JP2002518058A - 水不溶性α−１，４−グルカンの製造方法 - Google Patents
水不溶性α−１，４−グルカンの製造方法Info
- Publication number
- JP2002518058A JP2002518058A JP2000556052A JP2000556052A JP2002518058A JP 2002518058 A JP2002518058 A JP 2002518058A JP 2000556052 A JP2000556052 A JP 2000556052A JP 2000556052 A JP2000556052 A JP 2000556052A JP 2002518058 A JP2002518058 A JP 2002518058A
- Authority
- JP
- Japan
- Prior art keywords
- amylosucrase
- glucan
- insoluble
- buffer
- sucrose
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 229920001503 Glucan Polymers 0.000 title claims abstract description 34
- 238000004519 manufacturing process Methods 0.000 title claims abstract description 15
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 claims abstract description 25
- 229930006000 Sucrose Natural products 0.000 claims abstract description 24
- 238000000338 in vitro Methods 0.000 claims abstract description 13
- 238000000034 method Methods 0.000 claims description 52
- 108010033764 Amylosucrase Proteins 0.000 claims description 49
- 238000006243 chemical reaction Methods 0.000 claims description 37
- 102000004190 Enzymes Human genes 0.000 claims description 23
- 108090000790 Enzymes Proteins 0.000 claims description 23
- 239000005720 sucrose Substances 0.000 claims description 23
- 229930091371 Fructose Natural products 0.000 claims description 18
- 239000005715 Fructose Substances 0.000 claims description 18
- RFSUNEUAIZKAJO-ARQDHWQXSA-N Fructose Chemical compound OC[C@H]1O[C@](O)(CO)[C@@H](O)[C@@H]1O RFSUNEUAIZKAJO-ARQDHWQXSA-N 0.000 claims description 18
- 230000000694 effects Effects 0.000 claims description 8
- 150000001720 carbohydrates Chemical class 0.000 claims description 6
- 239000000463 material Substances 0.000 claims description 6
- 241000894006 Bacteria Species 0.000 claims description 5
- 241000588653 Neisseria Species 0.000 claims description 4
- 239000012062 aqueous buffer Substances 0.000 claims 1
- 235000013681 dietary sucrose Nutrition 0.000 abstract 1
- 229960004793 sucrose Drugs 0.000 abstract 1
- 108090000623 proteins and genes Proteins 0.000 description 32
- 102000004169 proteins and genes Human genes 0.000 description 25
- 210000004027 cell Anatomy 0.000 description 20
- 239000000047 product Substances 0.000 description 18
- 239000000370 acceptor Substances 0.000 description 14
- 239000000872 buffer Substances 0.000 description 14
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 12
- 239000000284 extract Substances 0.000 description 12
- 150000004676 glycans Chemical class 0.000 description 12
- 229920001282 polysaccharide Polymers 0.000 description 12
- 239000005017 polysaccharide Substances 0.000 description 12
- 230000008901 benefit Effects 0.000 description 10
- 108010076504 Protein Sorting Signals Proteins 0.000 description 9
- 241000588660 Neisseria polysaccharea Species 0.000 description 8
- 239000000337 buffer salt Substances 0.000 description 7
- 235000013305 food Nutrition 0.000 description 7
- 238000000746 purification Methods 0.000 description 7
- 150000003839 salts Chemical group 0.000 description 7
- 239000000243 solution Substances 0.000 description 7
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 6
- RAXXELZNTBOGNW-UHFFFAOYSA-N imidazole Natural products C1=CNC=N1 RAXXELZNTBOGNW-UHFFFAOYSA-N 0.000 description 6
- 244000005700 microbiome Species 0.000 description 6
- 239000011780 sodium chloride Substances 0.000 description 6
- 238000013518 transcription Methods 0.000 description 6
- 230000035897 transcription Effects 0.000 description 6
- 235000014633 carbohydrates Nutrition 0.000 description 5
- 230000008569 process Effects 0.000 description 5
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 5
- 229920000856 Amylose Polymers 0.000 description 4
- 108020004414 DNA Proteins 0.000 description 4
- 229920001353 Dextrin Polymers 0.000 description 4
- 239000004375 Dextrin Substances 0.000 description 4
- 241000588724 Escherichia coli Species 0.000 description 4
- 229920002527 Glycogen Polymers 0.000 description 4
- 235000019425 dextrin Nutrition 0.000 description 4
- 229940096919 glycogen Drugs 0.000 description 4
- 239000001963 growth medium Substances 0.000 description 4
- 239000011541 reaction mixture Substances 0.000 description 4
- 239000001509 sodium citrate Substances 0.000 description 4
- NLJMYIDDQXHKNR-UHFFFAOYSA-K sodium citrate Chemical compound O.O.[Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O NLJMYIDDQXHKNR-UHFFFAOYSA-K 0.000 description 4
- 102000005731 Glucose-6-phosphate isomerase Human genes 0.000 description 3
- 108010070600 Glucose-6-phosphate isomerase Proteins 0.000 description 3
- 102000005548 Hexokinase Human genes 0.000 description 3
- 108700040460 Hexokinases Proteins 0.000 description 3
- 108091028043 Nucleic acid sequence Proteins 0.000 description 3
- 240000004808 Saccharomyces cerevisiae Species 0.000 description 3
- 230000001580 bacterial effect Effects 0.000 description 3
- 238000001727 in vivo Methods 0.000 description 3
- 235000011073 invertase Nutrition 0.000 description 3
- 239000012429 reaction media Substances 0.000 description 3
- 230000009467 reduction Effects 0.000 description 3
- 238000003786 synthesis reaction Methods 0.000 description 3
- 238000012360 testing method Methods 0.000 description 3
- 230000014616 translation Effects 0.000 description 3
- 238000010626 work up procedure Methods 0.000 description 3
- 229920000945 Amylopectin Polymers 0.000 description 2
- KRKNYBCHXYNGOX-UHFFFAOYSA-K Citrate Chemical compound [O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O KRKNYBCHXYNGOX-UHFFFAOYSA-K 0.000 description 2
- NBSCHQHZLSJFNQ-GASJEMHNSA-N D-Glucose 6-phosphate Chemical compound OC1O[C@H](COP(O)(O)=O)[C@@H](O)[C@H](O)[C@H]1O NBSCHQHZLSJFNQ-GASJEMHNSA-N 0.000 description 2
- 101710088194 Dehydrogenase Proteins 0.000 description 2
- VFRROHXSMXFLSN-UHFFFAOYSA-N Glc6P Natural products OP(=O)(O)OCC(O)C(O)C(O)C(O)C=O VFRROHXSMXFLSN-UHFFFAOYSA-N 0.000 description 2
- 241000192130 Leuconostoc mesenteroides Species 0.000 description 2
- 229910019142 PO4 Inorganic materials 0.000 description 2
- 239000002033 PVDF binder Substances 0.000 description 2
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 2
- VMHLLURERBWHNL-UHFFFAOYSA-M Sodium acetate Chemical compound [Na+].CC([O-])=O VMHLLURERBWHNL-UHFFFAOYSA-M 0.000 description 2
- 238000010521 absorption reaction Methods 0.000 description 2
- 238000001042 affinity chromatography Methods 0.000 description 2
- 108010051210 beta-Fructofuranosidase Proteins 0.000 description 2
- 238000010352 biotechnological method Methods 0.000 description 2
- 238000013452 biotechnological production Methods 0.000 description 2
- 230000036983 biotransformation Effects 0.000 description 2
- 239000007853 buffer solution Substances 0.000 description 2
- 238000004587 chromatography analysis Methods 0.000 description 2
- 238000007796 conventional method Methods 0.000 description 2
- VHJLVAABSRFDPM-QWWZWVQMSA-N dithiothreitol Chemical compound SC[C@@H](O)[C@H](O)CS VHJLVAABSRFDPM-QWWZWVQMSA-N 0.000 description 2
- 230000002255 enzymatic effect Effects 0.000 description 2
- 108020001507 fusion proteins Proteins 0.000 description 2
- 102000037865 fusion proteins Human genes 0.000 description 2
- 230000001939 inductive effect Effects 0.000 description 2
- 230000007246 mechanism Effects 0.000 description 2
- 239000002609 medium Substances 0.000 description 2
- 239000012528 membrane Substances 0.000 description 2
- 150000002772 monosaccharides Chemical class 0.000 description 2
- 229930027945 nicotinamide-adenine dinucleotide Natural products 0.000 description 2
- BOPGDPNILDQYTO-NNYOXOHSSA-N nicotinamide-adenine dinucleotide Chemical compound C1=CCC(C(=O)N)=CN1[C@H]1[C@H](O)[C@H](O)[C@@H](COP(O)(=O)OP(O)(=O)OC[C@@H]2[C@H]([C@@H](O)[C@@H](O2)N2C3=NC=NC(N)=C3N=C2)O)O1 BOPGDPNILDQYTO-NNYOXOHSSA-N 0.000 description 2
- 235000015097 nutrients Nutrition 0.000 description 2
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 2
- 239000010452 phosphate Substances 0.000 description 2
- 229920000642 polymer Polymers 0.000 description 2
- 229920001184 polypeptide Polymers 0.000 description 2
- 229920002981 polyvinylidene fluoride Polymers 0.000 description 2
- 239000011148 porous material Substances 0.000 description 2
- 108090000765 processed proteins & peptides Proteins 0.000 description 2
- 102000004196 processed proteins & peptides Human genes 0.000 description 2
- 238000012545 processing Methods 0.000 description 2
- 230000010076 replication Effects 0.000 description 2
- 238000012552 review Methods 0.000 description 2
- 230000028327 secretion Effects 0.000 description 2
- 239000001632 sodium acetate Substances 0.000 description 2
- 235000017281 sodium acetate Nutrition 0.000 description 2
- 239000007858 starting material Substances 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 239000006228 supernatant Substances 0.000 description 2
- 238000013519 translation Methods 0.000 description 2
- BIRSGZKFKXLSJQ-SQOUGZDYSA-N 6-Phospho-D-gluconate Chemical compound OP(=O)(O)OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C(O)=O BIRSGZKFKXLSJQ-SQOUGZDYSA-N 0.000 description 1
- 102100031126 6-phosphogluconolactonase Human genes 0.000 description 1
- 108010029731 6-phosphogluconolactonase Proteins 0.000 description 1
- FHVDTGUDJYJELY-UHFFFAOYSA-N 6-{[2-carboxy-4,5-dihydroxy-6-(phosphanyloxy)oxan-3-yl]oxy}-4,5-dihydroxy-3-phosphanyloxane-2-carboxylic acid Chemical compound O1C(C(O)=O)C(P)C(O)C(O)C1OC1C(C(O)=O)OC(OP)C(O)C1O FHVDTGUDJYJELY-UHFFFAOYSA-N 0.000 description 1
- 229920000936 Agarose Polymers 0.000 description 1
- 241000588676 Bergeriella denitrificans Species 0.000 description 1
- 108091026890 Coding region Proteins 0.000 description 1
- 229920002261 Corn starch Polymers 0.000 description 1
- 235000019750 Crude protein Nutrition 0.000 description 1
- 241000195493 Cryptophyta Species 0.000 description 1
- 241000196324 Embryophyta Species 0.000 description 1
- 241000233866 Fungi Species 0.000 description 1
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 1
- 108010018962 Glucosephosphate Dehydrogenase Proteins 0.000 description 1
- 241000588749 Klebsiella oxytoca Species 0.000 description 1
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 description 1
- 241000588675 Neisseria canis Species 0.000 description 1
- 241000588654 Neisseria cinerea Species 0.000 description 1
- 241001464937 Neisseria perflava Species 0.000 description 1
- 241000588645 Neisseria sicca Species 0.000 description 1
- 241001136170 Neisseria subflava Species 0.000 description 1
- 239000004677 Nylon Substances 0.000 description 1
- 101710184309 Probable sucrose-6-phosphate hydrolase Proteins 0.000 description 1
- 229920005654 Sephadex Polymers 0.000 description 1
- 239000012507 Sephadex™ Substances 0.000 description 1
- 108010034546 Serratia marcescens nuclease Proteins 0.000 description 1
- 244000061456 Solanum tuberosum Species 0.000 description 1
- 235000002595 Solanum tuberosum Nutrition 0.000 description 1
- 102400000472 Sucrase Human genes 0.000 description 1
- 101710112652 Sucrose-6-phosphate hydrolase Proteins 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 150000007513 acids Chemical class 0.000 description 1
- 238000005273 aeration Methods 0.000 description 1
- 238000013019 agitation Methods 0.000 description 1
- 229940072056 alginate Drugs 0.000 description 1
- 235000010443 alginic acid Nutrition 0.000 description 1
- 229920000615 alginic acid Polymers 0.000 description 1
- 238000004458 analytical method Methods 0.000 description 1
- 239000003242 anti bacterial agent Substances 0.000 description 1
- 229940088710 antibiotic agent Drugs 0.000 description 1
- 239000007864 aqueous solution Substances 0.000 description 1
- 238000003556 assay Methods 0.000 description 1
- 239000012131 assay buffer Substances 0.000 description 1
- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 239000008366 buffered solution Substances 0.000 description 1
- 230000003139 buffering effect Effects 0.000 description 1
- 125000000484 butyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
- 239000003054 catalyst Substances 0.000 description 1
- 238000006555 catalytic reaction Methods 0.000 description 1
- 230000003915 cell function Effects 0.000 description 1
- 230000010261 cell growth Effects 0.000 description 1
- 210000000170 cell membrane Anatomy 0.000 description 1
- 210000003850 cellular structure Anatomy 0.000 description 1
- 239000001913 cellulose Substances 0.000 description 1
- 229920002678 cellulose Polymers 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 239000007795 chemical reaction product Substances 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 239000008120 corn starch Substances 0.000 description 1
- 239000002537 cosmetic Substances 0.000 description 1
- 230000003247 decreasing effect Effects 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 238000000502 dialysis Methods 0.000 description 1
- 230000029087 digestion Effects 0.000 description 1
- 239000012895 dilution Substances 0.000 description 1
- 238000010790 dilution Methods 0.000 description 1
- MSJMDZAOKORVFC-UAIGNFCESA-L disodium maleate Chemical compound [Na+].[Na+].[O-]C(=O)\C=C/C([O-])=O MSJMDZAOKORVFC-UAIGNFCESA-L 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 238000001952 enzyme assay Methods 0.000 description 1
- 239000013604 expression vector Substances 0.000 description 1
- 235000021433 fructose syrup Nutrition 0.000 description 1
- 230000006870 function Effects 0.000 description 1
- 238000002523 gelfiltration Methods 0.000 description 1
- 239000008103 glucose Substances 0.000 description 1
- 230000012010 growth Effects 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- 230000002209 hydrophobic effect Effects 0.000 description 1
- 230000003100 immobilizing effect Effects 0.000 description 1
- 238000009776 industrial production Methods 0.000 description 1
- 230000003993 interaction Effects 0.000 description 1
- 238000005342 ion exchange Methods 0.000 description 1
- 238000004255 ion exchange chromatography Methods 0.000 description 1
- 239000008101 lactose Substances 0.000 description 1
- 238000012423 maintenance Methods 0.000 description 1
- 239000003550 marker Substances 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 230000001404 mediated effect Effects 0.000 description 1
- 238000010327 methods by industry Methods 0.000 description 1
- 230000011987 methylation Effects 0.000 description 1
- 238000007069 methylation reaction Methods 0.000 description 1
- 230000000813 microbial effect Effects 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 239000002773 nucleotide Substances 0.000 description 1
- 125000003729 nucleotide group Chemical group 0.000 description 1
- 229920001778 nylon Polymers 0.000 description 1
- 229920001542 oligosaccharide Polymers 0.000 description 1
- 150000002482 oligosaccharides Chemical class 0.000 description 1
- YBYRMVIVWMBXKQ-UHFFFAOYSA-N phenylmethanesulfonyl fluoride Chemical compound FS(=O)(=O)CC1=CC=CC=C1 YBYRMVIVWMBXKQ-UHFFFAOYSA-N 0.000 description 1
- 229920002401 polyacrylamide Polymers 0.000 description 1
- 238000006116 polymerization reaction Methods 0.000 description 1
- 238000001556 precipitation Methods 0.000 description 1
- 238000011045 prefiltration Methods 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 238000001742 protein purification Methods 0.000 description 1
- 238000001243 protein synthesis Methods 0.000 description 1
- 238000005086 pumping Methods 0.000 description 1
- 230000001105 regulatory effect Effects 0.000 description 1
- 238000001223 reverse osmosis Methods 0.000 description 1
- 238000004007 reversed phase HPLC Methods 0.000 description 1
- 238000005070 sampling Methods 0.000 description 1
- 230000003248 secreting effect Effects 0.000 description 1
- 239000000377 silicon dioxide Substances 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 230000009870 specific binding Effects 0.000 description 1
- 238000010561 standard procedure Methods 0.000 description 1
- 239000012536 storage buffer Substances 0.000 description 1
- 239000000758 substrate Substances 0.000 description 1
- 239000011573 trace mineral Substances 0.000 description 1
- 235000013619 trace mineral Nutrition 0.000 description 1
- 230000009261 transgenic effect Effects 0.000 description 1
- 230000003612 virological effect Effects 0.000 description 1
- 235000013343 vitamin Nutrition 0.000 description 1
- 239000011782 vitamin Substances 0.000 description 1
- 229940088594 vitamin Drugs 0.000 description 1
- 229930003231 vitamin Natural products 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P19/00—Preparation of compounds containing saccharide radicals
- C12P19/18—Preparation of compounds containing saccharide radicals produced by the action of a glycosyl transferase, e.g. alpha-, beta- or gamma-cyclodextrins
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Wood Science & Technology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Microbiology (AREA)
- General Chemical & Material Sciences (AREA)
- Biotechnology (AREA)
- Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
- Enzymes And Modification Thereof (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19827978.7 | 1998-06-24 | ||
| DE19827978A DE19827978C2 (de) | 1998-06-24 | 1998-06-24 | Verfahren zur Herstellung wasserunlöslicher alpha-1,4 Glucane |
| PCT/EP1999/004199 WO1999067412A1 (de) | 1998-06-24 | 1999-06-17 | VERFAHREN ZUR HERSTELLUNG WASSENRUNLÖSLICHER α-1,4-GLUCANE |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| JP2002518058A true JP2002518058A (ja) | 2002-06-25 |
Family
ID=7871764
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2000556052A Pending JP2002518058A (ja) | 1998-06-24 | 1999-06-17 | 水不溶性α−１，４−グルカンの製造方法 |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US20020052029A1 (de) |
| EP (1) | EP1095157B1 (de) |
| JP (1) | JP2002518058A (de) |
| KR (1) | KR20010025078A (de) |
| CN (1) | CN1306581A (de) |
| AT (1) | ATE275634T1 (de) |
| AU (1) | AU4773399A (de) |
| CA (1) | CA2332373A1 (de) |
| DE (2) | DE19827978C2 (de) |
| DK (1) | DK1095157T3 (de) |
| HU (1) | HUP0102474A2 (de) |
| NO (1) | NO20006427L (de) |
| PL (1) | PL345055A1 (de) |
| WO (1) | WO1999067412A1 (de) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2007508832A (ja) * | 2003-10-24 | 2007-04-12 | バイエル クロップサイエンス ゲーエムベーハー | 耐性デンプンとしての、直鎖ポリ−α−１，４−グルカンの使用 |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE19860371A1 (de) | 1998-12-28 | 2000-06-29 | Aventis Res & Tech Gmbh & Co | Kosmetische oder medizinische Zubereitung für die topische Anwendung |
| DE19860366A1 (de) * | 1998-12-28 | 2000-06-29 | Aventis Res & Tech Gmbh & Co | Kosmetische oder medizinische Zubereitung für die topische Anwendung |
| DK1139978T3 (da) | 1998-12-28 | 2006-03-06 | Suedzucker Ag | Solbeskyttelsesmiddel med mikropartikler på basis af vanduoplöselig lineær polyglucan |
| DE19902917C2 (de) * | 1999-01-26 | 2001-03-29 | Aventis Res & Tech Gmbh & Co | Wasserunlösliche lineare Polysaccharide zur Filtration |
| CA2618699C (en) * | 2005-08-11 | 2012-10-02 | J. Craig Venter Institute, Inc. | In vitro recombination method |
| CN102796783B (zh) * | 2012-08-23 | 2015-02-11 | 江南大学 | 一种聚合度为3-8功能葡聚糖的生物加工方法 |
| CN113480677B (zh) * | 2021-08-03 | 2022-06-07 | 青岛科技大学 | 一种丹皮线性α-D-1,4-葡聚糖及其制备方法和应用 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2626583B1 (fr) * | 1988-01-29 | 1991-03-15 | Bioeurope | Procede de preparation enzymatique d'oligodextranes utiles dans la fabrication de substituts du sucre, et nouveaux oligodextranes |
| DE69308531T2 (de) * | 1992-12-28 | 1997-06-26 | Kikkoman Corp | Cycloisomaltooligosaccharide; Enzym und Verfahren zu ihrer Herstellung, und Verfahren zur Herstellung von dem Enzym |
| ATE368118T1 (de) * | 1994-05-18 | 2007-08-15 | Bayer Bioscience Gmbh | Für enzyme, die die fähigkeit besitzen lineare alpha 1,4-glucane in pflanzen, pilzen und mikroorganismen zu synthesieren, kodierende dna sequenzen |
-
1998
- 1998-06-24 DE DE19827978A patent/DE19827978C2/de not_active Expired - Fee Related
-
1999
- 1999-06-17 WO PCT/EP1999/004199 patent/WO1999067412A1/de active IP Right Grant
- 1999-06-17 CA CA002332373A patent/CA2332373A1/en not_active Abandoned
- 1999-06-17 EP EP99931089A patent/EP1095157B1/de not_active Expired - Lifetime
- 1999-06-17 PL PL99345055A patent/PL345055A1/xx unknown
- 1999-06-17 CN CN99807620A patent/CN1306581A/zh active Pending
- 1999-06-17 JP JP2000556052A patent/JP2002518058A/ja active Pending
- 1999-06-17 KR KR1020007013069A patent/KR20010025078A/ko not_active Application Discontinuation
- 1999-06-17 DE DE59910464T patent/DE59910464D1/de not_active Expired - Fee Related
- 1999-06-17 HU HU0102474A patent/HUP0102474A2/hu unknown
- 1999-06-17 AT AT99931089T patent/ATE275634T1/de not_active IP Right Cessation
- 1999-06-17 AU AU47733/99A patent/AU4773399A/en not_active Abandoned
- 1999-06-17 DK DK99931089T patent/DK1095157T3/da active
-
2000
- 2000-12-15 NO NO20006427A patent/NO20006427L/no not_active Application Discontinuation
- 2000-12-21 US US09/740,824 patent/US20020052029A1/en not_active Abandoned
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2007508832A (ja) * | 2003-10-24 | 2007-04-12 | バイエル クロップサイエンス ゲーエムベーハー | 耐性デンプンとしての、直鎖ポリ−α−１，４−グルカンの使用 |
Also Published As
| Publication number | Publication date |
|---|---|
| EP1095157B1 (de) | 2004-09-08 |
| ATE275634T1 (de) | 2004-09-15 |
| HUP0102474A2 (hu) | 2001-10-28 |
| KR20010025078A (ko) | 2001-03-26 |
| US20020052029A1 (en) | 2002-05-02 |
| DE59910464D1 (de) | 2004-10-14 |
| NO20006427D0 (no) | 2000-12-15 |
| DK1095157T3 (da) | 2004-11-22 |
| DE19827978A1 (de) | 1999-12-30 |
| EP1095157A1 (de) | 2001-05-02 |
| NO20006427L (no) | 2001-02-23 |
| PL345055A1 (en) | 2001-11-19 |
| CN1306581A (zh) | 2001-08-01 |
| CA2332373A1 (en) | 1999-12-29 |
| WO1999067412A1 (de) | 1999-12-29 |
| AU4773399A (en) | 2000-01-10 |
| DE19827978C2 (de) | 2000-11-30 |
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