JP2002513541A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2002513541A5 JP2002513541A5 JP2000523554A JP2000523554A JP2002513541A5 JP 2002513541 A5 JP2002513541 A5 JP 2002513541A5 JP 2000523554 A JP2000523554 A JP 2000523554A JP 2000523554 A JP2000523554 A JP 2000523554A JP 2002513541 A5 JP2002513541 A5 JP 2002513541A5
- Authority
- JP
- Japan
- Prior art keywords
- hla
- cells
- cell
- nkg2
- receptor
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 210000004027 cell Anatomy 0.000 description 32
- 102100028970 HLA class I histocompatibility antigen, alpha chain E Human genes 0.000 description 27
- 101000986085 Homo sapiens HLA class I histocompatibility antigen, alpha chain E Proteins 0.000 description 27
- 238000000034 method Methods 0.000 description 23
- 102100021462 Natural killer cells antigen CD94 Human genes 0.000 description 17
- 101000971513 Homo sapiens Natural killer cells antigen CD94 Proteins 0.000 description 15
- 101001109508 Homo sapiens NKG2-A/NKG2-B type II integral membrane protein Proteins 0.000 description 13
- 102100022682 NKG2-A/NKG2-B type II integral membrane protein Human genes 0.000 description 13
- 150000001875 compounds Chemical class 0.000 description 4
- 102000005962 receptors Human genes 0.000 description 4
- 108020003175 receptors Proteins 0.000 description 4
- 108010001880 NK Cell Lectin-Like Receptor Subfamily C Proteins 0.000 description 2
- 102000000834 NK Cell Lectin-Like Receptor Subfamily C Human genes 0.000 description 2
- 108091008877 NK cell receptors Proteins 0.000 description 2
- 239000003795 chemical substances by application Substances 0.000 description 2
- 239000012636 effector Substances 0.000 description 2
- 210000004962 mammalian cell Anatomy 0.000 description 2
- 210000000822 natural killer cell Anatomy 0.000 description 2
- 108090001008 Avidin Proteins 0.000 description 1
- 108010090804 Streptavidin Proteins 0.000 description 1
- 210000001744 T-lymphocyte Anatomy 0.000 description 1
- 230000004071 biological effect Effects 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 230000000415 inactivating effect Effects 0.000 description 1
- 230000002401 inhibitory effect Effects 0.000 description 1
- 150000007523 nucleic acids Chemical class 0.000 description 1
- 102000039446 nucleic acids Human genes 0.000 description 1
- 108020004707 nucleic acids Proteins 0.000 description 1
- 210000000056 organ Anatomy 0.000 description 1
- 230000001737 promoting effect Effects 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 231100000167 toxic agent Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
- 239000003440 toxic substance Substances 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB9725764.6A GB9725764D0 (en) | 1997-12-04 | 1997-12-04 | HLA-E binding |
| GB9725764.6 | 1997-12-04 | ||
| PCT/GB1998/003686 WO1999028748A2 (en) | 1997-12-04 | 1998-12-04 | Hla-e binding |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008314107A Division JP4437160B2 (ja) | 1997-12-04 | 2008-12-10 | Ｈｌａ−ｅ結合 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2002513541A JP2002513541A (ja) | 2002-05-14 |
| JP2002513541A5 true JP2002513541A5 (cg-RX-API-DMAC7.html) | 2006-01-19 |
| JP4336451B2 JP4336451B2 (ja) | 2009-09-30 |
Family
ID=10823165
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2000523554A Expired - Lifetime JP4336451B2 (ja) | 1997-12-04 | 1998-12-04 | Ｈｌａ−ｅ結合 |
| JP2008314107A Expired - Lifetime JP4437160B2 (ja) | 1997-12-04 | 2008-12-10 | Ｈｌａ−ｅ結合 |
| JP2009191564A Expired - Lifetime JP5268828B2 (ja) | 1997-12-04 | 2009-08-21 | Ｈｌａ−ｅ結合 |
| JP2013006244A Abandoned JP2013081478A (ja) | 1997-12-04 | 2013-01-17 | Ｈｌａ−ｅ結合 |
Family Applications After (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008314107A Expired - Lifetime JP4437160B2 (ja) | 1997-12-04 | 2008-12-10 | Ｈｌａ−ｅ結合 |
| JP2009191564A Expired - Lifetime JP5268828B2 (ja) | 1997-12-04 | 2009-08-21 | Ｈｌａ−ｅ結合 |
| JP2013006244A Abandoned JP2013081478A (ja) | 1997-12-04 | 2013-01-17 | Ｈｌａ−ｅ結合 |
Country Status (7)
| Country | Link |
|---|---|
| US (3) | US7410767B1 (cg-RX-API-DMAC7.html) |
| EP (2) | EP1036327B1 (cg-RX-API-DMAC7.html) |
| JP (4) | JP4336451B2 (cg-RX-API-DMAC7.html) |
| AT (1) | ATE438096T1 (cg-RX-API-DMAC7.html) |
| DE (1) | DE69841020D1 (cg-RX-API-DMAC7.html) |
| GB (1) | GB9725764D0 (cg-RX-API-DMAC7.html) |
| WO (1) | WO1999028748A2 (cg-RX-API-DMAC7.html) |
Families Citing this family (41)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9725764D0 (en) * | 1997-12-04 | 1998-02-04 | Isis Innovation | HLA-E binding |
| JP2005523236A (ja) * | 2001-07-31 | 2005-08-04 | ペプジェン コーポレイション | 免疫応答調節組成物および方法 |
| US20040072262A1 (en) | 2002-10-11 | 2004-04-15 | Montero-Julian Felix A. | Methods and systems for detecting MHC class I binding peptides |
| ATE405591T1 (de) * | 2003-08-26 | 2008-09-15 | Univ Danmarks Tekniske | Kontinuierliches verfahren zur anordnung von makromolekulären substanzen und die anschliessende aufnahme und isolierung einer makromolekulären anordnung, sowie ein für dieses verfahren geeignetes system |
| US20050287611A1 (en) * | 2004-05-07 | 2005-12-29 | Nugent C T Iv | MHC bridging system for detecting CTL-mediated lysis of antigen presenting cells |
| EP1781313A4 (en) | 2004-06-17 | 2009-08-26 | Beckman Coulter Inc | MYCOBACTERIUM TUBERCULOSIS EPITOPES AND METHODS OF USE |
| PT2476705E (pt) | 2004-12-28 | 2016-02-09 | Innate Pharma | Anticorpos monoclonais contra nkg2a |
| JP5368301B2 (ja) * | 2006-06-22 | 2013-12-18 | ノボ・ノルデイスク・エー／エス | 可溶性ヘテロ二量体レセプター及びその使用 |
| MX2008015830A (es) | 2006-06-30 | 2009-01-09 | Novo Nordisk As | Anticuerpos anti-nkg2a y usos de los mismos. |
| US8796427B2 (en) | 2008-01-24 | 2014-08-05 | Novo Nordisk A/S | Humanized anti-human NKG2A monoclonal antibody |
| MX342131B (es) | 2011-06-17 | 2016-09-14 | Novo Nordisk As | Eliminacion selectiva de celulas erosivas. |
| WO2014037422A1 (en) | 2012-09-04 | 2014-03-13 | Inven2 As | Selective and controlled expansion of educated nk cells |
| US20150037304A1 (en) * | 2013-03-12 | 2015-02-05 | Sangamo Biosciences, Inc. | Methods and compositions for modification of hla |
| EP2970426B1 (en) | 2013-03-15 | 2019-08-28 | Michael C. Milone | Targeting cytotoxic cells with chimeric receptors for adoptive immunotherapy |
| EP3087101B1 (en) | 2013-12-20 | 2024-06-05 | Novartis AG | Regulatable chimeric antigen receptor |
| WO2015142661A1 (en) * | 2014-03-15 | 2015-09-24 | Novartis Ag | Regulatable chimeric antigen receptor |
| WO2015148960A1 (en) * | 2014-03-28 | 2015-10-01 | The Board Of Regents Of The University Of Oklahoma | Compositions comprising soluble hla/m. tuberculosis-specific ligand complexes and methods of production and use thereof |
| CA2948462A1 (en) | 2014-05-15 | 2015-11-19 | National University Of Singapore | Modified natural killer cells and uses thereof |
| KR20240141862A (ko) | 2014-09-16 | 2024-09-27 | 이나뜨 파르마 에스.에이. | 항-ｎｋｇ2ａ 항체를 사용한 치료 요법 |
| DK3193931T3 (da) | 2014-09-16 | 2020-10-19 | Innate Pharma | Neutralisering af hæmmende veje i lymfocytter |
| KR20210149228A (ko) | 2014-09-17 | 2021-12-08 | 노파르티스 아게 | 입양 면역요법을 위한 키메라 수용체에 의한 세포독성 세포의 표적화 |
| JP6889660B2 (ja) | 2014-10-23 | 2021-06-18 | イナート・ファルマ・ソシエテ・アノニムＩｎｎａｔｅ Ｐｈａｒｍａ Ｐｈａｒｍａ Ｓ．Ａ． | 抗ｎｋｇ２ａ剤を用いた癌の処置 |
| HUE054356T2 (hu) | 2016-01-21 | 2021-09-28 | Innate Pharma | Gátlási reakcióutak semlegesítése limfocitákban |
| CN110809580A (zh) * | 2017-01-24 | 2020-02-18 | 安贝科思生物制剂公司 | 用于靶向癌症中包含非典型hla-i和新抗原的复合体的方法和组合物 |
| EP3600356A4 (en) | 2017-03-27 | 2020-12-23 | National University of Singapore | TRUNCATED NKG2D CHEMERIC RECEPTORS AND THEIR USES IN NATURAL KILLER CELL IMMUNOTHERAPY |
| KR102624509B1 (ko) | 2017-03-27 | 2024-01-12 | 싱가포르국립대학교 | 자연 살해 세포의 ex vivo 확장 및 활성화를 위한 자극성 세포주 |
| JP7360174B2 (ja) * | 2018-02-09 | 2023-10-12 | ナショナル ユニヴァーシティー オブ シンガポール | ナチュラルキラー細胞免疫療法における活性化キメラ受容体及びその使用 |
| US20200399377A1 (en) * | 2018-02-23 | 2020-12-24 | Abexxa Biologics Inc. | Combination cancer therapy with anti-cancer agents and antibodies targeting a complex comprising non-classical hla-i and neoantigen |
| US11464840B2 (en) | 2018-02-26 | 2022-10-11 | Swey-Shen Chen | Universal non-classical MHC I vaccines: HLA-E-restricted antigenic peptides as universal vaccines to treat allergy, inflammation, autoimmune and infectious diseases, and cancers |
| US11795222B2 (en) | 2018-03-13 | 2023-10-24 | Innate Pharma | Treatment of head and neck cancer |
| EP3539552A1 (en) * | 2018-03-16 | 2019-09-18 | Deutsches Rheuma-Forschungszentrum Berlin | Activation and expansion of nkg2c+ nk cells |
| JP7334985B2 (ja) | 2018-04-02 | 2023-08-29 | ナショナル ユニヴァーシティー オブ シンガポール | 免疫細胞で発現される膜結合抗サイトカイン非シグナル伝達バインダーによるヒトサイトカインの中和 |
| CN112601758A (zh) | 2018-08-29 | 2021-04-02 | 新加坡国立大学 | 特异性刺激经基因修饰免疫细胞的存活和扩增的方法 |
| PE20211284A1 (es) | 2018-11-16 | 2021-07-19 | Bristol Myers Squibb Co | Anticuerpos anti-nkg2a y usos de los mismos |
| MX2021006194A (es) * | 2018-12-02 | 2021-06-30 | Fate Therapeutics Inc | Inmunoterapias mediante el uso de celulas efectoras potenciadas derivadas de ipsc. |
| CN118546959A (zh) | 2019-03-05 | 2024-08-27 | 恩卡尔塔公司 | Cd19定向性嵌合抗原受体及其在免疫疗法中的用途 |
| GB201909509D0 (en) * | 2019-07-02 | 2019-08-14 | Immunocore Ltd | Peptide-MHC complexes |
| WO2023023663A1 (en) * | 2021-08-20 | 2023-02-23 | Duke University | Antibodies that target hla-e-host peptide complexes and uses thereof |
| CA3197662A1 (en) | 2020-09-30 | 2022-04-07 | Dren Bio, Inc. | Anti-cd94 antibodies and methods of use thereof |
| CN120019146A (zh) * | 2022-08-11 | 2025-05-16 | 宾夕法尼亚大学理事会 | 通用t细胞和组合物及它们的使用方法 |
| WO2024206190A1 (en) * | 2023-03-24 | 2024-10-03 | Duke University | Antibodies that target hla-e-host peptide complexes and uses thereof |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH03112486A (ja) * | 1989-09-22 | 1991-05-14 | Olympus Optical Co Ltd | Ｈｌａ―ｂ３５遺伝子およびｄｎａプローブ並びに形質転換細胞 |
| JPH03112487A (ja) * | 1989-09-22 | 1991-05-14 | Olympus Optical Co Ltd | ＨＬＡ―Ｂｗ５３遺伝子およびＤＮＡプローブ並びに形質転換細胞 |
| JPH03112485A (ja) * | 1989-09-22 | 1991-05-14 | Olympus Optical Co Ltd | Ｈｌａ―ｃ遺伝子およびｄｎａプローブ並びに形質転換細胞 |
| GB9725764D0 (en) * | 1997-12-04 | 1998-02-04 | Isis Innovation | HLA-E binding |
-
1997
- 1997-12-04 GB GBGB9725764.6A patent/GB9725764D0/en not_active Ceased
-
1998
- 1998-12-04 EP EP98959027A patent/EP1036327B1/en not_active Expired - Lifetime
- 1998-12-04 WO PCT/GB1998/003686 patent/WO1999028748A2/en not_active Ceased
- 1998-12-04 EP EP09165917A patent/EP2144065A1/en not_active Withdrawn
- 1998-12-04 US US09/555,555 patent/US7410767B1/en not_active Expired - Fee Related
- 1998-12-04 JP JP2000523554A patent/JP4336451B2/ja not_active Expired - Lifetime
- 1998-12-04 DE DE69841020T patent/DE69841020D1/de not_active Expired - Lifetime
- 1998-12-04 AT AT98959027T patent/ATE438096T1/de not_active IP Right Cessation
-
2008
- 2008-04-25 US US12/109,990 patent/US20080274475A1/en not_active Abandoned
- 2008-12-10 JP JP2008314107A patent/JP4437160B2/ja not_active Expired - Lifetime
-
2009
- 2009-08-21 JP JP2009191564A patent/JP5268828B2/ja not_active Expired - Lifetime
-
2013
- 2013-01-17 JP JP2013006244A patent/JP2013081478A/ja not_active Abandoned
-
2015
- 2015-04-10 US US14/683,835 patent/US20150361180A1/en not_active Abandoned
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2002513541A5 (cg-RX-API-DMAC7.html) | ||
| JP2009106299A5 (cg-RX-API-DMAC7.html) | ||
| Orlando et al. | Analysis of chromatin structure byin VivoFormaldehyde cross-linking | |
| US9447454B2 (en) | Method of purifying RNA binding protein-RNA complexes | |
| JP2854904B2 (ja) | 遺伝子の検査方法 | |
| DE3586660T2 (de) | Hybridisierungstest fuer nukleinsaeure. | |
| CA2262403A1 (en) | Biomarkers and targets for diagnosis, prognosis and management of prostate disease | |
| WO2002055985A3 (en) | Methods and reagents for identifying rare fetal cells in the material circulation | |
| EP1483415A4 (en) | NON-INVASIVE DIAGNOSTIC TEST USING HISTONE MODIFICATION MARKERS | |
| JPH04228076A (ja) | アビジン−ビオチン開裂による一本鎖ビオチニル化核酸の調製および単離 | |
| CA2425545A1 (en) | Methods of identification and isolation of polynucleotides containing nucleic acid differences | |
| JPH10500290A (ja) | 核酸転移の方法 | |
| EP3269813A1 (en) | Method for separating nucleic acids from fepe tissue | |
| JPH0427840B2 (cg-RX-API-DMAC7.html) | ||
| Becker et al. | Genomic footprinting | |
| US20180355437A1 (en) | Plasma/serum target enrichment | |
| JP2006517181A (ja) | Ｂｂｂ−特異的タンパク質およびその断片を同定する方法 | |
| US8105787B2 (en) | Applications of nucleic acid fragments | |
| JP2004531227A5 (cg-RX-API-DMAC7.html) | ||
| CN101550441A (zh) | 含有生物标志物样本的高通量分析方法和样本库制备 | |
| Brinkman et al. | Allele-specific quantification of TNFA transcripts in rheumatoid arthritis | |
| Mc Donnell et al. | Molecular identification of the exotic slug Arion subfuscus sensu stricto (Gastropoda: Pulmonata) in California, with comments on the source location of introduced populations | |
| CA3087670A1 (en) | Semi-automated research instrument system | |
| JP2003509066A5 (cg-RX-API-DMAC7.html) | ||
| JP4735926B2 (ja) | 核酸の高効率回収方法 |