DE69910378T2 - Vorrichtungen mit chlorhexidingluconat enthaltenden beschichtungen, zusammensetzungen und verfahren - Google Patents
Vorrichtungen mit chlorhexidingluconat enthaltenden beschichtungen, zusammensetzungen und verfahren Download PDFInfo
- Publication number
- DE69910378T2 DE69910378T2 DE69910378T DE69910378T DE69910378T2 DE 69910378 T2 DE69910378 T2 DE 69910378T2 DE 69910378 T DE69910378 T DE 69910378T DE 69910378 T DE69910378 T DE 69910378T DE 69910378 T2 DE69910378 T2 DE 69910378T2
- Authority
- DE
- Germany
- Prior art keywords
- chlorhexidine gluconate
- glycol
- coating
- chg
- water
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 239000000203 mixture Substances 0.000 title claims description 70
- 238000000034 method Methods 0.000 title claims description 30
- RGHNJXZEOKUKBD-SQOUGZDYSA-M D-gluconate Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C([O-])=O RGHNJXZEOKUKBD-SQOUGZDYSA-M 0.000 title 1
- 229940050410 gluconate Drugs 0.000 title 1
- YZIYKJHYYHPJIB-UUPCJSQJSA-N chlorhexidine gluconate Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C(O)=O.OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C(O)=O.C1=CC(Cl)=CC=C1NC(=N)NC(=N)NCCCCCCNC(=N)NC(=N)NC1=CC=C(Cl)C=C1 YZIYKJHYYHPJIB-UUPCJSQJSA-N 0.000 claims description 143
- 229960003333 chlorhexidine gluconate Drugs 0.000 claims description 143
- 238000000576 coating method Methods 0.000 claims description 80
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 claims description 70
- 241000628997 Flos Species 0.000 claims description 57
- 239000011248 coating agent Substances 0.000 claims description 57
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 56
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 51
- QSNSCYSYFYORTR-UHFFFAOYSA-N 4-chloroaniline Chemical compound NC1=CC=C(Cl)C=C1 QSNSCYSYFYORTR-UHFFFAOYSA-N 0.000 claims description 37
- WGCNASOHLSPBMP-UHFFFAOYSA-N hydroxyacetaldehyde Natural products OCC=O WGCNASOHLSPBMP-UHFFFAOYSA-N 0.000 claims description 33
- 239000008199 coating composition Substances 0.000 claims description 17
- 239000004094 surface-active agent Substances 0.000 claims description 16
- 150000003839 salts Chemical class 0.000 claims description 13
- 239000002253 acid Substances 0.000 claims description 12
- 150000007513 acids Chemical class 0.000 claims description 12
- 230000003381 solubilizing effect Effects 0.000 claims description 12
- 239000004744 fabric Substances 0.000 claims description 11
- 238000002360 preparation method Methods 0.000 claims description 9
- 210000000214 mouth Anatomy 0.000 claims description 7
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 claims description 6
- 239000000463 material Substances 0.000 claims description 6
- 239000002202 Polyethylene glycol Substances 0.000 claims description 5
- 229920001223 polyethylene glycol Polymers 0.000 claims description 5
- 229920003171 Poly (ethylene oxide) Polymers 0.000 claims description 4
- 238000002156 mixing Methods 0.000 claims description 4
- 229920000223 polyglycerol Polymers 0.000 claims description 4
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 claims description 3
- FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 claims description 3
- -1 polyoxyethylene Polymers 0.000 claims description 3
- 239000000600 sorbitol Substances 0.000 claims description 3
- 235000010585 Ammi visnaga Nutrition 0.000 claims description 2
- 244000153158 Ammi visnaga Species 0.000 claims description 2
- 229920002153 Hydroxypropyl cellulose Polymers 0.000 claims description 2
- 125000005907 alkyl ester group Chemical group 0.000 claims description 2
- 150000005215 alkyl ethers Chemical class 0.000 claims description 2
- 239000001913 cellulose Substances 0.000 claims description 2
- 229920002678 cellulose Polymers 0.000 claims description 2
- 150000002148 esters Chemical class 0.000 claims description 2
- 150000002170 ethers Chemical class 0.000 claims description 2
- 150000002191 fatty alcohols Chemical class 0.000 claims description 2
- 238000011049 filling Methods 0.000 claims description 2
- 239000001863 hydroxypropyl cellulose Substances 0.000 claims description 2
- 235000010977 hydroxypropyl cellulose Nutrition 0.000 claims description 2
- 229920000191 poly(N-vinyl pyrrolidone) Polymers 0.000 claims description 2
- 229920005862 polyol Polymers 0.000 claims description 2
- 238000004108 freeze drying Methods 0.000 claims 1
- 230000000052 comparative effect Effects 0.000 description 24
- RGHNJXZEOKUKBD-SQOUGZDYSA-N D-gluconic acid Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C(O)=O RGHNJXZEOKUKBD-SQOUGZDYSA-N 0.000 description 22
- 238000004128 high performance liquid chromatography Methods 0.000 description 20
- 239000000126 substance Substances 0.000 description 19
- ZMANZCXQSJIPKH-UHFFFAOYSA-N Triethylamine Chemical compound CCN(CC)CC ZMANZCXQSJIPKH-UHFFFAOYSA-N 0.000 description 18
- 235000011187 glycerol Nutrition 0.000 description 17
- 239000000243 solution Substances 0.000 description 17
- 239000011550 stock solution Substances 0.000 description 16
- WEVYAHXRMPXWCK-UHFFFAOYSA-N Acetonitrile Chemical compound CC#N WEVYAHXRMPXWCK-UHFFFAOYSA-N 0.000 description 15
- RGHNJXZEOKUKBD-UHFFFAOYSA-N D-gluconic acid Natural products OCC(O)C(O)C(O)C(O)C(O)=O RGHNJXZEOKUKBD-UHFFFAOYSA-N 0.000 description 11
- 239000000174 gluconic acid Substances 0.000 description 11
- 235000012208 gluconic acid Nutrition 0.000 description 11
- GHXZTYHSJHQHIJ-UHFFFAOYSA-N Chlorhexidine Chemical compound C=1C=C(Cl)C=CC=1NC(N)=NC(N)=NCCCCCCN=C(N)N=C(N)NC1=CC=C(Cl)C=C1 GHXZTYHSJHQHIJ-UHFFFAOYSA-N 0.000 description 10
- 229920002565 Polyethylene Glycol 400 Polymers 0.000 description 10
- 229960003260 chlorhexidine Drugs 0.000 description 10
- 239000012458 free base Substances 0.000 description 10
- 239000002585 base Substances 0.000 description 9
- 239000008367 deionised water Substances 0.000 description 9
- 229910021641 deionized water Inorganic materials 0.000 description 9
- NBIIXXVUZAFLBC-UHFFFAOYSA-N Phosphoric acid Chemical compound OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 description 8
- 239000000796 flavoring agent Substances 0.000 description 8
- 235000019634 flavors Nutrition 0.000 description 8
- 239000000523 sample Substances 0.000 description 7
- 238000003756 stirring Methods 0.000 description 7
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 6
- 238000011088 calibration curve Methods 0.000 description 6
- 239000003205 fragrance Substances 0.000 description 6
- 238000002844 melting Methods 0.000 description 6
- 230000008018 melting Effects 0.000 description 6
- 229920001992 poloxamer 407 Polymers 0.000 description 6
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 5
- 244000246386 Mentha pulegium Species 0.000 description 5
- 235000016257 Mentha pulegium Nutrition 0.000 description 5
- 235000004357 Mentha x piperita Nutrition 0.000 description 5
- 235000001050 hortel pimenta Nutrition 0.000 description 5
- 239000007788 liquid Substances 0.000 description 5
- 238000005259 measurement Methods 0.000 description 5
- 239000002904 solvent Substances 0.000 description 5
- 239000001993 wax Substances 0.000 description 5
- 230000032683 aging Effects 0.000 description 4
- 229910000147 aluminium phosphate Inorganic materials 0.000 description 4
- 150000002334 glycols Chemical class 0.000 description 4
- 238000002347 injection Methods 0.000 description 4
- 239000007924 injection Substances 0.000 description 4
- 229920002523 polyethylene Glycol 1000 Polymers 0.000 description 4
- 229920002562 Polyethylene Glycol 3350 Polymers 0.000 description 3
- 230000015556 catabolic process Effects 0.000 description 3
- 238000006243 chemical reaction Methods 0.000 description 3
- 238000006731 degradation reaction Methods 0.000 description 3
- 239000000835 fiber Substances 0.000 description 3
- 239000003973 paint Substances 0.000 description 3
- 239000012086 standard solution Substances 0.000 description 3
- 238000010998 test method Methods 0.000 description 3
- RFVNOJDQRGSOEL-UHFFFAOYSA-N 2-hydroxyethyl octadecanoate Chemical compound CCCCCCCCCCCCCCCCCC(=O)OCCO RFVNOJDQRGSOEL-UHFFFAOYSA-N 0.000 description 2
- 238000010268 HPLC based assay Methods 0.000 description 2
- 208000025157 Oral disease Diseases 0.000 description 2
- 229960000583 acetic acid Drugs 0.000 description 2
- 239000000654 additive Substances 0.000 description 2
- 239000003945 anionic surfactant Substances 0.000 description 2
- 239000006227 byproduct Substances 0.000 description 2
- 239000003795 chemical substances by application Substances 0.000 description 2
- 239000006185 dispersion Substances 0.000 description 2
- 238000011065 in-situ storage Methods 0.000 description 2
- 238000004519 manufacturing process Methods 0.000 description 2
- 208000030194 mouth disease Diseases 0.000 description 2
- 229920000642 polymer Polymers 0.000 description 2
- 229920001296 polysiloxane Polymers 0.000 description 2
- 239000011148 porous material Substances 0.000 description 2
- 238000011045 prefiltration Methods 0.000 description 2
- 239000012488 sample solution Substances 0.000 description 2
- 239000000741 silica gel Substances 0.000 description 2
- 229910002027 silica gel Inorganic materials 0.000 description 2
- 239000000377 silicon dioxide Substances 0.000 description 2
- 239000007787 solid Substances 0.000 description 2
- 230000000087 stabilizing effect Effects 0.000 description 2
- 231100000331 toxic Toxicity 0.000 description 2
- 230000002588 toxic effect Effects 0.000 description 2
- DQWPFSLDHJDLRL-UHFFFAOYSA-N triethyl phosphate Chemical compound CCOP(=O)(OCC)OCC DQWPFSLDHJDLRL-UHFFFAOYSA-N 0.000 description 2
- AGNTUZCMJBTHOG-UHFFFAOYSA-N 3-[3-(2,3-dihydroxypropoxy)-2-hydroxypropoxy]propane-1,2-diol Chemical compound OCC(O)COCC(O)COCC(O)CO AGNTUZCMJBTHOG-UHFFFAOYSA-N 0.000 description 1
- WOKDXPHSIQRTJF-UHFFFAOYSA-N 3-[3-[3-[3-[3-[3-[3-[3-[3-(2,3-dihydroxypropoxy)-2-hydroxypropoxy]-2-hydroxypropoxy]-2-hydroxypropoxy]-2-hydroxypropoxy]-2-hydroxypropoxy]-2-hydroxypropoxy]-2-hydroxypropoxy]-2-hydroxypropoxy]propane-1,2-diol Chemical compound OCC(O)COCC(O)COCC(O)COCC(O)COCC(O)COCC(O)COCC(O)COCC(O)COCC(O)COCC(O)CO WOKDXPHSIQRTJF-UHFFFAOYSA-N 0.000 description 1
- OCKGFTQIICXDQW-ZEQRLZLVSA-N 5-[(1r)-1-hydroxy-2-[4-[(2r)-2-hydroxy-2-(4-methyl-1-oxo-3h-2-benzofuran-5-yl)ethyl]piperazin-1-yl]ethyl]-4-methyl-3h-2-benzofuran-1-one Chemical compound C1=C2C(=O)OCC2=C(C)C([C@@H](O)CN2CCN(CC2)C[C@H](O)C2=CC=C3C(=O)OCC3=C2C)=C1 OCKGFTQIICXDQW-ZEQRLZLVSA-N 0.000 description 1
- DJHGAFSJWGLOIV-UHFFFAOYSA-K Arsenate3- Chemical class [O-][As]([O-])([O-])=O DJHGAFSJWGLOIV-UHFFFAOYSA-K 0.000 description 1
- 241001561902 Chaetodon citrinellus Species 0.000 description 1
- XTEGARKTQYYJKE-UHFFFAOYSA-M Chlorate Chemical class [O-]Cl(=O)=O XTEGARKTQYYJKE-UHFFFAOYSA-M 0.000 description 1
- PHOQVHQSTUBQQK-SQOUGZDYSA-N D-glucono-1,5-lactone Chemical compound OC[C@H]1OC(=O)[C@H](O)[C@@H](O)[C@@H]1O PHOQVHQSTUBQQK-SQOUGZDYSA-N 0.000 description 1
- 229940090898 Desensitizer Drugs 0.000 description 1
- KRHYYFGTRYWZRS-UHFFFAOYSA-M Fluoride anion Chemical compound [F-] KRHYYFGTRYWZRS-UHFFFAOYSA-M 0.000 description 1
- 240000001238 Gaultheria procumbens Species 0.000 description 1
- 235000007297 Gaultheria procumbens Nutrition 0.000 description 1
- 208000034619 Gingival inflammation Diseases 0.000 description 1
- 229910019142 PO4 Inorganic materials 0.000 description 1
- ABLZXFCXXLZCGV-UHFFFAOYSA-N Phosphorous acid Chemical class OP(O)=O ABLZXFCXXLZCGV-UHFFFAOYSA-N 0.000 description 1
- 229920002701 Polyoxyl 40 Stearate Polymers 0.000 description 1
- ULUAUXLGCMPNKK-UHFFFAOYSA-N Sulfobutanedioic acid Chemical class OC(=O)CC(C(O)=O)S(O)(=O)=O ULUAUXLGCMPNKK-UHFFFAOYSA-N 0.000 description 1
- 208000004509 Tooth Discoloration Diseases 0.000 description 1
- 206010044032 Tooth discolouration Diseases 0.000 description 1
- 150000001242 acetic acid derivatives Chemical class 0.000 description 1
- 125000000129 anionic group Chemical group 0.000 description 1
- 230000000845 anti-microbial effect Effects 0.000 description 1
- 235000013871 bee wax Nutrition 0.000 description 1
- 239000012166 beeswax Substances 0.000 description 1
- 230000000740 bleeding effect Effects 0.000 description 1
- 230000000711 cancerogenic effect Effects 0.000 description 1
- 150000004649 carbonic acid derivatives Chemical class 0.000 description 1
- 150000001735 carboxylic acids Chemical class 0.000 description 1
- 231100000357 carcinogen Toxicity 0.000 description 1
- 239000003183 carcinogenic agent Substances 0.000 description 1
- 239000000679 carrageenan Substances 0.000 description 1
- 235000010418 carrageenan Nutrition 0.000 description 1
- 229920001525 carrageenan Polymers 0.000 description 1
- 229940113118 carrageenan Drugs 0.000 description 1
- 229940044683 chemotherapy drug Drugs 0.000 description 1
- ZCDOYSPFYFSLEW-UHFFFAOYSA-N chromate(2-) Chemical class [O-][Cr]([O-])(=O)=O ZCDOYSPFYFSLEW-UHFFFAOYSA-N 0.000 description 1
- 239000003086 colorant Substances 0.000 description 1
- 239000000356 contaminant Substances 0.000 description 1
- 238000000354 decomposition reaction Methods 0.000 description 1
- 239000007857 degradation product Substances 0.000 description 1
- 239000003599 detergent Substances 0.000 description 1
- 230000001627 detrimental effect Effects 0.000 description 1
- 238000002845 discoloration Methods 0.000 description 1
- 238000004090 dissolution Methods 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 238000013265 extended release Methods 0.000 description 1
- 238000001125 extrusion Methods 0.000 description 1
- 239000011152 fibreglass Substances 0.000 description 1
- 235000003599 food sweetener Nutrition 0.000 description 1
- 208000007565 gingivitis Diseases 0.000 description 1
- 239000012362 glacial acetic acid Substances 0.000 description 1
- 150000004820 halides Chemical class 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- 239000003906 humectant Substances 0.000 description 1
- 150000004679 hydroxides Chemical class 0.000 description 1
- 238000007654 immersion Methods 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 238000011835 investigation Methods 0.000 description 1
- ICIWUVCWSCSTAQ-UHFFFAOYSA-N iodic acid Chemical class OI(=O)=O ICIWUVCWSCSTAQ-UHFFFAOYSA-N 0.000 description 1
- 150000002596 lactones Chemical class 0.000 description 1
- 238000010030 laminating Methods 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 230000014759 maintenance of location Effects 0.000 description 1
- 239000012528 membrane Substances 0.000 description 1
- 239000002184 metal Substances 0.000 description 1
- QCAWEPFNJXQPAN-UHFFFAOYSA-N methoxyfenozide Chemical compound COC1=CC=CC(C(=O)NN(C(=O)C=2C=C(C)C=C(C)C=2)C(C)(C)C)=C1C QCAWEPFNJXQPAN-UHFFFAOYSA-N 0.000 description 1
- OSWPMRLSEDHDFF-UHFFFAOYSA-N methyl salicylate Chemical compound COC(=O)C1=CC=CC=C1O OSWPMRLSEDHDFF-UHFFFAOYSA-N 0.000 description 1
- 239000004200 microcrystalline wax Substances 0.000 description 1
- 235000019808 microcrystalline wax Nutrition 0.000 description 1
- 230000007935 neutral effect Effects 0.000 description 1
- 150000002823 nitrates Chemical class 0.000 description 1
- 150000002825 nitriles Chemical class 0.000 description 1
- 150000003891 oxalate salts Chemical class 0.000 description 1
- RARSHUDCJQSEFJ-UHFFFAOYSA-N p-Hydroxypropiophenone Chemical compound CCC(=O)C1=CC=C(O)C=C1 RARSHUDCJQSEFJ-UHFFFAOYSA-N 0.000 description 1
- 238000004806 packaging method and process Methods 0.000 description 1
- 239000002245 particle Substances 0.000 description 1
- 239000007967 peppermint flavor Substances 0.000 description 1
- 208000028169 periodontal disease Diseases 0.000 description 1
- 230000003239 periodontal effect Effects 0.000 description 1
- 235000021317 phosphate Nutrition 0.000 description 1
- 150000003013 phosphoric acid derivatives Chemical class 0.000 description 1
- 239000003755 preservative agent Substances 0.000 description 1
- 239000000047 product Substances 0.000 description 1
- 230000035484 reaction time Effects 0.000 description 1
- CVHZOJJKTDOEJC-UHFFFAOYSA-N saccharin Chemical compound C1=CC=C2C(=O)NS(=O)(=O)C2=C1 CVHZOJJKTDOEJC-UHFFFAOYSA-N 0.000 description 1
- 229940081974 saccharin Drugs 0.000 description 1
- 235000019204 saccharin Nutrition 0.000 description 1
- 239000000901 saccharin and its Na,K and Ca salt Substances 0.000 description 1
- 239000002002 slurry Substances 0.000 description 1
- 238000005507 spraying Methods 0.000 description 1
- 239000003381 stabilizer Substances 0.000 description 1
- 238000003860 storage Methods 0.000 description 1
- 150000003871 sulfonates Chemical class 0.000 description 1
- 150000003467 sulfuric acid derivatives Chemical class 0.000 description 1
- 239000003765 sweetening agent Substances 0.000 description 1
- 150000003567 thiocyanates Chemical class 0.000 description 1
- 150000003568 thioethers Chemical class 0.000 description 1
- 230000036367 tooth discoloration Effects 0.000 description 1
- UHVMMEOXYDMDKI-JKYCWFKZSA-L zinc;1-(5-cyanopyridin-2-yl)-3-[(1s,2s)-2-(6-fluoro-2-hydroxy-3-propanoylphenyl)cyclopropyl]urea;diacetate Chemical compound [Zn+2].CC([O-])=O.CC([O-])=O.CCC(=O)C1=CC=C(F)C([C@H]2[C@H](C2)NC(=O)NC=2N=CC(=CC=2)C#N)=C1O UHVMMEOXYDMDKI-JKYCWFKZSA-L 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/345—Alcohols containing more than one hydroxy group
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/43—Guanidines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T428/00—Stock material or miscellaneous articles
- Y10T428/29—Coated or structually defined flake, particle, cell, strand, strand portion, rod, filament, macroscopic fiber or mass thereof
- Y10T428/2913—Rod, strand, filament or fiber
- Y10T428/2933—Coated or with bond, impregnation or core
- Y10T428/2938—Coating on discrete and individual rods, strands or filaments
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Birds (AREA)
- Emergency Medicine (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- Cosmetics (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US89872 | 1993-07-09 | ||
| US09/089,872 US6458341B1 (en) | 1998-06-04 | 1998-06-04 | Devices with coatings containing chlorhexidine gluconate, compositions and methods |
| PCT/US1999/010372 WO1999062470A1 (en) | 1998-06-04 | 1999-05-11 | Devices with coatings containing chlorhexidine gluconate, compositions and methods |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE69910378D1 DE69910378D1 (de) | 2003-09-18 |
| DE69910378T2 true DE69910378T2 (de) | 2004-06-24 |
Family
ID=22220003
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE69910378T Expired - Lifetime DE69910378T2 (de) | 1998-06-04 | 1999-05-11 | Vorrichtungen mit chlorhexidingluconat enthaltenden beschichtungen, zusammensetzungen und verfahren |
Country Status (7)
| Country | Link |
|---|---|
| US (2) | US6458341B1 (enExample) |
| EP (1) | EP1082089B1 (enExample) |
| JP (2) | JP2002516832A (enExample) |
| AU (1) | AU3983199A (enExample) |
| CA (1) | CA2333009A1 (enExample) |
| DE (1) | DE69910378T2 (enExample) |
| WO (1) | WO1999062470A1 (enExample) |
Families Citing this family (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20060034782A1 (en) * | 2001-12-04 | 2006-02-16 | Brown Dale G | Biofilm therapy interproximal devices |
| DE10242476B4 (de) * | 2002-09-11 | 2006-10-26 | Heraeus Kulzer Gmbh | Antibiotikum-/Antibiotika-Polymer-Kombination |
| US20040247654A1 (en) * | 2003-06-05 | 2004-12-09 | 3M Innovative Properties Company | Hydrophilic adhesives for delivery of herbal medicines |
| US9278155B2 (en) * | 2003-06-05 | 2016-03-08 | 3M Innovative Properties Company | Adhesive compositions, articles incorporating same and methods of manufacture |
| US20050191247A1 (en) * | 2004-03-01 | 2005-09-01 | David Drake | Chlorhexidine compositions |
| US20060034899A1 (en) * | 2004-08-12 | 2006-02-16 | Ylitalo Caroline M | Biologically-active adhesive articles and methods of manufacture |
| US20060035039A1 (en) * | 2004-08-12 | 2006-02-16 | 3M Innovative Properties Company | Silver-releasing articles and methods of manufacture |
| US20060243298A1 (en) * | 2005-04-28 | 2006-11-02 | The Procter & Gamble Company | Dental floss compositions comprising menthol and carboxamides |
| US7845351B2 (en) * | 2005-08-31 | 2010-12-07 | Kimberly-Clark Worldwide Inc. | Germicidal face mask |
| US20070181144A1 (en) * | 2006-02-07 | 2007-08-09 | Whitehill Oral Technologies, Inc. | Coated dental devices with dry-to-the-touch, flavor-absorbing, saliva soluble coatings and methods for manufacturing |
| US7824122B2 (en) * | 2006-02-14 | 2010-11-02 | Carefusion 2200, Inc. | Liquid applicator and method for reducing the concentration of by-products from antiseptic |
| WO2008100451A2 (en) * | 2007-02-09 | 2008-08-21 | Dentsply International Inc. | A method of treatment of the dental pulp and filling root canals using water-based materials |
| US9981069B2 (en) | 2007-06-20 | 2018-05-29 | The Trustees Of Columbia University In The City Of New York | Bio-film resistant surfaces |
| EP2427184B1 (en) * | 2009-05-08 | 2017-08-30 | 3M Innovative Properties Company | Oral care method and kit |
| US20110195105A1 (en) * | 2010-02-08 | 2011-08-11 | Nanos John I | Foam Cellular Matrix Impregnated With Anti-Microbial Active Agent For Use In Negative Pressure Wound Therapy Applications And Process For Producing The Same |
| WO2012100244A2 (en) | 2011-01-21 | 2012-07-26 | Avery Dennison Corporation | Chlorhexidine gluconate containing solvent adhesive |
| WO2012158483A2 (en) | 2011-05-16 | 2012-11-22 | Avery Dennison Corporation | Adhesive containing microparticles |
| WO2014035971A2 (en) * | 2012-08-28 | 2014-03-06 | 3M Innovative Properties Company | Chlorhexidine gluconate solubilized in a hydrophobic monoacylglyceride |
| MX354749B (es) | 2012-08-28 | 2018-03-20 | 3M Innovative Properties Co | Composiciones de gluconato de clorhexidina, sistemas de resinas y articulos. |
| PL2954019T3 (pl) | 2013-02-07 | 2019-01-31 | Avery Dennison Corporation | Kleje przeciwbakteryjne o ulepszonych właściwościach |
| EP2968014B1 (en) | 2013-03-15 | 2019-04-24 | Avery Dennison Corporation | Transparent cover dressing application system and inclusion of label strip |
| EP3043786A4 (en) | 2013-09-13 | 2017-03-01 | 3M Innovative Properties Company | Cationic antiseptic compositions, method and kit |
| US9970303B2 (en) | 2014-05-13 | 2018-05-15 | Entrotech, Inc. | Erosion protection sleeve |
| EP3789014A1 (en) | 2014-06-05 | 2021-03-10 | Avery Dennison Corporation | Articles with active agent concentrated at the substrate contacting surface and related methods |
| WO2016093815A1 (en) | 2014-12-10 | 2016-06-16 | Colgate-Palmolive Company | Dental floss coating composition |
| EP3694439A4 (en) | 2017-10-12 | 2021-12-15 | Medline Industries, Inc. | ANTISEPTIC WIPES |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5098711A (en) | 1988-11-14 | 1992-03-24 | Ira Hill | Method of treating the oral cavity with dental floss containing chemotherapeutic agents |
| US5165913A (en) | 1988-11-14 | 1992-11-24 | Ira Hill | Controlled release interproximal delivery system |
| US4911927A (en) | 1988-11-14 | 1990-03-27 | Hill Ira D | Method and apparatus for adding chemotherapeutic agents to dental floss |
| US5328698A (en) * | 1990-08-06 | 1994-07-12 | Becton, Dickinson And Company | Method for rendering a substrate surface antithrombogenic and/or anti-infective |
| US5213803A (en) | 1990-10-04 | 1993-05-25 | Northeastern Ohio Universities College Of Medicine | Antiviral composition and method |
| JP2959833B2 (ja) | 1990-11-06 | 1999-10-06 | ライオン株式会社 | 徐放性口腔内疾患治療剤およびその製法 |
| GB9206509D0 (en) * | 1992-03-25 | 1992-05-06 | Jevco Ltd | Heteromorphic sponges containing active agents |
| GB9209327D0 (en) * | 1992-04-30 | 1992-06-17 | Johnson & Johnson Medical | Freeze-dried pad |
| BR9301968A (pt) | 1993-06-08 | 1994-12-27 | Johnson & Johnson | Fio dental dotado de agentes quimioterápicos |
| US5711935A (en) | 1994-05-10 | 1998-01-27 | Whitehill Oral Technologies, Inc. | Dental floss |
| EP0782850A4 (en) * | 1994-10-13 | 1998-03-04 | Wakamoto Pharma Co Ltd | LYOPHILIZED PREPARATION FOR PRODUCING A REVERSIBLE THERMOGELING MEDICINAL WATER-BASED |
| US5603921A (en) | 1995-03-13 | 1997-02-18 | Whalen Biomedical Incorporated | Medicated dental floss and method of preparation |
-
1998
- 1998-06-04 US US09/089,872 patent/US6458341B1/en not_active Expired - Lifetime
-
1999
- 1999-05-11 WO PCT/US1999/010372 patent/WO1999062470A1/en not_active Ceased
- 1999-05-11 EP EP99922947A patent/EP1082089B1/en not_active Expired - Lifetime
- 1999-05-11 CA CA002333009A patent/CA2333009A1/en not_active Abandoned
- 1999-05-11 DE DE69910378T patent/DE69910378T2/de not_active Expired - Lifetime
- 1999-05-11 JP JP2000551727A patent/JP2002516832A/ja not_active Withdrawn
- 1999-05-11 AU AU39831/99A patent/AU3983199A/en not_active Abandoned
-
2002
- 2002-09-26 US US10/256,032 patent/US6733745B2/en not_active Expired - Lifetime
-
2009
- 2009-01-05 JP JP2009000393A patent/JP2009137985A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| US20030138492A1 (en) | 2003-07-24 |
| EP1082089B1 (en) | 2003-08-13 |
| JP2002516832A (ja) | 2002-06-11 |
| EP1082089A1 (en) | 2001-03-14 |
| WO1999062470A1 (en) | 1999-12-09 |
| JP2009137985A (ja) | 2009-06-25 |
| US6733745B2 (en) | 2004-05-11 |
| CA2333009A1 (en) | 1999-12-09 |
| US6458341B1 (en) | 2002-10-01 |
| AU3983199A (en) | 1999-12-20 |
| DE69910378D1 (de) | 2003-09-18 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| DE69910378T2 (de) | Vorrichtungen mit chlorhexidingluconat enthaltenden beschichtungen, zusammensetzungen und verfahren | |
| DE69007268T2 (de) | Stabiles orales Zink enthaltendes Präparat. | |
| DE69108924T2 (de) | Mundwasser. | |
| DE69626297T2 (de) | Zahnbleichende zusammensetzungen | |
| DE3587691T2 (de) | Zahnreinigendes wasser. | |
| DE3005134C2 (enExample) | ||
| EP0063222B1 (de) | Zahnpflegemittel | |
| DE2846085A1 (de) | Truebungs- und niederschlagsfreies mundwasser auf basis von natriumricinoleat | |
| DE1617744A1 (de) | Reinigungsmittel fuer Zahnprothesen | |
| EP0154922B1 (de) | Strukturviskos eingestellte Silikonpasten und deren Verwendung als Abformmassen | |
| DE69816822T2 (de) | Zahnseide enthaltend eingekapselten geschmacksstoff | |
| EP0164058B1 (de) | Fliessfähige Perlglanzdispersion mit niedrigem Tensidanteil | |
| DE2649449A1 (de) | Zahnputzmittel | |
| DE69105369T2 (de) | Pastenzusammensetzung und Verfahren zu deren Herstellung. | |
| DE60012404T2 (de) | Zahnpaste | |
| EP2386287B1 (de) | Tenside enthaltende Zusammensetzung zur dentalen Abformung | |
| DE2639505B2 (enExample) | ||
| EP0656049B1 (de) | Giessfähige flüssige wässrige reinigungsmittelkonzentrate | |
| JP4142571B2 (ja) | ソルビトールシロップを用いた練り歯磨きの調製方法 | |
| EP1555008B1 (de) | Mittel zum Bleichen von Zähnen | |
| JP7034993B2 (ja) | 口腔用組成物の製造方法 | |
| DE69500114T2 (de) | Präparate mit einem Schleifmittel- und einem Tensid-System | |
| DE3502830A1 (de) | Zahnpflegemittelzusammensetzung | |
| JP3120880B2 (ja) | 歯磨剤組成物 | |
| DE905307C (de) | Zahnreinigungs- und Mundpflegemittel |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8364 | No opposition during term of opposition |