CA2333009A1 - Devices with coatings containing chlorhexidine gluconate, compositions and methods - Google Patents
Devices with coatings containing chlorhexidine gluconate, compositions and methods Download PDFInfo
- Publication number
- CA2333009A1 CA2333009A1 CA002333009A CA2333009A CA2333009A1 CA 2333009 A1 CA2333009 A1 CA 2333009A1 CA 002333009 A CA002333009 A CA 002333009A CA 2333009 A CA2333009 A CA 2333009A CA 2333009 A1 CA2333009 A1 CA 2333009A1
- Authority
- CA
- Canada
- Prior art keywords
- chlorhexidine gluconate
- coating
- glycol
- modulus
- solubilizing
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
- 229960003333 chlorhexidine gluconate Drugs 0.000 title claims abstract description 32
- YZIYKJHYYHPJIB-UUPCJSQJSA-N chlorhexidine gluconate Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C(O)=O.OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C(O)=O.C1=CC(Cl)=CC=C1NC(=N)NC(=N)NCCCCCCNC(=N)NC(=N)NC1=CC=C(Cl)C=C1 YZIYKJHYYHPJIB-UUPCJSQJSA-N 0.000 title claims abstract description 32
- 238000000576 coating method Methods 0.000 title claims abstract description 26
- 239000000203 mixture Substances 0.000 title claims abstract description 16
- 238000000034 method Methods 0.000 title claims abstract description 11
- 239000008199 coating composition Substances 0.000 claims abstract description 7
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 claims description 46
- 239000011248 coating agent Substances 0.000 claims description 23
- WGCNASOHLSPBMP-UHFFFAOYSA-N hydroxyacetaldehyde Natural products OCC=O WGCNASOHLSPBMP-UHFFFAOYSA-N 0.000 claims description 23
- 230000003381 solubilizing effect Effects 0.000 claims description 17
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 14
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 8
- 241000628997 Flos Species 0.000 claims description 7
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 claims description 6
- 230000002708 enhancing effect Effects 0.000 claims description 6
- 239000000463 material Substances 0.000 claims description 6
- 239000004094 surface-active agent Substances 0.000 claims description 6
- 239000000835 fiber Substances 0.000 claims description 5
- 229920003171 Poly (ethylene oxide) Polymers 0.000 claims description 4
- 125000005907 alkyl ester group Chemical group 0.000 claims description 4
- 235000011187 glycerol Nutrition 0.000 claims description 4
- 239000001993 wax Substances 0.000 claims description 4
- 125000000217 alkyl group Chemical group 0.000 claims description 3
- 238000012856 packing Methods 0.000 claims description 3
- GHXZTYHSJHQHIJ-UHFFFAOYSA-N Chlorhexidine Chemical compound C=1C=C(Cl)C=CC=1NC(N)=NC(N)=NCCCCCCN=C(N)N=C(N)NC1=CC=C(Cl)C=C1 GHXZTYHSJHQHIJ-UHFFFAOYSA-N 0.000 claims description 2
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 claims description 2
- FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 claims description 2
- 229920002153 Hydroxypropyl cellulose Polymers 0.000 claims description 2
- 239000002202 Polyethylene glycol Substances 0.000 claims description 2
- 150000005215 alkyl ethers Chemical class 0.000 claims description 2
- 239000001913 cellulose Substances 0.000 claims description 2
- 229920002678 cellulose Polymers 0.000 claims description 2
- 229960003260 chlorhexidine Drugs 0.000 claims description 2
- 150000002148 esters Chemical class 0.000 claims description 2
- 150000002170 ethers Chemical class 0.000 claims description 2
- 150000002191 fatty alcohols Chemical class 0.000 claims description 2
- 239000001863 hydroxypropyl cellulose Substances 0.000 claims description 2
- 235000010977 hydroxypropyl cellulose Nutrition 0.000 claims description 2
- 239000012528 membrane Substances 0.000 claims description 2
- 229920000191 poly(N-vinyl pyrrolidone) Polymers 0.000 claims description 2
- 229920001223 polyethylene glycol Polymers 0.000 claims description 2
- 229920000223 polyglycerol Polymers 0.000 claims description 2
- -1 polyoxyethylene Polymers 0.000 claims description 2
- 239000000600 sorbitol Substances 0.000 claims description 2
- 150000005846 sugar alcohols Polymers 0.000 claims description 2
- 230000002939 deleterious effect Effects 0.000 claims 4
- 150000003839 salts Chemical class 0.000 claims 4
- 239000002253 acid Substances 0.000 claims 3
- 150000007513 acids Chemical class 0.000 claims 3
- RGHNJXZEOKUKBD-SQOUGZDYSA-M D-gluconate Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C([O-])=O RGHNJXZEOKUKBD-SQOUGZDYSA-M 0.000 claims 1
- 238000013270 controlled release Methods 0.000 claims 1
- 238000004108 freeze drying Methods 0.000 claims 1
- 229940050410 gluconate Drugs 0.000 claims 1
- KUXUALPOSMRJSW-IFWQJVLJSA-N 2-[6-[[amino-[[amino-(4-chloroanilino)methylidene]amino]methylidene]amino]hexyl]-1-[amino-(4-chloroanilino)methylidene]guanidine;(2r,3s,4r,5r)-2,3,4,5,6-pentahydroxyhexanoic acid Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C(O)=O.C1=CC(Cl)=CC=C1NC(=N)NC(=N)NCCCCCCNC(=N)NC(=N)NC1=CC=C(Cl)C=C1 KUXUALPOSMRJSW-IFWQJVLJSA-N 0.000 description 15
- 150000002334 glycols Chemical class 0.000 description 4
- QSNSCYSYFYORTR-UHFFFAOYSA-N 4-chloroaniline Chemical compound NC1=CC=C(Cl)C=C1 QSNSCYSYFYORTR-UHFFFAOYSA-N 0.000 description 2
- 238000011156 evaluation Methods 0.000 description 2
- AGNTUZCMJBTHOG-UHFFFAOYSA-N 3-[3-(2,3-dihydroxypropoxy)-2-hydroxypropoxy]propane-1,2-diol Chemical compound OCC(O)COCC(O)COCC(O)CO AGNTUZCMJBTHOG-UHFFFAOYSA-N 0.000 description 1
- WOKDXPHSIQRTJF-UHFFFAOYSA-N 3-[3-[3-[3-[3-[3-[3-[3-[3-(2,3-dihydroxypropoxy)-2-hydroxypropoxy]-2-hydroxypropoxy]-2-hydroxypropoxy]-2-hydroxypropoxy]-2-hydroxypropoxy]-2-hydroxypropoxy]-2-hydroxypropoxy]-2-hydroxypropoxy]propane-1,2-diol Chemical compound OCC(O)COCC(O)COCC(O)COCC(O)COCC(O)COCC(O)COCC(O)COCC(O)COCC(O)COCC(O)CO WOKDXPHSIQRTJF-UHFFFAOYSA-N 0.000 description 1
- 241001209177 Akis Species 0.000 description 1
- 101000912181 Arabidopsis thaliana Cysteine synthase, mitochondrial Proteins 0.000 description 1
- 206010013911 Dysgeusia Diseases 0.000 description 1
- 101000713585 Homo sapiens Tubulin beta-4A chain Proteins 0.000 description 1
- 102100036788 Tubulin beta-4A chain Human genes 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 239000006227 byproduct Substances 0.000 description 1
- 230000001815 facial effect Effects 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- 208000007565 gingivitis Diseases 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 238000004806 packaging method and process Methods 0.000 description 1
- 230000000087 stabilizing effect Effects 0.000 description 1
- 231100000606 suspected carcinogen Toxicity 0.000 description 1
- 230000036344 tooth staining Effects 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/345—Alcohols containing more than one hydroxy group
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/43—Guanidines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T428/00—Stock material or miscellaneous articles
- Y10T428/29—Coated or structually defined flake, particle, cell, strand, strand portion, rod, filament, macroscopic fiber or mass thereof
- Y10T428/2913—Rod, strand, filament or fiber
- Y10T428/2933—Coated or with bond, impregnation or core
- Y10T428/2938—Coating on discrete and individual rods, strands or filaments
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Birds (AREA)
- Emergency Medicine (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- Cosmetics (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US09/089,872 | 1998-06-04 | ||
| US09/089,872 US6458341B1 (en) | 1998-06-04 | 1998-06-04 | Devices with coatings containing chlorhexidine gluconate, compositions and methods |
| PCT/US1999/010372 WO1999062470A1 (en) | 1998-06-04 | 1999-05-11 | Devices with coatings containing chlorhexidine gluconate, compositions and methods |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2333009A1 true CA2333009A1 (en) | 1999-12-09 |
Family
ID=22220003
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002333009A Abandoned CA2333009A1 (en) | 1998-06-04 | 1999-05-11 | Devices with coatings containing chlorhexidine gluconate, compositions and methods |
Country Status (7)
| Country | Link |
|---|---|
| US (2) | US6458341B1 (enExample) |
| EP (1) | EP1082089B1 (enExample) |
| JP (2) | JP2002516832A (enExample) |
| AU (1) | AU3983199A (enExample) |
| CA (1) | CA2333009A1 (enExample) |
| DE (1) | DE69910378T2 (enExample) |
| WO (1) | WO1999062470A1 (enExample) |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9764059B2 (en) | 2011-01-21 | 2017-09-19 | Avery Dennison Corporation | Chlorhexidine gluconate containing solvent adhesive |
| US10456498B2 (en) | 2013-02-07 | 2019-10-29 | Avery Dennison Corporation | Antimicrobial adhesives having improved properties |
| US11058793B2 (en) | 2011-05-16 | 2021-07-13 | Avery Dennison Corporation | Adhesive containing microparticles |
| US11213432B2 (en) | 2013-03-15 | 2022-01-04 | Avery Dennison Corporation | Transparent cover dressing application system and inclusion of label strip |
| US11337940B2 (en) | 2014-06-05 | 2022-05-24 | Avery Dennison Corporation | Articles with active agent concentrated at the substrate contacting surface and related methods |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20060034782A1 (en) * | 2001-12-04 | 2006-02-16 | Brown Dale G | Biofilm therapy interproximal devices |
| DE10242476B4 (de) * | 2002-09-11 | 2006-10-26 | Heraeus Kulzer Gmbh | Antibiotikum-/Antibiotika-Polymer-Kombination |
| US20040247654A1 (en) * | 2003-06-05 | 2004-12-09 | 3M Innovative Properties Company | Hydrophilic adhesives for delivery of herbal medicines |
| US9278155B2 (en) * | 2003-06-05 | 2016-03-08 | 3M Innovative Properties Company | Adhesive compositions, articles incorporating same and methods of manufacture |
| US20050191247A1 (en) * | 2004-03-01 | 2005-09-01 | David Drake | Chlorhexidine compositions |
| US20060034899A1 (en) * | 2004-08-12 | 2006-02-16 | Ylitalo Caroline M | Biologically-active adhesive articles and methods of manufacture |
| US20060035039A1 (en) * | 2004-08-12 | 2006-02-16 | 3M Innovative Properties Company | Silver-releasing articles and methods of manufacture |
| US20060243298A1 (en) * | 2005-04-28 | 2006-11-02 | The Procter & Gamble Company | Dental floss compositions comprising menthol and carboxamides |
| US7845351B2 (en) * | 2005-08-31 | 2010-12-07 | Kimberly-Clark Worldwide Inc. | Germicidal face mask |
| US20070181144A1 (en) * | 2006-02-07 | 2007-08-09 | Whitehill Oral Technologies, Inc. | Coated dental devices with dry-to-the-touch, flavor-absorbing, saliva soluble coatings and methods for manufacturing |
| US7824122B2 (en) * | 2006-02-14 | 2010-11-02 | Carefusion 2200, Inc. | Liquid applicator and method for reducing the concentration of by-products from antiseptic |
| WO2008100451A2 (en) * | 2007-02-09 | 2008-08-21 | Dentsply International Inc. | A method of treatment of the dental pulp and filling root canals using water-based materials |
| US9981069B2 (en) | 2007-06-20 | 2018-05-29 | The Trustees Of Columbia University In The City Of New York | Bio-film resistant surfaces |
| EP2427184B1 (en) * | 2009-05-08 | 2017-08-30 | 3M Innovative Properties Company | Oral care method and kit |
| US20110195105A1 (en) * | 2010-02-08 | 2011-08-11 | Nanos John I | Foam Cellular Matrix Impregnated With Anti-Microbial Active Agent For Use In Negative Pressure Wound Therapy Applications And Process For Producing The Same |
| WO2014035971A2 (en) * | 2012-08-28 | 2014-03-06 | 3M Innovative Properties Company | Chlorhexidine gluconate solubilized in a hydrophobic monoacylglyceride |
| MX354749B (es) | 2012-08-28 | 2018-03-20 | 3M Innovative Properties Co | Composiciones de gluconato de clorhexidina, sistemas de resinas y articulos. |
| EP3043786A4 (en) | 2013-09-13 | 2017-03-01 | 3M Innovative Properties Company | Cationic antiseptic compositions, method and kit |
| US9970303B2 (en) | 2014-05-13 | 2018-05-15 | Entrotech, Inc. | Erosion protection sleeve |
| WO2016093815A1 (en) | 2014-12-10 | 2016-06-16 | Colgate-Palmolive Company | Dental floss coating composition |
| EP3694439A4 (en) | 2017-10-12 | 2021-12-15 | Medline Industries, Inc. | ANTISEPTIC WIPES |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5098711A (en) | 1988-11-14 | 1992-03-24 | Ira Hill | Method of treating the oral cavity with dental floss containing chemotherapeutic agents |
| US5165913A (en) | 1988-11-14 | 1992-11-24 | Ira Hill | Controlled release interproximal delivery system |
| US4911927A (en) | 1988-11-14 | 1990-03-27 | Hill Ira D | Method and apparatus for adding chemotherapeutic agents to dental floss |
| US5328698A (en) * | 1990-08-06 | 1994-07-12 | Becton, Dickinson And Company | Method for rendering a substrate surface antithrombogenic and/or anti-infective |
| US5213803A (en) | 1990-10-04 | 1993-05-25 | Northeastern Ohio Universities College Of Medicine | Antiviral composition and method |
| JP2959833B2 (ja) | 1990-11-06 | 1999-10-06 | ライオン株式会社 | 徐放性口腔内疾患治療剤およびその製法 |
| GB9206509D0 (en) * | 1992-03-25 | 1992-05-06 | Jevco Ltd | Heteromorphic sponges containing active agents |
| GB9209327D0 (en) * | 1992-04-30 | 1992-06-17 | Johnson & Johnson Medical | Freeze-dried pad |
| BR9301968A (pt) | 1993-06-08 | 1994-12-27 | Johnson & Johnson | Fio dental dotado de agentes quimioterápicos |
| US5711935A (en) | 1994-05-10 | 1998-01-27 | Whitehill Oral Technologies, Inc. | Dental floss |
| EP0782850A4 (en) * | 1994-10-13 | 1998-03-04 | Wakamoto Pharma Co Ltd | LYOPHILIZED PREPARATION FOR PRODUCING A REVERSIBLE THERMOGELING MEDICINAL WATER-BASED |
| US5603921A (en) | 1995-03-13 | 1997-02-18 | Whalen Biomedical Incorporated | Medicated dental floss and method of preparation |
-
1998
- 1998-06-04 US US09/089,872 patent/US6458341B1/en not_active Expired - Lifetime
-
1999
- 1999-05-11 WO PCT/US1999/010372 patent/WO1999062470A1/en not_active Ceased
- 1999-05-11 EP EP99922947A patent/EP1082089B1/en not_active Expired - Lifetime
- 1999-05-11 CA CA002333009A patent/CA2333009A1/en not_active Abandoned
- 1999-05-11 DE DE69910378T patent/DE69910378T2/de not_active Expired - Lifetime
- 1999-05-11 JP JP2000551727A patent/JP2002516832A/ja not_active Withdrawn
- 1999-05-11 AU AU39831/99A patent/AU3983199A/en not_active Abandoned
-
2002
- 2002-09-26 US US10/256,032 patent/US6733745B2/en not_active Expired - Lifetime
-
2009
- 2009-01-05 JP JP2009000393A patent/JP2009137985A/ja active Pending
Cited By (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9764059B2 (en) | 2011-01-21 | 2017-09-19 | Avery Dennison Corporation | Chlorhexidine gluconate containing solvent adhesive |
| US11058793B2 (en) | 2011-05-16 | 2021-07-13 | Avery Dennison Corporation | Adhesive containing microparticles |
| US11707549B2 (en) | 2011-05-16 | 2023-07-25 | Avery Dennison Corporation | Adhesive containing microparticles |
| US12036335B2 (en) | 2011-05-16 | 2024-07-16 | Avery Dennison Corporation | Adhesive containing microparticles |
| US10456498B2 (en) | 2013-02-07 | 2019-10-29 | Avery Dennison Corporation | Antimicrobial adhesives having improved properties |
| US11318223B2 (en) | 2013-02-07 | 2022-05-03 | Avery Dennison Corporation | Antimicrobial adhesives having improved properties |
| US11213432B2 (en) | 2013-03-15 | 2022-01-04 | Avery Dennison Corporation | Transparent cover dressing application system and inclusion of label strip |
| US11337940B2 (en) | 2014-06-05 | 2022-05-24 | Avery Dennison Corporation | Articles with active agent concentrated at the substrate contacting surface and related methods |
| US12109180B2 (en) | 2014-06-05 | 2024-10-08 | Avery Dennison Corporation | Articles with active agent concentrated at the substrate contacting surface and related methods |
Also Published As
| Publication number | Publication date |
|---|---|
| US20030138492A1 (en) | 2003-07-24 |
| EP1082089B1 (en) | 2003-08-13 |
| JP2002516832A (ja) | 2002-06-11 |
| EP1082089A1 (en) | 2001-03-14 |
| WO1999062470A1 (en) | 1999-12-09 |
| JP2009137985A (ja) | 2009-06-25 |
| US6733745B2 (en) | 2004-05-11 |
| US6458341B1 (en) | 2002-10-01 |
| DE69910378T2 (de) | 2004-06-24 |
| AU3983199A (en) | 1999-12-20 |
| DE69910378D1 (de) | 2003-09-18 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FZDE | Discontinued |