JP2002516872A5 - - Google Patents

Info

Publication number

JP2002516872A5

JP2002516872A5 JP2000551795A JP2000551795A JP2002516872A5 JP 2002516872 A5 JP2002516872 A5 JP 2002516872A5 JP 2000551795 A JP2000551795 A JP 2000551795A JP 2000551795 A JP2000551795 A JP 2000551795A JP 2002516872 A5 JP2002516872 A5 JP 2002516872A5

Authority

JP

Japan

Prior art keywords

mrp

lys

trp

phe

ala

Prior art date

1999-05-28

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Pending

Links

• Espacenet
• Global Dossier
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• 108090000765 processed proteins & peptides Proteins 0.000 description 11
• 0 *C(*)N(CC[C@@]1(C2)N(*)CCC1)C2=O Chemical compound *C(*)N(CC[C@@]1(C2)N(*)CCC1)C2=O 0.000 description 7
• 150000001875 compounds Chemical class 0.000 description 6
• COLNVLDHVKWLRT-MRVPVSSYSA-N D-phenylalanine Chemical compound OC(=O)[C@H](N)CC1=CC=CC=C1 COLNVLDHVKWLRT-MRVPVSSYSA-N 0.000 description 5
• 238000000034 method Methods 0.000 description 5
• KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 description 4
• 239000004472 Lysine Substances 0.000 description 4
• 239000003814 drug Substances 0.000 description 4
• 239000000203 mixture Substances 0.000 description 4
• 241000124008 Mammalia Species 0.000 description 3
• OCYROESYHWUPBP-CIUDSAMLSA-N Pro-Ile Chemical compound CC[C@H](C)[C@@H](C([O-])=O)NC(=O)[C@@H]1CCC[NH2+]1 OCYROESYHWUPBP-CIUDSAMLSA-N 0.000 description 3
• 125000000217 alkyl group Chemical group 0.000 description 3
• 108010015796 prolylisoleucine Proteins 0.000 description 3
• KCYCGNHQFGTGSS-UWVGGRQHSA-N (2S,5S)-5-amino-4-oxo-1,2,4,5,6,7-hexahydroazepino[3,2,1-hi]indole-2-carboxylic acid Chemical compound O=C1[C@@H](N)CCC2=CC=CC3=C2N1[C@H](C(O)=O)C3 KCYCGNHQFGTGSS-UWVGGRQHSA-N 0.000 description 2
• -1 Ala-His-D-Mrp Chemical compound 0.000 description 2
• KDXKERNSBIXSRK-RXMQYKEDSA-N D-lysine Chemical compound NCCCC[C@@H](N)C(O)=O KDXKERNSBIXSRK-RXMQYKEDSA-N 0.000 description 2
• QIVBCDIJIAJPQS-SECBINFHSA-N D-tryptophane Chemical compound C1=CC=C2C(C[C@@H](N)C(O)=O)=CNC2=C1 QIVBCDIJIAJPQS-SECBINFHSA-N 0.000 description 2
• 206010019280 Heart failures Diseases 0.000 description 2
• 101000711793 Homo sapiens SOSS complex subunit C Proteins 0.000 description 2
• COLNVLDHVKWLRT-QMMMGPOBSA-N L-phenylalanine Chemical compound OC(=O)[C@@H](N)CC1=CC=CC=C1 COLNVLDHVKWLRT-QMMMGPOBSA-N 0.000 description 2
• 102100034200 SOSS complex subunit C Human genes 0.000 description 2
• 125000004432 carbon atom Chemical group C* 0.000 description 2
• 230000000747 cardiac effect Effects 0.000 description 2
• 239000000816 peptidomimetic Substances 0.000 description 2
• NQPDZGIKBAWPEJ-UHFFFAOYSA-N valeric acid Chemical compound CCCCC(O)=O NQPDZGIKBAWPEJ-UHFFFAOYSA-N 0.000 description 2
• MGSNWNLPMHXGDD-DFWOJPNQSA-N (2s)-6-amino-2-[[(2r)-2-[[(2s)-2-[[(2r)-6-amino-2-[[(2r)-2-[[(2s)-2-amino-3-(1h-imidazol-5-yl)propanoyl]amino]-3-(1h-indol-3-yl)propanoyl]amino]hexanoyl]amino]-3-(1h-indol-3-yl)propanoyl]amino]-3-phenylpropanoyl]amino]hexanamide Chemical compound C([C@H](C(=O)N[C@@H](CCCCN)C(N)=O)NC(=O)[C@H](CC=1C2=CC=CC=C2NC=1)NC(=O)[C@@H](CCCCN)NC(=O)[C@@H](CC=1C2=CC=CC=C2NC=1)NC(=O)[C@@H](N)CC=1NC=NC=1)C1=CC=CC=C1 MGSNWNLPMHXGDD-DFWOJPNQSA-N 0.000 description 1
• KUSYIGBGHPOWEL-UHFFFAOYSA-N 2-methyl nonaoic acid Chemical compound CCCCCCCC(C)C(O)=O KUSYIGBGHPOWEL-UHFFFAOYSA-N 0.000 description 1
• GRIFPSOFWFIICX-GOPGUHFVSA-N Ala-His-Trp Chemical compound [H]N[C@@H](C)C(=O)N[C@@H](CC1=CNC=N1)C(=O)N[C@@H](CC1=CNC2=C1C=CC=C2)C(O)=O GRIFPSOFWFIICX-GOPGUHFVSA-N 0.000 description 1
• 125000002698 D-tryptophano group Chemical group C(=O)(O)[C@@H](CC1=CNC2=CC=CC=C12)N* 0.000 description 1
• DZHDVYLBNKMLMB-ZFWWWQNUSA-N Trp-Lys Chemical compound C1=CC=C2C(C[C@H](N)C(=O)N[C@@H](CCCCN)C(O)=O)=CNC2=C1 DZHDVYLBNKMLMB-ZFWWWQNUSA-N 0.000 description 1
• JZSLIZLZGWOJBJ-PMVMPFDFSA-N Trp-Phe-Lys Chemical compound C1=CC=C(C=C1)C[C@@H](C(=O)N[C@@H](CCCCN)C(=O)O)NC(=O)[C@H](CC2=CNC3=CC=CC=C32)N JZSLIZLZGWOJBJ-PMVMPFDFSA-N 0.000 description 1
• 150000001413 amino acids Chemical class 0.000 description 1
• 125000002619 bicyclic group Chemical group 0.000 description 1
• 230000037396 body weight Effects 0.000 description 1
• 201000010099 disease Diseases 0.000 description 1
• 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
• 230000004064 dysfunction Effects 0.000 description 1
• 230000004217 heart function Effects 0.000 description 1
• 230000001771 impaired effect Effects 0.000 description 1
• 238000004519 manufacturing process Methods 0.000 description 1
• 208000031225 myocardial ischemia Diseases 0.000 description 1
• 230000002685 pulmonary effect Effects 0.000 description 1