JP2002516832A - グルコン酸クロルヘキシジンを含有する被覆を備える装置、組成物、および方法 - Google Patents
グルコン酸クロルヘキシジンを含有する被覆を備える装置、組成物、および方法Info
- Publication number
- JP2002516832A JP2002516832A JP2000551727A JP2000551727A JP2002516832A JP 2002516832 A JP2002516832 A JP 2002516832A JP 2000551727 A JP2000551727 A JP 2000551727A JP 2000551727 A JP2000551727 A JP 2000551727A JP 2002516832 A JP2002516832 A JP 2002516832A
- Authority
- JP
- Japan
- Prior art keywords
- chlorhexidine gluconate
- coating
- glycol
- chg
- water
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 229960003333 chlorhexidine gluconate Drugs 0.000 title claims abstract description 135
- YZIYKJHYYHPJIB-UUPCJSQJSA-N chlorhexidine gluconate Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C(O)=O.OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C(O)=O.C1=CC(Cl)=CC=C1NC(=N)NC(=N)NCCCCCCNC(=N)NC(=N)NC1=CC=C(Cl)C=C1 YZIYKJHYYHPJIB-UUPCJSQJSA-N 0.000 title claims abstract description 135
- 239000000203 mixture Substances 0.000 title claims abstract description 74
- 238000000576 coating method Methods 0.000 title claims abstract description 65
- 238000000034 method Methods 0.000 title claims abstract description 34
- 239000011248 coating agent Substances 0.000 claims abstract description 56
- 239000008199 coating composition Substances 0.000 claims abstract description 17
- 241000628997 Flos Species 0.000 claims description 60
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 claims description 54
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 53
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 42
- WGCNASOHLSPBMP-UHFFFAOYSA-N hydroxyacetaldehyde Natural products OCC=O WGCNASOHLSPBMP-UHFFFAOYSA-N 0.000 claims description 26
- 239000004094 surface-active agent Substances 0.000 claims description 22
- 235000011187 glycerol Nutrition 0.000 claims description 20
- 150000003839 salts Chemical class 0.000 claims description 13
- 239000002253 acid Substances 0.000 claims description 12
- 150000007513 acids Chemical class 0.000 claims description 9
- 239000000463 material Substances 0.000 claims description 9
- 229920001223 polyethylene glycol Polymers 0.000 claims description 8
- 239000002202 Polyethylene glycol Substances 0.000 claims description 7
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 claims description 6
- 239000000835 fiber Substances 0.000 claims description 6
- 239000001993 wax Substances 0.000 claims description 6
- 238000002156 mixing Methods 0.000 claims description 5
- 229920003171 Poly (ethylene oxide) Polymers 0.000 claims description 4
- 125000005907 alkyl ester group Chemical group 0.000 claims description 4
- -1 polyoxyethylene Polymers 0.000 claims description 4
- 230000003381 solubilizing effect Effects 0.000 claims description 4
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 claims description 3
- FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 claims description 3
- 125000000217 alkyl group Chemical group 0.000 claims description 3
- 230000001627 detrimental effect Effects 0.000 claims description 3
- 238000011049 filling Methods 0.000 claims description 3
- 239000000600 sorbitol Substances 0.000 claims description 3
- 229920002153 Hydroxypropyl cellulose Polymers 0.000 claims description 2
- 150000005215 alkyl ethers Chemical class 0.000 claims description 2
- 239000001913 cellulose Substances 0.000 claims description 2
- 229920002678 cellulose Polymers 0.000 claims description 2
- 150000002148 esters Chemical class 0.000 claims description 2
- 150000002170 ethers Chemical class 0.000 claims description 2
- 150000002191 fatty alcohols Chemical class 0.000 claims description 2
- 239000001863 hydroxypropyl cellulose Substances 0.000 claims description 2
- 235000010977 hydroxypropyl cellulose Nutrition 0.000 claims description 2
- 239000012188 paraffin wax Substances 0.000 claims description 2
- 229920000191 poly(N-vinyl pyrrolidone) Polymers 0.000 claims description 2
- 229920000223 polyglycerol Polymers 0.000 claims description 2
- 150000005846 sugar alcohols Polymers 0.000 claims description 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- 208000005888 Periodontal Pocket Diseases 0.000 claims 1
- 238000013270 controlled release Methods 0.000 claims 1
- 239000012528 membrane Substances 0.000 claims 1
- QSNSCYSYFYORTR-UHFFFAOYSA-N 4-chloroaniline Chemical compound NC1=CC=C(Cl)C=C1 QSNSCYSYFYORTR-UHFFFAOYSA-N 0.000 description 27
- 238000004128 high performance liquid chromatography Methods 0.000 description 22
- 239000000243 solution Substances 0.000 description 21
- 230000000052 comparative effect Effects 0.000 description 19
- ZMANZCXQSJIPKH-UHFFFAOYSA-N triethylamine Natural products CCN(CC)CC ZMANZCXQSJIPKH-UHFFFAOYSA-N 0.000 description 17
- 239000011550 stock solution Substances 0.000 description 16
- WEVYAHXRMPXWCK-UHFFFAOYSA-N Acetonitrile Chemical compound CC#N WEVYAHXRMPXWCK-UHFFFAOYSA-N 0.000 description 15
- NBIIXXVUZAFLBC-UHFFFAOYSA-N Phosphoric acid Chemical compound OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 description 12
- 239000000126 substance Substances 0.000 description 12
- RGHNJXZEOKUKBD-SQOUGZDYSA-N D-gluconic acid Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C(O)=O RGHNJXZEOKUKBD-SQOUGZDYSA-N 0.000 description 11
- GHXZTYHSJHQHIJ-UHFFFAOYSA-N Chlorhexidine Chemical compound C=1C=C(Cl)C=CC=1NC(N)=NC(N)=NCCCCCCN=C(N)N=C(N)NC1=CC=C(Cl)C=C1 GHXZTYHSJHQHIJ-UHFFFAOYSA-N 0.000 description 10
- RGHNJXZEOKUKBD-UHFFFAOYSA-N D-gluconic acid Natural products OCC(O)C(O)C(O)C(O)C(O)=O RGHNJXZEOKUKBD-UHFFFAOYSA-N 0.000 description 10
- 229960003260 chlorhexidine Drugs 0.000 description 10
- 239000000174 gluconic acid Substances 0.000 description 10
- 235000012208 gluconic acid Nutrition 0.000 description 10
- 239000000523 sample Substances 0.000 description 10
- 239000008367 deionised water Substances 0.000 description 9
- 229910021641 deionized water Inorganic materials 0.000 description 9
- 239000012458 free base Substances 0.000 description 9
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 8
- 239000002585 base Substances 0.000 description 8
- 238000010998 test method Methods 0.000 description 8
- 229920002565 Polyethylene Glycol 400 Polymers 0.000 description 7
- 239000000796 flavoring agent Substances 0.000 description 7
- 235000019634 flavors Nutrition 0.000 description 7
- 238000003756 stirring Methods 0.000 description 7
- 235000016257 Mentha pulegium Nutrition 0.000 description 6
- 235000004357 Mentha x piperita Nutrition 0.000 description 6
- 229910000147 aluminium phosphate Inorganic materials 0.000 description 6
- 238000011088 calibration curve Methods 0.000 description 6
- 239000003205 fragrance Substances 0.000 description 6
- 235000001050 hortel pimenta Nutrition 0.000 description 6
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 5
- 238000007598 dipping method Methods 0.000 description 5
- 238000009472 formulation Methods 0.000 description 5
- 239000002304 perfume Substances 0.000 description 5
- 244000246386 Mentha pulegium Species 0.000 description 4
- 150000002334 glycols Chemical class 0.000 description 4
- 238000002347 injection Methods 0.000 description 4
- 239000007924 injection Substances 0.000 description 4
- 238000005259 measurement Methods 0.000 description 4
- 229920001992 poloxamer 407 Polymers 0.000 description 4
- 239000000377 silicon dioxide Substances 0.000 description 4
- 239000006227 byproduct Substances 0.000 description 3
- 230000015556 catabolic process Effects 0.000 description 3
- 238000006243 chemical reaction Methods 0.000 description 3
- 238000006731 degradation reaction Methods 0.000 description 3
- 238000004090 dissolution Methods 0.000 description 3
- 238000010438 heat treatment Methods 0.000 description 3
- 239000003973 paint Substances 0.000 description 3
- 229920002523 polyethylene Glycol 1000 Polymers 0.000 description 3
- 239000002904 solvent Substances 0.000 description 3
- 239000012086 standard solution Substances 0.000 description 3
- 231100000331 toxic Toxicity 0.000 description 3
- 230000002588 toxic effect Effects 0.000 description 3
- RFVNOJDQRGSOEL-UHFFFAOYSA-N 2-hydroxyethyl octadecanoate Chemical compound CCCCCCCCCCCCCCCCCC(=O)OCCO RFVNOJDQRGSOEL-UHFFFAOYSA-N 0.000 description 2
- 241001479543 Mentha x piperita Species 0.000 description 2
- 239000004698 Polyethylene Substances 0.000 description 2
- 229960000583 acetic acid Drugs 0.000 description 2
- 239000003945 anionic surfactant Substances 0.000 description 2
- 239000006185 dispersion Substances 0.000 description 2
- 239000013020 final formulation Substances 0.000 description 2
- 239000012634 fragment Substances 0.000 description 2
- 208000007565 gingivitis Diseases 0.000 description 2
- 238000011065 in-situ storage Methods 0.000 description 2
- 229920001296 polysiloxane Polymers 0.000 description 2
- 239000011148 porous material Substances 0.000 description 2
- 238000011045 prefiltration Methods 0.000 description 2
- 239000000047 product Substances 0.000 description 2
- 239000012488 sample solution Substances 0.000 description 2
- 239000007787 solid Substances 0.000 description 2
- 241000894007 species Species 0.000 description 2
- BHKKSKOHRFHHIN-MRVPVSSYSA-N 1-[[2-[(1R)-1-aminoethyl]-4-chlorophenyl]methyl]-2-sulfanylidene-5H-pyrrolo[3,2-d]pyrimidin-4-one Chemical compound N[C@H](C)C1=C(CN2C(NC(C3=C2C=CN3)=O)=S)C=CC(=C1)Cl BHKKSKOHRFHHIN-MRVPVSSYSA-N 0.000 description 1
- AGNTUZCMJBTHOG-UHFFFAOYSA-N 3-[3-(2,3-dihydroxypropoxy)-2-hydroxypropoxy]propane-1,2-diol Chemical compound OCC(O)COCC(O)COCC(O)CO AGNTUZCMJBTHOG-UHFFFAOYSA-N 0.000 description 1
- WOKDXPHSIQRTJF-UHFFFAOYSA-N 3-[3-[3-[3-[3-[3-[3-[3-[3-(2,3-dihydroxypropoxy)-2-hydroxypropoxy]-2-hydroxypropoxy]-2-hydroxypropoxy]-2-hydroxypropoxy]-2-hydroxypropoxy]-2-hydroxypropoxy]-2-hydroxypropoxy]-2-hydroxypropoxy]propane-1,2-diol Chemical compound OCC(O)COCC(O)COCC(O)COCC(O)COCC(O)COCC(O)COCC(O)COCC(O)COCC(O)COCC(O)CO WOKDXPHSIQRTJF-UHFFFAOYSA-N 0.000 description 1
- OCKGFTQIICXDQW-ZEQRLZLVSA-N 5-[(1r)-1-hydroxy-2-[4-[(2r)-2-hydroxy-2-(4-methyl-1-oxo-3h-2-benzofuran-5-yl)ethyl]piperazin-1-yl]ethyl]-4-methyl-3h-2-benzofuran-1-one Chemical compound C1=C2C(=O)OCC2=C(C)C([C@@H](O)CN2CCN(CC2)C[C@H](O)C2=CC=C3C(=O)OCC3=C2C)=C1 OCKGFTQIICXDQW-ZEQRLZLVSA-N 0.000 description 1
- DJHGAFSJWGLOIV-UHFFFAOYSA-K Arsenate3- Chemical class [O-][As]([O-])([O-])=O DJHGAFSJWGLOIV-UHFFFAOYSA-K 0.000 description 1
- 241001561902 Chaetodon citrinellus Species 0.000 description 1
- XTEGARKTQYYJKE-UHFFFAOYSA-M Chlorate Chemical class [O-]Cl(=O)=O XTEGARKTQYYJKE-UHFFFAOYSA-M 0.000 description 1
- PHOQVHQSTUBQQK-SQOUGZDYSA-N D-glucono-1,5-lactone Chemical compound OC[C@H]1OC(=O)[C@H](O)[C@@H](O)[C@@H]1O PHOQVHQSTUBQQK-SQOUGZDYSA-N 0.000 description 1
- 229940090898 Desensitizer Drugs 0.000 description 1
- 206010018276 Gingival bleeding Diseases 0.000 description 1
- 229910019142 PO4 Inorganic materials 0.000 description 1
- ABLZXFCXXLZCGV-UHFFFAOYSA-N Phosphorous acid Chemical class OP(O)=O ABLZXFCXXLZCGV-UHFFFAOYSA-N 0.000 description 1
- 229920002562 Polyethylene Glycol 3350 Polymers 0.000 description 1
- 229920002701 Polyoxyl 40 Stearate Polymers 0.000 description 1
- ULUAUXLGCMPNKK-UHFFFAOYSA-N Sulfobutanedioic acid Chemical class OC(=O)CC(C(O)=O)S(O)(=O)=O ULUAUXLGCMPNKK-UHFFFAOYSA-N 0.000 description 1
- 150000001242 acetic acid derivatives Chemical class 0.000 description 1
- 239000000654 additive Substances 0.000 description 1
- 230000002411 adverse Effects 0.000 description 1
- 239000002246 antineoplastic agent Substances 0.000 description 1
- 235000013871 bee wax Nutrition 0.000 description 1
- 239000012166 beeswax Substances 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000000711 cancerogenic effect Effects 0.000 description 1
- 150000004649 carbonic acid derivatives Chemical class 0.000 description 1
- 150000001735 carboxylic acids Chemical class 0.000 description 1
- 231100000357 carcinogen Toxicity 0.000 description 1
- 239000003183 carcinogenic agent Substances 0.000 description 1
- 239000000679 carrageenan Substances 0.000 description 1
- 235000010418 carrageenan Nutrition 0.000 description 1
- 229920001525 carrageenan Polymers 0.000 description 1
- 229940113118 carrageenan Drugs 0.000 description 1
- ZCDOYSPFYFSLEW-UHFFFAOYSA-N chromate(2-) Chemical class [O-][Cr]([O-])(=O)=O ZCDOYSPFYFSLEW-UHFFFAOYSA-N 0.000 description 1
- 239000003086 colorant Substances 0.000 description 1
- 238000004040 coloring Methods 0.000 description 1
- 239000006071 cream Substances 0.000 description 1
- 229940127089 cytotoxic agent Drugs 0.000 description 1
- 238000000354 decomposition reaction Methods 0.000 description 1
- 239000003599 detergent Substances 0.000 description 1
- 238000011156 evaluation Methods 0.000 description 1
- 150000002222 fluorine compounds Chemical class 0.000 description 1
- 235000003599 food sweetener Nutrition 0.000 description 1
- 230000000855 fungicidal effect Effects 0.000 description 1
- 239000000417 fungicide Substances 0.000 description 1
- 239000012362 glacial acetic acid Substances 0.000 description 1
- 150000004820 halides Chemical class 0.000 description 1
- 239000003906 humectant Substances 0.000 description 1
- 150000004679 hydroxides Chemical class 0.000 description 1
- 239000012535 impurity Substances 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- ICIWUVCWSCSTAQ-UHFFFAOYSA-N iodic acid Chemical class OI(=O)=O ICIWUVCWSCSTAQ-UHFFFAOYSA-N 0.000 description 1
- 150000002596 lactones Chemical class 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 238000002844 melting Methods 0.000 description 1
- 230000008018 melting Effects 0.000 description 1
- QCAWEPFNJXQPAN-UHFFFAOYSA-N methoxyfenozide Chemical compound COC1=CC=CC(C(=O)NN(C(=O)C=2C=C(C)C=C(C)C=2)C(C)(C)C)=C1C QCAWEPFNJXQPAN-UHFFFAOYSA-N 0.000 description 1
- 239000004200 microcrystalline wax Substances 0.000 description 1
- 235000019808 microcrystalline wax Nutrition 0.000 description 1
- 230000007935 neutral effect Effects 0.000 description 1
- 150000002823 nitrates Chemical class 0.000 description 1
- 150000002825 nitriles Chemical class 0.000 description 1
- 150000003891 oxalate salts Chemical class 0.000 description 1
- RARSHUDCJQSEFJ-UHFFFAOYSA-N p-Hydroxypropiophenone Chemical compound CCC(=O)C1=CC=C(O)C=C1 RARSHUDCJQSEFJ-UHFFFAOYSA-N 0.000 description 1
- 238000004806 packaging method and process Methods 0.000 description 1
- 239000002245 particle Substances 0.000 description 1
- JLFNLZLINWHATN-UHFFFAOYSA-N pentaethylene glycol Chemical compound OCCOCCOCCOCCOCCO JLFNLZLINWHATN-UHFFFAOYSA-N 0.000 description 1
- 210000002379 periodontal ligament Anatomy 0.000 description 1
- 235000021317 phosphate Nutrition 0.000 description 1
- 150000003013 phosphoric acid derivatives Chemical class 0.000 description 1
- 239000003755 preservative agent Substances 0.000 description 1
- 230000002335 preservative effect Effects 0.000 description 1
- 230000002035 prolonged effect Effects 0.000 description 1
- 230000035484 reaction time Effects 0.000 description 1
- CVHZOJJKTDOEJC-UHFFFAOYSA-N saccharin Chemical compound C1=CC=C2C(=O)NS(=O)(=O)C2=C1 CVHZOJJKTDOEJC-UHFFFAOYSA-N 0.000 description 1
- 229940081974 saccharin Drugs 0.000 description 1
- 235000019204 saccharin Nutrition 0.000 description 1
- 239000000901 saccharin and its Na,K and Ca salt Substances 0.000 description 1
- 238000005507 spraying Methods 0.000 description 1
- 230000006641 stabilisation Effects 0.000 description 1
- 238000011105 stabilization Methods 0.000 description 1
- 239000003381 stabilizer Substances 0.000 description 1
- 238000003860 storage Methods 0.000 description 1
- 150000003871 sulfonates Chemical class 0.000 description 1
- 150000003467 sulfuric acid derivatives Chemical class 0.000 description 1
- 239000003765 sweetening agent Substances 0.000 description 1
- 150000003567 thiocyanates Chemical class 0.000 description 1
- 150000003568 thioethers Chemical class 0.000 description 1
- UHVMMEOXYDMDKI-JKYCWFKZSA-L zinc;1-(5-cyanopyridin-2-yl)-3-[(1s,2s)-2-(6-fluoro-2-hydroxy-3-propanoylphenyl)cyclopropyl]urea;diacetate Chemical compound [Zn+2].CC([O-])=O.CC([O-])=O.CCC(=O)C1=CC=C(F)C([C@H]2[C@H](C2)NC(=O)NC=2N=CC(=CC=2)C#N)=C1O UHVMMEOXYDMDKI-JKYCWFKZSA-L 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/345—Alcohols containing more than one hydroxy group
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/43—Guanidines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T428/00—Stock material or miscellaneous articles
- Y10T428/29—Coated or structually defined flake, particle, cell, strand, strand portion, rod, filament, macroscopic fiber or mass thereof
- Y10T428/2913—Rod, strand, filament or fiber
- Y10T428/2933—Coated or with bond, impregnation or core
- Y10T428/2938—Coating on discrete and individual rods, strands or filaments
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Birds (AREA)
- Emergency Medicine (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- Cosmetics (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US09/089,872 | 1998-06-04 | ||
| US09/089,872 US6458341B1 (en) | 1998-06-04 | 1998-06-04 | Devices with coatings containing chlorhexidine gluconate, compositions and methods |
| PCT/US1999/010372 WO1999062470A1 (en) | 1998-06-04 | 1999-05-11 | Devices with coatings containing chlorhexidine gluconate, compositions and methods |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009000393A Division JP2009137985A (ja) | 1998-06-04 | 2009-01-05 | グルコン酸クロルヘキシジンを含有する被覆を備える装置、組成物、および方法 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2002516832A true JP2002516832A (ja) | 2002-06-11 |
| JP2002516832A5 JP2002516832A5 (enExample) | 2006-06-29 |
Family
ID=22220003
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2000551727A Withdrawn JP2002516832A (ja) | 1998-06-04 | 1999-05-11 | グルコン酸クロルヘキシジンを含有する被覆を備える装置、組成物、および方法 |
| JP2009000393A Pending JP2009137985A (ja) | 1998-06-04 | 2009-01-05 | グルコン酸クロルヘキシジンを含有する被覆を備える装置、組成物、および方法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009000393A Pending JP2009137985A (ja) | 1998-06-04 | 2009-01-05 | グルコン酸クロルヘキシジンを含有する被覆を備える装置、組成物、および方法 |
Country Status (7)
| Country | Link |
|---|---|
| US (2) | US6458341B1 (enExample) |
| EP (1) | EP1082089B1 (enExample) |
| JP (2) | JP2002516832A (enExample) |
| AU (1) | AU3983199A (enExample) |
| CA (1) | CA2333009A1 (enExample) |
| DE (1) | DE69910378T2 (enExample) |
| WO (1) | WO1999062470A1 (enExample) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2012526142A (ja) * | 2009-05-08 | 2012-10-25 | スリーエム イノベイティブ プロパティズ カンパニー | 口腔ケア方法及びキット |
| JP2015529667A (ja) * | 2012-08-28 | 2015-10-08 | スリーエム イノベイティブ プロパティズ カンパニー | グルコン酸クロルヘキシジン組成物、樹脂系、及び物品 |
| JP2016065102A (ja) * | 2007-02-09 | 2016-04-28 | デンツプライ インターナショナル インコーポレーテッド | 歯科用組成物 |
Families Citing this family (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20060034782A1 (en) * | 2001-12-04 | 2006-02-16 | Brown Dale G | Biofilm therapy interproximal devices |
| DE10242476B4 (de) * | 2002-09-11 | 2006-10-26 | Heraeus Kulzer Gmbh | Antibiotikum-/Antibiotika-Polymer-Kombination |
| US20040247654A1 (en) * | 2003-06-05 | 2004-12-09 | 3M Innovative Properties Company | Hydrophilic adhesives for delivery of herbal medicines |
| US9278155B2 (en) * | 2003-06-05 | 2016-03-08 | 3M Innovative Properties Company | Adhesive compositions, articles incorporating same and methods of manufacture |
| US20050191247A1 (en) * | 2004-03-01 | 2005-09-01 | David Drake | Chlorhexidine compositions |
| US20060034899A1 (en) * | 2004-08-12 | 2006-02-16 | Ylitalo Caroline M | Biologically-active adhesive articles and methods of manufacture |
| US20060035039A1 (en) * | 2004-08-12 | 2006-02-16 | 3M Innovative Properties Company | Silver-releasing articles and methods of manufacture |
| US20060243298A1 (en) * | 2005-04-28 | 2006-11-02 | The Procter & Gamble Company | Dental floss compositions comprising menthol and carboxamides |
| US7845351B2 (en) * | 2005-08-31 | 2010-12-07 | Kimberly-Clark Worldwide Inc. | Germicidal face mask |
| US20070181144A1 (en) * | 2006-02-07 | 2007-08-09 | Whitehill Oral Technologies, Inc. | Coated dental devices with dry-to-the-touch, flavor-absorbing, saliva soluble coatings and methods for manufacturing |
| US7824122B2 (en) * | 2006-02-14 | 2010-11-02 | Carefusion 2200, Inc. | Liquid applicator and method for reducing the concentration of by-products from antiseptic |
| US9981069B2 (en) | 2007-06-20 | 2018-05-29 | The Trustees Of Columbia University In The City Of New York | Bio-film resistant surfaces |
| US20110195105A1 (en) * | 2010-02-08 | 2011-08-11 | Nanos John I | Foam Cellular Matrix Impregnated With Anti-Microbial Active Agent For Use In Negative Pressure Wound Therapy Applications And Process For Producing The Same |
| WO2012100244A2 (en) | 2011-01-21 | 2012-07-26 | Avery Dennison Corporation | Chlorhexidine gluconate containing solvent adhesive |
| WO2012158483A2 (en) | 2011-05-16 | 2012-11-22 | Avery Dennison Corporation | Adhesive containing microparticles |
| WO2014035971A2 (en) * | 2012-08-28 | 2014-03-06 | 3M Innovative Properties Company | Chlorhexidine gluconate solubilized in a hydrophobic monoacylglyceride |
| PL2954019T3 (pl) | 2013-02-07 | 2019-01-31 | Avery Dennison Corporation | Kleje przeciwbakteryjne o ulepszonych właściwościach |
| EP2968014B1 (en) | 2013-03-15 | 2019-04-24 | Avery Dennison Corporation | Transparent cover dressing application system and inclusion of label strip |
| EP3043786A4 (en) | 2013-09-13 | 2017-03-01 | 3M Innovative Properties Company | Cationic antiseptic compositions, method and kit |
| US9970303B2 (en) | 2014-05-13 | 2018-05-15 | Entrotech, Inc. | Erosion protection sleeve |
| EP3789014A1 (en) | 2014-06-05 | 2021-03-10 | Avery Dennison Corporation | Articles with active agent concentrated at the substrate contacting surface and related methods |
| WO2016093815A1 (en) | 2014-12-10 | 2016-06-16 | Colgate-Palmolive Company | Dental floss coating composition |
| EP3694439A4 (en) | 2017-10-12 | 2021-12-15 | Medline Industries, Inc. | ANTISEPTIC WIPES |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5098711A (en) | 1988-11-14 | 1992-03-24 | Ira Hill | Method of treating the oral cavity with dental floss containing chemotherapeutic agents |
| US5165913A (en) | 1988-11-14 | 1992-11-24 | Ira Hill | Controlled release interproximal delivery system |
| US4911927A (en) | 1988-11-14 | 1990-03-27 | Hill Ira D | Method and apparatus for adding chemotherapeutic agents to dental floss |
| US5328698A (en) * | 1990-08-06 | 1994-07-12 | Becton, Dickinson And Company | Method for rendering a substrate surface antithrombogenic and/or anti-infective |
| US5213803A (en) | 1990-10-04 | 1993-05-25 | Northeastern Ohio Universities College Of Medicine | Antiviral composition and method |
| JP2959833B2 (ja) | 1990-11-06 | 1999-10-06 | ライオン株式会社 | 徐放性口腔内疾患治療剤およびその製法 |
| GB9206509D0 (en) * | 1992-03-25 | 1992-05-06 | Jevco Ltd | Heteromorphic sponges containing active agents |
| GB9209327D0 (en) * | 1992-04-30 | 1992-06-17 | Johnson & Johnson Medical | Freeze-dried pad |
| BR9301968A (pt) | 1993-06-08 | 1994-12-27 | Johnson & Johnson | Fio dental dotado de agentes quimioterápicos |
| US5711935A (en) | 1994-05-10 | 1998-01-27 | Whitehill Oral Technologies, Inc. | Dental floss |
| EP0782850A4 (en) * | 1994-10-13 | 1998-03-04 | Wakamoto Pharma Co Ltd | LYOPHILIZED PREPARATION FOR PRODUCING A REVERSIBLE THERMOGELING MEDICINAL WATER-BASED |
| US5603921A (en) | 1995-03-13 | 1997-02-18 | Whalen Biomedical Incorporated | Medicated dental floss and method of preparation |
-
1998
- 1998-06-04 US US09/089,872 patent/US6458341B1/en not_active Expired - Lifetime
-
1999
- 1999-05-11 WO PCT/US1999/010372 patent/WO1999062470A1/en not_active Ceased
- 1999-05-11 EP EP99922947A patent/EP1082089B1/en not_active Expired - Lifetime
- 1999-05-11 CA CA002333009A patent/CA2333009A1/en not_active Abandoned
- 1999-05-11 DE DE69910378T patent/DE69910378T2/de not_active Expired - Lifetime
- 1999-05-11 JP JP2000551727A patent/JP2002516832A/ja not_active Withdrawn
- 1999-05-11 AU AU39831/99A patent/AU3983199A/en not_active Abandoned
-
2002
- 2002-09-26 US US10/256,032 patent/US6733745B2/en not_active Expired - Lifetime
-
2009
- 2009-01-05 JP JP2009000393A patent/JP2009137985A/ja active Pending
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2016065102A (ja) * | 2007-02-09 | 2016-04-28 | デンツプライ インターナショナル インコーポレーテッド | 歯科用組成物 |
| JP2012526142A (ja) * | 2009-05-08 | 2012-10-25 | スリーエム イノベイティブ プロパティズ カンパニー | 口腔ケア方法及びキット |
| JP2016006104A (ja) * | 2009-05-08 | 2016-01-14 | スリーエム イノベイティブ プロパティズ カンパニー | 口腔ケア方法及びキット |
| JP2015529667A (ja) * | 2012-08-28 | 2015-10-08 | スリーエム イノベイティブ プロパティズ カンパニー | グルコン酸クロルヘキシジン組成物、樹脂系、及び物品 |
Also Published As
| Publication number | Publication date |
|---|---|
| US20030138492A1 (en) | 2003-07-24 |
| EP1082089B1 (en) | 2003-08-13 |
| EP1082089A1 (en) | 2001-03-14 |
| WO1999062470A1 (en) | 1999-12-09 |
| JP2009137985A (ja) | 2009-06-25 |
| US6733745B2 (en) | 2004-05-11 |
| CA2333009A1 (en) | 1999-12-09 |
| US6458341B1 (en) | 2002-10-01 |
| DE69910378T2 (de) | 2004-06-24 |
| AU3983199A (en) | 1999-12-20 |
| DE69910378D1 (de) | 2003-09-18 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2002516832A (ja) | グルコン酸クロルヘキシジンを含有する被覆を備える装置、組成物、および方法 | |
| US5851514A (en) | Stable aqueous abrasive peroxide tooth whitening dentifrice | |
| JP2001509475A (ja) | 歯を白くする安定な水性研磨性過酸化物歯磨剤 | |
| RU2279864C2 (ru) | Зубная нить, покрытая гемостатическим агентом, зубная лента, покрытая гемостатическим агентом, и способ их выполнения | |
| FR2559388A1 (fr) | Composition buccale aqueuse contenant du peroxyde d'hydrogene | |
| JP6751027B2 (ja) | 非晶質リン酸カルシウムを供給する口腔ケア処方システム | |
| EP0663205B1 (fr) | Compositions cosmétiques pour la décoloration des cheveux, procédé de synthèse et utilisation | |
| JPH04210907A (ja) | 局部塗付用組成物 | |
| JP2023100640A (ja) | 水性口腔ケアフッ化物処置組成物、及び方法 | |
| JP2594884B2 (ja) | 毛髪の漂白に使える、粒状形の漂白組成物及びその製造方法 | |
| HUP0100211A2 (hu) | Új polietoxilezett ricinusolaj, eljárás annak előállítására és azt tartalmazó készítmények | |
| JPS5846012A (ja) | 亜鉛及び弗化物化合物を含有している安定な口内用組成物 | |
| US5871715A (en) | Stannous fluoride gel with improved stand-up | |
| EP1050294B1 (en) | Tooth pastes | |
| EP0180483A2 (en) | Oral fine dispersions sprays and emulsions | |
| JP2000026260A (ja) | 口腔用組成物 | |
| CN1039965C (zh) | 水基凝胶形式的洁牙剂组合物 | |
| FR2576790A1 (fr) | Composition a usage buccal contenant du peroxyde d'hydrogene et un fluorure | |
| JPH06183939A (ja) | 口腔用組成物 | |
| KR101898448B1 (ko) | 액체 또는 액상의 구강용 조성물 및 설태 부착 억제제 | |
| JP2002255772A (ja) | 口腔用組成物用基剤及び口腔用組成物 | |
| WO2016105432A1 (en) | Zinc phosphate complex for oral care | |
| JPH08337518A (ja) | 洗口剤組成物 | |
| JP2000016927A (ja) | 液体口腔用組成物 | |
| KR0180119B1 (ko) | 안정한 과산화물 함유 치약 조성물 |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20060501 |
|
| A621 | Written request for application examination |
Free format text: JAPANESE INTERMEDIATE CODE: A621 Effective date: 20060501 |
|
| A977 | Report on retrieval |
Free format text: JAPANESE INTERMEDIATE CODE: A971007 Effective date: 20071004 |
|
| A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20071016 |
|
| A601 | Written request for extension of time |
Free format text: JAPANESE INTERMEDIATE CODE: A601 Effective date: 20080111 |
|
| A602 | Written permission of extension of time |
Free format text: JAPANESE INTERMEDIATE CODE: A602 Effective date: 20080121 |
|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20080416 |
|
| A02 | Decision of refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A02 Effective date: 20080902 |
|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20090105 |
|
| A911 | Transfer to examiner for re-examination before appeal (zenchi) |
Free format text: JAPANESE INTERMEDIATE CODE: A911 Effective date: 20090223 |
|
| A912 | Re-examination (zenchi) completed and case transferred to appeal board |
Free format text: JAPANESE INTERMEDIATE CODE: A912 Effective date: 20090508 |
|
| A761 | Written withdrawal of application |
Free format text: JAPANESE INTERMEDIATE CODE: A761 Effective date: 20110630 |