JP2002512947A5 - - Google Patents
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- Publication number
- JP2002512947A5 JP2002512947A5 JP2000545506A JP2000545506A JP2002512947A5 JP 2002512947 A5 JP2002512947 A5 JP 2002512947A5 JP 2000545506 A JP2000545506 A JP 2000545506A JP 2000545506 A JP2000545506 A JP 2000545506A JP 2002512947 A5 JP2002512947 A5 JP 2002512947A5
- Authority
- JP
- Japan
- Prior art keywords
- pharmaceutical composition
- fviii
- colloidal particles
- protein
- particles
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000002245 particle Substances 0.000 description 26
- 239000008194 pharmaceutical composition Substances 0.000 description 24
- 102000001690 Factor VIII Human genes 0.000 description 17
- 108010054218 Factor VIII Proteins 0.000 description 17
- 229960000301 factor viii Drugs 0.000 description 14
- 150000002632 lipids Chemical class 0.000 description 9
- 229920001184 polypeptide Polymers 0.000 description 9
- 102000004196 processed proteins & peptides Human genes 0.000 description 9
- 108090000765 processed proteins & peptides Proteins 0.000 description 9
- 102000004169 proteins and genes Human genes 0.000 description 9
- 108090000623 proteins and genes Proteins 0.000 description 9
- 229920000642 polymer Polymers 0.000 description 7
- 239000002202 Polyethylene glycol Substances 0.000 description 5
- 229920001477 hydrophilic polymer Polymers 0.000 description 5
- 230000007935 neutral effect Effects 0.000 description 5
- 238000007911 parenteral administration Methods 0.000 description 5
- 229920001223 polyethylene glycol Polymers 0.000 description 5
- 229940105778 coagulation factor viii Drugs 0.000 description 3
- 238000000034 method Methods 0.000 description 3
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 2
- JZNWSCPGTDBMEW-UHFFFAOYSA-N Glycerophosphorylethanolamin Natural products NCCOP(O)(=O)OCC(O)CO JZNWSCPGTDBMEW-UHFFFAOYSA-N 0.000 description 2
- 208000031220 Hemophilia Diseases 0.000 description 2
- 208000009292 Hemophilia A Diseases 0.000 description 2
- 230000002401 inhibitory effect Effects 0.000 description 2
- 150000008104 phosphatidylethanolamines Chemical class 0.000 description 2
- 229920000954 Polyglycolide Polymers 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- WTJKGGKOPKCXLL-RRHRGVEJSA-N phosphatidylcholine Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCCCCCCC=CCCCCCCCC WTJKGGKOPKCXLL-RRHRGVEJSA-N 0.000 description 1
- 150000003904 phospholipids Chemical class 0.000 description 1
- 229920000747 poly(lactic acid) Polymers 0.000 description 1
- 239000004633 polyglycolic acid Substances 0.000 description 1
- 239000004626 polylactic acid Substances 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IL124224 | 1998-04-27 | ||
| IL12422498 | 1998-04-27 | ||
| PCT/IL1999/000217 WO1999055306A1 (en) | 1998-04-27 | 1999-04-23 | Pharmaceutical composition comprising factor viii and neutral liposomes |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2002512947A JP2002512947A (ja) | 2002-05-08 |
| JP2002512947A5 true JP2002512947A5 (https=) | 2006-01-05 |
| JP4545928B2 JP4545928B2 (ja) | 2010-09-15 |
Family
ID=11071435
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2000545506A Expired - Fee Related JP4545928B2 (ja) | 1998-04-27 | 1999-04-23 | 第ｖｉｉｉ因子及び中性リポソームを含有する薬学的組成物 |
Country Status (12)
| Country | Link |
|---|---|
| US (2) | US6593294B1 (https=) |
| EP (1) | EP1079805B1 (https=) |
| JP (1) | JP4545928B2 (https=) |
| AT (1) | ATE283034T1 (https=) |
| AU (1) | AU747391B2 (https=) |
| BR (1) | BR9909978A (https=) |
| CA (1) | CA2329768C (https=) |
| DE (1) | DE69922189T2 (https=) |
| ES (1) | ES2233036T3 (https=) |
| MX (1) | MXPA00010241A (https=) |
| PT (1) | PT1079805E (https=) |
| WO (1) | WO1999055306A1 (https=) |
Families Citing this family (45)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7625584B2 (en) * | 2000-11-30 | 2009-12-01 | The Research Foundation Of State University Of New York | Method of complexing a protein by the use of a dispersed system and proteins thereof |
| US20020132982A1 (en) * | 2000-11-30 | 2002-09-19 | Balasubramanian Sathyamangalam V. | AHF associated dispersion system and method for preparation |
| US8110218B2 (en) | 2000-11-30 | 2012-02-07 | The Research Foundation Of State University Of New York | Compositions and methods for less immunogenic protein-lipid complexes |
| EP1536843B1 (en) * | 2002-07-02 | 2010-12-22 | Board Of Regents, The University Of Texas System | Radiolabeled compounds and liposomes and their methods of making and using the same |
| US7351688B2 (en) * | 2003-02-05 | 2008-04-01 | The Research Foundation Of State University Of New York | Compositions and methods for less immunogenic protein formulations |
| EP1633440B1 (en) * | 2003-04-15 | 2008-05-14 | Opperbas Holding B.V. | Pharmaceutical composition comprising proteins and/or polypeptides and colloidal particles |
| CA2534565C (en) * | 2003-08-05 | 2012-06-19 | The Research Foundation Of State University Of New York | Reconstitution medium for protein and peptide formulations |
| WO2005079185A2 (en) * | 2003-09-02 | 2005-09-01 | Board Of Regents, The University Of Texas System | Neutral liposome-encapsulated compounds and methods of making and using thereof |
| US7208174B2 (en) * | 2003-12-18 | 2007-04-24 | Hoffmann-La Roche Inc. | Liposome compositions |
| EP1713446B1 (en) * | 2004-01-23 | 2010-12-01 | Camurus Ab | Ternary non-lamellar lipid compositions |
| KR101468345B1 (ko) | 2004-11-12 | 2014-12-03 | 바이엘 헬스케어 엘엘씨 | Ｆｖｉｉｉ의 부위 지향 변형 |
| WO2006113679A2 (en) * | 2005-04-15 | 2006-10-26 | Board Of Regents, The University Of Texas System | Delivery of sirna by neutral lipid compositions |
| CN101304757A (zh) * | 2005-06-29 | 2008-11-12 | 纽约州立大学研究基金会 | 免疫原性较低的蛋白质-脂质复合物的组合物和方法 |
| WO2007021822A2 (en) * | 2005-08-09 | 2007-02-22 | The Research Foundation Of State Of University Of New York At Buffalo | Compositions and methods of preparation of liposomal microparticulate il-12 |
| EP1816201A1 (en) | 2006-02-06 | 2007-08-08 | CSL Behring GmbH | Modified coagulation factor VIIa with extended half-life |
| AU2007235463B2 (en) * | 2006-03-30 | 2012-11-22 | The Research Foundation Of State University Of New York | Compositions of less immunogenic and long-circulating protein-lipid complexes |
| US7875288B2 (en) * | 2006-03-30 | 2011-01-25 | The Research Foundation Of State University Of New York | Method for treating blood coagulation disorders |
| CA2670618C (en) | 2006-12-15 | 2016-10-04 | Baxter International Inc. | Factor viia- (poly) sialic acid conjugate having prolonged in vivo half-life |
| AU2007338298B2 (en) | 2006-12-22 | 2013-02-07 | Csl Behring Gmbh | Modified coagulation factors with prolonged in vivo half-life |
| KR101648734B1 (ko) | 2008-06-24 | 2016-08-18 | 체에스엘 베링 게엠베하 | 연장된 생체내 반감기를 갖는 인자 ｖｉｉｉ, 폰 빌레브란트 인자 또는 이들의 복합체 |
| DK2299953T3 (en) | 2008-07-14 | 2017-06-19 | Polypid Ltd | CARBON COMPOSITION FOR MEDICINAL PRODUCTS WITH CONTINUOUS EXPOSURE |
| WO2010135714A2 (en) | 2009-05-22 | 2010-11-25 | The Methodist Hospital Research Institute | Methods for modulating adipocyte expression using microrna compositions |
| IN2012DN00570A (https=) | 2009-07-14 | 2015-06-12 | Polypid Ltd | |
| EP2470287A4 (en) | 2009-08-28 | 2015-01-21 | Univ Columbia | SYSTEMS, METHODS AND DEVICES FOR PRODUCING GAS-FILLED MICROBUBBLES |
| EP2512588A4 (en) | 2009-12-16 | 2014-06-04 | Univ Columbia | METHODS, DEVICES AND SYSTEMS FOR ULTRASOUND-RELEASED ON-DEMAND AGGREGATE FREEZING |
| US20130028959A1 (en) | 2009-12-16 | 2013-01-31 | Massachusetts Institute Of Technology | Liposomes for Preventing the Spread of HIV |
| CN102892406B (zh) | 2010-01-19 | 2015-04-08 | 波利皮得有限公司 | 缓释核酸基质组合物 |
| US8637448B2 (en) | 2010-09-14 | 2014-01-28 | University Of Rochester | Recombinant factor VIII having enhanced stability following mutation at the A1-C2 domain interface |
| DE102010043733A1 (de) | 2010-11-10 | 2012-05-10 | Oxprotect Gmbh | Unbeladene PEGylierte Liposomen zur Verwendung als Arzneimittel zur Prophylaxe und Therapie von hämorrhagischen und thrombo- embolischen Erkrankungen |
| WO2013120939A1 (en) | 2012-02-15 | 2013-08-22 | Csl Behring Gmbh | Von willebrand factor variants having improved factor viii binding affinity |
| EP2796145B1 (en) | 2013-04-22 | 2017-11-01 | CSL Ltd. | A covalent complex of von willebrand factor and faktor viii linked by a disulphide bridge |
| CA2953593C (en) | 2014-07-02 | 2023-09-26 | Csl Limited | Modified von willebrand factor |
| GB201417589D0 (en) | 2014-10-06 | 2014-11-19 | Cantab Biopharmaceuticals Patents Ltd | Pharmaceutical Formulations |
| ES2772933T3 (es) | 2015-03-06 | 2020-07-08 | CSL Behring Lengnau AG | Factor de von Willebrand modificado que tiene una semivida mejorada |
| WO2016188905A1 (en) | 2015-05-22 | 2016-12-01 | Csl Behring Recombinant Facility Ag | Methods for preparing modified von willebrand factor |
| RU2017145014A (ru) | 2015-05-22 | 2019-06-24 | Цсл Беринг Ленгнау Аг | Усеченные полипептиды фактора фон виллебранда для лечения гемофилии |
| GB201518170D0 (en) | 2015-10-14 | 2015-11-25 | Cantab Biopharmaceuticals Patents Ltd | Colloidal particles for subcutaneous administration with intravenous administration of therapeutic agent |
| GB201518171D0 (en) | 2015-10-14 | 2015-11-25 | Cantab Biopharmaceuticals Patents Ltd | Colloidal particles for topical administration with therapeutic agent |
| GB201518172D0 (en) | 2015-10-14 | 2015-11-25 | Cantab Biopharmaceuticals Patents Ltd | Colloidal particles for use in medicine |
| WO2017117630A1 (en) | 2016-01-07 | 2017-07-13 | Csl Limited | Mutated von willebrand factor |
| JP6851381B6 (ja) | 2016-01-07 | 2021-04-21 | ツェー・エス・エル・ベーリング・レングナウ・アクチエンゲゼルシャフト | 変異切断型フォンウィルブランド因子 |
| WO2017220099A1 (en) | 2016-06-24 | 2017-12-28 | Statens Serum Institut | Adjuvants with modified drainage properties |
| WO2018005657A1 (en) | 2016-06-28 | 2018-01-04 | Verily Life Sciences Llc | Serial filtration to generate small cholesterol-containing liposomes |
| SG10201912360SA (en) | 2016-11-11 | 2020-02-27 | CSL Behring Lengnau AG | Truncated von willebrand factor polypeptides for treating hemophilia |
| CA3043397A1 (en) | 2016-11-11 | 2018-05-17 | CSL Behring Lengnau AG | Truncated von willebrand factor polypeptides for extravascular administration in the treatment or prophylaxis of a blood coagulation disorder |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NL7900459A (nl) | 1979-01-19 | 1980-07-22 | Hendrik Coenraad Hemker Prof D | Farmaceutisch preparaat en werkwijze ter bereiding daarvan. |
| JPS56127307A (en) * | 1980-03-11 | 1981-10-06 | Green Cross Corp:The | Blood-coagulation factor 8 pharmaceutical for oral administration |
| US4348384A (en) | 1980-10-17 | 1982-09-07 | Dainippon Pharmaceutical Co., Ltd. | Pharmaceutical composition for oral administration containing coagulation factor VIII or IX |
| US5527528A (en) * | 1989-10-20 | 1996-06-18 | Sequus Pharmaceuticals, Inc. | Solid-tumor treatment method |
| US5013556A (en) * | 1989-10-20 | 1991-05-07 | Liposome Technology, Inc. | Liposomes with enhanced circulation time |
| WO1991012021A2 (en) * | 1990-02-13 | 1991-08-22 | Oxford Virology Plc | Therapeutic agents, and intermediates for the synthesis thereof |
| US6326353B1 (en) | 1993-03-23 | 2001-12-04 | Sequus Pharmaceuticals, Inc. | Enhanced circulation effector composition and method |
-
1999
- 1999-04-23 JP JP2000545506A patent/JP4545928B2/ja not_active Expired - Fee Related
- 1999-04-23 AU AU34414/99A patent/AU747391B2/en not_active Ceased
- 1999-04-23 EP EP99916022A patent/EP1079805B1/en not_active Expired - Lifetime
- 1999-04-23 BR BR9909978-0A patent/BR9909978A/pt not_active Application Discontinuation
- 1999-04-23 AT AT99916022T patent/ATE283034T1/de active
- 1999-04-23 WO PCT/IL1999/000217 patent/WO1999055306A1/en not_active Ceased
- 1999-04-23 US US09/673,412 patent/US6593294B1/en not_active Expired - Lifetime
- 1999-04-23 MX MXPA00010241A patent/MXPA00010241A/es active IP Right Grant
- 1999-04-23 CA CA002329768A patent/CA2329768C/en not_active Expired - Fee Related
- 1999-04-23 ES ES99916022T patent/ES2233036T3/es not_active Expired - Lifetime
- 1999-04-23 PT PT99916022T patent/PT1079805E/pt unknown
- 1999-04-23 DE DE69922189T patent/DE69922189T2/de not_active Expired - Lifetime
-
2002
- 2002-12-26 US US10/327,970 patent/US6930087B2/en not_active Expired - Lifetime
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