JP2002510649A5 - - Google Patents
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- Publication number
- JP2002510649A5 JP2002510649A5 JP2000542036A JP2000542036A JP2002510649A5 JP 2002510649 A5 JP2002510649 A5 JP 2002510649A5 JP 2000542036 A JP2000542036 A JP 2000542036A JP 2000542036 A JP2000542036 A JP 2000542036A JP 2002510649 A5 JP2002510649 A5 JP 2002510649A5
- Authority
- JP
- Japan
- Prior art keywords
- amino acid
- polypeptide
- identity
- seq
- acid sequence
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 150000001413 amino acids Chemical group 0.000 description 26
- 229960005486 vaccine Drugs 0.000 description 24
- 108090000765 processed proteins & peptides Proteins 0.000 description 23
- 229920001184 polypeptide Polymers 0.000 description 22
- 102000004196 processed proteins & peptides Human genes 0.000 description 22
- OEYIOHPDSNJKLS-UHFFFAOYSA-N choline Chemical compound C[N+](C)(C)CCO OEYIOHPDSNJKLS-UHFFFAOYSA-N 0.000 description 8
- 229960001231 choline Drugs 0.000 description 8
- 239000002253 acid Substances 0.000 description 7
- 108091033319 polynucleotide Proteins 0.000 description 7
- 102000040430 polynucleotide Human genes 0.000 description 7
- 239000002157 polynucleotide Substances 0.000 description 7
- 108020004414 DNA Proteins 0.000 description 6
- 208000015181 infectious disease Diseases 0.000 description 6
- -1 Amino Chemical group 0.000 description 5
- 230000002163 immunogen Effects 0.000 description 4
- 238000000034 method Methods 0.000 description 4
- 208000035109 Pneumococcal Infections Diseases 0.000 description 3
- 108091026890 Coding region Proteins 0.000 description 2
- 108091033380 Coding strand Proteins 0.000 description 2
- 206010033078 Otitis media Diseases 0.000 description 2
- 108091016312 choline binding proteins Proteins 0.000 description 2
- 239000012634 fragment Substances 0.000 description 2
- 241000894006 Bacteria Species 0.000 description 1
- 101710164918 Choline-binding protein Proteins 0.000 description 1
- 108091035707 Consensus sequence Proteins 0.000 description 1
- ONIBWKKTOPOVIA-BYPYZUCNSA-N L-Proline Chemical compound OC(=O)[C@@H]1CCCN1 ONIBWKKTOPOVIA-BYPYZUCNSA-N 0.000 description 1
- 208000032923 Lobar pneumonia Diseases 0.000 description 1
- 201000009906 Meningitis Diseases 0.000 description 1
- 206010035664 Pneumonia Diseases 0.000 description 1
- ONIBWKKTOPOVIA-UHFFFAOYSA-N Proline Natural products OC(=O)C1CCCN1 ONIBWKKTOPOVIA-UHFFFAOYSA-N 0.000 description 1
- 206010040047 Sepsis Diseases 0.000 description 1
- 239000004480 active ingredient Substances 0.000 description 1
- 230000000692 anti-sense effect Effects 0.000 description 1
- 210000004899 c-terminal region Anatomy 0.000 description 1
- 230000000295 complement effect Effects 0.000 description 1
- 239000002299 complementary DNA Substances 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 239000003937 drug carrier Substances 0.000 description 1
- 230000002068 genetic effect Effects 0.000 description 1
- 230000002458 infectious effect Effects 0.000 description 1
- 238000002955 isolation Methods 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- YHHSONZFOIEMCP-UHFFFAOYSA-O phosphocholine Chemical compound C[N+](C)(C)CCOP(O)(O)=O YHHSONZFOIEMCP-UHFFFAOYSA-O 0.000 description 1
- 229950004354 phosphorylcholine Drugs 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US8087898P | 1998-04-07 | 1998-04-07 | |
| US60/080,878 | 1998-04-07 | ||
| US8574398P | 1998-05-15 | 1998-05-15 | |
| US60/085,743 | 1998-05-15 | ||
| PCT/US1999/007680 WO1999051266A2 (en) | 1998-04-07 | 1999-04-06 | Derivatives of pneumococcal choline binding proteins for vaccines |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2002510649A JP2002510649A (ja) | 2002-04-09 |
| JP2002510649A5 true JP2002510649A5 (https=) | 2006-06-01 |
Family
ID=26764078
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2000542036A Pending JP2002510649A (ja) | 1998-04-07 | 1999-04-06 | 肺炎球菌コリン結合タンパク質誘導体を利用するワクチンと抗体 |
Country Status (16)
| Country | Link |
|---|---|
| US (3) | US6503511B1 (https=) |
| EP (1) | EP1067962B1 (https=) |
| JP (1) | JP2002510649A (https=) |
| KR (2) | KR20060126844A (https=) |
| CN (1) | CN1200731C (https=) |
| AT (1) | ATE461709T1 (https=) |
| AU (1) | AU766455C (https=) |
| BR (1) | BR9909483A (https=) |
| CA (1) | CA2325340A1 (https=) |
| DE (1) | DE69942176D1 (https=) |
| ES (1) | ES2343492T3 (https=) |
| HU (1) | HUP0102617A3 (https=) |
| IL (2) | IL138798A0 (https=) |
| NO (1) | NO20004972L (https=) |
| NZ (2) | NZ530277A (https=) |
| WO (1) | WO1999051266A2 (https=) |
Families Citing this family (38)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7078042B2 (en) * | 1995-09-15 | 2006-07-18 | Uab Research Foundation | Pneumococcal surface protein C (PspC), epitopic regions and strain selection thereof, and uses therefor |
| IL138939A0 (en) * | 1998-04-07 | 2001-11-25 | St Jude Childrens Res Hospital | A polypeptide comprising the amino acid of an n-terminal choline binding protein a truncate, vaccine derived therefrom and uses thereof |
| DE69942176D1 (de) * | 1998-04-07 | 2010-05-06 | Medimmune Llc | Choline-bindende proteine derivate aus pneumokoken als impfstoff |
| US6858706B2 (en) | 1998-04-07 | 2005-02-22 | St. Jude Children's Research Hospital | Polypeptide comprising the amino acid of an N-terminal choline binding protein a truncate, vaccine derived therefrom and uses thereof |
| US20010016200A1 (en) | 1998-04-23 | 2001-08-23 | Briles David E. | Pneumococcal surface protein C (PspC), epitopic regions and strain selection thereof, and uses therefor |
| US7128918B1 (en) | 1998-12-23 | 2006-10-31 | Id Biomedical Corporation | Streptococcus antigens |
| ATE459373T1 (de) | 1999-03-19 | 2010-03-15 | Glaxosmithkline Biolog Sa | Impfstoff gegen kapsulare polysaccharide von streptococcus pneumoniae |
| GB9918319D0 (en) | 1999-08-03 | 1999-10-06 | Smithkline Beecham Biolog | Vaccine composition |
| US20040091495A1 (en) * | 2000-07-20 | 2004-05-13 | Lars Bjorck | Protein |
| GB0022742D0 (en) | 2000-09-15 | 2000-11-01 | Smithkline Beecham Biolog | Vaccine |
| US6674504B1 (en) | 2000-09-29 | 2004-01-06 | Kent Optronics, Inc. | Single layer multi-state ultra-fast cholesteric liquid crystal device and the fabrication methods thereof |
| US20060057160A1 (en) | 2002-08-02 | 2006-03-16 | Ralph Biemans | Vaccine composition |
| CA2503946C (en) | 2002-11-01 | 2016-08-16 | Glaxosmithkline Biologicals S.A. | Drying process |
| EP1667712B1 (en) | 2003-10-02 | 2010-07-21 | GlaxoSmithKline Biologicals S.A. | B. pertussis antigens and use thereof in vaccination |
| GB0505996D0 (en) | 2005-03-23 | 2005-04-27 | Glaxosmithkline Biolog Sa | Fermentation process |
| US8052971B2 (en) * | 2005-11-21 | 2011-11-08 | MG Biologics | Oral use of specific antibodies for intestinal health |
| TWI457133B (zh) | 2005-12-13 | 2014-10-21 | Glaxosmithkline Biolog Sa | 新穎組合物 |
| GB0607088D0 (en) | 2006-04-07 | 2006-05-17 | Glaxosmithkline Biolog Sa | Vaccine |
| KR101515078B1 (ko) | 2005-12-22 | 2015-04-24 | 글락소스미스클라인 바이오로지칼즈 에스.에이. | 백신 |
| MY150105A (en) | 2006-01-17 | 2013-11-29 | Forsgren Arne | A novel surface exposed haemophilus influenzae protein (protein e; pe) |
| WO2008039838A2 (en) | 2006-09-27 | 2008-04-03 | St. Jude Children's Research Hospital | Synthetic streptococcus pneumoniae vaccine |
| CA2690708A1 (en) | 2007-06-26 | 2008-12-31 | Glaxosmithkline Biologicals S.A. | Vaccine |
| JP5056490B2 (ja) * | 2008-03-10 | 2012-10-24 | 富士通株式会社 | 歪み補償係数更新装置および歪み補償増幅器 |
| ES2553113T3 (es) | 2008-04-16 | 2015-12-04 | Glaxosmithkline Biologicals S.A. | Vacuna |
| GB201003924D0 (en) | 2010-03-09 | 2010-04-21 | Glaxosmithkline Biolog Sa | Immunogenic composition |
| CA2792687A1 (en) | 2010-03-10 | 2011-09-15 | Glaxosmithkline Biologicals S.A. | Immunogenic composition |
| GB201015132D0 (en) | 2010-09-10 | 2010-10-27 | Univ Bristol | Vaccine composition |
| EP3351641A1 (en) | 2011-04-08 | 2018-07-25 | Tufts Medical Center, Inc. | Pepducin design and use |
| CN103533953A (zh) | 2011-05-17 | 2014-01-22 | 葛兰素史密丝克莱恩生物有限公司 | 针对肺炎链球菌的疫苗 |
| JP2014000016A (ja) * | 2012-06-15 | 2014-01-09 | National Agriculture & Food Research Organization | 豚丹毒菌の新規な抗原タンパク質、その遺伝子、及び組換えベクターとその利用 |
| GB201318170D0 (en) * | 2013-10-14 | 2013-11-27 | Univ Edinburgh | Proteins with Diagnostic and Therapeutic Uses |
| GB201518684D0 (en) | 2015-10-21 | 2015-12-02 | Glaxosmithkline Biolog Sa | Vaccine |
| WO2017083618A1 (en) | 2015-11-13 | 2017-05-18 | Oasis Pharmaceuticals, LLC | Protease-activated receptor-2 modulators |
| US10729763B2 (en) | 2017-06-10 | 2020-08-04 | Inventprise, Llc | Mixtures of polysaccharide-protein pegylated compounds |
| WO2018227177A1 (en) | 2017-06-10 | 2018-12-13 | Inventprise, Llc | Multivalent conjugate vaccines with bivalent or multivalent conjugate polysaccharides that provide improved immunogenicity and avidity |
| GB201711635D0 (en) | 2017-07-19 | 2017-08-30 | Glaxosmithkline Biologicals Sa | Immunogenic composition |
| GB201714478D0 (en) * | 2017-09-08 | 2017-10-25 | Univ Bristol | Sensor |
| WO2022035816A1 (en) | 2020-08-10 | 2022-02-17 | Inventprise, Llc | Multivalent pneumococcal glycoconjugate vaccines containing emerging serotype 24f |
Family Cites Families (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6231870B1 (en) * | 1995-06-02 | 2001-05-15 | Uab Research Foundation | Oral administration of pneumoccal antigens |
| US6042838A (en) * | 1991-02-15 | 2000-03-28 | Uab Research Foundation | immunogenic compositions for mucosal administration of pneumococcal surface protein A (PspA) |
| US6027734A (en) * | 1991-02-15 | 2000-02-22 | Uab Research Foundation | Mucosal administration of pneumococcal antigens |
| US6592876B1 (en) | 1993-04-20 | 2003-07-15 | Uab Research Foundation | Pneumococcal genes, portions thereof, expression products therefrom, and uses of such genes, portions and products |
| US5980909A (en) * | 1991-02-15 | 1999-11-09 | Uab Research Foundation | Epitopic regions of pneumococcal surface protein A |
| US6232116B1 (en) * | 1991-02-15 | 2001-05-15 | University Of Alabama At Birmingham Research Foundation | Oral administration of pneumococcal antigens |
| US7078042B2 (en) * | 1995-09-15 | 2006-07-18 | Uab Research Foundation | Pneumococcal surface protein C (PspC), epitopic regions and strain selection thereof, and uses therefor |
| US6245335B1 (en) * | 1996-05-01 | 2001-06-12 | The Rockefeller University | Choline binding proteins for anti-pneumococcal vaccines |
| ES2262177T3 (es) * | 1996-05-01 | 2006-11-16 | The Rockefeller University | Proteinas de union a colina para vacunas frente a neumococos. |
| JP4469026B2 (ja) * | 1996-10-31 | 2010-05-26 | ヒューマン ジノーム サイエンシーズ，インコーポレイテッド | Ｓｔｒｅｐｔｏｃｏｃｃｕｓ ｐｎｅｕｍｏｎｉａｅの抗原およびワクチン |
| JP2001508648A (ja) * | 1996-11-06 | 2001-07-03 | ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア | 腫瘍壊死因子レセプター放出酵素、酵素を含む組成物、およびその使用方法 |
| JP2002503087A (ja) * | 1996-11-12 | 2002-01-29 | リージェンツ オブ ザ ユニバーシティ オブ ミネソタ | ストレプトコッカス・ニューモニアのｃ３結合タンパク質 |
| DE19708537A1 (de) | 1997-03-03 | 1998-09-10 | Biotechnolog Forschung Gmbh | Neues Oberflächenprotein (SpsA-Protein) von Streptococcus pneumoniae etc. |
| US7018637B2 (en) * | 1998-02-23 | 2006-03-28 | Aventis Pasteur, Inc | Multi-oligosaccharide glycoconjugate bacterial meningitis vaccines |
| US6858706B2 (en) * | 1998-04-07 | 2005-02-22 | St. Jude Children's Research Hospital | Polypeptide comprising the amino acid of an N-terminal choline binding protein a truncate, vaccine derived therefrom and uses thereof |
| DE69942176D1 (de) * | 1998-04-07 | 2010-05-06 | Medimmune Llc | Choline-bindende proteine derivate aus pneumokoken als impfstoff |
| US6936252B2 (en) * | 1998-07-27 | 2005-08-30 | Microbial Technics Limited | Streptococcus pneumoniae proteins and nucleic acid molecules |
| EP1140157B1 (en) * | 1998-12-21 | 2009-02-18 | MedImmune, Inc. | Streptococcus pneumoniae proteins and immunogenic fragments for vaccines |
| JP2003530872A (ja) * | 2000-04-27 | 2003-10-21 | メディミューン，インコーポレイテッド | 免疫原肺炎連鎖球菌タンパク質とそのワクチン組成物 |
| EP2921924B1 (de) * | 2014-03-21 | 2018-09-19 | Asco Numatics GmbH | Vorrichtung zur Bereitstellung eines Fluids mit geregeltem Ausgangsdruck |
| US9741151B2 (en) * | 2015-04-14 | 2017-08-22 | International Business Machines Corporation | Mobile interactive comparison chart |
-
1999
- 1999-04-06 DE DE69942176T patent/DE69942176D1/de not_active Expired - Lifetime
- 1999-04-06 KR KR1020067023524A patent/KR20060126844A/ko not_active Ceased
- 1999-04-06 KR KR1020007011119A patent/KR100794394B1/ko not_active Expired - Fee Related
- 1999-04-06 AU AU33869/99A patent/AU766455C/en not_active Ceased
- 1999-04-06 NZ NZ530277A patent/NZ530277A/en unknown
- 1999-04-06 HU HU0102617A patent/HUP0102617A3/hu unknown
- 1999-04-06 ES ES99915326T patent/ES2343492T3/es not_active Expired - Lifetime
- 1999-04-06 NZ NZ507717A patent/NZ507717A/xx not_active Application Discontinuation
- 1999-04-06 CN CNB99807022XA patent/CN1200731C/zh not_active Expired - Fee Related
- 1999-04-06 WO PCT/US1999/007680 patent/WO1999051266A2/en not_active Ceased
- 1999-04-06 IL IL13879899A patent/IL138798A0/xx unknown
- 1999-04-06 EP EP99915326A patent/EP1067962B1/en not_active Expired - Lifetime
- 1999-04-06 AT AT99915326T patent/ATE461709T1/de not_active IP Right Cessation
- 1999-04-06 US US09/286,981 patent/US6503511B1/en not_active Expired - Lifetime
- 1999-04-06 BR BR9909483-5A patent/BR9909483A/pt not_active IP Right Cessation
- 1999-04-06 CA CA002325340A patent/CA2325340A1/en not_active Abandoned
- 1999-04-06 JP JP2000542036A patent/JP2002510649A/ja active Pending
-
2000
- 2000-09-29 IL IL138798A patent/IL138798A/en not_active IP Right Cessation
- 2000-10-03 NO NO20004972A patent/NO20004972L/no not_active Application Discontinuation
-
2002
- 2002-09-25 US US10/254,995 patent/US6863893B2/en not_active Expired - Fee Related
-
2005
- 2005-02-18 US US11/062,080 patent/US7435421B2/en not_active Expired - Fee Related
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