾール誘導体及びｆｘｒアゴニストとしてのその使用
JP2020532494A (ja) * 2017-07-20 2020-11-12 アールイーヴァイラル リミテッド 医薬化合物

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EE04592B1 (et) * 1999-06-28 2006-02-15 Janssen Pharmaceutica N.V. Respiratoorse süntsütiaalviiruse replikatsiooni inhibiitorid, nende valmistamismeetod, kasutamine ja vaheühendid, farmatseutiline kompositsioon ja selle valmistamismeetod ning produkt
JP2003531867A (ja) * 2000-05-03 2003-10-28 メディミューン，インコーポレイテッド 抗体および抗炎症薬を用いた呼吸器疾患の組合せ治療法
US6489338B2 (en) 2000-06-13 2002-12-03 Bristol-Myers Squibb Company Imidazopyridine and imidazopyrimidine antiviral agents
US6506738B1 (en) 2000-09-27 2003-01-14 Bristol-Myers Squibb Company Benzimidazolone antiviral agents
US6774134B2 (en) * 2000-12-20 2004-08-10 Bristol-Myers Squibb Company Heterocyclic substituted 2-methyl-benzimidazole antiviral agents
US7030150B2 (en) 2001-05-11 2006-04-18 Trimeris, Inc. Benzimidazole compounds and antiviral uses thereof
US6919331B2 (en) * 2001-12-10 2005-07-19 Bristol-Myers Squibb Company Substituted 2-methyl-benzimidazole respiratory syncytial virus antiviral agents
WO2004010935A2 (en) * 2002-07-25 2004-02-05 Medimmune, Inc. Methods of treating and preventing rsv, hmpv, and piv using anti-rsv, anti-hmpv, and anti-piv antibodies
US7157471B2 (en) * 2003-08-25 2007-01-02 Boehringer Ingelheim International Gmbh Haloalkyl- and piperidine-substituted benzimidazole-derivatives
WO2005042530A1 (en) 2003-10-30 2005-05-12 Boehringer Ingelheim (Canada) Ltd. Rsv polymerase inhibitors
GB0406280D0 (en) * 2004-03-19 2004-04-21 Arrow Therapeutics Ltd Chemical compounds
GB0406282D0 (en) * 2004-03-19 2004-04-21 Arrow Therapeutics Ltd Therapeutic compounds
BRPI0520554A2 (pt) 2005-09-19 2009-06-13 Arrow Therapeutics Ltd uso de uma benzodiazepina ou um sal farmaceuticamente aceitável do mesmo, método para tratar ou prevenir uma infecção por hcv em um paciente, derivado de benzodiazepina ou um sal famaceuticamente aceitável do mesmo, e, composição farmacêutica
GB0520475D0 (en) * 2005-10-07 2005-11-16 Arrow Therapeutics Ltd Chemical compounds
KR20080083139A (ko) * 2006-01-11 2008-09-16 애로우 쎄라퓨틱스 리미티드 항-바이러스제로 사용하기 위한트리아졸로아닐리노피리미딘 유도체
MX2010002278A (es) 2007-08-27 2010-03-17 Siga Technologies Inc Farmacos antivirales para el tratamiento de una infeccion por arenavirus.
RU2407738C1 (ru) * 2009-07-03 2010-12-27 Общество с ограниченной ответственностью "Интеллектуальный Диалог" Противовирусный активный компонент, фармацевтическая композиция, лекарственное средство, способ лечения вирусных заболеваний
WO2015085844A1 (zh) 2013-12-10 2015-06-18 南京明德新药研发股份有限公司 作为抗病毒剂的咪唑衍生物及其制药用途
CN107709328B (zh) 2015-06-08 2021-03-05 山东丹红制药有限公司 咪唑衍生物及其中间体的制备方法和晶型
CN105820156A (zh) * 2016-04-21 2016-08-03 广东工业大学 苯并三氮唑基苯并咪唑啉及其制备方法和应用

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3394141A (en) 1965-11-12 1968-07-23 Fabio Sparatore Z-benzyaminobenzimidazoles
US4324794A (en) * 1980-08-26 1982-04-13 Research Triangle Institute Inhibition of respiratory syncytial virus-induced cell fusion by amidino compounds
DK154078C (da) 1981-02-06 1989-05-22 Ucb Sa Analogifremgangsmaade til fremstilling af 2-(2-(4-(diphenyl-methyl)-1-piperazinyl)ethoxy)-acetamider eller syreadditionssalte heraf
US5066656A (en) * 1989-11-01 1991-11-19 Janssen Pharmaceutica N.V. Pharmacologically active (6,7-dihydro-5H-pyrrolo[1,2-c]imidazol-5-yl)- and (5,6,7,8-tetrahydroimidazo[1,5-a]pyridin-5-yl) substituted 1H-benzotriazole derivatives
US5256668A (en) 1993-03-17 1993-10-26 American Home Products Corporation Aminopyrimidine derivatives as antiviral agents for respiratory syncytial virus
BR9700939A (pt) 1996-02-13 1998-09-01 American Cyanamid Co Compostos aniônicos contendo traiazina úteis como agentes antivirais
US6919331B2 (en) * 2001-12-10 2005-07-19 Bristol-Myers Squibb Company Substituted 2-methyl-benzimidazole respiratory syncytial virus antiviral agents

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2008528564A (ja) * 2005-01-31 2008-07-31 アロウ セラピューティクス リミテッド 抗ウイルス剤としてのキナゾリン誘導体
JP2011503136A (ja) * 2007-11-15 2011-01-27 エフ．ホフマン−ラ ロシュ アーゲー ベンゾイミダゾール誘導体及びｆｘｒアゴニストとしてのその使用
JP2020532494A (ja) * 2017-07-20 2020-11-12 アールイーヴァイラル リミテッド 医薬化合物

Also Published As

Publication number Publication date
US6908936B2 (en) 2005-06-21
US20050038085A1 (en) 2005-02-17
AU5080999A (en) 2000-02-14
US7030140B2 (en) 2006-04-18
US20030139450A1 (en) 2003-07-24
EP1098644A1 (en) 2001-05-16
WO2000004900A1 (en) 2000-02-03
AU741946B2 (en) 2001-12-13
CA2338147A1 (en) 2000-02-03

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