CN1200731C - 用作疫苗的肺炎球菌胆碱结合蛋白衍生物 - Google Patents

用作疫苗的肺炎球菌胆碱结合蛋白衍生物 Download PDF

Info

Publication number
CN1200731C
CN1200731C CNB99807022XA CN99807022A CN1200731C CN 1200731 C CN1200731 C CN 1200731C CN B99807022X A CNB99807022X A CN B99807022XA CN 99807022 A CN99807022 A CN 99807022A CN 1200731 C CN1200731 C CN 1200731C
Authority
CN
China
Prior art keywords
lys
glu
ala
thr
leu
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CNB99807022XA
Other languages
English (en)
Chinese (zh)
Other versions
CN1315870A (zh
Inventor
T·M·维泽曼
S·科尼格
L·S·约翰逊
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Immunomedics Inc
Original Assignee
Immunomedics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Immunomedics Inc filed Critical Immunomedics Inc
Publication of CN1315870A publication Critical patent/CN1315870A/zh
Application granted granted Critical
Publication of CN1200731C publication Critical patent/CN1200731C/zh
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Images

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/02—Bacterial antigens
    • A61K39/09—Lactobacillales, e.g. aerococcus, enterococcus, lactobacillus, lactococcus, streptococcus
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/315—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Streptococcus (G), e.g. Enterococci
    • C07K14/3156—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Streptococcus (G), e.g. Enterococci from Streptococcus pneumoniae (Pneumococcus)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Pulmonology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Saccharide Compounds (AREA)
CNB99807022XA 1998-04-07 1999-04-06 用作疫苗的肺炎球菌胆碱结合蛋白衍生物 Expired - Fee Related CN1200731C (zh)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US8087898P 1998-04-07 1998-04-07
US60/080,878 1998-04-07
US8574398P 1998-05-15 1998-05-15
US60/085,743 1998-05-15

Publications (2)

Publication Number Publication Date
CN1315870A CN1315870A (zh) 2001-10-03
CN1200731C true CN1200731C (zh) 2005-05-11

Family

ID=26764078

Family Applications (1)

Application Number Title Priority Date Filing Date
CNB99807022XA Expired - Fee Related CN1200731C (zh) 1998-04-07 1999-04-06 用作疫苗的肺炎球菌胆碱结合蛋白衍生物

Country Status (16)

Country Link
US (3) US6503511B1 (https=)
EP (1) EP1067962B1 (https=)
JP (1) JP2002510649A (https=)
KR (2) KR20060126844A (https=)
CN (1) CN1200731C (https=)
AT (1) ATE461709T1 (https=)
AU (1) AU766455C (https=)
BR (1) BR9909483A (https=)
CA (1) CA2325340A1 (https=)
DE (1) DE69942176D1 (https=)
ES (1) ES2343492T3 (https=)
HU (1) HUP0102617A3 (https=)
IL (2) IL138798A0 (https=)
NO (1) NO20004972L (https=)
NZ (2) NZ530277A (https=)
WO (1) WO1999051266A2 (https=)

Families Citing this family (38)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7078042B2 (en) * 1995-09-15 2006-07-18 Uab Research Foundation Pneumococcal surface protein C (PspC), epitopic regions and strain selection thereof, and uses therefor
IL138939A0 (en) * 1998-04-07 2001-11-25 St Jude Childrens Res Hospital A polypeptide comprising the amino acid of an n-terminal choline binding protein a truncate, vaccine derived therefrom and uses thereof
DE69942176D1 (de) * 1998-04-07 2010-05-06 Medimmune Llc Choline-bindende proteine derivate aus pneumokoken als impfstoff
US6858706B2 (en) 1998-04-07 2005-02-22 St. Jude Children's Research Hospital Polypeptide comprising the amino acid of an N-terminal choline binding protein a truncate, vaccine derived therefrom and uses thereof
US20010016200A1 (en) 1998-04-23 2001-08-23 Briles David E. Pneumococcal surface protein C (PspC), epitopic regions and strain selection thereof, and uses therefor
US7128918B1 (en) 1998-12-23 2006-10-31 Id Biomedical Corporation Streptococcus antigens
ATE459373T1 (de) 1999-03-19 2010-03-15 Glaxosmithkline Biolog Sa Impfstoff gegen kapsulare polysaccharide von streptococcus pneumoniae
GB9918319D0 (en) 1999-08-03 1999-10-06 Smithkline Beecham Biolog Vaccine composition
US20040091495A1 (en) * 2000-07-20 2004-05-13 Lars Bjorck Protein
GB0022742D0 (en) 2000-09-15 2000-11-01 Smithkline Beecham Biolog Vaccine
US6674504B1 (en) 2000-09-29 2004-01-06 Kent Optronics, Inc. Single layer multi-state ultra-fast cholesteric liquid crystal device and the fabrication methods thereof
US20060057160A1 (en) 2002-08-02 2006-03-16 Ralph Biemans Vaccine composition
CA2503946C (en) 2002-11-01 2016-08-16 Glaxosmithkline Biologicals S.A. Drying process
EP1667712B1 (en) 2003-10-02 2010-07-21 GlaxoSmithKline Biologicals S.A. B. pertussis antigens and use thereof in vaccination
GB0505996D0 (en) 2005-03-23 2005-04-27 Glaxosmithkline Biolog Sa Fermentation process
US8052971B2 (en) * 2005-11-21 2011-11-08 MG Biologics Oral use of specific antibodies for intestinal health
TWI457133B (zh) 2005-12-13 2014-10-21 Glaxosmithkline Biolog Sa 新穎組合物
GB0607088D0 (en) 2006-04-07 2006-05-17 Glaxosmithkline Biolog Sa Vaccine
KR101515078B1 (ko) 2005-12-22 2015-04-24 글락소스미스클라인 바이오로지칼즈 에스.에이. 백신
MY150105A (en) 2006-01-17 2013-11-29 Forsgren Arne A novel surface exposed haemophilus influenzae protein (protein e; pe)
WO2008039838A2 (en) 2006-09-27 2008-04-03 St. Jude Children's Research Hospital Synthetic streptococcus pneumoniae vaccine
CA2690708A1 (en) 2007-06-26 2008-12-31 Glaxosmithkline Biologicals S.A. Vaccine
JP5056490B2 (ja) * 2008-03-10 2012-10-24 富士通株式会社 歪み補償係数更新装置および歪み補償増幅器
ES2553113T3 (es) 2008-04-16 2015-12-04 Glaxosmithkline Biologicals S.A. Vacuna
GB201003924D0 (en) 2010-03-09 2010-04-21 Glaxosmithkline Biolog Sa Immunogenic composition
CA2792687A1 (en) 2010-03-10 2011-09-15 Glaxosmithkline Biologicals S.A. Immunogenic composition
GB201015132D0 (en) 2010-09-10 2010-10-27 Univ Bristol Vaccine composition
EP3351641A1 (en) 2011-04-08 2018-07-25 Tufts Medical Center, Inc. Pepducin design and use
CN103533953A (zh) 2011-05-17 2014-01-22 葛兰素史密丝克莱恩生物有限公司 针对肺炎链球菌的疫苗
JP2014000016A (ja) * 2012-06-15 2014-01-09 National Agriculture & Food Research Organization 豚丹毒菌の新規な抗原タンパク質、その遺伝子、及び組換えベクターとその利用
GB201318170D0 (en) * 2013-10-14 2013-11-27 Univ Edinburgh Proteins with Diagnostic and Therapeutic Uses
GB201518684D0 (en) 2015-10-21 2015-12-02 Glaxosmithkline Biolog Sa Vaccine
WO2017083618A1 (en) 2015-11-13 2017-05-18 Oasis Pharmaceuticals, LLC Protease-activated receptor-2 modulators
US10729763B2 (en) 2017-06-10 2020-08-04 Inventprise, Llc Mixtures of polysaccharide-protein pegylated compounds
WO2018227177A1 (en) 2017-06-10 2018-12-13 Inventprise, Llc Multivalent conjugate vaccines with bivalent or multivalent conjugate polysaccharides that provide improved immunogenicity and avidity
GB201711635D0 (en) 2017-07-19 2017-08-30 Glaxosmithkline Biologicals Sa Immunogenic composition
GB201714478D0 (en) * 2017-09-08 2017-10-25 Univ Bristol Sensor
WO2022035816A1 (en) 2020-08-10 2022-02-17 Inventprise, Llc Multivalent pneumococcal glycoconjugate vaccines containing emerging serotype 24f

Family Cites Families (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6231870B1 (en) * 1995-06-02 2001-05-15 Uab Research Foundation Oral administration of pneumoccal antigens
US6042838A (en) * 1991-02-15 2000-03-28 Uab Research Foundation immunogenic compositions for mucosal administration of pneumococcal surface protein A (PspA)
US6027734A (en) * 1991-02-15 2000-02-22 Uab Research Foundation Mucosal administration of pneumococcal antigens
US6592876B1 (en) 1993-04-20 2003-07-15 Uab Research Foundation Pneumococcal genes, portions thereof, expression products therefrom, and uses of such genes, portions and products
US5980909A (en) * 1991-02-15 1999-11-09 Uab Research Foundation Epitopic regions of pneumococcal surface protein A
US6232116B1 (en) * 1991-02-15 2001-05-15 University Of Alabama At Birmingham Research Foundation Oral administration of pneumococcal antigens
US7078042B2 (en) * 1995-09-15 2006-07-18 Uab Research Foundation Pneumococcal surface protein C (PspC), epitopic regions and strain selection thereof, and uses therefor
US6245335B1 (en) * 1996-05-01 2001-06-12 The Rockefeller University Choline binding proteins for anti-pneumococcal vaccines
ES2262177T3 (es) * 1996-05-01 2006-11-16 The Rockefeller University Proteinas de union a colina para vacunas frente a neumococos.
JP4469026B2 (ja) * 1996-10-31 2010-05-26 ヒューマン ジノーム サイエンシーズ，インコーポレイテッド Ｓｔｒｅｐｔｏｃｏｃｃｕｓ ｐｎｅｕｍｏｎｉａｅの抗原およびワクチン
JP2001508648A (ja) * 1996-11-06 2001-07-03 ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア 腫瘍壊死因子レセプター放出酵素、酵素を含む組成物、およびその使用方法
JP2002503087A (ja) * 1996-11-12 2002-01-29 リージェンツ オブ ザ ユニバーシティ オブ ミネソタ ストレプトコッカス・ニューモニアのｃ３結合タンパク質
DE19708537A1 (de) 1997-03-03 1998-09-10 Biotechnolog Forschung Gmbh Neues Oberflächenprotein (SpsA-Protein) von Streptococcus pneumoniae etc.
US7018637B2 (en) * 1998-02-23 2006-03-28 Aventis Pasteur, Inc Multi-oligosaccharide glycoconjugate bacterial meningitis vaccines
US6858706B2 (en) * 1998-04-07 2005-02-22 St. Jude Children's Research Hospital Polypeptide comprising the amino acid of an N-terminal choline binding protein a truncate, vaccine derived therefrom and uses thereof
DE69942176D1 (de) * 1998-04-07 2010-05-06 Medimmune Llc Choline-bindende proteine derivate aus pneumokoken als impfstoff
US6936252B2 (en) * 1998-07-27 2005-08-30 Microbial Technics Limited Streptococcus pneumoniae proteins and nucleic acid molecules
EP1140157B1 (en) * 1998-12-21 2009-02-18 MedImmune, Inc. Streptococcus pneumoniae proteins and immunogenic fragments for vaccines
JP2003530872A (ja) * 2000-04-27 2003-10-21 メディミューン，インコーポレイテッド 免疫原肺炎連鎖球菌タンパク質とそのワクチン組成物
EP2921924B1 (de) * 2014-03-21 2018-09-19 Asco Numatics GmbH Vorrichtung zur Bereitstellung eines Fluids mit geregeltem Ausgangsdruck
US9741151B2 (en) * 2015-04-14 2017-08-22 International Business Machines Corporation Mobile interactive comparison chart

Also Published As

Publication number Publication date
EP1067962B1 (en) 2010-03-24
AU766455C (en) 2004-12-02
CA2325340A1 (en) 1999-10-14
US20030138447A1 (en) 2003-07-24
AU3386999A (en) 1999-10-25
BR9909483A (pt) 2001-10-09
NZ507717A (en) 2004-02-27
HUP0102617A3 (en) 2006-04-28
NO20004972D0 (no) 2000-10-03
US7435421B2 (en) 2008-10-14
HUP0102617A2 (hu) 2001-11-28
CN1315870A (zh) 2001-10-03
WO1999051266A3 (en) 1999-12-09
NZ530277A (en) 2005-08-26
WO1999051266A2 (en) 1999-10-14
NO20004972L (no) 2000-12-05
JP2002510649A (ja) 2002-04-09
IL138798A0 (en) 2001-10-31
EP1067962A2 (en) 2001-01-17
IL138798A (en) 2008-11-03
US20050142145A1 (en) 2005-06-30
ES2343492T3 (es) 2010-08-02
KR20060126844A (ko) 2006-12-08
KR20010034752A (ko) 2001-04-25
ATE461709T1 (de) 2010-04-15
US6503511B1 (en) 2003-01-07
US6863893B2 (en) 2005-03-08
KR100794394B1 (ko) 2008-01-15
DE69942176D1 (de) 2010-05-06
AU766455B2 (en) 2003-10-16

Similar Documents

Publication Publication Date Title
CN1200731C (zh) 用作疫苗的肺炎球菌胆碱结合蛋白衍生物
CN1268745C (zh) B组链球菌抗原
CN1191362C (zh) 新颖的链球菌抗原
CN1201818C (zh) 疫苗
CN1449446A (zh) 链球菌抗原
CN1298848C (zh) 具有减弱的蛋白酶活性的嗜血杆菌Hin47类似物
CN1918176A (zh) 用于诱导针对金黄色葡萄球菌的保护性免疫反应的多肽
CN1556857A (zh) 呼吸道合胞病毒(rsv)g蛋白的新肽及其在疫苗中的应用
CN1711105A (zh) 治疗或预防肺炎球菌感染的组合物与方法
CN1680434A (zh) 肺炎链球菌抗原
CN1934240A (zh) 减毒的革兰氏阴性细菌
CN1211487C (zh) 链球菌毒素a突变体及其使用方法
CN1741818A (zh) 线虫多肽佐剂
CN1198918C (zh) 减毒的活胸膜肺炎放线杆菌
CN1191851C (zh) 包含胆碱结合蛋白an－末端截取物的氨基酸的多肽、由该多肽衍生的疫苗及其应用
CN1867588A (zh) 包含c4bp核心蛋白质和单体抗原的产品及其用途
CN1653084A (zh) 酶活性减少的非典型流感嗜血杆菌的p4蛋白突变体
CN1894272A (zh) 蛋白质表达
CN1629188A (zh) 日本血吸虫的特异性抗原及用途
CN1210401C (zh) 源自粘膜炎莫拉氏菌的化合物
CN1198931C (zh) 粘膜炎莫拉氏菌basb034多肽及应用
CN1899610A (zh) 幽门螺杆菌抗原重组疫苗
CN1631438A (zh) 人和易感动物0157菌基因工程多价亚单位疫苗及制备方法
CN1545552A (zh) 基因和蛋白质及它们的用途
CN1351661A (zh) 新化合物

Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
C14 Grant of patent or utility model
GR01 Patent grant
C19 Lapse of patent right due to non-payment of the annual fee
CF01 Termination of patent right due to non-payment of annual fee