JP2002516872A - 心疾患の治療のためのリシン含有ペプチド - Google Patents

心疾患の治療のためのリシン含有ペプチド

Info

Publication number
JP2002516872A
JP2002516872A JP2000551795A JP2000551795A JP2002516872A JP 2002516872 A JP2002516872 A JP 2002516872A JP 2000551795 A JP2000551795 A JP 2000551795A JP 2000551795 A JP2000551795 A JP 2000551795A JP 2002516872 A JP2002516872 A JP 2002516872A
Authority
JP
Japan
Prior art keywords
mrp
lys
trp
phe
ala
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2000551795A
Other languages
English (en)
Japanese (ja)
Other versions
JP2002516872A5 (enExample
Inventor
デゲンギ，ロマノ
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of JP2002516872A publication Critical patent/JP2002516872A/ja
Publication of JP2002516872A5 publication Critical patent/JP2002516872A5/ja
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/08—Peptides having 5 to 11 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Cardiology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
JP2000551795A 1998-06-03 1999-05-28 心疾患の治療のためのリシン含有ペプチド Pending JP2002516872A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US09/089,955 1998-06-03
US09/089,955 US5932548A (en) 1998-06-03 1998-06-03 Lysine containing peptides for treatment of heart disease
PCT/EP1999/003731 WO1999062539A1 (en) 1998-06-03 1999-05-28 Lysine containing peptides for treatment of heart disease

Publications (2)

Publication Number Publication Date
JP2002516872A true JP2002516872A (ja) 2002-06-11
JP2002516872A5 JP2002516872A5 (enExample) 2006-07-06

Family

ID=22220375

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2000551795A Pending JP2002516872A (ja) 1998-06-03 1999-05-28 心疾患の治療のためのリシン含有ペプチド

Country Status (11)

Country Link
US (1) US5932548A (enExample)
EP (2) EP1616571A3 (enExample)
JP (1) JP2002516872A (enExample)
AT (1) ATE314083T1 (enExample)
AU (1) AU4371799A (enExample)
CA (1) CA2330567A1 (enExample)
DE (1) DE69929188T2 (enExample)
DK (1) DK1082128T3 (enExample)
ES (1) ES2259834T3 (enExample)
PT (1) PT1082128E (enExample)
WO (1) WO1999062539A1 (enExample)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK1783222T3 (da) 1998-10-23 2012-07-09 Kirin Amgen Inc Dimere trombopoietiske peptidomimetika, der binder til MPL-receptor og har trombopoietisk aktivitet
US7488590B2 (en) 1998-10-23 2009-02-10 Amgen Inc. Modified peptides as therapeutic agents
US20030130185A1 (en) * 2000-09-29 2003-07-10 David Bar-Or Metal-binding compounds and uses therefor
US7592304B2 (en) 1999-10-01 2009-09-22 Dmi Life Sciences, Inc. Metal-binding compounds and uses therefor
US7632803B2 (en) * 1999-10-01 2009-12-15 Dmi Life Sciences, Inc. Metal-binding compounds and uses therefor
US6211156B1 (en) * 1999-11-10 2001-04-03 Asta Medica A.G. Peptides for treatment of erectile dysfunction
JP3498041B2 (ja) 2000-05-29 2004-02-16 科研製薬株式会社 プラルモレリン含有点鼻用製剤
WO2001097831A1 (fr) * 2000-06-23 2001-12-27 Kaken Pharmaceutical Co., Ltd. Agents therapeutiques et prophylactiques destines a l'insuffisance cardiaque
WO2003007686A2 (en) * 2001-07-19 2003-01-30 Dmi Biosciences, Inc. Use of copper chelators to inhibit the inactivation of protein c
TWI331922B (en) * 2002-08-09 2010-10-21 Ipsen Pharma Sas Growth hormone releasing peptides
EP1620066A4 (en) * 2003-05-07 2010-11-03 Dmi Biosciences Inc ORAL CARE PROCESSES AND PRODUCTS
MX2007003320A (es) 2004-09-24 2007-05-18 Amgen Inc Moleculas fc modificadas.
US8008453B2 (en) 2005-08-12 2011-08-30 Amgen Inc. Modified Fc molecules
GB0603295D0 (en) 2006-02-18 2006-03-29 Ardana Bioscience Ltd Methods and kits
US9283260B2 (en) 2006-04-21 2016-03-15 Amgen Inc. Lyophilized therapeutic peptibody formulations
WO2007127457A2 (en) * 2006-04-28 2007-11-08 The Administrators Of The Tulane Educational Fund Ghrelin/growth hormone releasing peptide/growth hormone secretatogue receptor antagonists and uses thereof
TW200916113A (en) * 2007-08-08 2009-04-16 Sod Conseils Rech Applic Method for inhibiting inflammation and pro-inflammatory cytokine/chemokine expression using a ghrelin analogue
GB2454549B (en) * 2007-09-25 2009-09-23 Medical & Pharm Ind Tech & Dev Uses of 2-[piperidinyl]methyl-2,3-dihydroimidazo[1,2-c]quinazolin-5(6H)-one for providing an anti-allergic effect and histamine H1 receptor antagonism effect
US8476408B2 (en) * 2008-06-13 2013-07-02 Alize Pharma Sas Unacylated ghrelin and analogs as therapeutic agents for vascular remodeling in diabetic patients and treatment of cardiovascular disease
WO2010033240A2 (en) 2008-09-19 2010-03-25 Nektar Therapeutics Carbohydrate-based drug delivery polymers and conjugates thereof
US9724381B2 (en) 2009-05-12 2017-08-08 The Administrators Of The Tulane Educational Fund Methods of inhibiting the ghrelin/growth hormone secretatogue receptor pathway and uses thereof
RU2404793C1 (ru) 2009-06-04 2010-11-27 Общество с ограниченной ответственностью Био Пептид Стимулятор половой, сексуальной и репродуктивной функции
RU2507212C3 (ru) 2012-03-28 2022-05-04 Общество С Ограниченной Ответственностью "Айвикс" Способ получения рекомбинантного пептида и полученный пептид
RU2626002C1 (ru) 2016-10-24 2017-07-21 Общество С Ограниченной Ответственностью "Айвикс" Новая группа пептидов для лечения женской сексуальной дисфункции

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996010040A1 (en) * 1994-09-27 1996-04-04 Romano Deghenghi Polypeptide compounds containing d-2-alkyltryptophan capable of promoting the release of growth hormone
WO1998022124A1 (en) * 1996-11-22 1998-05-28 Pharmacia & Upjohn Ab Use of growth hormone secretagogue compound for treating cardiac failure or related vascular dysfunction

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5668254A (en) * 1990-05-11 1997-09-16 Romano Deghenghi D-2-alkyl-tryptophan and peptides containing same
US5661122A (en) * 1994-04-15 1997-08-26 Genentech, Inc. Treatment of congestive heart failure
US5798337A (en) * 1994-11-16 1998-08-25 Genentech, Inc. Low molecular weight peptidomimetic growth hormone secretagogues
IT1277113B1 (it) * 1995-12-20 1997-11-04 Romano Deghenghi Composti oligopeptidici contenenti d-2-alchiltriptofano in grado di promuovere la liberazione dell'ormone della crescita
US5798102A (en) * 1997-03-04 1998-08-25 Milkhaus Laboratory, Inc. Treatment of cardiomyopathy
ZA987383B (en) * 1997-08-19 2000-02-17 Lilly Co Eli Treatment of congestive heart failure with growth hormone secretagogues.

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996010040A1 (en) * 1994-09-27 1996-04-04 Romano Deghenghi Polypeptide compounds containing d-2-alkyltryptophan capable of promoting the release of growth hormone
WO1998022124A1 (en) * 1996-11-22 1998-05-28 Pharmacia & Upjohn Ab Use of growth hormone secretagogue compound for treating cardiac failure or related vascular dysfunction

Also Published As

Publication number Publication date
DE69929188D1 (de) 2006-02-02
EP1082128A1 (en) 2001-03-14
DK1082128T3 (da) 2006-04-10
WO1999062539A1 (en) 1999-12-09
PT1082128E (pt) 2006-05-31
EP1082128B1 (en) 2005-12-28
HK1035863A1 (en) 2001-12-14
AU4371799A (en) 1999-12-20
DE69929188T2 (de) 2006-08-17
US5932548A (en) 1999-08-03
ATE314083T1 (de) 2006-01-15
ES2259834T3 (es) 2006-10-16
EP1616571A2 (en) 2006-01-18
CA2330567A1 (en) 1999-12-09
EP1616571A3 (en) 2008-08-13

Similar Documents

Publication Publication Date Title
US5932548A (en) Lysine containing peptides for treatment of heart disease
US6025471A (en) Diazaspiro, azepino and azabicyclo therapeutic peptides
TWI331922B (en) Growth hormone releasing peptides
JPH09507217A (ja) 成長ホルモン放出特性を持つ化合物
CN102821775B (zh) 生长激素促分泌素受体配体的药物组合物
ES2200178T3 (es) Analogos de hgh-rh(1-29)nh2 que tienen actividad antagonista.
US5480869A (en) Anti-inflammatory peptide analogs and treatment to inhibit vascular leakage in injured tissues
JPH08225595A (ja) 環状ペプチドおよびその用途
RU2335506C2 (ru) Пептидные аналоги gh-rh с антагонистическим действием, способ снижения уровня gh, способ снижения уровня igf-i и igf-ii, применение для ингибирования роста раковых клеток, фармакологически приемлемая композиция (варианты)
US6124263A (en) Treatment of tumors by administration of growth hormone releasing compounds and their antagonists
JP2837352B2 (ja) 胃腸運動活性を抑制するモチリン類似ポリペプチド
KR100369104B1 (ko) 성장호르몬의유리를촉진하는2-알킬트립토판함유-올리고펩티드화합물
KR20010101079A (ko) Ｉｇｆ-ⅰ 및 -ⅱ를 억제하는 ｇｈ-ｒｈ의 길항 유사체
SK284550B6 (sk) Peptidy, farmaceutický prostriedok s ich obsahom a ich použitie
RU96123269A (ru) Три-, тетра-, пента- и полипептиды и их терапевтическое применение в качестве антидепрессивного агента
US5962409A (en) Somatostatin-analogous cyclic peptides with inhibitory activity on growth hormone
US5807985A (en) Oligopeptide compounds containing D-2-alkyltryptophan capable of promoting the release of growth hormone
Sakura et al. Structure-activity relationships of neuromedin U. IV. Absolute requirement of the arginine residue at position 7 of dog neuromedin U-8 for contractile activity
Janecka et al. Reduced-size antagonists of luteinizing hormone-releasing hormone active in vitro
HK1083068A (en) Lysine containing peptides for treatment of heart disease
HK1035863B (en) Lysine containing peptides for treatment of heart disease
HK1008225B (en) Somatostatin-analogous cyclic peptides with inhibitory activity on growth hormone
AU1270600A (en) Treatment of tumors by administration of growth hormone releasing compounds and their antagonists
WO2005105828A1 (en) Pseudopeptides growth hormone secretagogues

Legal Events

Date Code Title Description
A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20060516

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20060516

RD02 Notification of acceptance of power of attorney

Free format text: JAPANESE INTERMEDIATE CODE: A7422

Effective date: 20081031

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A821

Effective date: 20081031

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20090818

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20091118

A602 Written permission of extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A602

Effective date: 20091126

A02 Decision of refusal

Free format text: JAPANESE INTERMEDIATE CODE: A02

Effective date: 20100427