JP2002512989A5 - - Google Patents
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- Publication number
- JP2002512989A5 JP2002512989A5 JP2000545584A JP2000545584A JP2002512989A5 JP 2002512989 A5 JP2002512989 A5 JP 2002512989A5 JP 2000545584 A JP2000545584 A JP 2000545584A JP 2000545584 A JP2000545584 A JP 2000545584A JP 2002512989 A5 JP2002512989 A5 JP 2002512989A5
- Authority
- JP
- Japan
- Prior art keywords
- compound
- alkyl
- halogen
- con
- pharmaceutically acceptable
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 150000001875 compounds Chemical class 0.000 description 36
- 229910052736 halogen Inorganic materials 0.000 description 25
- 150000002367 halogens Chemical group 0.000 description 25
- 150000003839 salts Chemical class 0.000 description 15
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 description 14
- 125000000217 alkyl group Chemical group 0.000 description 11
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 description 10
- PXHVJJICTQNCMI-UHFFFAOYSA-N Nickel Chemical compound [Ni] PXHVJJICTQNCMI-UHFFFAOYSA-N 0.000 description 10
- 229910052739 hydrogen Inorganic materials 0.000 description 6
- 239000001257 hydrogen Substances 0.000 description 6
- 229910052751 metal Inorganic materials 0.000 description 6
- 239000002184 metal Substances 0.000 description 6
- RYGMFSIKBFXOCR-UHFFFAOYSA-N Copper Chemical compound [Cu] RYGMFSIKBFXOCR-UHFFFAOYSA-N 0.000 description 5
- HCHKCACWOHOZIP-UHFFFAOYSA-N Zinc Chemical compound [Zn] HCHKCACWOHOZIP-UHFFFAOYSA-N 0.000 description 5
- 229910017052 cobalt Inorganic materials 0.000 description 5
- 239000010941 cobalt Substances 0.000 description 5
- GUTLYIVDDKVIGB-UHFFFAOYSA-N cobalt atom Chemical compound [Co] GUTLYIVDDKVIGB-UHFFFAOYSA-N 0.000 description 5
- 229910052802 copper Inorganic materials 0.000 description 5
- 239000010949 copper Substances 0.000 description 5
- 229910052742 iron Inorganic materials 0.000 description 5
- WPBNNNQJVZRUHP-UHFFFAOYSA-L manganese(2+);methyl n-[[2-(methoxycarbonylcarbamothioylamino)phenyl]carbamothioyl]carbamate;n-[2-(sulfidocarbothioylamino)ethyl]carbamodithioate Chemical compound [Mn+2].[S-]C(=S)NCCNC([S-])=S.COC(=O)NC(=S)NC1=CC=CC=C1NC(=S)NC(=O)OC WPBNNNQJVZRUHP-UHFFFAOYSA-L 0.000 description 5
- 229910052759 nickel Inorganic materials 0.000 description 5
- 239000011701 zinc Substances 0.000 description 5
- 229910052725 zinc Inorganic materials 0.000 description 5
- 150000002431 hydrogen Chemical class 0.000 description 4
- 239000000126 substance Substances 0.000 description 4
- 208000019693 Lung disease Diseases 0.000 description 3
- PWHULOQIROXLJO-UHFFFAOYSA-N Manganese Chemical compound [Mn] PWHULOQIROXLJO-UHFFFAOYSA-N 0.000 description 3
- 210000004027 cell Anatomy 0.000 description 3
- 239000003814 drug Substances 0.000 description 3
- 230000002757 inflammatory effect Effects 0.000 description 3
- 229910052748 manganese Inorganic materials 0.000 description 3
- 239000011572 manganese Substances 0.000 description 3
- 238000004519 manufacturing process Methods 0.000 description 3
- 238000000034 method Methods 0.000 description 3
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 description 2
- MWUXSHHQAYIFBG-UHFFFAOYSA-N Nitric oxide Chemical compound O=[N] MWUXSHHQAYIFBG-UHFFFAOYSA-N 0.000 description 2
- 208000027866 inflammatory disease Diseases 0.000 description 2
- 239000007800 oxidant agent Substances 0.000 description 2
- 230000001590 oxidative effect Effects 0.000 description 2
- 230000001988 toxicity Effects 0.000 description 2
- 231100000419 toxicity Toxicity 0.000 description 2
- 208000027775 Bronchopulmonary disease Diseases 0.000 description 1
- 208000006673 asthma Diseases 0.000 description 1
- 230000015556 catabolic process Effects 0.000 description 1
- 238000006731 degradation reaction Methods 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 238000000338 in vitro Methods 0.000 description 1
- 210000004962 mammalian cell Anatomy 0.000 description 1
- 230000001575 pathological effect Effects 0.000 description 1
- 230000001681 protective effect Effects 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US8288198P | 1998-04-24 | 1998-04-24 | |
| US60/082,881 | 1998-04-24 | ||
| PCT/US1999/008905 WO1999055388A1 (en) | 1998-04-24 | 1999-04-23 | Substituted porphyrins |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2002512989A JP2002512989A (ja) | 2002-05-08 |
| JP2002512989A5 true JP2002512989A5 (https=) | 2010-10-07 |
| JP4648542B2 JP4648542B2 (ja) | 2011-03-09 |
Family
ID=22174053
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2000545584A Expired - Fee Related JP4648542B2 (ja) | 1998-04-24 | 1999-04-23 | 置換ポルフィリン |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US6479477B1 (https=) |
| EP (1) | EP1071474B1 (https=) |
| JP (1) | JP4648542B2 (https=) |
| AT (1) | ATE311206T1 (https=) |
| AU (1) | AU771259B2 (https=) |
| CA (1) | CA2329751C (https=) |
| DE (1) | DE69928655T2 (https=) |
| DK (1) | DK1071474T3 (https=) |
| ES (1) | ES2257858T3 (https=) |
| WO (1) | WO1999055388A1 (https=) |
Families Citing this family (32)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6127356A (en) | 1993-10-15 | 2000-10-03 | Duke University | Oxidant scavengers |
| IL135949A0 (en) | 1997-11-03 | 2001-05-20 | Univ Duke | Substituted porphyrins |
| AU771259B2 (en) | 1998-04-24 | 2004-03-18 | Aeolus Sciences, Inc. | Substituted porphyrins |
| WO2000009111A2 (en) * | 1998-08-11 | 2000-02-24 | The Government Of The United States Of America, Represented By The Secretary, Department Of Health And Human Services | Inhibitors of amyloid formation |
| DK1616869T3 (da) | 1999-01-25 | 2012-05-07 | Nat Jewish Health | Substituerede porphyriner og deres terapeutiske anvendelse |
| US6403788B1 (en) | 2000-07-11 | 2002-06-11 | Eukarion, Inc. | Non-genotoxic metalloporphyrins as synthetic catalytic scavengers of reactive oxygen species |
| AU2002312194B8 (en) * | 2001-06-01 | 2008-05-15 | Aeolus Sciences, Inc. | Oxidant scavengers for treatment of diabetes or use in transplantation or induction of immune tolerance |
| JP2003012547A (ja) * | 2001-06-27 | 2003-01-15 | Meiji Seika Kaisha Ltd | インスリン依存性糖尿病の診断剤および治療剤 |
| US20040132706A1 (en) * | 2001-10-05 | 2004-07-08 | Daniela Salvemini | Composition comprising a catalyst for the dismutation of superoxide and use of the composition for preventing and treating hypotension |
| AU2003237500A1 (en) | 2002-06-07 | 2003-12-22 | Duke University | Substituted porphyrins |
| EP1539751B1 (en) * | 2002-07-15 | 2008-05-07 | Scinopharm Taiwan, Ltd. | Process for the preparation of imidazo(1,2-a)pyridine-3-acetamides |
| GB2397067B (en) | 2002-12-23 | 2005-05-11 | Destiny Pharma Ltd | Porphin & azaporphin derivatives with at least one cationic-nitrogen-containing meso-substituent for use in photodynamic therapy & in vitro sterilisation |
| WO2005000854A2 (en) * | 2003-06-06 | 2005-01-06 | Eukarion, Inc. | Orally bioavailable low molecular weight metalloporphyrins as antioxidants |
| US7299082B2 (en) | 2003-10-31 | 2007-11-20 | Abbott Diabetes Care, Inc. | Method of calibrating an analyte-measurement device, and associated methods, devices and systems |
| EP1718201B1 (en) * | 2004-02-09 | 2016-09-14 | Duke University | Substituted porphyrins |
| US7699964B2 (en) | 2004-02-09 | 2010-04-20 | Abbott Diabetes Care Inc. | Membrane suitable for use in an analyte sensor, analyte sensor, and associated method |
| US8165651B2 (en) | 2004-02-09 | 2012-04-24 | Abbott Diabetes Care Inc. | Analyte sensor, and associated system and method employing a catalytic agent |
| EA010834B1 (ru) | 2004-03-29 | 2008-12-30 | Инотек Фармасьютикалз Корпорейшн | Пиридилзамещённые порфириновые соединения и способы их применения |
| GB2415372A (en) | 2004-06-23 | 2005-12-28 | Destiny Pharma Ltd | Non photodynamical or sonodynamical antimicrobial use of porphyrins and azaporphyrins containing at least one cationic-nitrogen-containing substituent |
| US7885698B2 (en) | 2006-02-28 | 2011-02-08 | Abbott Diabetes Care Inc. | Method and system for providing continuous calibration of implantable analyte sensors |
| US20080289053A1 (en) * | 2007-05-15 | 2008-11-20 | The Regents Of The University Of California | Methods and systems for identifying modulators of longevity |
| CA2751058A1 (en) * | 2008-01-31 | 2009-08-06 | Technion Research And Development Foundation Ltd | Corroles for neuroprotection and neurorescue |
| US11382895B2 (en) | 2008-05-23 | 2022-07-12 | National Jewish Health | Methods for treating injury associated with exposure to an alkylating species |
| KR101932149B1 (ko) * | 2010-10-06 | 2018-12-26 | 앨루스 사이언스, 인코포레이티드 | 포르피린을 이용한 신경퇴행성 질환 치료 |
| KR20140109386A (ko) | 2011-12-02 | 2014-09-15 | 더 리전츠 오브 더 유니버시티 오브 콜로라도, 어 바디 코퍼레이트 | 금속포르피린 신경 치료 |
| US10646595B2 (en) * | 2013-02-12 | 2020-05-12 | The Governing Council Of The University Of Toronto | Porphyrin compounds and their use as MRI contrast agents |
| WO2015034777A1 (en) | 2013-09-03 | 2015-03-12 | Biomimetix J.V., Llc | Methods of treating biofilms |
| US11229382B2 (en) | 2013-12-31 | 2022-01-25 | Abbott Diabetes Care Inc. | Self-powered analyte sensor and devices using the same |
| US10064871B2 (en) | 2014-01-22 | 2018-09-04 | Biomimetix Jv, Llc | Methods of treating skin disorders |
| US10080759B2 (en) | 2014-01-22 | 2018-09-25 | Duke University | Methods of treating pruritus |
| KR101894575B1 (ko) | 2017-01-03 | 2018-09-04 | 주식회사 인트론바이오테크놀로지 | 돼지 피로부터 유래되지 않은 헴철을 제조할 수 있는 화학적 방법 |
| WO2022074014A1 (en) * | 2020-10-05 | 2022-04-14 | Biolitec Unternehmensbeteiligungs Ii Ag | Tetrapyrrole-based compounds and their formulations for anti-microbial therapy |
Family Cites Families (58)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US465902A (en) * | 1891-12-29 | Cultivator | ||
| US2951799A (en) | 1957-11-13 | 1960-09-06 | Monsanto Chemicals | Photoxidation processes using heterocyclic photosensitizers |
| EP0127797B1 (de) | 1983-06-03 | 1987-06-16 | F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft | Markermoleküle für Fluoreszenz-Immuno-Assays sowie Verfahren und Zwischenprodukte zu deren Herstellung |
| US4963367A (en) | 1984-04-27 | 1990-10-16 | Medaphore, Inc. | Drug delivery compositions and methods |
| GB8429845D0 (en) | 1984-11-26 | 1985-01-03 | Efamol Ltd | Porphyrins & cancer treatment |
| US4758422A (en) | 1985-01-04 | 1988-07-19 | Salutar Inc. | Ferrioxamine paramagnetic contrast agents for MR imaging |
| DE3686025T2 (de) | 1985-05-22 | 1993-01-07 | Liposome Technology Inc | Verfahren und system zum einatmen von liposomen. |
| DK402785D0 (da) | 1985-09-03 | 1985-09-03 | Syn Tek Ab | Fremgangsmaade til fremstilling af et enzym |
| US5248603A (en) | 1985-09-03 | 1993-09-28 | Symbicom Aktiebolag | Superoxide dismutase |
| US4746735A (en) | 1986-11-21 | 1988-05-24 | The Dow Chemical Company | Regiospecific aryl nitration of meso-substituted tetraarylporphyrins |
| EP0282899B1 (de) | 1987-03-14 | 1996-01-10 | BOEHRINGER INGELHEIM INTERNATIONAL GmbH | Humane Mangan-Superoxiddismutase (hMn-SOD) |
| US5227405A (en) | 1987-03-31 | 1993-07-13 | Duke University | Superoxide dismutase mimic |
| US5223538A (en) | 1987-03-31 | 1993-06-29 | Duke University | Superoxide dismutase mimic |
| US4892941A (en) | 1987-04-17 | 1990-01-09 | Dolphin David H | Porphyrins |
| US4851403A (en) | 1987-04-21 | 1989-07-25 | Johnson Matthey, Inc. | Radiation sensitizers |
| US4885114A (en) | 1987-04-22 | 1989-12-05 | Barnes Engineering Co. | Metallized tetra((meso)-5-methyl-2-thiophene)porphines, platinum (5-bromo octaethylporphine) and optical filters containing same |
| US5051337A (en) | 1987-06-10 | 1991-09-24 | Director-General Of Agency Of Industrial Science And Technology | Optical recording material |
| GB8805849D0 (en) | 1988-03-11 | 1988-04-13 | Efamol Holdings | Porphyrins & cancer treatment |
| US5162519A (en) | 1988-03-11 | 1992-11-10 | Efamol Holdings Plc | Porphyrins and cancer treatment |
| US5284647A (en) | 1988-03-18 | 1994-02-08 | Schering Aktiengesellschaft | Mesotetraphenylporphyrin complex compounds, process for their production and pharmaceutical agents containing them |
| DE3809671A1 (de) | 1988-03-18 | 1989-09-28 | Schering Ag | Porphyrin-komplexverbindungen, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische mittel |
| US5109016A (en) | 1988-05-23 | 1992-04-28 | Georgia State University Foundation, Inc. | Method for inhibiting infection or replication of human immunodeficiency virus with porphyrin and phthalocyanine antiviral compositions |
| FR2632187B1 (fr) | 1988-06-02 | 1990-09-14 | Centre Nat Rech Scient | Derives de metalloporphyrines, leur preparation, leur application en therapeutique et leur utilisation pour la preparation de molecules hybrides |
| US5171680A (en) | 1988-06-14 | 1992-12-15 | Chiron Corporation | Superoxide dismutase analogs having novel binding properties |
| DE69027383T2 (de) | 1989-03-06 | 1996-11-14 | Masayasu Inoue | Neue superoxyd-dismutase |
| DK455789D0 (da) | 1989-09-15 | 1989-09-15 | Symbicom Ab | Polypeptid |
| EP0424033A3 (en) | 1989-10-19 | 1991-07-31 | Pola Chemical Industries Inc | External skin preparation |
| US5236915A (en) | 1990-05-31 | 1993-08-17 | Health Research, Inc. | Meso poly(4-sulfonatophenyl) porphines as MRI image enhancing agents |
| EP0462836A3 (en) | 1990-06-20 | 1992-08-26 | Mitsui Toatsu Chemicals, Inc. | Recombinant vector plasmid capable of expressing human manganese superoxide dismutase, and process of producing this enzyme |
| US5217966A (en) | 1990-09-13 | 1993-06-08 | The Regents Of The University Of California | Synthetic drug molecules that mimic metalloenzymes |
| US5202317A (en) | 1990-09-13 | 1993-04-13 | The Regents Of The University Of California | Synthetic drug molecules that mimic metalloenzymes |
| AU8947791A (en) | 1990-11-01 | 1992-05-26 | Scripps Research Institute, The | Glycosaminoglycan-targeted fusion proteins, their design, construction and compositions |
| US5192757A (en) * | 1990-12-20 | 1993-03-09 | Glaxo Inc. | Cobalt porphyrins |
| GB9103991D0 (en) | 1991-02-26 | 1991-04-10 | Nat Res Dev | Molecular electronic devices |
| FR2676738B1 (fr) | 1991-05-22 | 1995-05-05 | Ir2M | Nouveau derive organique de metal de transition a structure porphyrinique, composition therapeutique le contenant, en particulier a activite hypoglycemiante. |
| CA2072934C (en) | 1991-07-19 | 2007-08-28 | Karl William Aston | Manganese complexes of nitrogen-containing macrocyclic ligands effective as catalysts for dismutating superoxide |
| ES2113952T3 (es) | 1991-07-19 | 1998-05-16 | Monsanto Co | Complejos de manganeso con ligandos macrociclicos nitrogenados eficaces como catalizadores para dismutar superoxidos. |
| US5262532A (en) | 1991-07-22 | 1993-11-16 | E.R. Squibb & Sons, Inc. | Paramagnetic metalloporphyrins as contrast agents for magnetic resonance imaging |
| US5212300A (en) | 1991-09-12 | 1993-05-18 | Sun Company, Inc. (R&M) | Cyano- and polycyanometallo-porphyrins as catalysts for alkane oxidation |
| US5599924A (en) * | 1992-08-14 | 1997-02-04 | Trustees Of The University Of Pennsylvania | Electron-deficient porphyrins and processes and intermediates for preparing same |
| US5493017A (en) | 1992-08-14 | 1996-02-20 | The Trustees Of The University Of Pennsylvania | Ring-metalated porphyrins |
| US5371199B1 (en) | 1992-08-14 | 1995-12-26 | Univ Pennsylvania | Substituted porphyrins porphyrin-containing polymers and synthetic methods therefor |
| WO1994005285A1 (en) * | 1992-09-03 | 1994-03-17 | The Regents Of The University Of California | Metallo porphyrin compositions |
| US5696109A (en) | 1992-12-07 | 1997-12-09 | Eukarion, Inc. | Synthetic catalytic free radical scavengers useful as antioxidants for prevention and therapy of disease |
| DE4305523A1 (de) | 1993-02-17 | 1994-08-18 | Diagnostikforschung Inst | Meso-Tetraphenylporphyrin-Komplexverbindungen, Verfahren zu ihrer Herstellung und diese enthaltende pharmazeutische Mittel |
| US5747026A (en) | 1993-10-15 | 1998-05-05 | University Of Alabama At Birmingham Research Foundation | Antioxidants |
| US5994339A (en) | 1993-10-15 | 1999-11-30 | University Of Alabama At Birmingham Research Foundation | Oxidant scavengers |
| US6127356A (en) | 1993-10-15 | 2000-10-03 | Duke University | Oxidant scavengers |
| BR9507643A (pt) | 1994-05-13 | 1997-09-23 | Monsanto Co | Métodos de uso para catalisadores de decomposição de peroxinitrito composições farmacéuticas para os mesmos |
| WO1996009053A1 (en) | 1994-09-20 | 1996-03-28 | Duke University | Oxidoreductase activity of manganic porphyrins |
| CA2132690A1 (en) | 1994-09-22 | 1996-03-23 | Dean Willis | Control and modulation of inflammatory response in humans in need of such control and modulation |
| IL122451A0 (en) | 1995-06-07 | 1998-06-15 | Univ Duke | Oxidant scavengers |
| US6087493A (en) | 1997-02-05 | 2000-07-11 | Regents Of The University Of Texas System | Porphyrin compounds as telomerase inhibitors |
| IL135949A0 (en) | 1997-11-03 | 2001-05-20 | Univ Duke | Substituted porphyrins |
| AU771259B2 (en) | 1998-04-24 | 2004-03-18 | Aeolus Sciences, Inc. | Substituted porphyrins |
| DK1616869T3 (da) | 1999-01-25 | 2012-05-07 | Nat Jewish Health | Substituerede porphyriner og deres terapeutiske anvendelse |
| WO2001026655A1 (en) | 1999-10-13 | 2001-04-19 | Uab Research Foundation | Metalloporphyrin treatment of neurologic disease |
| EP1320532A1 (en) | 2000-06-14 | 2003-06-25 | Duke University | Tetrapyrroles |
-
1999
- 1999-04-23 AU AU37588/99A patent/AU771259B2/en not_active Ceased
- 1999-04-23 AT AT99919995T patent/ATE311206T1/de not_active IP Right Cessation
- 1999-04-23 WO PCT/US1999/008905 patent/WO1999055388A1/en not_active Ceased
- 1999-04-23 CA CA2329751A patent/CA2329751C/en not_active Expired - Fee Related
- 1999-04-23 EP EP99919995A patent/EP1071474B1/en not_active Expired - Lifetime
- 1999-04-23 US US09/296,615 patent/US6479477B1/en not_active Expired - Lifetime
- 1999-04-23 DK DK99919995T patent/DK1071474T3/da active
- 1999-04-23 JP JP2000545584A patent/JP4648542B2/ja not_active Expired - Fee Related
- 1999-04-23 ES ES99919995T patent/ES2257858T3/es not_active Expired - Lifetime
- 1999-04-23 DE DE69928655T patent/DE69928655T2/de not_active Expired - Lifetime
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